HUP9904086A2 - 4-es Helyzetben szubsztituált piperidinszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

4-es Helyzetben szubsztituált piperidinszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9904086A2
HUP9904086A2 HU9904086A HUP9904086A HUP9904086A2 HU P9904086 A2 HUP9904086 A2 HU P9904086A2 HU 9904086 A HU9904086 A HU 9904086A HU P9904086 A HUP9904086 A HU P9904086A HU P9904086 A2 HUP9904086 A2 HU P9904086A2
Authority
HU
Hungary
Prior art keywords
piperidine derivatives
pharmaceutical compositions
compositions containing
substituted piperidine
compounds
Prior art date
Application number
HU9904086A
Other languages
English (en)
Inventor
Aurelio Orjales Venero
Carmen Pumar Duran
Antonio Toledo Avello
Original Assignee
Faes, Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes, Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. filed Critical Faes, Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A.
Publication of HU9904086D0 publication Critical patent/HU9904086D0/hu
Publication of HUP9904086A2 publication Critical patent/HUP9904086A2/hu
Publication of HUP9904086A3 publication Critical patent/HUP9904086A3/hu
Publication of HU227558B1 publication Critical patent/HU227558B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya (I) általános képletű 4-es helyzetben szubsztituáltúj piperidinszármazékok, ahol R1 és R2 jelentése szubsztituálatlan arilcsoport vagy mono- vagypoliszubsztituált arilcsoport, itt a szubsztituens jelentésehalogénatom, így fluor-, klór-, bróm-, jódatom, alkil-, alkoxi-,ciano-, trifluormetoxi-, trifluor-metil-, benzoil-, fenil-, nitro-,amino-, amino- alkil-, amino-aril- vagy karbonil-amino-csoport. ésszervetlen és szerves savakkal alkotott, gyógyszerészetilegalkalmazható sóik. A vegyületek gyógyszerként alkalmazhatók központiidegrendszeri rendellenességek kezelésére. A találmány a vegyületekettartalmazó gyógyszerkészítményeket is magában foglalja. Ó
HU9904086A 1998-11-18 1999-11-08 4-substituted piperidine derivatives and pharmaceutical compositions containing them HU227558B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802420A ES2157148B1 (es) 1998-11-18 1998-11-18 Nuevas piperidinas 4-sustituidas.

Publications (4)

Publication Number Publication Date
HU9904086D0 HU9904086D0 (en) 2000-01-28
HUP9904086A2 true HUP9904086A2 (hu) 2000-11-28
HUP9904086A3 HUP9904086A3 (en) 2001-11-28
HU227558B1 HU227558B1 (en) 2011-08-29

Family

ID=8305832

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904086A HU227558B1 (en) 1998-11-18 1999-11-08 4-substituted piperidine derivatives and pharmaceutical compositions containing them

Country Status (21)

Country Link
EP (1) EP1002794B1 (hu)
JP (1) JP4667552B2 (hu)
KR (1) KR100646675B1 (hu)
AR (1) AR028805A1 (hu)
AT (1) ATE422199T1 (hu)
AU (1) AU757177B2 (hu)
BR (1) BR9905634B1 (hu)
CA (1) CA2288533C (hu)
CY (1) CY1108955T1 (hu)
CZ (1) CZ296053B6 (hu)
DE (1) DE69940378D1 (hu)
DK (1) DK1002794T3 (hu)
ES (2) ES2157148B1 (hu)
HR (1) HRP990354B1 (hu)
HU (1) HU227558B1 (hu)
IL (1) IL132862A0 (hu)
NO (1) NO314401B1 (hu)
PL (1) PL196329B1 (hu)
PT (1) PT1002794E (hu)
RU (1) RU2232753C2 (hu)
TR (1) TR199902839A2 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1513510A1 (en) * 2002-05-30 2005-03-16 Head Explorer A/S The use of milnacipran for the treatment of tension-type headache
UA77536C2 (en) * 2002-07-03 2006-12-15 Lundbeck & Co As H Secondary aminoaniline piperidines as mch1 antagonists and their use
WO2005092885A1 (en) * 2004-02-27 2005-10-06 Eli Lilly And Company 4-amino-piperidine derivatives as monoamine uptake inhibitors
CN1968932A (zh) 2004-06-18 2007-05-23 惠氏公司 制备6－烷基－5－芳基磺酰基－二氢菲啶的方法
EP1854785A1 (en) * 2006-05-12 2007-11-14 Faes Farma, S.A. 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions
CN101506164A (zh) * 2006-08-23 2009-08-12 辉瑞产品公司 哌啶衍生物
AU2009313951B2 (en) * 2008-11-14 2015-03-12 Theravance Biopharma R&D Ip, Llc 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
WO2010120910A1 (en) * 2009-04-15 2010-10-21 Theravance, Inc. 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
US20130131079A1 (en) 2010-05-24 2013-05-23 Faes Farma, S.A. Flufenoxine derivatives for the treatment and prevention of amyloid pathologies
EP2390248A1 (en) 2010-05-24 2011-11-30 Faes Farma, S.A. Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203149A (en) * 1968-06-10 1970-08-26 Ici Ltd Piperidine derivatives
JPH0615529B2 (ja) * 1985-04-01 1994-03-02 エーザイ株式会社 新規ピペリジン誘導体
JPH0840999A (ja) * 1994-08-04 1996-02-13 Yamanouchi Pharmaceut Co Ltd フルオロインダン誘導体
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina

Also Published As

Publication number Publication date
HRP990354A2 (en) 2000-06-30
HRP990354B1 (en) 2008-11-30
AR028805A1 (es) 2003-05-28
JP2000154176A (ja) 2000-06-06
HU9904086D0 (en) 2000-01-28
JP4667552B2 (ja) 2011-04-13
TR199902839A3 (tr) 2000-09-21
DE69940378D1 (de) 2009-03-19
RU2232753C2 (ru) 2004-07-20
HUP9904086A3 (en) 2001-11-28
CA2288533C (en) 2009-01-06
ES2157148A1 (es) 2001-08-01
KR20000035525A (ko) 2000-06-26
AU5936699A (en) 2000-05-25
NO995643L (no) 2000-05-19
NO314401B1 (no) 2003-03-17
EP1002794B1 (en) 2009-02-04
PL336607A1 (en) 2000-05-22
BR9905634B1 (pt) 2012-09-04
CZ296053B6 (cs) 2005-12-14
ATE422199T1 (de) 2009-02-15
PT1002794E (pt) 2009-03-25
CY1108955T1 (el) 2014-07-02
ES2157148B1 (es) 2002-03-01
EP1002794A1 (en) 2000-05-24
BR9905634A (pt) 2000-09-26
AU757177B2 (en) 2003-02-06
HU227558B1 (en) 2011-08-29
ES2323742T3 (es) 2009-07-23
CA2288533A1 (en) 2000-05-18
IL132862A0 (en) 2001-03-19
CZ399599A3 (cs) 2000-08-16
KR100646675B1 (ko) 2006-11-17
PL196329B1 (pl) 2007-12-31
NO995643D0 (no) 1999-11-17
TR199902839A2 (xx) 2000-09-21
DK1002794T3 (da) 2009-04-14

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Legal Events

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MM4A Lapse of definitive patent protection due to non-payment of fees