MD1738F2 - Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei - Google Patents

Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei

Info

Publication number
MD1738F2
MD1738F2 MD97-0230A MD970230A MD1738F2 MD 1738 F2 MD1738 F2 MD 1738F2 MD 970230 A MD970230 A MD 970230A MD 1738 F2 MD1738 F2 MD 1738F2
Authority
MD
Moldova
Prior art keywords
obtaining
pharmaceutical composition
salt
composition based
diclavulanate
Prior art date
Application number
MD97-0230A
Other languages
English (en)
Russian (ru)
Other versions
MD970230A (ro
Inventor
George Leo Callewaert
Original Assignee
Spurcourt Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spurcourt Limited filed Critical Spurcourt Limited
Publication of MD970230A publication Critical patent/MD970230A/ro
Publication of MD1738F2 publication Critical patent/MD1738F2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Invenţia se referă la compuşi chimici noi cu activitate biologică, în particular, la compuşii care amplifică acţiunea antibioticelor.Este revendicată sarea de diclavulanat, derivată de la acidul clavulanic şi diaminoeterul,cu formula Iîn care substituenţii au semnificaţia, indicată în descriere.De asemenea, sunt revendicate un procedeu de obţinere a ei şi o compoziţie farmaceutică, conţinând o sare acceptabilă farmaceutic a acidului clavulanic şi un purtător, diluant sau excipient acceptabili farmaceutic şi, preferabil, un antibiotic β-lactamic.
MD97-0230A 1994-12-24 1995-12-22 Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei MD1738F2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426261.5A GB9426261D0 (en) 1994-12-24 1994-12-24 Clavulanic acid salts
PCT/GB1995/003039 WO1996020199A2 (en) 1994-12-24 1995-12-22 Diclavulanate salt with a diamino ether and process of preparation

Publications (2)

Publication Number Publication Date
MD970230A MD970230A (ro) 1999-05-31
MD1738F2 true MD1738F2 (ro) 2001-09-30

Family

ID=10766624

Family Applications (1)

Application Number Title Priority Date Filing Date
MD97-0230A MD1738F2 (ro) 1994-12-24 1995-12-22 Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei

Country Status (40)

Country Link
US (1) US5786351A (ro)
EP (1) EP0799233B1 (ro)
JP (1) JPH10511386A (ro)
KR (1) KR100416946B1 (ro)
CN (1) CN1081640C (ro)
AP (1) AP670A (ro)
AR (1) AR004165A1 (ro)
AT (1) ATE178606T1 (ro)
AU (1) AU702968B2 (ro)
BG (1) BG62971B1 (ro)
BR (1) BR9510250A (ro)
CA (1) CA2208520C (ro)
CZ (1) CZ289287B6 (ro)
DE (1) DE69508962T2 (ro)
DK (1) DK0799233T3 (ro)
EE (1) EE9700139A (ro)
ES (1) ES2132756T3 (ro)
FI (1) FI972464L (ro)
GB (1) GB9426261D0 (ro)
GE (1) GEP20002212B (ro)
GR (1) GR3030629T3 (ro)
HU (1) HUT77090A (ro)
IL (1) IL116498A (ro)
IS (1) IS4501A (ro)
MD (1) MD1738F2 (ro)
MY (1) MY114213A (ro)
NO (1) NO313200B1 (ro)
NZ (1) NZ297857A (ro)
OA (1) OA10861A (ro)
PL (1) PL182364B1 (ro)
RO (1) RO118429B1 (ro)
RU (1) RU2152948C1 (ro)
SE (1) SE520665C2 (ro)
SI (2) SI9520145A (ro)
SK (1) SK282663B6 (ro)
TJ (1) TJ269B (ro)
TR (1) TR199501675A2 (ro)
TW (1) TW401409B (ro)
WO (1) WO1996020199A2 (ro)
ZA (1) ZA9510880B (ro)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
AU5551698A (en) * 1996-11-11 1998-06-03 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
PT1284978E (pt) 2000-05-13 2004-12-31 Smithkline Beecham Plc Processo para a purificacao de um sal de acido clavulanico
EP2276840A1 (en) 2008-04-02 2011-01-26 DSM IP Assets B.V. Diamine salts of carboxylic acids

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
EP0026044A1 (en) * 1979-08-24 1981-04-01 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
EP0387178A1 (en) * 1989-03-01 1990-09-12 Smithkline Beecham Plc Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp.
GB2264944A (en) * 1992-03-10 1993-09-15 Biochemie Gmbh 2-amino-2,4,4-trimethylpentane salt of clavulanic acid
EP0562583A1 (de) * 1992-03-26 1993-09-29 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Neue Alkylendiammonium-diclavulanat-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung
WO1993025557A1 (en) * 1992-06-11 1993-12-23 Smithkline Beecham Plc Process for the preparation of clavulanic acid
WO1994022873A1 (en) * 1993-03-26 1994-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
US4255332A (en) * 1977-09-01 1981-03-10 Beecham Group Limited Process for the preparation of potassium clavulanate from lithium clavulanate
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE3853962T2 (de) 1987-01-29 1996-02-08 Beecham Group Plc Verfahren zur Kristallisation von Kalium-Clavulanat.
US5288861A (en) 1987-01-29 1994-02-22 Beecham Group Plc Potassium clavulanate in rosette form
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
EP0026044A1 (en) * 1979-08-24 1981-04-01 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
EP0387178A1 (en) * 1989-03-01 1990-09-12 Smithkline Beecham Plc Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp.
GB2264944A (en) * 1992-03-10 1993-09-15 Biochemie Gmbh 2-amino-2,4,4-trimethylpentane salt of clavulanic acid
EP0562583A1 (de) * 1992-03-26 1993-09-29 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Neue Alkylendiammonium-diclavulanat-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung
WO1993025557A1 (en) * 1992-06-11 1993-12-23 Smithkline Beecham Plc Process for the preparation of clavulanic acid
WO1994022873A1 (en) * 1993-03-26 1994-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid

Also Published As

Publication number Publication date
ZA9510880B (en) 1996-08-07
AR004165A1 (es) 1998-11-04
TR199501675A2 (tr) 1997-07-21
AP670A (en) 1998-09-04
JPH10511386A (ja) 1998-11-04
GEP20002212B (en) 2000-08-25
TJ269B (en) 2000-08-07
PL321092A1 (en) 1997-11-24
EE9700139A (et) 1997-12-15
PL182364B1 (pl) 2001-12-31
MY114213A (en) 2002-08-30
FI972464A7 (fi) 1997-08-21
IL116498A (en) 2000-07-26
SE9702306L (sv) 1997-08-25
IS4501A (is) 1997-06-09
EP0799233B1 (en) 1999-04-07
SE9702306D0 (sv) 1997-06-17
DK0799233T3 (da) 1999-10-18
NO313200B1 (no) 2002-08-26
CN1081640C (zh) 2002-03-27
CA2208520C (en) 2003-10-07
DE69508962T2 (de) 1999-08-12
NO972946D0 (no) 1997-06-23
AP9701013A0 (en) 1997-07-31
US5786351A (en) 1998-07-28
CZ192097A3 (cs) 1998-08-12
RU2152948C1 (ru) 2000-07-20
KR100416946B1 (ko) 2004-05-10
HUT77090A (hu) 1998-03-02
SK77697A3 (en) 1998-01-14
TW401409B (en) 2000-08-11
WO1996020199A2 (en) 1996-07-04
ATE178606T1 (de) 1999-04-15
SK282663B6 (sk) 2002-11-06
FI972464L (fi) 1997-08-21
EP0799233A2 (en) 1997-10-08
BR9510250A (pt) 1997-11-04
RO118429B1 (ro) 2003-05-30
CA2208520A1 (en) 1996-07-04
AU4311096A (en) 1996-07-19
GB9426261D0 (en) 1995-02-22
BG62971B1 (bg) 2000-12-29
DE69508962D1 (de) 1999-05-12
GR3030629T3 (en) 1999-10-29
SI9520145A (sl) 1998-02-28
NZ297857A (en) 1997-11-24
SI0799233T1 (en) 1999-08-31
CN1171111A (zh) 1998-01-21
OA10861A (en) 2003-02-17
SE520665C2 (sv) 2003-08-05
AU702968B2 (en) 1999-03-11
FI972464A0 (fi) 1997-06-10
WO1996020199A3 (en) 1996-09-12
MX9704693A (es) 1998-06-30
ES2132756T3 (es) 1999-08-16
IL116498A0 (en) 1996-03-31
BG101671A (bg) 1998-09-30
NO972946L (no) 1997-06-23
CZ289287B6 (cs) 2001-12-12
MD970230A (ro) 1999-05-31

Similar Documents

Publication Publication Date Title
EA199600104A1 (ru) Повышенная биодоступность биологически активных соединений при связывании с производными полипирролкарбоксамидонафталиновой кислоты
NO920957D0 (no) Cykliske urinstoffderivater og legemidler inneholdende disse forbindelser
RU95114376A (ru) Нитроэфиры, обладающие фармакологической активностью, и способ их получения
EA200400432A1 (ru) Производные мочевины
AP9701041A0 (en) Pyridylpyrrole compounds.
IL118889A (en) Pharmaceutical compositions containing n-(aroyl) glycine hydroxamic acid and related compounds and some such novel compounds
TR200200749T2 (tr) Kinazolin bileşikleri ve bunları içeren farmasötik bileşikler.
JO1502B1 (en) New pharmacy vehicles
ZA9710796B (en) Oxyiminopregnanecarbolactones.
ATE250622T1 (de) 4'-c-ethynyl-pyrimidine nukleoside
PL285248A1 (en) Method of obtaining novel aminophenol derivatives
NO996108L (no) 9-oksinerytromycinderivater
BG103219A (bg) Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие
NZ503912A (en) Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
CA2336412A1 (en) Medicament for treatment of diabetes
MX9708696A (es) Cefalosporinas antibacterianas.
TNSN90021A1 (fr) Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales
PT736029E (pt) Sulfamatos de pseudofructopiranose anticonvulsivos
MD1738F2 (ro) Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei
ES2163396T3 (es) Aminas biologicamente activas.
TW367326B (en) Pyrimidine derivative, process for the preparation thereof and a pharmaceutical composition containing same
YU5893A (sh) Sulfonilkarbamid i postupak za njegovo dobijanje
HUT45081A (en) Process for producing amino acid derivatives and pharmaceuticals comprising these compounds as active ingredient
MX9804828A (es) Benzotiazolona etanaminas biologicamente activas.
HRP20010885B1 (en) Ethanesulfonyl-piperidine derivatives

Legal Events

Date Code Title Description
PD99 Pending application