IE81174B1 - Chiral 1,5-diiodo-2-methoxy or benyzloxy intermediates and process for their preparation - Google Patents

Chiral 1,5-diiodo-2-methoxy or benyzloxy intermediates and process for their preparation

Info

Publication number
IE81174B1
IE81174B1 IE454390A IE454390A IE81174B1 IE 81174 B1 IE81174 B1 IE 81174B1 IE 454390 A IE454390 A IE 454390A IE 454390 A IE454390 A IE 454390A IE 81174 B1 IE81174 B1 IE 81174B1
Authority
IE
Ireland
Prior art keywords
oxa
tlc
pentane
preparation
diiodo
Prior art date
Application number
IE454390A
Other languages
English (en)
Other versions
IE904543A1 (en
Inventor
Daniela Faiardi
Alberto Bargiotti
Maria Grandi
Antonino Suarato
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IE904543A1 publication Critical patent/IE904543A1/en
Publication of IE81174B1 publication Critical patent/IE81174B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
IE454390A 1989-12-19 1990-12-17 Chiral 1,5-diiodo-2-methoxy or benyzloxy intermediates and process for their preparation IE81174B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation

Publications (2)

Publication Number Publication Date
IE904543A1 IE904543A1 (en) 1991-06-19
IE81174B1 true IE81174B1 (en) 2000-06-14

Family

ID=26296395

Family Applications (1)

Application Number Title Priority Date Filing Date
IE454390A IE81174B1 (en) 1989-12-19 1990-12-17 Chiral 1,5-diiodo-2-methoxy or benyzloxy intermediates and process for their preparation

Country Status (28)

Country Link
EP (1) EP0434960B1 (enExample)
JP (1) JP3300342B2 (enExample)
KR (1) KR0183033B1 (enExample)
CN (2) CN1024922C (enExample)
AT (1) ATE143023T1 (enExample)
AU (1) AU636429B2 (enExample)
CA (1) CA2046857C (enExample)
CZ (1) CZ281949B6 (enExample)
DE (1) DE69028610T2 (enExample)
DK (1) DK0434960T3 (enExample)
ES (1) ES2094136T3 (enExample)
FI (1) FI97389C (enExample)
GR (1) GR3021557T3 (enExample)
HR (1) HRP921226B1 (enExample)
HU (2) HU209433B (enExample)
IE (1) IE81174B1 (enExample)
IL (3) IL111527A (enExample)
MY (1) MY119192A (enExample)
NO (2) NO175533C (enExample)
NZ (1) NZ243695A (enExample)
PT (1) PT96226B (enExample)
RU (1) RU2100366C1 (enExample)
SI (1) SI9012379B (enExample)
SK (1) SK621990A3 (enExample)
TW (1) TW208019B (enExample)
UA (1) UA27108A1 (enExample)
WO (1) WO1991009046A1 (enExample)
YU (1) YU48136B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
ES2274823T3 (es) * 1999-12-29 2007-06-01 Immunogen, Inc. Agentes cototoxicos que comprenden doxorrubicinas y daunorrubicinas y su utilizacion terapeutica.
CA2484761C (en) 2002-05-24 2010-11-09 Angiotech International Ag Compositions and methods for coating medical implants
JP2006515186A (ja) 2002-09-26 2006-05-25 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 血管周囲ラップ
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1605951A1 (en) * 2003-03-18 2005-12-21 Pharmacia Italia S.p.A. Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
EA200970116A1 (ru) * 2006-07-12 2009-08-28 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Кристаллический гидрохлорид неморубицина
AU2009235897B2 (en) * 2008-04-11 2012-04-12 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
ES2533710T3 (es) * 2010-12-02 2015-04-14 Nerviano Medical Sciences S.R.L. Proceso para la preparación de derivados de morfolinil antraciclina
US9828405B2 (en) 2013-04-29 2017-11-28 Nerviano Medical Sciences S.R.L. Morpholinyl anthracycline derivatives
EP3779446A1 (en) 2013-12-11 2021-02-17 University of Massachusetts Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)
WO2016071418A1 (en) 2014-11-05 2016-05-12 Nerviano Medical Sciences S.R.L. Functionalized morpholinyl anthracycline derivatives
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
FI913887A0 (fi) 1991-08-16
HUT59693A (en) 1992-06-29
HRP921226A2 (en) 1995-12-31
TW208019B (enExample) 1993-06-21
YU48136B (sh) 1997-05-28
NO175533C (no) 1994-10-26
HU208148B (en) 1993-08-30
AU6919491A (en) 1991-07-18
CN1053238A (zh) 1991-07-24
ATE143023T1 (de) 1996-10-15
UA27108A1 (uk) 2000-02-28
DE69028610T2 (de) 1997-02-06
PT96226B (pt) 1998-06-30
WO1991009046A1 (en) 1991-06-27
KR0183033B1 (ko) 1999-04-01
IL111527A0 (en) 1995-01-24
KR920701228A (ko) 1992-08-11
CN1039708C (zh) 1998-09-09
ES2094136T3 (es) 1997-01-16
IL111527A (en) 1998-02-22
SK278994B6 (sk) 1998-05-06
CN1024922C (zh) 1994-06-08
NO940831L (no) 1991-08-14
CZ621990A3 (en) 1997-01-15
SK621990A3 (en) 1998-05-06
MY119192A (en) 2005-04-30
HRP921226B1 (en) 1998-10-31
IL96643A0 (en) 1991-09-16
JP3300342B2 (ja) 2002-07-08
SI9012379B (sl) 2000-02-29
AU636429B2 (en) 1993-04-29
HUT60232A (en) 1992-08-28
CZ281949B6 (cs) 1997-04-16
HU9200656D0 (en) 1992-05-28
RU2100366C1 (ru) 1997-12-27
IE904543A1 (en) 1991-06-19
HU912994D0 (en) 1992-01-28
NO176911C (no) 1995-06-21
YU237990A (sh) 1993-05-28
CA2046857A1 (en) 1991-06-20
FI97389C (fi) 1996-12-10
DK0434960T3 (da) 1996-10-14
DE69028610D1 (de) 1996-10-24
NO940831D0 (no) 1994-03-09
JPH04503679A (ja) 1992-07-02
PT96226A (pt) 1991-09-30
EP0434960A1 (en) 1991-07-03
FI97389B (fi) 1996-08-30
NO913176D0 (no) 1991-08-14
NO175533B (no) 1994-07-18
NO176911B (no) 1995-03-13
SI9012379A (en) 1997-12-31
HU209433B (en) 1994-06-28
GR3021557T3 (en) 1997-02-28
NO913176L (no) 1991-08-14
EP0434960B1 (en) 1996-09-18
NZ243695A (en) 1993-06-25
IL96643A (en) 1995-01-24
CA2046857C (en) 2001-06-12
CN1079215A (zh) 1993-12-08

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