ES2173425T3 - Analogos de la vitamina d - Google Patents

Analogos de la vitamina d

Info

Publication number
ES2173425T3
ES2173425T3 ES97910261T ES97910261T ES2173425T3 ES 2173425 T3 ES2173425 T3 ES 2173425T3 ES 97910261 T ES97910261 T ES 97910261T ES 97910261 T ES97910261 T ES 97910261T ES 2173425 T3 ES2173425 T3 ES 2173425T3
Authority
ES
Spain
Prior art keywords
hydrogen
group
methylene
well
optionally replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97910261T
Other languages
English (en)
Inventor
Martin John Galverley
Henrik Pedersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of ES2173425T3 publication Critical patent/ES2173425T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) EN LA QUE X ES HIDROGENO O HIDROXI; R 1 Y R 2 , QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN HIDROGENO O HIDROCARBILO C 1 - C 5 ; O R 1 Y R 2 , JUNTO C ON EL ATOMO DE CARBONO QUE LLEVA EL GRUPO X, PUEDEN FORMAR UN ANILLO CARBOCICLICO C 3 - C 8 ; Q ES METILENO, ETILENO, TRI - O TETRA - METILENO Y SE PUEDE SUSTITUIR OPCIONALMENTE POR UN GRUPO OXI, - OR 3 , EN EL QUE R 3 ES HIDROGENO, METILO O ETILO; Y ES BIEN UN ENLACE SENCILLO O BIEN UN HIDROCARBILENO C 1 - C 2 ; Y UNO O MAS CARBONOS PUDIENDO SER R 1 , R 2 Y/O Y OPCIONALMENTE SUSTITUIDOS POR UNO O MAS ATOMOS DE FLUOR O POR UN GRUPO HIDROXILO. LOS COMPUESTOS PRESENTAN UNOS EFECTOS ANTIIFLAMATORIOS E INMUNOMODULADORES ASI COMO UNA FUERTE ACTIVIDAD PARA INDUCIR LA DIFERENCIACION E INHIBIR LA PROLIFERACION NO DESEADA DE CIERTAS CELULAS.
ES97910261T 1996-10-30 1997-10-27 Analogos de la vitamina d Expired - Lifetime ES2173425T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9622590.9A GB9622590D0 (en) 1996-10-30 1996-10-30 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2173425T3 true ES2173425T3 (es) 2002-10-16

Family

ID=10802170

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97910261T Expired - Lifetime ES2173425T3 (es) 1996-10-30 1997-10-27 Analogos de la vitamina d

Country Status (21)

Country Link
US (1) US6310226B1 (es)
EP (1) EP0937038B1 (es)
JP (1) JP3907010B2 (es)
KR (1) KR100526644B1 (es)
CN (1) CN1107669C (es)
AT (1) ATE216361T1 (es)
AU (1) AU722659B2 (es)
CA (1) CA2266479C (es)
CZ (1) CZ290933B6 (es)
DE (1) DE69712086T2 (es)
DK (1) DK0937038T3 (es)
ES (1) ES2173425T3 (es)
GB (1) GB9622590D0 (es)
HK (1) HK1022298A1 (es)
HU (1) HUP9904333A3 (es)
NZ (1) NZ334328A (es)
PL (1) PL192660B1 (es)
PT (1) PT937038E (es)
RO (1) RO120338B1 (es)
RU (1) RU2183622C2 (es)
WO (1) WO1998018759A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2296145A1 (en) * 1997-07-17 1999-01-28 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bonds in the side chain
EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
JP4667450B2 (ja) * 2004-03-18 2011-04-13 レオ ファーマ アクティーゼルスカブ ビタミンd類似体の立体選択的合成
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
EP1883626B1 (en) * 2005-04-25 2017-10-11 OPKO Ireland Global Holdings, Ltd. Low-calcemic 16,23-diene 25-oxime analogs of 1alpha,25-dihydroxy vitamin d3
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20080051380A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
WO2008024485A2 (en) 2006-08-25 2008-02-28 Cougar Biotechnology, Inc. Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent
WO2008027532A2 (en) * 2006-08-29 2008-03-06 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions including vitamin d and corticosteroid
EA026334B1 (ru) 2009-01-27 2017-03-31 БЕРГ ЭлЭлСи Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении
US20120184514A1 (en) * 2009-07-01 2012-07-19 Vitamin Derivatives Inc. Vitamin d compounds and methods for preparing same
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
CN112156097A (zh) 2013-05-29 2021-01-01 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
CA3031705A1 (en) 2016-07-29 2018-02-01 Janssen Pharmaceutica Nv Treatment of prostate cancer with niraparib

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8914963D0 (en) 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
GB9206648D0 (en) * 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
US5552392A (en) 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
JP3228488B2 (ja) * 1993-12-24 2001-11-12 株式会社クラレ 20−エピステロイド誘導体およびその製造方法
JPH0888281A (ja) * 1994-09-19 1996-04-02 Fujitsu Ltd 半導体装置
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DK0937038T3 (da) 2002-07-15
PL333068A1 (en) 1999-11-08
DE69712086D1 (de) 2002-05-23
JP2001503403A (ja) 2001-03-13
EP0937038B1 (en) 2002-04-17
HK1022298A1 (en) 2000-08-04
RU2183622C2 (ru) 2002-06-20
PT937038E (pt) 2002-09-30
DE69712086T2 (de) 2002-11-14
CN1107669C (zh) 2003-05-07
GB9622590D0 (en) 1997-01-08
ATE216361T1 (de) 2002-05-15
EP0937038A1 (en) 1999-08-25
HUP9904333A2 (hu) 2000-06-28
CA2266479A1 (en) 1998-05-07
CZ290933B6 (cs) 2002-11-13
RO120338B1 (ro) 2005-12-30
KR20000036233A (ko) 2000-06-26
NZ334328A (en) 2000-09-29
HUP9904333A3 (en) 2001-06-28
US6310226B1 (en) 2001-10-30
CN1232448A (zh) 1999-10-20
CA2266479C (en) 2008-09-23
KR100526644B1 (ko) 2005-11-08
AU722659B2 (en) 2000-08-10
CZ135899A3 (cs) 1999-07-14
AU4771797A (en) 1998-05-22
JP3907010B2 (ja) 2007-04-18
PL192660B1 (pl) 2006-11-30
WO1998018759A1 (en) 1998-05-07

Similar Documents

Publication Publication Date Title
ES2173425T3 (es) Analogos de la vitamina d
ES2189476T3 (es) Odorizado de gases.
AR000929A1 (es) Compuestos herbicidas de bencisoxazol y bencisotiazol substituido, composicion que los comprende y metodos para controlar con los mismos especiesde plantas indeseables.
BR0300968A (pt) Misturas estabilizadoras
BR9709427A (pt) Oxa ácidos e compostos relacionados para tratamento de condições da pele
AR015740A1 (es) CETOENOLES CíCLICOS ARILFENIL-SUBSTITUIDOS, PROCEDIMIENTO PARA SU OBTENCIoN , COMPUESTOS uTILES PARA PREPARAR DICHOS CETOENOLES, COMPOSICIONES PESTICIDAS, Y /O HERBICIDAS,EMPLEO DE DICHOS CETOENOLES,MÉTODO PARA CONTROLAR LAS PESTES, Y , MÉTODO PARA LA PREPARACIoN DE DICHAS COMPOSICIONES PESTICIDAS Y
BR0215052A (pt) Composições acaricidas e métodos
PE46497A1 (es) ANTAGONISTAS a1-ADRENOCEPTORES, SUS EMPLEOS COMO AGENTES TERAPEUTICOS Y LOS METODOS DE SU PREPARACION
ES2160237T3 (es) O-carbamoil-fenilalaninol que tiene sustituyente en anillo de benceno, sus sales farmaceuticamente utiles, y metodo para la preparacion de los mismos.
ES2195577T3 (es) Derivados de epotilon, procedimiento para su preparacion y su utilizacion.
ES2179996T3 (es) Cefalosporinas de vinil-pirrolidinona con sustituyentes basicos.
ES2181766T3 (es) Analogos de delda 12,13-isotaxol, uso antineoplasico y composiciones farmaceuticas que los contienen.
BR0316576A (pt) Método cosmético para o clareamento da pele e composição cosmética
EA200200098A1 (ru) Ароматические сложные эфиры для маркировки или мечения нефтепродуктов
ES2164340T3 (es) Agentes y procedimiento para la lucha contra los hongos dañinos.
AR007005A1 (es) Composiciones repelentes de artropodos y procedimiento para repeler artropodos
GT200000049A (es) Compuestos quimicos.
FI951134A (fi) Fluorattu D3-vitamiinijohdannainen
ES2148816T3 (es) Analogo de vitamina d.
MX168469B (es) Procedimiento para la preparacion de derivados aminoalcoholes acilados
MX9203567A (es) Derivado de monocolin, procedimiento para su preparacion y medicamento que contiene este derivado.
ES2190222T3 (es) Derivados de 3-(2-oxo-(1,3')bipirrolindinil-3-iliden-metil)-cefem.
ES2180972T3 (es) Composicion contra el helicobacter pilori que contiene derivados de 1-metilcarbapenem como ingrediente activo.
MX9303863A (es) 2-4-dialquil-6-alquilfenoles secundarios.
BR0315647A (pt) Novos compostos para composições de tingimento de cabelos

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 937038

Country of ref document: ES