RU93058351A - Замещенные 3-аминохинуклидины, фармацевтические композиции на его основе, способы лечения, способ получения, промежуточные соединения - Google Patents
Замещенные 3-аминохинуклидины, фармацевтические композиции на его основе, способы лечения, способ получения, промежуточные соединенияInfo
- Publication number
- RU93058351A RU93058351A RU93058351/04A RU93058351A RU93058351A RU 93058351 A RU93058351 A RU 93058351A RU 93058351/04 A RU93058351/04 A RU 93058351/04A RU 93058351 A RU93058351 A RU 93058351A RU 93058351 A RU93058351 A RU 93058351A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- aminochinuclidines
- substituted
- producing
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 200000000018 inflammatory disease Diseases 0.000 claims 2
- ADNPLDHMAVUMIW-CUZNLEPHSA-N (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-y Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 208000008665 Gastrointestinal Disease Diseases 0.000 claims 1
- 102100002996 TAC1 Human genes 0.000 claims 1
- 101700065588 TAC1 Proteins 0.000 claims 1
- 230000003042 antagnostic Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3/146826 | 1991-05-22 | ||
JP3/14826 | 1991-05-22 | ||
JP14682691 | 1991-05-22 | ||
PCT/US1992/004002 WO1992020676A1 (en) | 1991-05-22 | 1992-05-19 | Substituted 3-aminoquinuclidines |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93058351A true RU93058351A (ru) | 1996-12-27 |
RU2092486C1 RU2092486C1 (ru) | 1997-10-10 |
Family
ID=15416402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9293058351A RU2092486C1 (ru) | 1991-05-22 | 1992-05-19 | Замещенные 3-аминохинуклидины |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0585328B1 (ru) |
KR (1) | KR100246065B1 (ru) |
CN (1) | CN1041827C (ru) |
AT (1) | ATE211743T1 (ru) |
AU (1) | AU658898B2 (ru) |
BR (1) | BR9206044A (ru) |
CA (1) | CA2109415C (ru) |
CZ (1) | CZ247993A3 (ru) |
DE (2) | DE9290057U1 (ru) |
DK (1) | DK0585328T3 (ru) |
EG (1) | EG20218A (ru) |
ES (1) | ES2168260T3 (ru) |
FI (1) | FI935134A (ru) |
HU (1) | HUT65771A (ru) |
IE (1) | IE921662A1 (ru) |
IL (1) | IL101960A (ru) |
MX (1) | MX9202449A (ru) |
NO (1) | NO305173B1 (ru) |
NZ (2) | NZ272941A (ru) |
PL (4) | PL171921B1 (ru) |
PT (1) | PT100514B (ru) |
RU (1) | RU2092486C1 (ru) |
UA (1) | UA26401C2 (ru) |
WO (1) | WO1992020676A1 (ru) |
ZA (1) | ZA923773B (ru) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5138060A (en) * | 1991-01-03 | 1992-08-11 | Pfizer Inc. | Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines |
DE69213451T2 (de) * | 1991-06-20 | 1997-01-09 | Pfizer Inc., New York | Fluoralkoxybenzylaminoderivate stickstoffhaltiger heterocyclen |
JP2656702B2 (ja) * | 1992-03-23 | 1997-09-24 | ファイザー製薬株式会社 | ペプチド性キヌクリジン |
ES2164072T3 (es) * | 1992-08-19 | 2002-02-16 | Pfizer | Heterociclos no aromaticos que contienen nitrogeno sustituidos con bencilamino. |
JP2656699B2 (ja) * | 1992-10-21 | 1997-09-24 | ファイザー製薬株式会社 | 置換ベンジルアミノキヌクリジン |
JP2656700B2 (ja) * | 1992-10-28 | 1997-09-24 | ファイザー製薬株式会社 | 置換キヌクリジン誘導体 |
US5837711A (en) * | 1992-10-28 | 1998-11-17 | Pfizer Inc. | Substituted quinuclidines as substance P antagonists |
ES2147759T3 (es) * | 1992-12-10 | 2000-10-01 | Pfizer | Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p. |
JP2822274B2 (ja) * | 1993-05-19 | 1998-11-11 | ファイザー製薬株式会社 | P物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類 |
IL109646A0 (en) * | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
CA2167198C (en) * | 1993-07-15 | 1999-03-16 | Kunio Satake | Benzylaminoquinuclidines |
ATE265432T1 (de) * | 1993-09-17 | 2004-05-15 | Pfizer | 3-amino-5-carboxy-substituierte piperidine und 3- amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten |
US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
EP0653208A3 (en) * | 1993-11-17 | 1995-10-11 | Pfizer | Substance P antagonists for the treatment or prevention of sunburn. |
EP0659409A3 (en) * | 1993-11-23 | 1995-08-09 | Pfizer | Substance P antagonists for the inhibition of angiogenesis. |
EP0655246A1 (en) * | 1993-11-30 | 1995-05-31 | Pfizer Inc. | Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria |
FR2728166A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Composition topique contenant un antagoniste de substance p |
FR2728165A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene |
FR2728169A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales |
PE8798A1 (es) * | 1995-07-17 | 1998-03-02 | Pfizer | Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil] |
TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
FR2741262B1 (fr) | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
MX9706944A (es) * | 1996-09-12 | 1998-08-30 | Pfizer | Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p. |
NZ329807A (en) * | 1997-04-23 | 2000-07-28 | Pfizer | NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome |
CA2389306C (en) | 1999-11-03 | 2010-03-30 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
CA2415532C (en) | 2000-07-11 | 2010-05-11 | Albany Molecular Research, Inc. | Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof |
DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
US6861526B2 (en) | 2002-10-16 | 2005-03-01 | Pfizer Inc. | Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine |
MX2007000428A (es) | 2004-07-15 | 2008-03-05 | Amr Technology Inc | Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina. |
ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
MX2008000717A (es) | 2005-07-15 | 2008-03-18 | Amr Technology Inc | Tetrahidrobenzazepinas substituidas con arilo y heteroarilo y uso de las mismas para bloquear la reabsorcion de norepinefrina, dopamina, y serotonina. |
BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
EP2946778A1 (en) | 2006-09-22 | 2015-11-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
KR101591656B1 (ko) | 2007-01-10 | 2016-02-19 | 엠에스디 이탈리아 에스.알.엘. | 폴리(adp-리보오스) 폴리머라아제(parp) 억제제로서의 아미드 치환된 인다졸 |
EA200970706A1 (ru) | 2007-01-24 | 2010-02-26 | Глэксо Груп Лимитед | Новые фармацевтические композиции |
JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Msd株式会社 | インドールジオン誘導体 |
WO2009002495A1 (en) | 2007-06-27 | 2008-12-31 | Merck & Co., Inc. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
AU2009222122A1 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
EP2413932A4 (en) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | INHIBITORS OF AKT ACTIVITY |
US9034899B2 (en) | 2009-05-12 | 2015-05-19 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
CN102638982B (zh) | 2009-05-12 | 2015-07-08 | 百时美施贵宝公司 | (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途 |
DK2429296T3 (en) | 2009-05-12 | 2018-03-12 | Albany Molecular Res Inc | 7 - ([1,2,4,] TRIAZOLO [1,5, -A] PYRIDIN-6-YL) -4- (3,4-DICHLORPHENYL) -1,2,3,4- TETRAHYDROISOQUINOLINE AND USE thereof |
EP2488028B1 (en) | 2009-10-14 | 2020-08-19 | Merck Sharp & Dohme Corp. | Substituted piperidines that increase p53 activity and the uses thereof |
EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
WO2012018754A2 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
AU2011292261B2 (en) | 2010-08-17 | 2015-05-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
WO2012027236A1 (en) | 2010-08-23 | 2012-03-01 | Schering Corporation | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
ES2663009T3 (es) | 2010-10-29 | 2018-04-10 | Sirna Therapeutics, Inc. | Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
EP2699568A1 (en) | 2011-04-21 | 2014-02-26 | Piramal Enterprises Limited | A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
WO2013165816A2 (en) | 2012-05-02 | 2013-11-07 | Merck Sharp & Dohme Corp. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
WO2014052563A2 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
CA2892361A1 (en) | 2012-11-28 | 2014-06-05 | Merck Sharp & Dohme Corp. | Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels |
AU2013361694B2 (en) | 2012-12-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
-
1992
- 1992-05-19 HU HU9303307A patent/HUT65771A/hu unknown
- 1992-05-19 RU RU9293058351A patent/RU2092486C1/ru active
- 1992-05-19 AU AU19275/92A patent/AU658898B2/en not_active Ceased
- 1992-05-19 PL PL92311526A patent/PL171921B1/pl unknown
- 1992-05-19 CZ CS932479A patent/CZ247993A3/cs unknown
- 1992-05-19 PL PL92301418A patent/PL170513B1/pl unknown
- 1992-05-19 AT AT92911350T patent/ATE211743T1/de not_active IP Right Cessation
- 1992-05-19 DE DE9290057U patent/DE9290057U1/de not_active Expired - Lifetime
- 1992-05-19 PL PL92311527A patent/PL170525B1/pl unknown
- 1992-05-19 CA CA002109415A patent/CA2109415C/en not_active Expired - Fee Related
- 1992-05-19 DK DK92911350T patent/DK0585328T3/da active
- 1992-05-19 PL PL92311525A patent/PL172069B1/pl unknown
- 1992-05-19 ES ES92911350T patent/ES2168260T3/es not_active Expired - Lifetime
- 1992-05-19 BR BR9206044A patent/BR9206044A/pt not_active Application Discontinuation
- 1992-05-19 DE DE69232334T patent/DE69232334T2/de not_active Expired - Fee Related
- 1992-05-19 EP EP92911350A patent/EP0585328B1/en not_active Expired - Lifetime
- 1992-05-19 UA UA93003970A patent/UA26401C2/uk unknown
- 1992-05-19 WO PCT/US1992/004002 patent/WO1992020676A1/en active IP Right Grant
- 1992-05-21 IL IL10196092A patent/IL101960A/en not_active IP Right Cessation
- 1992-05-21 EG EG27092A patent/EG20218A/xx active
- 1992-05-22 PT PT100514A patent/PT100514B/pt active IP Right Grant
- 1992-05-22 MX MX9202449A patent/MX9202449A/es not_active IP Right Cessation
- 1992-05-22 NZ NZ272941A patent/NZ272941A/en unknown
- 1992-05-22 ZA ZA923773A patent/ZA923773B/xx unknown
- 1992-05-22 NZ NZ242880A patent/NZ242880A/en unknown
- 1992-05-22 CN CN92104860A patent/CN1041827C/zh not_active Expired - Fee Related
- 1992-07-01 IE IE166292A patent/IE921662A1/en not_active IP Right Cessation
-
1993
- 1993-11-19 NO NO934195A patent/NO305173B1/no not_active IP Right Cessation
- 1993-11-19 FI FI935134A patent/FI935134A/fi unknown
- 1993-11-20 KR KR1019930703532A patent/KR100246065B1/ko not_active IP Right Cessation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU93058351A (ru) | Замещенные 3-аминохинуклидины, фармацевтические композиции на его основе, способы лечения, способ получения, промежуточные соединения | |
RU93058555A (ru) | Производные хинуклидина, способ их получения, фармацевтическая композиция, способ лечения или профилактики | |
DE69232334D1 (de) | Substituierte 3-aminochinuclidine | |
RU92004593A (ru) | Производные гетероциклилметил-хромана в виде смеси изомеров или отдельных изомеров или их соли, способ их получения и лекарственное средство | |
RU93058531A (ru) | Фторалкоксибензиламинные производные азотсодержащих гетероциклов, фармацевтическая композиция, способ лечения | |
EA200100570A1 (ru) | Карбоновые кислоты и карбоновокислотные изостеры n-гетероциклических соединений | |
RU93048636A (ru) | 7-/замещенные/-8-/замещенные/-9-/замещенные амино/-6-диметил-6-дезокситетрациклины, промежуточные соединения, способы получения соединений, способ профилактики и лечения и фармацевтическая композиция | |
RU94013439A (ru) | Гетероциклические соединения, способ их получения, фармацевтическая композиция и способ лечения | |
MY130145A (en) | Quinuclidine derivative for treatment of inflammatory and gastrointestinal disorders. | |
EP0709375A3 (en) | Therapeutic heterocycles | |
EP0709376A3 (en) | Therapeutic compounds | |
ATE334668T1 (de) | Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen | |
RU93005168A (ru) | Индолиновые производные, способ их получения, промежуточные соединения синтеза, использование промежуточных соединений и фармацевтическая композиция | |
RU94011321A (ru) | Способ профилактики и лечения заболеваний кожи | |
RU94021365A (ru) | Производные метилпиперазиназепина, способ их получения, фармацевтическая композиция на их основе и использование производных в качестве фармацевтически активного вещества | |
RU93004901A (ru) | Хинуклидиновые производные, способ их получения, фармацевтическая композиция, способ лечения | |
RU93004708A (ru) | Производные замещенного пирролидина и их терапевтически приемлемые соли, способ их получения и фармацевтическая композиция | |
RU94013118A (ru) | Гетероциклические соединения и содержащие их фармацевтические соединения | |
RU2000114634A (ru) | Ингибиторы металлопротеаз | |
RU93005068A (ru) | Азотсодержащие гетероциклы, способ их получения, фармацевтическая композиция, способ лечения и профилактики, промежуточные продукты | |
RU93004721A (ru) | Сульфонамидные соединения, способ их получения и фармацевтическая композиция | |
RU92016532A (ru) | Бензохиназолиновые соединения, способ их получения, фармацевтическая композиция и способ лечения | |
RU93058599A (ru) | Новые диметиламинооксиалкандифосфоновые кислоты и их соли, способ их получения, содержащие их фармацевтические составы, применение | |
RU94019332A (ru) | 2-замещенные пергидро-1-h-пиридо/1,2-а/пиразины, способ их получения, фармацевтическая композиция и способ лечения | |
RU95116290A (ru) | Применение 5-морфолино-3-(4-хлорбензилиденамин)-2-оксазолидинона, фармацевтическая композиция на его основе, способ лечения |