IE49558B1 - Process for the preparation of 2,5-bis(2,2,2-trifluoro-ethoxy-n-(2-piperidylmethyl)benzamide - Google Patents

Process for the preparation of 2,5-bis(2,2,2-trifluoro-ethoxy-n-(2-piperidylmethyl)benzamide

Info

Publication number
IE49558B1
IE49558B1 IE549/80A IE54980A IE49558B1 IE 49558 B1 IE49558 B1 IE 49558B1 IE 549/80 A IE549/80 A IE 549/80A IE 54980 A IE54980 A IE 54980A IE 49558 B1 IE49558 B1 IE 49558B1
Authority
IE
Ireland
Prior art keywords
bis
trifluoroethoxy
hereinbefore described
reacting
product
Prior art date
Application number
IE549/80A
Other languages
English (en)
Other versions
IE800549L (en
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Priority to IE284/84A priority Critical patent/IE49559B1/en
Publication of IE800549L publication Critical patent/IE800549L/xx
Publication of IE49558B1 publication Critical patent/IE49558B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
IE549/80A 1979-03-19 1980-03-18 Process for the preparation of 2,5-bis(2,2,2-trifluoro-ethoxy-n-(2-piperidylmethyl)benzamide IE49558B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE284/84A IE49559B1 (en) 1979-03-19 1980-03-18 Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy)benzene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2133179A 1979-03-19 1979-03-19
US2133279A 1979-03-19 1979-03-19

Publications (2)

Publication Number Publication Date
IE800549L IE800549L (en) 1980-09-19
IE49558B1 true IE49558B1 (en) 1985-10-30

Family

ID=26694559

Family Applications (1)

Application Number Title Priority Date Filing Date
IE549/80A IE49558B1 (en) 1979-03-19 1980-03-18 Process for the preparation of 2,5-bis(2,2,2-trifluoro-ethoxy-n-(2-piperidylmethyl)benzamide

Country Status (14)

Country Link
JP (8) JPH01125342A (ja)
CA (1) CA1137486A (ja)
CH (1) CH643829A5 (ja)
DE (1) DE3010195A1 (ja)
DK (3) DK167062B1 (ja)
ES (1) ES8104227A1 (ja)
FR (7) FR2454438A1 (ja)
GB (2) GB2045760B (ja)
IE (1) IE49558B1 (ja)
IL (1) IL59623A (ja)
IT (1) IT1195262B (ja)
NL (1) NL191486C (ja)
PT (1) PT70967A (ja)
SE (5) SE447992B (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519975A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylcetones
FR2519979A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylsulfones
FR2519974A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede d'acylation d'halogeno ou trihalogenomethylbenzenes
FR2519980A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de sulfonylation d'halogeno ou trihalogenomethylbenzenes
FR2525588A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim Procede de preparation de phenylcetones a partir d'halogeno ou trihalogenomethylbenzenes et de composes aliphatiques ou aromatiques trihalogenomethyles
EP0175188A1 (de) * 1984-09-11 1986-03-26 Nihon Tokushu Noyaku Seizo K.K. Carbamoylimidazol-Derivate
US4675448A (en) * 1985-02-13 1987-06-23 Ethyl Corporation Chlorination process
FR2579594B1 (fr) * 1985-03-29 1987-06-05 Rhone Poulenc Spec Chim Procede de preparation de trifluoroethoxy ou trifluoroethylthiobenzenes
FR2579591B1 (fr) * 1985-03-29 1988-10-14 Rhone Poulenc Spec Chim Procede de preparation de derives pentafluoroethoxy et pentafluoroethylthiobenzeniques
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
DE3786037T2 (de) * 1986-04-25 1993-11-25 Abbott Lab Tracer zur Benutzung in immunologischen Fluoreszenz-Polarisationsverfahren zum Nachweis von Flecainid.
DE3644798A1 (de) * 1986-12-31 1988-07-14 Hoechst Ag Neue nitrohaloalkoxybenzole, verfahren zu ihrer herstellung und ihre verwendung
FR2640262B1 (fr) * 1988-12-14 1991-05-31 Rhone Poulenc Chimie Procede de preparation de cetones aryliques trifluoroethoxylees
IL120715A (en) 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
US6316627B1 (en) * 1997-04-21 2001-11-13 Fine Tech Ltd. Process for the preparation of flecainide
IL121288A (en) 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
US7196197B2 (en) 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
JP4894226B2 (ja) * 2005-10-31 2012-03-14 Ｄｉｃ株式会社 ハイドロキノン骨格を有する含フッ素液晶化合物の製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539642A (en) * 1967-07-19 1970-11-10 Geigy Chem Corp 2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) * 1969-10-30 1973-11-13 Hoffmann La Roche 4-hydroxy-isoquinolines and processes for their preparation
US3655728A (en) 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3967949A (en) * 1973-06-18 1976-07-06 Eli Lilly And Company Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US4013670A (en) * 1974-04-01 1977-03-22 Riker Laboratories, Inc. Derivatives of pyrrolidine and piperidine
US4005209A (en) * 1974-04-01 1977-01-25 Riker Laboratories, Inc. Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
US3900481A (en) 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
IL49803A (en) * 1975-06-28 1979-11-30 Fisons Ltd Preparation of pyrogallol
DE2616478C2 (de) * 1976-04-14 1986-05-22 Brickl, Rolf, Dr., 7951 Warthausen Fluoracylresorcine enthaltende Arzneimittel, Biocide und Kosmetika
JPS6023656B2 (ja) * 1976-09-02 1985-06-08 川研フアインケミカル株式会社 アルコキシ芳香族化合物の製造方法
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine

Also Published As

Publication number Publication date
JPH0149695B2 (ja) 1989-10-25
FR2468569B1 (ja) 1983-03-11
IL59623A0 (en) 1980-06-30
ES489629A0 (es) 1981-04-01
NL191486B (nl) 1995-04-03
JPH01125343A (ja) 1989-05-17
GB2097000A (en) 1982-10-27
DK79891A (da) 1991-04-30
DK164857B (da) 1992-08-31
FR2468570B1 (ja) 1983-03-11
SE8401555L (sv) 1984-03-21
JPH022870B2 (ja) 1990-01-19
SE8401555D0 (sv) 1984-03-21
SE8901532D0 (sv) 1989-04-27
SE8901533L (sv) 1989-04-27
DK79891D0 (da) 1991-04-30
FR2468576A1 (fr) 1981-05-08
FR2468576B1 (ja) 1983-01-21
DK122290A (da) 1990-05-17
FR2468590B1 (ja) 1983-09-23
DE3010195A1 (de) 1980-10-02
JPH01125342A (ja) 1989-05-17
SE447993B (sv) 1987-01-12
FR2468570A1 (fr) 1981-05-08
SE8401554L (sv) 1984-03-21
DK167062B1 (da) 1993-08-23
JPH0251906B2 (ja) 1990-11-08
SE447992B (sv) 1987-01-12
JPH01104043A (ja) 1989-04-21
DE3010195C2 (ja) 1990-10-25
JPH01125339A (ja) 1989-05-17
SE463260B (sv) 1990-10-29
IE800549L (en) 1980-09-19
CA1137486A (en) 1982-12-14
IT8020746A0 (it) 1980-03-18
FR2454438A1 (fr) 1980-11-14
FR2468590A1 (fr) 1981-05-08
NL8001551A (nl) 1980-09-23
FR2468591A1 (fr) 1981-05-08
IT1195262B (it) 1988-10-12
ES8104227A1 (es) 1981-04-01
SE463419B (sv) 1990-11-19
GB2097000B (en) 1983-11-30
SE8401554D0 (sv) 1984-03-21
FR2468571B1 (ja) 1983-03-11
FR2468571A1 (fr) 1981-05-08
NL191486C (nl) 1995-08-04
DK122290D0 (da) 1990-05-17
SE8901532L (sv) 1989-04-27
JPH01125344A (ja) 1989-05-17
JPH01104045A (ja) 1989-04-21
FR2454438B1 (ja) 1982-07-23
DK112180A (da) 1980-09-20
JPH0251907B2 (ja) 1990-11-08
SE8002003L (sv) 1980-09-20
PT70967A (en) 1980-04-01
SE8901533D0 (sv) 1989-04-27
JPH0339498B2 (ja) 1991-06-14
GB2045760B (en) 1983-05-11
JPH022869B2 (ja) 1990-01-19
JPH0372212B2 (ja) 1991-11-18
JPH01125341A (ja) 1989-05-17
FR2468569A1 (fr) 1981-05-08
DK164857C (da) 1993-01-18
IL59623A (en) 1983-07-31
CH643829A5 (de) 1984-06-29
JPH01104044A (ja) 1989-04-21
FR2468591B1 (ja) 1983-07-22
GB2045760A (en) 1980-11-05
SE463418B (sv) 1990-11-19
JPH0251908B2 (ja) 1990-11-08

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