IT8020746A0 - Processo per la preparazione di2,5-bis (2, 2,2-trifluoroetossi)-n-(2-piperidilme til)benzamide. - Google Patents

Processo per la preparazione di2,5-bis (2, 2,2-trifluoroetossi)-n-(2-piperidilme til)benzamide.

Info

Publication number
IT8020746A0
IT8020746A0 IT8020746A IT2074680A IT8020746A0 IT 8020746 A0 IT8020746 A0 IT 8020746A0 IT 8020746 A IT8020746 A IT 8020746A IT 2074680 A IT2074680 A IT 2074680A IT 8020746 A0 IT8020746 A0 IT 8020746A0
Authority
IT
Italy
Prior art keywords
piperidilme
trifluoroethoxy
til
benzamide
bis
Prior art date
Application number
IT8020746A
Other languages
English (en)
Other versions
IT1195262B (it
Inventor
Leir Charles Martin
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of IT8020746A0 publication Critical patent/IT8020746A0/it
Application granted granted Critical
Publication of IT1195262B publication Critical patent/IT1195262B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT20746/80A 1979-03-19 1980-03-18 Processo per la preparazione di 2,5-bis (2,2,2-trifluroetossi)-n-(2-piperidilmetil)benzamide IT1195262B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2133279A 1979-03-19 1979-03-19
US2133179A 1979-03-19 1979-03-19

Publications (2)

Publication Number Publication Date
IT8020746A0 true IT8020746A0 (it) 1980-03-18
IT1195262B IT1195262B (it) 1988-10-12

Family

ID=26694559

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20746/80A IT1195262B (it) 1979-03-19 1980-03-18 Processo per la preparazione di 2,5-bis (2,2,2-trifluroetossi)-n-(2-piperidilmetil)benzamide

Country Status (14)

Country Link
JP (8) JPH01104044A (it)
CA (1) CA1137486A (it)
CH (1) CH643829A5 (it)
DE (1) DE3010195A1 (it)
DK (3) DK167062B1 (it)
ES (1) ES8104227A1 (it)
FR (7) FR2454438A1 (it)
GB (2) GB2045760B (it)
IE (1) IE49558B1 (it)
IL (1) IL59623A (it)
IT (1) IT1195262B (it)
NL (1) NL191486C (it)
PT (1) PT70967A (it)
SE (5) SE447992B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519980A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de sulfonylation d'halogeno ou trihalogenomethylbenzenes
FR2519974A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede d'acylation d'halogeno ou trihalogenomethylbenzenes
FR2519979A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylsulfones
FR2519975A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylcetones
FR2525588A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim Procede de preparation de phenylcetones a partir d'halogeno ou trihalogenomethylbenzenes et de composes aliphatiques ou aromatiques trihalogenomethyles
EP0175188A1 (de) * 1984-09-11 1986-03-26 Nihon Tokushu Noyaku Seizo K.K. Carbamoylimidazol-Derivate
US4675448A (en) * 1985-02-13 1987-06-23 Ethyl Corporation Chlorination process
FR2579591B1 (fr) * 1985-03-29 1988-10-14 Rhone Poulenc Spec Chim Procede de preparation de derives pentafluoroethoxy et pentafluoroethylthiobenzeniques
FR2579594B1 (fr) * 1985-03-29 1987-06-05 Rhone Poulenc Spec Chim Procede de preparation de trifluoroethoxy ou trifluoroethylthiobenzenes
EP0242847B1 (en) * 1986-04-25 1993-06-02 Abbott Laboratories Tracers for use in flecainide fluorescence polarization immunoassay
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
DE3644798A1 (de) * 1986-12-31 1988-07-14 Hoechst Ag Neue nitrohaloalkoxybenzole, verfahren zu ihrer herstellung und ihre verwendung
FR2640262B1 (fr) * 1988-12-14 1991-05-31 Rhone Poulenc Chimie Procede de preparation de cetones aryliques trifluoroethoxylees
IL120715A (en) * 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
IL121288A (en) 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
US6316627B1 (en) 1997-04-21 2001-11-13 Fine Tech Ltd. Process for the preparation of flecainide
US7196197B2 (en) 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
JP4894226B2 (ja) * 2005-10-31 2012-03-14 Ｄｉｃ株式会社 ハイドロキノン骨格を有する含フッ素液晶化合物の製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539642A (en) * 1967-07-19 1970-11-10 Geigy Chem Corp 2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) * 1969-10-30 1973-11-13 Hoffmann La Roche 4-hydroxy-isoquinolines and processes for their preparation
US3655728A (en) 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3967949A (en) * 1973-06-18 1976-07-06 Eli Lilly And Company Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US4013670A (en) * 1974-04-01 1977-03-22 Riker Laboratories, Inc. Derivatives of pyrrolidine and piperidine
US4005209A (en) * 1974-04-01 1977-01-25 Riker Laboratories, Inc. Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
US3900481A (en) 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
IL49803A (en) * 1975-06-28 1979-11-30 Fisons Ltd Preparation of pyrogallol
DE2616478C2 (de) * 1976-04-14 1986-05-22 Brickl, Rolf, Dr., 7951 Warthausen Fluoracylresorcine enthaltende Arzneimittel, Biocide und Kosmetika
JPS6023656B2 (ja) * 1976-09-02 1985-06-08 川研フアインケミカル株式会社 アルコキシ芳香族化合物の製造方法
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea

Also Published As

Publication number Publication date
ES489629A0 (es) 1981-04-01
SE8901533D0 (sv) 1989-04-27
JPH01104045A (ja) 1989-04-21
SE8901532D0 (sv) 1989-04-27
DK122290D0 (da) 1990-05-17
SE8901532L (sv) 1989-04-27
JPH01125342A (ja) 1989-05-17
FR2468571B1 (it) 1983-03-11
IE800549L (en) 1980-09-19
PT70967A (en) 1980-04-01
JPH0251908B2 (it) 1990-11-08
FR2468591B1 (it) 1983-07-22
SE8401555L (sv) 1984-03-21
CH643829A5 (de) 1984-06-29
NL8001551A (nl) 1980-09-23
SE8401555D0 (sv) 1984-03-21
DK112180A (da) 1980-09-20
DE3010195A1 (de) 1980-10-02
SE447992B (sv) 1987-01-12
JPH0251906B2 (it) 1990-11-08
FR2468570A1 (fr) 1981-05-08
ES8104227A1 (es) 1981-04-01
CA1137486A (en) 1982-12-14
DK79891D0 (da) 1991-04-30
DK164857B (da) 1992-08-31
SE8401554L (sv) 1984-03-21
FR2468569B1 (it) 1983-03-11
IL59623A (en) 1983-07-31
SE463418B (sv) 1990-11-19
FR2468590A1 (fr) 1981-05-08
JPH0251907B2 (it) 1990-11-08
JPH01104044A (ja) 1989-04-21
GB2045760B (en) 1983-05-11
JPH022870B2 (it) 1990-01-19
NL191486B (nl) 1995-04-03
DK79891A (da) 1991-04-30
FR2454438A1 (fr) 1980-11-14
GB2045760A (en) 1980-11-05
DK167062B1 (da) 1993-08-23
NL191486C (nl) 1995-08-04
JPH0339498B2 (it) 1991-06-14
FR2468570B1 (it) 1983-03-11
SE463419B (sv) 1990-11-19
FR2468576B1 (it) 1983-01-21
JPH01125339A (ja) 1989-05-17
SE8401554D0 (sv) 1984-03-21
FR2468571A1 (fr) 1981-05-08
JPH022869B2 (it) 1990-01-19
JPH0149695B2 (it) 1989-10-25
JPH01125344A (ja) 1989-05-17
DE3010195C2 (it) 1990-10-25
IE49558B1 (en) 1985-10-30
DK122290A (da) 1990-05-17
JPH01125341A (ja) 1989-05-17
GB2097000A (en) 1982-10-27
FR2468576A1 (fr) 1981-05-08
IT1195262B (it) 1988-10-12
FR2454438B1 (it) 1982-07-23
DK164857C (da) 1993-01-18
JPH01125343A (ja) 1989-05-17
GB2097000B (en) 1983-11-30
JPH01104043A (ja) 1989-04-21
JPH0372212B2 (it) 1991-11-18
FR2468591A1 (fr) 1981-05-08
FR2468590B1 (it) 1983-09-23
FR2468569A1 (fr) 1981-05-08
SE463260B (sv) 1990-10-29
SE8002003L (sv) 1980-09-20
SE8901533L (sv) 1989-04-27
IL59623A0 (en) 1980-06-30
SE447993B (sv) 1987-01-12

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Legal Events

Date Code Title Description
ITCP Complementary protection certificate

Free format text: CCP 161

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 161, 19920424; RIKER LABORATORIES, INC.

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19980327