WO2001030751A3 - USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF - Google Patents

USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF Download PDF

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Publication number
WO2001030751A3
WO2001030751A3 PCT/GB2000/004120 GB0004120W WO0130751A3 WO 2001030751 A3 WO2001030751 A3 WO 2001030751A3 GB 0004120 W GB0004120 W GB 0004120W WO 0130751 A3 WO0130751 A3 WO 0130751A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
dihydroxy
derivatives
vitamin
diseases
Prior art date
Application number
PCT/GB2000/004120
Other languages
French (fr)
Other versions
WO2001030751A2 (en
Inventor
Michael Francis Holick
Milan Radoje Uskokovic
Original Assignee
Strakan Ltd
Michael Francis Holick
Milan Radoje Uskokovic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Strakan Ltd, Michael Francis Holick, Milan Radoje Uskokovic filed Critical Strakan Ltd
Priority to AU11532/01A priority Critical patent/AU1153201A/en
Publication of WO2001030751A2 publication Critical patent/WO2001030751A2/en
Publication of WO2001030751A3 publication Critical patent/WO2001030751A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,25-dihydroxy-5,6-trans vitamin D compounds and their derivatives, especially the esters, are useful in the treatment or prevention of diseases characterised by abnormall cell differentiation or cell proliferation, as well as other diseases or conditions treatable with vitamin D compounds, such as osteoporosis and other metabolic bone diseases, and are not associated with the degree of hypercalcaemia observed wtih 1,25-dihydroxy vitamin D3.
PCT/GB2000/004120 1999-10-25 2000-10-25 USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF WO2001030751A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU11532/01A AU1153201A (en) 1999-10-25 2000-10-25 Uses of 1,25-dihydroxy-5,6-trans vitamin D compounds and derivatives thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16106499P 1999-10-25 1999-10-25
US60/161,064 1999-10-25

Publications (2)

Publication Number Publication Date
WO2001030751A2 WO2001030751A2 (en) 2001-05-03
WO2001030751A3 true WO2001030751A3 (en) 2002-06-13

Family

ID=22579669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004120 WO2001030751A2 (en) 1999-10-25 2000-10-25 USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF

Country Status (2)

Country Link
AU (1) AU1153201A (en)
WO (1) WO2001030751A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027928A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
US7332482B2 (en) 2003-09-24 2008-02-19 Bioxell S.P.A. Method for treating benign prostatic hyperplasia
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
EP2515913A2 (en) * 2009-12-23 2012-10-31 Glycomyr Inc. Use of vitamin d glycosides and sulfates for treatment of disease

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56161368A (en) * 1980-05-16 1981-12-11 Chugai Pharmaceut Co Ltd Novel trans-vitamin d derivative
JPS6045516A (en) * 1983-08-02 1985-03-12 Kureha Chem Ind Co Ltd Physiologically active agent containing 1alpha- hydroxyvitamin d3
JPS61197573A (en) * 1985-02-26 1986-09-01 Chugai Pharmaceut Co Ltd 5,6-epoxidized trans-vitamin d3
US4728643A (en) * 1984-11-02 1988-03-01 The General Hospital Corporation Method of treating psoriasis
WO1993009093A1 (en) * 1991-11-07 1993-05-13 Holmes, Michael, John Vitamin d amide derivatives
US5554599A (en) * 1992-12-23 1996-09-10 Leo Pharmaceutical Products Ltd. 22-thio vitamin D derivatives
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5932565A (en) * 1996-04-03 1999-08-03 Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) Vitamin D analogues

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56161368A (en) * 1980-05-16 1981-12-11 Chugai Pharmaceut Co Ltd Novel trans-vitamin d derivative
JPS6045516A (en) * 1983-08-02 1985-03-12 Kureha Chem Ind Co Ltd Physiologically active agent containing 1alpha- hydroxyvitamin d3
US4728643A (en) * 1984-11-02 1988-03-01 The General Hospital Corporation Method of treating psoriasis
JPS61197573A (en) * 1985-02-26 1986-09-01 Chugai Pharmaceut Co Ltd 5,6-epoxidized trans-vitamin d3
WO1993009093A1 (en) * 1991-11-07 1993-05-13 Holmes, Michael, John Vitamin d amide derivatives
US5554599A (en) * 1992-12-23 1996-09-10 Leo Pharmaceutical Products Ltd. 22-thio vitamin D derivatives
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5932565A (en) * 1996-04-03 1999-08-03 Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) Vitamin D analogues

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANDREW S. CRAIG ET AL.: "Two Novel Allenic Side Chain Analogues of 1 alpha, 25- Dihydroxyvitamin D3", J. ORG. CHEM., vol. 57, no. 16, 1992, columbus ohio, pages 4374 - 4380, XP002086123 *
BRUNO FIGADÈRE ET AL.: "Arocalciferols: Synthesis and Biological Evaluation of Aromatic Side-chain Analogues of 1alpha,25-Dihydroxyvitamin D3", JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, no. 8, 1991, columbus ohio, pages 2452 - 2463, XP002101748 *
DATABASE WPI Week 198204, Derwent World Patents Index; AN 1982-06749E, XP002184307, "Trans vitamin- D deriv.-specifically (24R)-24,25-Di:hydroxy-5,6-trans vitamin D3" *
DATABASE WPI Week 8516, Derwent World Patents Index; AN 1985-096635, XP002184308, "Pharmaceutical 1 alpha-hydroxy vitamin-D3 cpds.-used for treating arterial sclerosis platelet aggregation thrombos inflammation etc." *
PATENT ABSTRACTS OF JAPAN vol. 110, no. 24 (C - 399) 23 January 1987 (1987-01-23) *

Also Published As

Publication number Publication date
AU1153201A (en) 2001-05-08
WO2001030751A2 (en) 2001-05-03

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