DE69431833D1 - Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden - Google Patents

Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden

Info

Publication number
DE69431833D1
DE69431833D1 DE69431833T DE69431833T DE69431833D1 DE 69431833 D1 DE69431833 D1 DE 69431833D1 DE 69431833 T DE69431833 T DE 69431833T DE 69431833 T DE69431833 T DE 69431833T DE 69431833 D1 DE69431833 D1 DE 69431833D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
production
treatment methods
antitumor compounds
novel taxanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69431833T
Other languages
English (en)
Other versions
DE69431833T2 (de
Inventor
Iwao Ojima
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Research Foundation of the State University of New York
Original Assignee
Indena SpA
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA, Research Foundation of the State University of New York filed Critical Indena SpA
Publication of DE69431833D1 publication Critical patent/DE69431833D1/de
Application granted granted Critical
Publication of DE69431833T2 publication Critical patent/DE69431833T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69431833T 1993-03-26 1994-03-24 Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden Expired - Lifetime DE69431833T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/040,189 US5475011A (en) 1993-03-26 1993-03-26 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
PCT/US1994/003215 WO1994022856A1 (en) 1993-03-26 1994-03-24 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Publications (2)

Publication Number Publication Date
DE69431833D1 true DE69431833D1 (de) 2003-01-16
DE69431833T2 DE69431833T2 (de) 2003-11-06

Family

ID=21909617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431833T Expired - Lifetime DE69431833T2 (de) 1993-03-26 1994-03-24 Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden

Country Status (19)

Country Link
US (3) US5475011A (de)
EP (1) EP0690856B1 (de)
JP (2) JP3157165B2 (de)
KR (1) KR100223720B1 (de)
CN (1) CN1067682C (de)
AT (1) ATE229018T1 (de)
AU (1) AU676041B2 (de)
CA (1) CA2158147C (de)
CZ (1) CZ288924B6 (de)
DE (1) DE69431833T2 (de)
DK (1) DK0690856T3 (de)
ES (1) ES2190440T3 (de)
HU (1) HUT73848A (de)
NO (1) NO311722B1 (de)
PL (2) PL179587B1 (de)
PT (1) PT690856E (de)
RU (1) RU2137764C1 (de)
SK (1) SK282317B6 (de)
WO (1) WO1994022856A1 (de)

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US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
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AU739303B2 (en) 1997-08-21 2001-10-11 Florida State University Method for the synthesis of taxanes
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
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ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
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JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
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ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
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EP1562927B1 (de) * 2002-10-09 2009-05-13 Chatham Biotec Ltd. Thio-analoga von paclitaxel und deren vorprodukte
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
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US20060045877A1 (en) * 2004-08-30 2006-03-02 Goldmakher Viktor S Immunoconjugates targeting syndecan-1 expressing cells and use thereof
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PL1871753T3 (pl) * 2005-03-31 2012-12-31 Accord Healthcare Inc Wytwarzanie taksanów z 9-dihydro-13-acetylobakatyny iii
ES2435724T3 (es) * 2005-11-04 2013-12-23 Accord Healthcare Inc. Nuevos métodos para la preparación de taxanos usando auxiliares quirales
US7615653B2 (en) * 2006-03-15 2009-11-10 The Research Foundation Of State University Of New York Anti-tuberculosis taxane compounds
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
AR069980A1 (es) * 2007-12-26 2010-03-03 Biotest Ag Inmunoconjugados dirigidos contra cd 138 y sus usos
US9011864B2 (en) * 2007-12-26 2015-04-21 Biotest Ag Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
DK2238168T3 (da) * 2007-12-26 2014-08-25 Biotest Ag Midler, der er målrettet mod cd138 og anvendelser deraf
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Also Published As

Publication number Publication date
US5705508A (en) 1998-01-06
CA2158147C (en) 1999-10-05
PL179587B1 (pl) 2000-09-29
DK0690856T3 (da) 2003-03-31
JPH11322737A (ja) 1999-11-24
JPH08508497A (ja) 1996-09-10
US5475011A (en) 1995-12-12
AU6491694A (en) 1994-10-24
WO1994022856A1 (en) 1994-10-13
JP3145993B2 (ja) 2001-03-12
JP3157165B2 (ja) 2001-04-16
KR100223720B1 (ko) 1999-10-15
US5599820A (en) 1997-02-04
NO953796D0 (no) 1995-09-25
CZ288924B6 (cs) 2001-09-12
RU2137764C1 (ru) 1999-09-20
NO311722B1 (no) 2002-01-14
CZ248095A3 (en) 1996-03-13
SK282317B6 (sk) 2002-01-07
NO953796L (no) 1995-11-15
PT690856E (pt) 2003-04-30
AU676041B2 (en) 1997-02-27
HUT73848A (en) 1996-09-30
EP0690856A1 (de) 1996-01-10
CN1067682C (zh) 2001-06-27
CN1123547A (zh) 1996-05-29
EP0690856B1 (de) 2002-12-04
DE69431833T2 (de) 2003-11-06
EP0690856A4 (de) 1996-02-07
CA2158147A1 (en) 1994-10-13
PL180708B1 (pl) 2001-03-30
KR960701045A (ko) 1996-02-24
ATE229018T1 (de) 2002-12-15
ES2190440T3 (es) 2003-08-01
HU9502642D0 (en) 1995-11-28
PL310827A1 (en) 1996-01-08
SK118395A3 (en) 1996-06-05

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