NZ334328A - Vitamin D analogues and their pharmaceutical use - Google Patents
Vitamin D analogues and their pharmaceutical useInfo
- Publication number
- NZ334328A NZ334328A NZ334328A NZ33432897A NZ334328A NZ 334328 A NZ334328 A NZ 334328A NZ 334328 A NZ334328 A NZ 334328A NZ 33432897 A NZ33432897 A NZ 33432897A NZ 334328 A NZ334328 A NZ 334328A
- Authority
- NZ
- New Zealand
- Prior art keywords
- diseases
- methylene
- ethyl
- substituted
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds of formula (I) show anti-inflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells. In formula (I); X is hydrogen or hydroxy; R1 and R2 which may be the same or different, are methyl or ethyl; Q is methylene, ethylene, tri- or tetra-methylene and may optionally be substituted with an oxy group, -OR3, in which R3 is hydrogen, methyl or ethyl; and Y is either a single bond or C1-C2 hydrocarbylene; wherein one or more carbons within R1, R2, and/or Y may optionally be substituted with one or more fluorine atoms, or with a hydroxyl group. The compounds can be used in a medicament to treat psoriasis and other disturbances of keratinisation; HlV-associated dermatoses; wound healing; cancer; diseases of, or imbalance in, the immune system, such as host versus graft and graft versus host reaction and transplant rejection; autoimmune diseases, such as discoid and systemic lupus; erythematosus; diabetes mellitus; chronic dermatoses of autoimmune type, e.g. scleroderma and pemphigus vulgaris; inflammatory diseases, such as rheumatoid arthritis; asthma; hyperparathyroidism, particularly secondary hyperparathyroidism associated with renal failure; cognitive impairment or senile dementia (Alzheimer's disease) and other neurodegenerative diseases; hypertension; acne; alopecia; skin atrophy, e.g. steroid induced skin atrophy, skin ageing, including photo-ageing; promoting osteogenesis; osteoporosis and osteomalacia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9622590.9A GB9622590D0 (en) | 1996-10-30 | 1996-10-30 | Chemical compounds |
| PCT/DK1997/000472 WO1998018759A1 (en) | 1996-10-30 | 1997-10-27 | Vitamin d analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ334328A true NZ334328A (en) | 2000-09-29 |
Family
ID=10802170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ334328A NZ334328A (en) | 1996-10-30 | 1997-10-27 | Vitamin D analogues and their pharmaceutical use |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6310226B1 (en) |
| EP (1) | EP0937038B1 (en) |
| JP (1) | JP3907010B2 (en) |
| KR (1) | KR100526644B1 (en) |
| CN (1) | CN1107669C (en) |
| AT (1) | ATE216361T1 (en) |
| AU (1) | AU722659B2 (en) |
| CA (1) | CA2266479C (en) |
| CZ (1) | CZ290933B6 (en) |
| DE (1) | DE69712086T2 (en) |
| DK (1) | DK0937038T3 (en) |
| ES (1) | ES2173425T3 (en) |
| GB (1) | GB9622590D0 (en) |
| HK (1) | HK1022298A1 (en) |
| HU (1) | HUP9904333A3 (en) |
| NZ (1) | NZ334328A (en) |
| PL (1) | PL192660B1 (en) |
| PT (1) | PT937038E (en) |
| RO (1) | RO120338B1 (en) |
| RU (1) | RU2183622C2 (en) |
| WO (1) | WO1998018759A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999003828A1 (en) * | 1997-07-17 | 1999-01-28 | F.Hoffmann-La Roche Ag | Dihomo-seco-cholestanes with two unsaturated bones in the side chain |
| AU2003291810A1 (en) * | 2002-11-18 | 2004-06-15 | Teva Pharmaceutical Industries Ltd. | A crystallization method for purification of calcipotriene |
| JP4667450B2 (en) * | 2004-03-18 | 2011-04-13 | レオ ファーマ アクティーゼルスカブ | Stereoselective synthesis of vitamin D analogues |
| WO2006051106A1 (en) | 2004-11-12 | 2006-05-18 | Bioxell Spa | Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer |
| EP1883626B1 (en) * | 2005-04-25 | 2017-10-11 | OPKO Ireland Global Holdings, Ltd. | Low-calcemic 16,23-diene 25-oxime analogs of 1alpha,25-dihydroxy vitamin d3 |
| EP2063963A2 (en) | 2006-08-25 | 2009-06-03 | Cougar Biotechnology, Inc. | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| KR20090039833A (en) * | 2006-08-29 | 2009-04-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | Pharmaceutical compositions including vitamin d and corticosteroid |
| SG173119A1 (en) | 2009-01-27 | 2011-08-29 | Berg Biosystems Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| US20120184514A1 (en) * | 2009-07-01 | 2012-07-19 | Vitamin Derivatives Inc. | Vitamin d compounds and methods for preparing same |
| BR112012003372A2 (en) | 2009-08-14 | 2019-09-24 | Berg Biosystems Llc | vitamin d3 and the like for the treatment of alopecia. |
| EP3003497B1 (en) | 2013-05-29 | 2024-02-14 | BPGbio, Inc. | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| KR20240115925A (en) | 2016-07-29 | 2024-07-26 | 얀센 파마슈티카 엔브이 | Methods of treating prostate cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
| US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| GB9206648D0 (en) * | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9223061D0 (en) * | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| JP3228488B2 (en) | 1993-12-24 | 2001-11-12 | 株式会社クラレ | 20-Episteroid derivative and method for producing the same |
| JPH0888281A (en) * | 1994-09-19 | 1996-04-02 | Fujitsu Ltd | Semiconductor device |
| CA2175881A1 (en) * | 1995-05-09 | 1996-11-10 | Andrzej Kutner | Vitamin d compounds and methods of preparing these compounds |
-
1996
- 1996-10-30 GB GBGB9622590.9A patent/GB9622590D0/en active Pending
-
1997
- 1997-10-27 KR KR10-1999-7002315A patent/KR100526644B1/en not_active IP Right Cessation
- 1997-10-27 AU AU47717/97A patent/AU722659B2/en not_active Expired
- 1997-10-27 DE DE69712086T patent/DE69712086T2/en not_active Expired - Lifetime
- 1997-10-27 CZ CZ19991358A patent/CZ290933B6/en not_active IP Right Cessation
- 1997-10-27 CN CN97198407A patent/CN1107669C/en not_active Expired - Lifetime
- 1997-10-27 JP JP51993198A patent/JP3907010B2/en not_active Expired - Lifetime
- 1997-10-27 CA CA002266479A patent/CA2266479C/en not_active Expired - Lifetime
- 1997-10-27 PL PL333068A patent/PL192660B1/en unknown
- 1997-10-27 ES ES97910261T patent/ES2173425T3/en not_active Expired - Lifetime
- 1997-10-27 WO PCT/DK1997/000472 patent/WO1998018759A1/en active IP Right Grant
- 1997-10-27 NZ NZ334328A patent/NZ334328A/en not_active IP Right Cessation
- 1997-10-27 EP EP97910261A patent/EP0937038B1/en not_active Expired - Lifetime
- 1997-10-27 HU HU9904333A patent/HUP9904333A3/en unknown
- 1997-10-27 RO RO99-00325A patent/RO120338B1/en unknown
- 1997-10-27 PT PT97910261T patent/PT937038E/en unknown
- 1997-10-27 US US09/297,387 patent/US6310226B1/en not_active Expired - Lifetime
- 1997-10-27 AT AT97910261T patent/ATE216361T1/en active
- 1997-10-27 RU RU99111777/04A patent/RU2183622C2/en active
- 1997-10-27 DK DK97910261T patent/DK0937038T3/en active
-
2000
- 2000-02-29 HK HK00101222A patent/HK1022298A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL333068A1 (en) | 1999-11-08 |
| CZ135899A3 (en) | 1999-07-14 |
| RU2183622C2 (en) | 2002-06-20 |
| KR100526644B1 (en) | 2005-11-08 |
| ES2173425T3 (en) | 2002-10-16 |
| DE69712086D1 (en) | 2002-05-23 |
| DE69712086T2 (en) | 2002-11-14 |
| ATE216361T1 (en) | 2002-05-15 |
| JP2001503403A (en) | 2001-03-13 |
| PL192660B1 (en) | 2006-11-30 |
| CN1232448A (en) | 1999-10-20 |
| EP0937038B1 (en) | 2002-04-17 |
| GB9622590D0 (en) | 1997-01-08 |
| DK0937038T3 (en) | 2002-07-15 |
| CA2266479A1 (en) | 1998-05-07 |
| HUP9904333A3 (en) | 2001-06-28 |
| WO1998018759A1 (en) | 1998-05-07 |
| CA2266479C (en) | 2008-09-23 |
| RO120338B1 (en) | 2005-12-30 |
| US6310226B1 (en) | 2001-10-30 |
| KR20000036233A (en) | 2000-06-26 |
| HUP9904333A2 (en) | 2000-06-28 |
| EP0937038A1 (en) | 1999-08-25 |
| JP3907010B2 (en) | 2007-04-18 |
| HK1022298A1 (en) | 2000-08-04 |
| AU4771797A (en) | 1998-05-22 |
| CN1107669C (en) | 2003-05-07 |
| PT937038E (en) | 2002-09-30 |
| CZ290933B6 (en) | 2002-11-13 |
| AU722659B2 (en) | 2000-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |