HUP9904333A2 - D-vitamin-analógok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
D-vitamin-analógok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9904333A2 HUP9904333A2 HU9904333A HUP9904333A HUP9904333A2 HU P9904333 A2 HUP9904333 A2 HU P9904333A2 HU 9904333 A HU9904333 A HU 9904333A HU P9904333 A HUP9904333 A HU P9904333A HU P9904333 A2 HUP9904333 A2 HU P9904333A2
- Authority
- HU
- Hungary
- Prior art keywords
- ring
- carbon
- hydrogen atom
- compounds
- carbon atoms
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940046008 vitamin d Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical group C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-IGMARMGPSA-N Protium Chemical compound [1H] YZCKVEUIGOORGS-IGMARMGPSA-N 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- -1 carbon atom hydrocarbon Chemical class 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
A találmány tárgya (I) általánős képletű vegyületek -, ahől X jelentése hidrőgénatőm vagy hidrőxilcsőpőrt; R1 és R2 lehet azőnős vagy különböző, és lehet hidrőgénatőm vagy 1-5szénatőmős szénhirőgén-csőpőrt; vagy R1 és R2 együtt a szénatőmmal, amely az őxigéncsőpőrtőt hőrdőzza, 3-8szénatőmős karbőciklűsős gyűrűt képezhet; Q jelentése metilén-, etilén-, tri- vagy tetrametilén-csőpőrt és adőttesetben őxicsőpőrttal vagy -OR3 csőpőrttal lehet helyettesítve, ahőlR3 hidrőgénatőm, metil- vagy etilcsőpőrt; Y jelentése vegyértékvőnal vagy 1-2 szénatőmős hidrőkarbilén-csőpőrt;és R1, R2 és/vagy Y egy vagy több szénatőmja szűbsztitűálva lehet adőttesetben egy, vagy több flűőratőmmal vagy hidrőxilcsőpőrt. A vegyületekgyűlladásgátló és imműnmődűláló hatást, valamint sejtdifferenciálódástelőidéző és nemkívánatős sejtbűrjánzást gátló hatást műtatnak. (I) ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9622590.9A GB9622590D0 (en) | 1996-10-30 | 1996-10-30 | Chemical compounds |
| PCT/DK1997/000472 WO1998018759A1 (en) | 1996-10-30 | 1997-10-27 | Vitamin d analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9904333A2 true HUP9904333A2 (hu) | 2000-06-28 |
| HUP9904333A3 HUP9904333A3 (en) | 2001-06-28 |
Family
ID=10802170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904333A HUP9904333A3 (en) | 1996-10-30 | 1997-10-27 | Vitamin d analogues, process for their production and medicaments containing of them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6310226B1 (hu) |
| EP (1) | EP0937038B1 (hu) |
| JP (1) | JP3907010B2 (hu) |
| KR (1) | KR100526644B1 (hu) |
| CN (1) | CN1107669C (hu) |
| AT (1) | ATE216361T1 (hu) |
| AU (1) | AU722659B2 (hu) |
| CA (1) | CA2266479C (hu) |
| CZ (1) | CZ290933B6 (hu) |
| DE (1) | DE69712086T2 (hu) |
| DK (1) | DK0937038T3 (hu) |
| ES (1) | ES2173425T3 (hu) |
| GB (1) | GB9622590D0 (hu) |
| HK (1) | HK1022298A1 (hu) |
| HU (1) | HUP9904333A3 (hu) |
| NZ (1) | NZ334328A (hu) |
| PL (1) | PL192660B1 (hu) |
| PT (1) | PT937038E (hu) |
| RO (1) | RO120338B1 (hu) |
| RU (1) | RU2183622C2 (hu) |
| WO (1) | WO1998018759A1 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2206981T3 (es) * | 1997-07-17 | 2004-05-16 | F.Hoffmann-La Roche Ag | Dihomo-seco-colestanos con dos enlaces insaturados en la cadena lateral. |
| AU2003291810A1 (en) * | 2002-11-18 | 2004-06-15 | Teva Pharmaceutical Industries Ltd. | A crystallization method for purification of calcipotriene |
| RU2380359C2 (ru) * | 2004-03-18 | 2010-01-27 | Лео Фарма А/С | Стереоселективный синтез аналогов витамина д |
| US20080293647A1 (en) | 2004-11-12 | 2008-11-27 | Luciano Adorini | Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer |
| WO2006113990A2 (en) * | 2005-04-25 | 2006-11-02 | Cytochroma Inc. | LOW-CALCEMIC 16,23-DIENE 25-OXIME ANALOGS OF 1α ,25-DIHYDROXY VITAMIN D3 |
| US20080051380A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| CA2838089A1 (en) | 2006-08-25 | 2008-02-28 | Cougar Biotechnology, Inc. | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| EP2056791A2 (en) * | 2006-08-29 | 2009-05-13 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical compositions including vitamin d and corticosteroid |
| BRPI1007415A2 (pt) | 2009-01-27 | 2016-02-16 | Berg Biosystems Llc | vitamina d3 e análogos da mesma para aliviar os efeitos colaterais associados com quimioterapia |
| WO2011002756A2 (en) * | 2009-07-01 | 2011-01-06 | Vitamin Derivatives, Inc. | Vitamin d compounds and methods for preparing same |
| CA2770683C (en) | 2009-08-14 | 2018-09-04 | Berg Biosystems, Llc | Vitamin d3 and analogs thereof for treating alopecia |
| SG11201509715UA (en) | 2013-05-29 | 2015-12-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| MX2019001224A (es) | 2016-07-29 | 2019-06-03 | Janssen Pharmaceutica Nv | Metodos para tratar el cancer de prostata. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
| US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
| GB9017890D0 (en) | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| GB9206648D0 (en) * | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9223061D0 (en) * | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| US5449668A (en) | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| JP3228488B2 (ja) * | 1993-12-24 | 2001-11-12 | 株式会社クラレ | ２０−エピステロイド誘導体およびその製造方法 |
| JPH0888281A (ja) * | 1994-09-19 | 1996-04-02 | Fujitsu Ltd | 半導体装置 |
| CA2175881A1 (en) * | 1995-05-09 | 1996-11-10 | Andrzej Kutner | Vitamin d compounds and methods of preparing these compounds |
-
1996
- 1996-10-30 GB GBGB9622590.9A patent/GB9622590D0/en active Pending
-
1997
- 1997-10-27 PT PT97910261T patent/PT937038E/pt unknown
- 1997-10-27 WO PCT/DK1997/000472 patent/WO1998018759A1/en active IP Right Grant
- 1997-10-27 CN CN97198407A patent/CN1107669C/zh not_active Expired - Lifetime
- 1997-10-27 KR KR10-1999-7002315A patent/KR100526644B1/ko not_active IP Right Cessation
- 1997-10-27 PL PL333068A patent/PL192660B1/pl unknown
- 1997-10-27 EP EP97910261A patent/EP0937038B1/en not_active Expired - Lifetime
- 1997-10-27 CA CA002266479A patent/CA2266479C/en not_active Expired - Lifetime
- 1997-10-27 NZ NZ334328A patent/NZ334328A/xx not_active IP Right Cessation
- 1997-10-27 ES ES97910261T patent/ES2173425T3/es not_active Expired - Lifetime
- 1997-10-27 CZ CZ19991358A patent/CZ290933B6/cs not_active IP Right Cessation
- 1997-10-27 JP JP51993198A patent/JP3907010B2/ja not_active Expired - Lifetime
- 1997-10-27 AU AU47717/97A patent/AU722659B2/en not_active Expired
- 1997-10-27 US US09/297,387 patent/US6310226B1/en not_active Expired - Lifetime
- 1997-10-27 DE DE69712086T patent/DE69712086T2/de not_active Expired - Lifetime
- 1997-10-27 RO RO99-00325A patent/RO120338B1/ro unknown
- 1997-10-27 RU RU99111777/04A patent/RU2183622C2/ru active
- 1997-10-27 DK DK97910261T patent/DK0937038T3/da active
- 1997-10-27 AT AT97910261T patent/ATE216361T1/de active
- 1997-10-27 HU HU9904333A patent/HUP9904333A3/hu unknown
-
2000
- 2000-02-29 HK HK00101222A patent/HK1022298A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL192660B1 (pl) | 2006-11-30 |
| AU4771797A (en) | 1998-05-22 |
| ES2173425T3 (es) | 2002-10-16 |
| RO120338B1 (ro) | 2005-12-30 |
| DE69712086T2 (de) | 2002-11-14 |
| WO1998018759A1 (en) | 1998-05-07 |
| PL333068A1 (en) | 1999-11-08 |
| CA2266479A1 (en) | 1998-05-07 |
| CN1107669C (zh) | 2003-05-07 |
| KR100526644B1 (ko) | 2005-11-08 |
| US6310226B1 (en) | 2001-10-30 |
| RU2183622C2 (ru) | 2002-06-20 |
| EP0937038A1 (en) | 1999-08-25 |
| GB9622590D0 (en) | 1997-01-08 |
| ATE216361T1 (de) | 2002-05-15 |
| HK1022298A1 (en) | 2000-08-04 |
| AU722659B2 (en) | 2000-08-10 |
| PT937038E (pt) | 2002-09-30 |
| DK0937038T3 (da) | 2002-07-15 |
| CN1232448A (zh) | 1999-10-20 |
| NZ334328A (en) | 2000-09-29 |
| CZ135899A3 (cs) | 1999-07-14 |
| CA2266479C (en) | 2008-09-23 |
| CZ290933B6 (cs) | 2002-11-13 |
| JP2001503403A (ja) | 2001-03-13 |
| DE69712086D1 (de) | 2002-05-23 |
| HUP9904333A3 (en) | 2001-06-28 |
| EP0937038B1 (en) | 2002-04-17 |
| KR20000036233A (ko) | 2000-06-26 |
| JP3907010B2 (ja) | 2007-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |