GB9220272D0 - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
GB9220272D0
GB9220272D0 GB929220272A GB9220272A GB9220272D0 GB 9220272 D0 GB9220272 D0 GB 9220272D0 GB 929220272 A GB929220272 A GB 929220272A GB 9220272 A GB9220272 A GB 9220272A GB 9220272 D0 GB9220272 D0 GB 9220272D0
Authority
GB
United Kingdom
Prior art keywords
pct
sec
carbon atoms
group
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB929220272A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Priority to GB929220272A priority Critical patent/GB9220272D0/en
Publication of GB9220272D0 publication Critical patent/GB9220272D0/en
Priority to US08/367,206 priority patent/US5612325A/en
Priority to EP93921828A priority patent/EP0662953B1/en
Priority to RU94046456/04A priority patent/RU2163234C2/en
Priority to NZ256386A priority patent/NZ256386A/en
Priority to AT93921828T priority patent/ATE154596T1/en
Priority to ES93921828T priority patent/ES2104177T3/en
Priority to DK93921828.5T priority patent/DK0662953T3/en
Priority to PCT/DK1993/000305 priority patent/WO1994007851A1/en
Priority to DE69311730T priority patent/DE69311730T2/en
Priority to CA002136451A priority patent/CA2136451A1/en
Priority to JP6508595A priority patent/JPH08501571A/en
Priority to KR1019940704550A priority patent/KR100295975B1/en
Priority to AU51076/93A priority patent/AU664779B2/en
Priority to FI951422A priority patent/FI108224B/en
Priority to GR970402139T priority patent/GR3024500T3/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

PCT No. PCT/DK95/00305 Sec. 371 Date Jan. 3, 1995 Sec. 102(e) Date Jan. 3, 1995 PCT Filed Sep. 23, 1993 PCT Pub. No. WO94/07851 PCT Pub. Date Apr. 14, 1994A compound of formula I <IMAGE> I wherein R stands for a straight or branched, saturated or unsaturated alkyl group containing from 4 to 12 carbon atoms optionally substituted with a hydroxy group, and possibly containing a ring structure, and in which at least one of the carbon atoms not bearing hydroxyl group is substituted with one or more halogen atoms or an azido group; and prodrugs of I in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo, in pure form or in mixtures. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells. The compounds are prepared by oxidizing 1(S),3(R)-bis-(tert-butyldimethylsilyloxy)-20(S)formyl-9,10-seco-pregna-5(E),7(E),10(19)-triene, reducing the resulting product; alkylating the reduction product and then subjecting the alkylated product to triplet-sensitized photoisomerization.
GB929220272A 1992-09-25 1992-09-25 Chemical compounds Pending GB9220272D0 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB929220272A GB9220272D0 (en) 1992-09-25 1992-09-25 Chemical compounds
AU51076/93A AU664779B2 (en) 1992-09-25 1993-09-23 Novel vitamin D analogues
ES93921828T ES2104177T3 (en) 1992-09-25 1993-09-23 NOVEL ANALOGS OF VITAMIN D.
PCT/DK1993/000305 WO1994007851A1 (en) 1992-09-25 1993-09-23 Novel vitamin d analogues
RU94046456/04A RU2163234C2 (en) 1992-09-25 1993-09-23 Analogs of vitamin d, method of their synthesis, diastereo- -isomer, pharmaceutical composition
NZ256386A NZ256386A (en) 1992-09-25 1993-09-23 20-(substituted alkoxy)-9,10-seco-pregnatriene derivatives and medicaments
AT93921828T ATE154596T1 (en) 1992-09-25 1993-09-23 NEW VITAMIN D DERIVATIVES
US08/367,206 US5612325A (en) 1992-09-25 1993-09-23 Vitamin D analogues having a halogen-or azido- substituted side chain
DK93921828.5T DK0662953T3 (en) 1992-09-25 1993-09-23 New Vitamin D Analogs
EP93921828A EP0662953B1 (en) 1992-09-25 1993-09-23 Novel vitamin d analogues
DE69311730T DE69311730T2 (en) 1992-09-25 1993-09-23 NEW VITAMIN D DERIVATIVES
CA002136451A CA2136451A1 (en) 1992-09-25 1993-09-23 Novel vitamin d analogues
JP6508595A JPH08501571A (en) 1992-09-25 1993-09-23 Novel vitamin D analog
KR1019940704550A KR100295975B1 (en) 1992-09-25 1993-09-23 New Vitamin D Homologs and Methods for Making the Same
FI951422A FI108224B (en) 1992-09-25 1995-03-24 Process for the preparation of new vitamin D analogs
GR970402139T GR3024500T3 (en) 1992-09-25 1997-08-21 Novel vitamin d analogues.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929220272A GB9220272D0 (en) 1992-09-25 1992-09-25 Chemical compounds

Publications (1)

Publication Number Publication Date
GB9220272D0 true GB9220272D0 (en) 1992-11-11

Family

ID=10722500

Family Applications (1)

Application Number Title Priority Date Filing Date
GB929220272A Pending GB9220272D0 (en) 1992-09-25 1992-09-25 Chemical compounds

Country Status (16)

Country Link
US (1) US5612325A (en)
EP (1) EP0662953B1 (en)
JP (1) JPH08501571A (en)
KR (1) KR100295975B1 (en)
AT (1) ATE154596T1 (en)
AU (1) AU664779B2 (en)
CA (1) CA2136451A1 (en)
DE (1) DE69311730T2 (en)
DK (1) DK0662953T3 (en)
ES (1) ES2104177T3 (en)
FI (1) FI108224B (en)
GB (1) GB9220272D0 (en)
GR (1) GR3024500T3 (en)
NZ (1) NZ256386A (en)
RU (1) RU2163234C2 (en)
WO (1) WO1994007851A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
SG77163A1 (en) * 1998-03-06 2000-12-19 John Francis Chong A method of implementing an acyclic directed graph structure using a relational database
KR20070086727A (en) * 2004-12-03 2007-08-27 니뽄 신야쿠 가부시키가이샤 9,10-secopregnane derivative and medicine
KR20150140872A (en) 2006-06-02 2015-12-16 니뽄 신야쿠 가부시키가이샤 9,10-secopregnane derivative and pharmaceutical
MX339746B (en) 2009-01-27 2016-06-08 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy.
AU2010282731C1 (en) 2009-08-14 2016-04-21 Berg Llc Vitamin D3 and analogs thereof for treating alopecia
US20130130102A1 (en) * 2010-07-30 2013-05-23 Zeon Corporation Ether compound, electrolyte composition for non-aqueous battery, binder composition for non-aqueous battery electrode, slurry composition for non-aqueous battery electrode, electrode for non-aqueous battery and non-aqueous battery
WO2012065050A1 (en) 2010-11-12 2012-05-18 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
EP3003497B1 (en) 2013-05-29 2024-02-14 BPGbio, Inc. Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378695A (en) * 1989-02-23 1995-01-03 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Vitamin D analogues
GB8904154D0 (en) * 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds
US5401732A (en) * 1989-02-23 1995-03-28 Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab Vitamin D analogues
US5053401A (en) * 1989-02-28 1991-10-01 Chugai Seiyaku Kabushiki Kaisha Osteogenesis promotion with use of vitamin d derivatives
US4948789A (en) * 1989-03-28 1990-08-14 Chugai Seiyaku Kabushiki Kaisha Suppression of parathyroid hormone synthesis and secretion
US5254538A (en) * 1989-10-04 1993-10-19 Trustees Of Boston University Method of treating periodontal disease
DK0521550T3 (en) * 1991-07-05 1996-11-04 Duphar Int Res Vitamin D compound, method of preparation of this compound and intermediate thereof
DE4141746A1 (en) * 1991-12-13 1993-06-17 Schering Ag 20-METHYL-SUBSTITUTED VITAMIN D DERIVATIVES
US5403832A (en) * 1992-03-12 1995-04-04 The Johns Hopkins University Vitamin D3 analogues

Also Published As

Publication number Publication date
FI951422A (en) 1995-03-24
KR100295975B1 (en) 2001-11-14
DE69311730T2 (en) 1998-02-05
DE69311730D1 (en) 1997-07-24
WO1994007851A1 (en) 1994-04-14
EP0662953B1 (en) 1997-06-18
AU5107693A (en) 1994-04-26
EP0662953A1 (en) 1995-07-19
GR3024500T3 (en) 1997-11-28
FI108224B (en) 2001-12-14
CA2136451A1 (en) 1994-04-14
ES2104177T3 (en) 1997-10-01
ATE154596T1 (en) 1997-07-15
AU664779B2 (en) 1995-11-30
JPH08501571A (en) 1996-02-20
US5612325A (en) 1997-03-18
RU94046456A (en) 1996-10-27
KR950701909A (en) 1995-05-17
NZ256386A (en) 1997-07-27
FI951422A0 (en) 1995-03-24
DK0662953T3 (en) 1997-10-13
RU2163234C2 (en) 2001-02-20

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