HUP9603607A2 - Tiazolidinszármazékok felhasználása osteoporosis kezelésére és megelőzésére alkalmas gyógyszerkészítmény előállítására - Google Patents
Tiazolidinszármazékok felhasználása osteoporosis kezelésére és megelőzésére alkalmas gyógyszerkészítmény előállításáraInfo
- Publication number
- HUP9603607A2 HUP9603607A2 HU9603607A HUP9603607A HUP9603607A2 HU P9603607 A2 HUP9603607 A2 HU P9603607A2 HU 9603607 A HU9603607 A HU 9603607A HU P9603607 A HUP9603607 A HU P9603607A HU P9603607 A2 HUP9603607 A2 HU P9603607A2
- Authority
- HU
- Hungary
- Prior art keywords
- pipe powder
- powder
- pipe
- alkyl
- naphthyl
- Prior art date
Links
- 208000001132 Osteoporosis Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 125000005310 triazolidinyl group Chemical class N1(NNCC1)* 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 8
- -1 phenylacetyl Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 239000001272 nitrous oxide Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgyát az ismert (I) általánős képletű vegyületek ésgyógyászatilag elfőgadható sóik képezik, új felhasználásra, ahőlR1, R2, R4 és R5 jelentése hidrőgén- vagy alkilcsőpőrt vagy R4 és R5együttesen egy 1-4 szénatőmős alkilén-diőxi-csőpőrtőt jelent;R3 jelentése hidrőgénatőm, alifás acilcsőpőrt, ciklőalkán-karbőnil-csőpőrt, benzőilcsőpőrt, naftőilcsőpőrt, őlyan benzőil- vagynaftőilcsőpőrt, amely legalább egy a-szűbsztitűenssel szűbsztitűált(alább definiálva), heterőciklűsős acilcsőpőrt, fenil-acetil-, fenil-prőpiőnil-csőpőrt, ami legalább egy halőgén szűbsztitűensselszűbsztitűált, cinnamőil-, alkőxi-karbőnil- vagy benzilőxi-karbőnil-csőpőrt;n jelentése 1, 2 vagy 3; Y és Z őxigénatőm vagy iminőcsőpőrt; és az a-szűbsztitűens az alábbiak közül választható: halőgénatőm, alkil-,alkőxi-, hidrőxil-, aminő-, alkil-aminő-, dialkil-aminő- ésnitrőcsőpőrt.A találmány szerinti vegyületek ősteőpőrősis ellen őlyan dózisbanhatékőnyak, amelynél azők űgyancsak hatékőnyak diabetes kezelésére is.ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33844095 | 1995-12-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9603607D0 HU9603607D0 (en) | 1997-02-28 |
| HUP9603607A2 true HUP9603607A2 (hu) | 1998-07-28 |
| HUP9603607A3 HUP9603607A3 (en) | 1999-03-29 |
Family
ID=18318184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9603607A HUP9603607A3 (en) | 1995-12-26 | 1996-12-27 | Use of triazolidine derivatives for the preparation of pharmaceutical compositions for the treatment and prophylaxis of osteoporosis |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5804590A (hu) |
| EP (1) | EP0783888A1 (hu) |
| AU (1) | AU714926B2 (hu) |
| CA (1) | CA2193751A1 (hu) |
| CZ (1) | CZ283229B6 (hu) |
| HU (1) | HUP9603607A3 (hu) |
| IL (1) | IL119894A (hu) |
| NO (1) | NO965563L (hu) |
| NZ (1) | NZ314003A (hu) |
| RU (1) | RU2146521C1 (hu) |
| TW (1) | TW401297B (hu) |
| ZA (1) | ZA9610901B (hu) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6008208A (en) * | 1995-10-23 | 1999-12-28 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973848B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| BR9711098B1 (pt) * | 1996-07-01 | 2011-10-04 | compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas. | |
| US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| EP0973513A4 (en) * | 1996-10-23 | 2003-03-19 | Zymogenetics Inc | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH BONE DEFICIT |
| US6313113B1 (en) * | 1997-04-15 | 2001-11-06 | Reddy-Cheminor, Inc. | Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
| AU7595298A (en) * | 1997-12-02 | 1998-12-11 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hy pertension |
| GB2335597A (en) * | 1998-03-27 | 1999-09-29 | Glaxo Group Ltd | Stereoisomers of Troglitazone in the Treatment of Diabetes |
| WO2000018748A1 (en) * | 1998-09-30 | 2000-04-06 | Roche Diagnostics Gmbh | Rhodanine derivatives for the treatment and prevention of metabolic bone disorders |
| AU6331099A (en) * | 1998-09-30 | 2000-04-17 | Roche Diagnostics Gmbh | Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders |
| AU6331199A (en) * | 1998-09-30 | 2000-04-17 | Roche Diagnostics Gmbh | Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders |
| CA2348910A1 (en) | 1998-10-29 | 2000-05-11 | Kirk L. Ives | Use of thiazolidinediones derivatives for preventing uterine contractions in premature labour or lactation |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6846496B1 (en) * | 1999-10-15 | 2005-01-25 | Orion Corporation | Treatment of osteoporosis |
| GB0003310D0 (en) * | 2000-02-15 | 2000-04-05 | Univ Sheffield | Bone formation |
| DE102005048483A1 (de) * | 2005-10-07 | 2007-06-14 | Schulz, Jörg, Prof. Dr.med. | Mittel zur Therapie und Prophylaxe des Diabetes mellitus |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6051189A (ja) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| JPS6054379A (ja) * | 1983-09-05 | 1985-03-28 | Takeda Chem Ind Ltd | 新規４ｈ−１−ベンゾピラン−４−オン誘導体，その製法および用途 |
| AR240698A1 (es) | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| NO179246C (no) | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| JP3502403B2 (ja) * | 1991-12-16 | 2004-03-02 | アベンティス ファーマ株式会社 | 骨吸収抑制剤 |
| NO302519B1 (no) | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
| NO302471B1 (no) | 1991-12-26 | 1998-03-09 | Sankyo Co | Tiazolidinforbindelser og farmasöytisk preparat |
| JPH05213763A (ja) * | 1992-02-10 | 1993-08-24 | Sanwa Kagaku Kenkyusho Co Ltd | 易吸収活性化カルシウム製剤 |
| CZ287027B6 (en) * | 1992-08-31 | 2000-08-16 | Sankyo Co | Oxazolidine derivatives, process of their preparation and pharmaceutical preparations containing thereof |
| JPH072848A (ja) * | 1993-04-23 | 1995-01-06 | Sankyo Co Ltd | モルホリンおよびチオモルホリン誘導体 |
| US5407947A (en) * | 1993-11-05 | 1995-04-18 | Eli Lilly And Company | Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans |
| JPH07258132A (ja) * | 1994-03-18 | 1995-10-09 | Sankyo Co Ltd | 新規ヒドロキノン化合物 |
| CA2145257A1 (en) | 1994-03-23 | 1995-09-24 | Takashi Fujita | Thiazolidine and oxazolidine derivatives, their preparation and their medical use |
| IL113313A (en) | 1994-04-11 | 1999-09-22 | Sankyo Co | Heterocyclic compounds and pharmaceutical compositions containing the same |
| US5476865A (en) * | 1994-07-06 | 1995-12-19 | Eli Lilly And Company | Methods of inhibiting bone loss |
| JPH0892249A (ja) * | 1994-07-20 | 1996-04-09 | Sankyo Co Ltd | スルホンアミド誘導体 |
| US5703096A (en) | 1994-10-07 | 1997-12-30 | Sankyo Company, Limited | Oxime derivatives, their preparation and their therapeutic use |
| JPH08157461A (ja) * | 1994-12-07 | 1996-06-18 | Sankyo Co Ltd | スルホン誘導体 |
| CZ293016B6 (cs) * | 1995-06-01 | 2004-01-14 | Sankyo Company Limited | Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem |
-
1996
- 1996-12-20 EP EP96309418A patent/EP0783888A1/en not_active Ceased
- 1996-12-23 CZ CZ963827A patent/CZ283229B6/cs not_active IP Right Cessation
- 1996-12-23 ZA ZA9610901A patent/ZA9610901B/xx unknown
- 1996-12-23 NZ NZ314003A patent/NZ314003A/xx unknown
- 1996-12-23 CA CA002193751A patent/CA2193751A1/en not_active Abandoned
- 1996-12-23 NO NO965563A patent/NO965563L/no not_active Application Discontinuation
- 1996-12-23 US US08/770,554 patent/US5804590A/en not_active Expired - Fee Related
- 1996-12-24 AU AU76503/96A patent/AU714926B2/en not_active Ceased
- 1996-12-24 IL IL11989496A patent/IL119894A/xx not_active IP Right Cessation
- 1996-12-25 RU RU96124376A patent/RU2146521C1/ru active
- 1996-12-26 TW TW085116096A patent/TW401297B/zh not_active IP Right Cessation
- 1996-12-27 HU HU9603607A patent/HUP9603607A3/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7650396A (en) | 1997-07-03 |
| NZ314003A (en) | 2000-12-22 |
| CA2193751A1 (en) | 1997-06-27 |
| AU714926B2 (en) | 2000-01-13 |
| EP0783888A1 (en) | 1997-07-16 |
| IL119894A0 (en) | 1997-03-18 |
| HUP9603607A3 (en) | 1999-03-29 |
| NO965563L (no) | 1997-06-27 |
| HU9603607D0 (en) | 1997-02-28 |
| IL119894A (en) | 2000-09-28 |
| RU2146521C1 (ru) | 2000-03-20 |
| US5804590A (en) | 1998-09-08 |
| CZ283229B6 (cs) | 1998-02-18 |
| ZA9610901B (en) | 1997-06-27 |
| TW401297B (en) | 2000-08-11 |
| CZ382796A3 (en) | 1997-07-16 |
| NO965563D0 (no) | 1996-12-23 |
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