IL118156A - Vitamin d compounds, their preparation and pharmaceutical compositions containing them - Google Patents

Vitamin d compounds, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL118156A
IL118156A IL11815696A IL11815696A IL118156A IL 118156 A IL118156 A IL 118156A IL 11815696 A IL11815696 A IL 11815696A IL 11815696 A IL11815696 A IL 11815696A IL 118156 A IL118156 A IL 118156A
Authority
IL
Israel
Prior art keywords
group
compounds
vitamin
preparation
pharmaceutical compositions
Prior art date
Application number
IL11815696A
Other versions
IL118156A0 (en
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of IL118156A0 publication Critical patent/IL118156A0/en
Publication of IL118156A publication Critical patent/IL118156A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

The invention relates to a vitamin D compound of the general formula <CHEM> wherein R1 is a hydrogen atom or a hydroxy group, R2 is a hydrogen atom or a substituent selected from the group consisting of (C1-C3)alkyl, phenyl and trifluoromethyl, R3 is a branched or unbranched (C1-C4)alkyl group or a cyclopropyl group or a CF, group, A and B are each individually hydrogen atoms or methyl groups, or A and B form together a methylene group, X is CH2 or O, n is 2 or 3. The invention further relates to methods of preparing these compounds, to methods for preparing a valuable intermediate in the preparation of these compounds and to their use in pharmacotherapy and cosmetics.
IL11815696A 1995-05-09 1996-05-06 Vitamin d compounds, their preparation and pharmaceutical compositions containing them IL118156A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95201184 1995-05-09

Publications (2)

Publication Number Publication Date
IL118156A0 IL118156A0 (en) 1996-09-12
IL118156A true IL118156A (en) 2001-08-26

Family

ID=8220269

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11815696A IL118156A (en) 1995-05-09 1996-05-06 Vitamin d compounds, their preparation and pharmaceutical compositions containing them

Country Status (9)

Country Link
US (1) US5817648A (en)
EP (1) EP0742203B1 (en)
JP (2) JP4010579B2 (en)
AT (1) ATE185135T1 (en)
CA (1) CA2175881A1 (en)
DE (1) DE69604442T2 (en)
DK (1) DK0742203T5 (en)
ES (1) ES2139305T3 (en)
IL (1) IL118156A (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9622590D0 (en) * 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6316642B1 (en) * 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
MA26481A1 (en) * 1997-04-21 2004-12-20 Hoffmann La Roche ARYLSECOCHOLADIAN DERIVATIVES
AU8860298A (en) * 1997-07-17 1999-02-10 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain
DE19744127B4 (en) * 1997-10-01 2006-10-05 Schering Ag New vitamin D derivatives with side-chain cyclopropyl rings, processes and intermediates for their preparation and their use in the manufacture of medicaments
AU2001248777A1 (en) * 2000-04-19 2001-10-30 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives
IL152942A (en) * 2000-05-31 2007-09-20 Wisconsin Alumni Res Found 2 - ethyl and - 2 - ethylidene - 19 - nor - vitamin d compounds and pharmaceutical compositions containing the same
JP4022144B2 (en) * 2000-09-08 2007-12-12 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and therapeutic applications thereof
JP2005504279A (en) * 2001-09-27 2005-02-10 ザ・コカ−コーラ・カンパニー Vitamin fortification of food
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
AU2004230948A1 (en) * 2003-04-10 2004-10-28 Wisconsin Alumni Research Foundation 2-propylidene-19-nor-vitamin D compounds
US6894037B2 (en) * 2003-07-03 2005-05-17 Wisconsin Alumni Research Foundation 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
US7713951B2 (en) * 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
MX2008012701A (en) * 2006-04-05 2009-01-07 Wisconsin Alumni Res Found 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof.
US20090281340A1 (en) * 2006-04-05 2009-11-12 Deluca Hector F 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53147051A (en) * 1977-05-24 1978-12-21 Teijin Ltd 1alpha-hydroxy-24-dehydro-vitamin d3 and its preparation
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
US5278155A (en) * 1991-06-05 1994-01-11 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and cell differentiation-inducing agent containing the same
DE69213844T2 (en) * 1991-07-05 1997-04-10 Duphar Int Res Vitamin D derivative, process for its production and intermediates therefor
DE4220757A1 (en) * 1992-06-24 1994-01-05 Schering Ag Derivatives in the vitamin D series with modifications in the 20-position, process for their preparation, intermediates for this process, pharmaceutical preparations containing these derivatives and their use in the manufacture of medicaments
GB9220272D0 (en) * 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs

Also Published As

Publication number Publication date
DK0742203T5 (en) 2000-09-04
DE69604442T2 (en) 2000-05-18
DE69604442D1 (en) 1999-11-04
ES2139305T3 (en) 2000-02-01
EP0742203A3 (en) 1996-12-04
ATE185135T1 (en) 1999-10-15
US5817648A (en) 1998-10-06
DK0742203T3 (en) 2000-04-10
JP2007326871A (en) 2007-12-20
JPH093040A (en) 1997-01-07
EP0742203B1 (en) 1999-09-29
JP4010579B2 (en) 2007-11-21
IL118156A0 (en) 1996-09-12
CA2175881A1 (en) 1996-11-10
EP0742203A2 (en) 1996-11-13

Similar Documents

Publication Publication Date Title
IL118156A (en) Vitamin d compounds, their preparation and pharmaceutical compositions containing them
IL109848A0 (en) Vitamin d compounds, their preparation and pharmaceutical and cosmetic compositions containing them
IL120266A (en) Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
IL99443A0 (en) Heterocyclic derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
NZ331457A (en) Methoxybenzophenone compounds, a process for their preparation and a method involving them for combating fungal growth
MX9700675A (en) Compounds useful as antiproliferative agents and garft inhibitors.
EP0997462A4 (en) Novel naphthyridine derivatives or salts thereof
DE68926981D1 (en) Cephem compounds and processes for their preparation
IL112362A0 (en) Vitamin D compounds, their preparation and pharmaceutical compositions containing them
IE901314L (en) 2- substituted-n,n&#39;-di(trimethoxybenzoyl)piperazines
HUP9903526A2 (en) Pyrimidine derivatives and pharmaceutical compositions containing the same
DE69129790D1 (en) 5-Amino-5,6,7,8-tetrahydroquinolines and related compounds, process for their preparation and their use as medicines
BG102429A (en) Derivatives of 5-naphthalen-1-yl-1,3-dioxan, their preparation and usage as therapeutical means
WO2000024389A3 (en) Benzoquinoline derivatives useful as antibacterial agents
ATE139767T1 (en) METHOD FOR PRODUCING 5-PYRAZOLOMERCAPTAN DERIVATIVES AND INTERMEDIATE PRODUCTS THEREOF
MY136142A (en) Novel substituted [1,4]benzodioxino[2,3-e]isoindole derivatives, method for preparing same and pharmaceutical compositions containing same
TW258661B (en)
TW430666B (en) New 5H-thiazolo[3,2-a]pyrimidin-5-one derivatives

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees