IE50621B1 - Laxative composition - Google Patents
Laxative compositionInfo
- Publication number
- IE50621B1 IE50621B1 IE74/81A IE7481A IE50621B1 IE 50621 B1 IE50621 B1 IE 50621B1 IE 74/81 A IE74/81 A IE 74/81A IE 7481 A IE7481 A IE 7481A IE 50621 B1 IE50621 B1 IE 50621B1
- Authority
- IE
- Ireland
- Prior art keywords
- weight
- parts
- psyllium
- ground
- laxative
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 230000002475 laxative effect Effects 0.000 title claims abstract description 43
- 239000008141 laxative Substances 0.000 title claims abstract description 38
- 244000090599 Plantago psyllium Species 0.000 claims abstract description 57
- 235000010451 Plantago psyllium Nutrition 0.000 claims abstract description 57
- 229940124513 senna glycoside Drugs 0.000 claims abstract description 51
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 43
- 235000006693 Cassia laevigata Nutrition 0.000 claims abstract description 41
- 241000522641 Senna Species 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 13
- 230000008961 swelling Effects 0.000 claims abstract description 13
- 239000011248 coating agent Substances 0.000 claims abstract description 4
- 238000000576 coating method Methods 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 28
- 239000010903 husk Substances 0.000 claims description 22
- 229930186851 sennoside Natural products 0.000 claims description 20
- 244000134552 Plantago ovata Species 0.000 claims description 16
- 235000003421 Plantago ovata Nutrition 0.000 claims description 16
- 239000009223 Psyllium Substances 0.000 claims description 16
- 229940070687 psyllium Drugs 0.000 claims description 16
- 229920001615 Tragacanth Polymers 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 10
- IPQVTOJGNYVQEO-KGFNBKMBSA-N sennoside A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1[C@@H]2[C@H]1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-KGFNBKMBSA-N 0.000 claims description 10
- 238000000227 grinding Methods 0.000 claims description 9
- 239000000305 astragalus gummifer gum Substances 0.000 claims description 7
- 241000416162 Astragalus gummifer Species 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 244000215068 Acacia senegal Species 0.000 claims description 5
- 229920000084 Gum arabic Polymers 0.000 claims description 5
- 239000000205 acacia gum Substances 0.000 claims description 5
- 235000010489 acacia gum Nutrition 0.000 claims description 5
- 239000000454 talc Substances 0.000 claims description 5
- 229910052623 talc Inorganic materials 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 241000209051 Saccharum Species 0.000 claims description 4
- 239000004407 iron oxides and hydroxides Substances 0.000 claims description 4
- 238000009826 distribution Methods 0.000 claims description 3
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- 238000001125 extrusion Methods 0.000 claims description 2
- 235000010487 tragacanth Nutrition 0.000 claims 1
- 239000000196 tragacanth Substances 0.000 claims 1
- 229940116362 tragacanth Drugs 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 31
- 239000000047 product Substances 0.000 description 29
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- 230000000694 effects Effects 0.000 description 13
- IPQVTOJGNYVQEO-UHFFFAOYSA-N 9-[2-carboxy-4-hydroxy-10-oxo-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9h-anthracen-9-yl]-4-hydroxy-10-oxo-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9h-anthracene-2-carboxylic acid Chemical class OC1C(O)C(O)C(CO)OC1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1C2C1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(OC3C(C(O)C(O)C(CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-UHFFFAOYSA-N 0.000 description 11
- 239000008188 pellet Substances 0.000 description 9
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- 239000008298 dragée Substances 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 4
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- 238000012453 sprague-dawley rat model Methods 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000007480 spreading Effects 0.000 description 3
- 238000003892 spreading Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 240000000467 Carum carvi Species 0.000 description 2
- 235000005747 Carum carvi Nutrition 0.000 description 2
- 229920000715 Mucilage Polymers 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000004872 arterial blood pressure Effects 0.000 description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
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- 238000006243 chemical reaction Methods 0.000 description 2
- 230000001989 choleretic effect Effects 0.000 description 2
- 230000007665 chronic toxicity Effects 0.000 description 2
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- 235000021316 daily nutritional intake Nutrition 0.000 description 2
- 238000011161 development Methods 0.000 description 2
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- 230000035619 diuresis Effects 0.000 description 2
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- 239000003814 drug Substances 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
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- 230000002349 favourable effect Effects 0.000 description 2
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- 206010020718 hyperplasia Diseases 0.000 description 2
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- 210000000265 leukocyte Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
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- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
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- 241000894006 Bacteria Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
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- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
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- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
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- 235000013681 dietary sucrose Nutrition 0.000 description 1
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- 230000013020 embryo development Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
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- 239000002198 insoluble material Substances 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000004220 muscle function Effects 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
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- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3001357A DE3001357C2 (de) | 1980-01-16 | 1980-01-16 | Granuliertes Abführmittel auf der Basis von Plantagosamen und Sennesfrüchten und Verfahren zur Herstellung desselben |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE810074L IE810074L (en) | 1981-07-16 |
| IE50621B1 true IE50621B1 (en) | 1986-05-28 |
Family
ID=6092153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE74/81A IE50621B1 (en) | 1980-01-16 | 1981-01-15 | Laxative composition |
Country Status (26)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4321263A (en) * | 1980-09-30 | 1982-03-23 | Rowell Laboratories, Inc. | Psyllium compositions |
| US5009916A (en) * | 1983-12-12 | 1991-04-23 | The Procter & Gamble Company | Psyllium mucilloid fiber food products |
| EP0144644B1 (en) * | 1983-12-12 | 1989-09-06 | THE PROCTER & GAMBLE COMPANY | Psyllium mucilloid products |
| US4950689A (en) * | 1987-03-31 | 1990-08-21 | Yang Robert K | Pectin delivery system |
| US5219570A (en) * | 1989-08-10 | 1993-06-15 | The Procter & Gamble Company | Agglomerated psyllium husk containing edible acid |
| ATE92328T1 (de) * | 1989-08-10 | 1993-08-15 | Procter & Gamble | Essbare saeure enthaltende agglomerierte psyllium- spelze. |
| US5126150A (en) * | 1990-10-01 | 1992-06-30 | The Procter & Gamble Company | Compositions containing psyllium |
| GB2272374B (en) * | 1992-11-13 | 1996-07-03 | Asta Medica Ag | Stable senna extract formulations |
| FR2723318B1 (fr) * | 1994-08-04 | 1999-09-03 | Chicouri Marcel | Nouvelles compositions laxatives et leur procede de preparation |
| US20050053676A1 (en) * | 2003-09-05 | 2005-03-10 | Madaus Ag | Powdered composition for use as laxative |
| ES2320827B1 (es) * | 2006-12-29 | 2010-03-03 | Madaus, S.A. | "composicion farmaceutica que contiene psyllium y senna". |
| DE202007007143U1 (de) | 2007-05-02 | 2008-06-12 | Madaus Gmbh | Neue pharmazeutische Zusammensetzung zur Verwendung als Laxativum |
| DE102007023397B4 (de) | 2007-05-02 | 2015-03-26 | Madaus Gmbh | Neue pharmazeutische Zusammensetzung zur Verwendung als Laxativum |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1847247A (en) * | 1931-02-14 | 1932-03-01 | Jones William Thomas | Mechanical laxative |
| DE1003916B (de) * | 1954-05-12 | 1957-03-07 | Westminster Lab Ltd | Verfahren zur Herstellung von Sennespraeparaten |
| GB829068A (en) * | 1958-04-09 | 1960-02-24 | Mundipharma Ag | Improvements in novel laxative agents |
| DE1103520B (de) * | 1959-08-12 | 1961-03-30 | Madaus & Co Dr | Verfahren zur Herstellung eines Abfuehrmittels |
| DE2629773C2 (de) * | 1976-07-02 | 1985-06-27 | Thiele, Henry, Dipl.-Ing. Dr., 7534 Birkenfeld | Produkt aus Kleie und Pektin |
-
1980
- 1980-01-16 DE DE3001357A patent/DE3001357C2/de not_active Expired
-
1981
- 1981-01-13 CA CA000368439A patent/CA1167769A/en not_active Expired
- 1981-01-14 FI FI810095A patent/FI75095C/fi not_active IP Right Cessation
- 1981-01-14 LU LU83058A patent/LU83058A1/de unknown
- 1981-01-14 GB GB8101047A patent/GB2067402B/en not_active Expired
- 1981-01-14 DK DK015181A patent/DK153774C/da not_active IP Right Cessation
- 1981-01-15 NO NO810133A patent/NO153594C/no unknown
- 1981-01-15 AU AU66241/81A patent/AU547152B2/en not_active Ceased
- 1981-01-15 CS CS81297A patent/CS227324B2/cs unknown
- 1981-01-15 GR GR63874A patent/GR73649B/el unknown
- 1981-01-15 NL NLAANVRAGE8100167,A patent/NL188452C/xx not_active IP Right Cessation
- 1981-01-15 PT PT72358A patent/PT72358B/pt not_active IP Right Cessation
- 1981-01-15 ZA ZA00810254A patent/ZA81254B/xx unknown
- 1981-01-15 AT AT0014681A patent/AT372280B/de not_active IP Right Cessation
- 1981-01-15 SE SE8100207A patent/SE454744B/sv not_active IP Right Cessation
- 1981-01-15 IE IE74/81A patent/IE50621B1/en not_active IP Right Cessation
- 1981-01-15 IT IT19154/81A patent/IT1135052B/it active
- 1981-01-15 CH CH247/81A patent/CH650403A5/de not_active IP Right Cessation
- 1981-01-16 SU SU813238931A patent/SU1145911A3/ru active
- 1981-01-16 MX MX819267U patent/MX7112E/es unknown
- 1981-01-16 YU YU95/81A patent/YU42551B/xx unknown
- 1981-01-16 NZ NZ196034A patent/NZ196034A/en unknown
- 1981-01-16 FR FR8100819A patent/FR2473311A1/fr active Granted
- 1981-01-16 BE BE0/203510A patent/BE887111A/fr not_active IP Right Cessation
- 1981-01-16 AR AR283983A patent/AR222269A1/es active
-
1984
- 1984-10-04 HK HK759/84A patent/HK75984A/xx not_active IP Right Cessation
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| MK9A | Patent expired |