MD1738F2 - Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei - Google Patents
Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza eiInfo
- Publication number
- MD1738F2 MD1738F2 MD97-0230A MD970230A MD1738F2 MD 1738 F2 MD1738 F2 MD 1738F2 MD 970230 A MD970230 A MD 970230A MD 1738 F2 MD1738 F2 MD 1738F2
- Authority
- MD
- Moldova
- Prior art keywords
- obtaining
- pharmaceutical composition
- salt
- base
- diclavulanate
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000000630 rising effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Invenţia se referă la compuşi chimici noi cu activitate biologică, în particular, la compuşii care amplifică acţiunea antibioticelor.Este revendicată sarea de diclavulanat, derivată de la acidul clavulanic şi diaminoeterul,cu formula Iîn care substituenţii au semnificaţia, indicată în descriere.De asemenea, sunt revendicate un procedeu de obţinere a ei şi o compoziţie farmaceutică, conţinând o sare acceptabilă farmaceutic a acidului clavulanic şi un purtător, diluant sau excipient acceptabili farmaceutic şi, preferabil, un antibiotic β-lactamic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426261.5A GB9426261D0 (en) | 1994-12-24 | 1994-12-24 | Clavulanic acid salts |
| PCT/GB1995/003039 WO1996020199A2 (en) | 1994-12-24 | 1995-12-22 | Diclavulanate salt with a diamino ether and process of preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD970230A MD970230A (ro) | 1999-05-31 |
| MD1738F2 true MD1738F2 (ro) | 2001-09-30 |
Family
ID=10766624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD97-0230A MD1738F2 (ro) | 1994-12-24 | 1995-12-22 | Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US5786351A (ro) |
| EP (1) | EP0799233B1 (ro) |
| JP (1) | JPH10511386A (ro) |
| KR (1) | KR100416946B1 (ro) |
| CN (1) | CN1081640C (ro) |
| AP (1) | AP670A (ro) |
| AR (1) | AR004165A1 (ro) |
| AT (1) | ATE178606T1 (ro) |
| AU (1) | AU702968B2 (ro) |
| BG (1) | BG62971B1 (ro) |
| BR (1) | BR9510250A (ro) |
| CA (1) | CA2208520C (ro) |
| CZ (1) | CZ289287B6 (ro) |
| DE (1) | DE69508962T2 (ro) |
| DK (1) | DK0799233T3 (ro) |
| EE (1) | EE9700139A (ro) |
| ES (1) | ES2132756T3 (ro) |
| FI (1) | FI972464A (ro) |
| GB (1) | GB9426261D0 (ro) |
| GE (1) | GEP20002212B (ro) |
| GR (1) | GR3030629T3 (ro) |
| HU (1) | HUT77090A (ro) |
| IL (1) | IL116498A (ro) |
| IS (1) | IS4501A (ro) |
| MD (1) | MD1738F2 (ro) |
| MY (1) | MY114213A (ro) |
| NO (1) | NO313200B1 (ro) |
| NZ (1) | NZ297857A (ro) |
| OA (1) | OA10861A (ro) |
| PL (1) | PL182364B1 (ro) |
| RO (1) | RO118429B1 (ro) |
| RU (1) | RU2152948C1 (ro) |
| SE (1) | SE520665C2 (ro) |
| SI (2) | SI0799233T1 (ro) |
| SK (1) | SK282663B6 (ro) |
| TJ (1) | TJ269B (ro) |
| TR (1) | TR199501675A2 (ro) |
| TW (1) | TW401409B (ro) |
| WO (1) | WO1996020199A2 (ro) |
| ZA (1) | ZA9510880B (ro) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
| GB9426261D0 (en) * | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
| SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
| PL333247A1 (en) * | 1996-11-11 | 1999-11-22 | Gist Brocades Bv | Method of manufacturing of salts and esters of clavulan acid |
| AT404728B (de) * | 1996-11-27 | 1999-02-25 | Biochemie Gmbh | Verfahren zur herstellung von clavulansäure-aminsalzen |
| WO2001087891A1 (en) | 2000-05-13 | 2001-11-22 | Smithkline Beecham P.L.C. | Process for the purification of a salt of clavulanic acid |
| WO2009121869A1 (en) * | 2008-04-02 | 2009-10-08 | Dsm Ip Assets B.V. | Diamine salts of carboxylic acids |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
| EP0026044A1 (en) * | 1979-08-24 | 1981-04-01 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
| EP0387178A1 (en) * | 1989-03-01 | 1990-09-12 | Smithkline Beecham Plc | Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp. |
| GB2264944A (en) * | 1992-03-10 | 1993-09-15 | Biochemie Gmbh | 2-amino-2,4,4-trimethylpentane salt of clavulanic acid |
| EP0562583A1 (de) * | 1992-03-26 | 1993-09-29 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | Neue Alkylendiammonium-diclavulanat-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung |
| WO1993025557A1 (en) * | 1992-06-11 | 1993-12-23 | Smithkline Beecham Plc | Process for the preparation of clavulanic acid |
| WO1994022873A1 (en) * | 1993-03-26 | 1994-10-13 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4144242A (en) * | 1975-02-07 | 1979-03-13 | Glaxo Laboratories Limited | Process for the purification of clavulanic acid |
| US4255332A (en) * | 1977-09-01 | 1981-03-10 | Beecham Group Limited | Process for the preparation of potassium clavulanate from lithium clavulanate |
| US4454069A (en) * | 1979-08-24 | 1984-06-12 | Beecham Group Limited | Clavulanic acid salts and their preparation from the tertiary butyl amine salt |
| US5288861A (en) | 1987-01-29 | 1994-02-22 | Beecham Group Plc | Potassium clavulanate in rosette form |
| NZ223316A (en) | 1987-01-29 | 1989-10-27 | Beecham Group Plc | Crystalline potassium clavulanate and pharmaceutical compositions |
| GB9305565D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
| GB9426261D0 (en) * | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
-
1994
- 1994-12-24 GB GBGB9426261.5A patent/GB9426261D0/en active Pending
-
1995
- 1995-12-21 IL IL11649895A patent/IL116498A/xx not_active IP Right Cessation
- 1995-12-21 ZA ZA9510880A patent/ZA9510880B/xx unknown
- 1995-12-21 AR ARP950100702A patent/AR004165A1/es active IP Right Grant
- 1995-12-22 TJ TJ97000473A patent/TJ269B/xx unknown
- 1995-12-22 US US08/737,891 patent/US5786351A/en not_active Expired - Fee Related
- 1995-12-22 CA CA002208520A patent/CA2208520C/en not_active Expired - Fee Related
- 1995-12-22 SI SI9530245T patent/SI0799233T1/xx unknown
- 1995-12-22 EE EE9700139A patent/EE9700139A/xx unknown
- 1995-12-22 KR KR1019970704332A patent/KR100416946B1/ko not_active IP Right Cessation
- 1995-12-22 CZ CZ19971920A patent/CZ289287B6/cs not_active IP Right Cessation
- 1995-12-22 SK SK776-97A patent/SK282663B6/sk unknown
- 1995-12-22 BR BR9510250A patent/BR9510250A/pt not_active IP Right Cessation
- 1995-12-22 WO PCT/GB1995/003039 patent/WO1996020199A2/en active IP Right Grant
- 1995-12-22 EP EP95941809A patent/EP0799233B1/en not_active Expired - Lifetime
- 1995-12-22 JP JP8520309A patent/JPH10511386A/ja active Pending
- 1995-12-22 PL PL95321092A patent/PL182364B1/pl not_active IP Right Cessation
- 1995-12-22 NZ NZ297857A patent/NZ297857A/en unknown
- 1995-12-22 DK DK95941809T patent/DK0799233T3/da active
- 1995-12-22 AP APAP/P/1997/001013A patent/AP670A/en active
- 1995-12-22 ES ES95941809T patent/ES2132756T3/es not_active Expired - Lifetime
- 1995-12-22 CN CN95197032A patent/CN1081640C/zh not_active Expired - Fee Related
- 1995-12-22 TR TR95/01675A patent/TR199501675A2/xx unknown
- 1995-12-22 GE GEAP19953795A patent/GEP20002212B/en unknown
- 1995-12-22 AU AU43110/96A patent/AU702968B2/en not_active Ceased
- 1995-12-22 RO RO97-01119A patent/RO118429B1/ro unknown
- 1995-12-22 AT AT95941809T patent/ATE178606T1/de not_active IP Right Cessation
- 1995-12-22 HU HU9701685A patent/HUT77090A/hu not_active Application Discontinuation
- 1995-12-22 SI SI9520145A patent/SI9520145A/sl unknown
- 1995-12-22 DE DE69508962T patent/DE69508962T2/de not_active Expired - Fee Related
- 1995-12-22 MD MD97-0230A patent/MD1738F2/ro unknown
- 1995-12-22 RU RU97112159/04A patent/RU2152948C1/ru not_active IP Right Cessation
- 1995-12-23 MY MYPI95004076A patent/MY114213A/en unknown
-
1996
- 1996-01-06 TW TW085100132A patent/TW401409B/zh not_active IP Right Cessation
-
1997
- 1997-06-09 IS IS4501A patent/IS4501A/is unknown
- 1997-06-10 FI FI972464A patent/FI972464A/fi unknown
- 1997-06-17 SE SE9702306A patent/SE520665C2/sv not_active IP Right Cessation
- 1997-06-23 NO NO19972946A patent/NO313200B1/no not_active IP Right Cessation
- 1997-06-24 OA OA70038A patent/OA10861A/en unknown
- 1997-06-25 BG BG101671A patent/BG62971B1/bg unknown
-
1999
- 1999-06-30 GR GR990401715T patent/GR3030629T3/el unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
| EP0026044A1 (en) * | 1979-08-24 | 1981-04-01 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
| EP0387178A1 (en) * | 1989-03-01 | 1990-09-12 | Smithkline Beecham Plc | Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp. |
| GB2264944A (en) * | 1992-03-10 | 1993-09-15 | Biochemie Gmbh | 2-amino-2,4,4-trimethylpentane salt of clavulanic acid |
| EP0562583A1 (de) * | 1992-03-26 | 1993-09-29 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | Neue Alkylendiammonium-diclavulanat-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung |
| WO1993025557A1 (en) * | 1992-06-11 | 1993-12-23 | Smithkline Beecham Plc | Process for the preparation of clavulanic acid |
| WO1994022873A1 (en) * | 1993-03-26 | 1994-10-13 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU9200823D0 (en) | Process for the production of cyclical carbamide derivatives and medical preparations containing them as active agents | |
| MY127718A (en) | Dolastatin 10 derivatives. | |
| AP9701041A0 (en) | Pyridylpyrrole compounds. | |
| DE60005502D1 (de) | 4'-c-ethynyl-purin-nukleoside | |
| MY101784A (en) | Novel pharmacological compounds | |
| GEP20022654B (en) | Indazole Amide Compounds As Serotoninergic Agents | |
| MX9708696A (es) | Cefalosporinas antibacterianas. | |
| GR1002573B (el) | Μικροβιακη μεθοδος παρασκευης μεβινολινης. | |
| GR1001597B (el) | Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών. | |
| HUT64518A (en) | Process for producing 4-phenyl-piperidine-4-carbixamide derivatives and pharmaceutical preparatives containing these compounds as active agents | |
| IL112098A0 (en) | Sulfamate derivatives and pharmaceutical compositions containing them | |
| HUT55054A (en) | Process for producing new antibioticum mersadicin and salts and pharmaceutical compositions containing them as active components | |
| MD1738F2 (ro) | Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei | |
| ES2097736T3 (es) | Peptido ciclico con actividad antagonista de sustancia p y sustancia k. | |
| HUT45081A (en) | Process for producing amino acid derivatives and pharmaceuticals comprising these compounds as active ingredient | |
| GR852395B (ro) | ||
| HUT42102A (en) | Process for preparing peptides with pharmaceutical activity | |
| MX9804828A (es) | Benzotiazolona etanaminas biologicamente activas. | |
| AU6853700A (en) | Chemical compounds | |
| EP0333000A3 (en) | Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them | |
| ZA925782B (en) | N-(isoquinolin-5-ylsulphonyl) azacycloalkanes, process for the preparation thereof and pharmaceutical compositions containing them. | |
| MXPA03009723A (es) | Procedimientos e intermediarios para preparar epoxidos substituidos de bencilo. | |
| GR860045B (en) | Novel piperazine derivatives processes for production thereof and pharmaceutical compositions comprising said compounds as active ingredient | |
| GR3031709T3 (en) | Octahydro-2-naphthalenecarboxylic acid derivative, its production and use. | |
| DK0865422T3 (da) | Anvendelse af aminoalkoholderivater som lægemidler, hidtil ukendte derivater og fremgangsmåde til fremstilling deraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD99 | Pending application |