AR028805A1 - Nuevas piperidinas 4-sustituidas, asi como sus sales farmaceuticas con acidos inoranicos y organicos, obtenidas como mezclas racemicas y como enantiomeros puros, mezclados con excipientes para administracion oral, parental y topica - Google Patents

Nuevas piperidinas 4-sustituidas, asi como sus sales farmaceuticas con acidos inoranicos y organicos, obtenidas como mezclas racemicas y como enantiomeros puros, mezclados con excipientes para administracion oral, parental y topica

Info

Publication number
AR028805A1
AR028805A1 ARP990105657A ARP990105657A AR028805A1 AR 028805 A1 AR028805 A1 AR 028805A1 AR P990105657 A ARP990105657 A AR P990105657A AR P990105657 A ARP990105657 A AR P990105657A AR 028805 A1 AR028805 A1 AR 028805A1
Authority
AR
Argentina
Prior art keywords
new
well
racemic mixtures
pure enantiomers
parental
Prior art date
Application number
ARP990105657A
Other languages
English (en)
Inventor
Venero Aurelio Orjales
Avello Antonio Toledo
Duran Carmen Pumar
Original Assignee
Faes Fabrica Espanola De Produ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Fabrica Espanola De Produ filed Critical Faes Fabrica Espanola De Produ
Publication of AR028805A1 publication Critical patent/AR028805A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nuevas piperidinas 4ûsustituidas, así como sus sales farmacéuticas con ácidos inorgánicos y orgánicos, obtenidas como mezclas racémicas y como enantiomeros puros, mezclados con excipientes para la administracion oral, parental y topica. Se describen nuevas piperidinas 4ûsustituidas de formula general (1), donde R1 y R2 son radicales arilo, sustituidos o sin sustituir, y que son obtenidas como mezclas racémicas y como enantiomeros puros. Estos compuestos, y sus sales farmacéuticamente aceptables, inhiben la recaptacion de serotonina y/o noradrenalina, siendo de utilidad como antidepresivos. Otras posibles aplicaciones terapéuticas de estos compuestos son el tratamiento de la bulimia nerviosa, los desordenes obsesivoûcompulsivos, la adiccion al alcohol, la ansiedad, el pánico, el dolor, el síndrome premenstrual y la fobia social, así como la profilaxis de la migrana.
ARP990105657A 1998-11-18 1999-11-09 Nuevas piperidinas 4-sustituidas, asi como sus sales farmaceuticas con acidos inoranicos y organicos, obtenidas como mezclas racemicas y como enantiomeros puros, mezclados con excipientes para administracion oral, parental y topica AR028805A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802420A ES2157148B1 (es) 1998-11-18 1998-11-18 Nuevas piperidinas 4-sustituidas.

Publications (1)

Publication Number Publication Date
AR028805A1 true AR028805A1 (es) 2003-05-28

Family

ID=8305832

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990105657A AR028805A1 (es) 1998-11-18 1999-11-09 Nuevas piperidinas 4-sustituidas, asi como sus sales farmaceuticas con acidos inoranicos y organicos, obtenidas como mezclas racemicas y como enantiomeros puros, mezclados con excipientes para administracion oral, parental y topica

Country Status (21)

Country Link
EP (1) EP1002794B1 (es)
JP (1) JP4667552B2 (es)
KR (1) KR100646675B1 (es)
AR (1) AR028805A1 (es)
AT (1) ATE422199T1 (es)
AU (1) AU757177B2 (es)
BR (1) BR9905634B1 (es)
CA (1) CA2288533C (es)
CY (1) CY1108955T1 (es)
CZ (1) CZ296053B6 (es)
DE (1) DE69940378D1 (es)
DK (1) DK1002794T3 (es)
ES (2) ES2157148B1 (es)
HR (1) HRP990354B1 (es)
HU (1) HU227558B1 (es)
IL (1) IL132862A0 (es)
NO (1) NO314401B1 (es)
PL (1) PL196329B1 (es)
PT (1) PT1002794E (es)
RU (1) RU2232753C2 (es)
TR (1) TR199902839A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101443A1 (en) * 2002-05-30 2003-12-11 Head Explorer A/S The use of milnacipran for the treatment of tension-type headache
UA77536C2 (en) * 2002-07-03 2006-12-15 Lundbeck & Co As H Secondary aminoaniline piperidines as mch1 antagonists and their use
EP1735302B1 (en) 2004-02-27 2010-06-16 Eli Lilly And Company 4-amino-piperidine derivatives as monoamine uptake inhibitors
CN1968932A (zh) 2004-06-18 2007-05-23 惠氏公司 制备6－烷基－5－芳基磺酰基－二氢菲啶的方法
EP1854785A1 (en) * 2006-05-12 2007-11-14 Faes Farma, S.A. 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions
CN101506164A (zh) * 2006-08-23 2009-08-12 辉瑞产品公司 哌啶衍生物
DK2358674T3 (da) * 2008-11-14 2013-04-08 Theravance Inc Fremgangsmåde til fremstilling af 4-[2-(2-fluorphenoxymethyl)phenyl]piperidinforbindelser
WO2010120910A1 (en) * 2009-04-15 2010-10-21 Theravance, Inc. 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
WO2011147780A1 (en) 2010-05-24 2011-12-01 Faes Farma, S.A. Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies
EP2390248A1 (en) 2010-05-24 2011-11-30 Faes Farma, S.A. Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203149A (en) * 1968-06-10 1970-08-26 Ici Ltd Piperidine derivatives
JPH0615529B2 (ja) * 1985-04-01 1994-03-02 エーザイ株式会社 新規ピペリジン誘導体
JPH0840999A (ja) * 1994-08-04 1996-02-13 Yamanouchi Pharmaceut Co Ltd フルオロインダン誘導体
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina

Also Published As

Publication number Publication date
BR9905634B1 (pt) 2012-09-04
EP1002794B1 (en) 2009-02-04
HU227558B1 (en) 2011-08-29
NO995643L (no) 2000-05-19
ATE422199T1 (de) 2009-02-15
IL132862A0 (en) 2001-03-19
EP1002794A1 (en) 2000-05-24
PT1002794E (pt) 2009-03-25
JP2000154176A (ja) 2000-06-06
AU757177B2 (en) 2003-02-06
CA2288533C (en) 2009-01-06
KR20000035525A (ko) 2000-06-26
HRP990354B1 (en) 2008-11-30
DE69940378D1 (de) 2009-03-19
ES2157148A1 (es) 2001-08-01
PL196329B1 (pl) 2007-12-31
ES2157148B1 (es) 2002-03-01
CY1108955T1 (el) 2014-07-02
HUP9904086A2 (hu) 2000-11-28
CA2288533A1 (en) 2000-05-18
TR199902839A3 (tr) 2000-09-21
TR199902839A2 (xx) 2000-09-21
PL336607A1 (en) 2000-05-22
NO314401B1 (no) 2003-03-17
NO995643D0 (no) 1999-11-17
KR100646675B1 (ko) 2006-11-17
BR9905634A (pt) 2000-09-26
ES2323742T3 (es) 2009-07-23
RU2232753C2 (ru) 2004-07-20
DK1002794T3 (da) 2009-04-14
CZ399599A3 (cs) 2000-08-16
HUP9904086A3 (en) 2001-11-28
CZ296053B6 (cs) 2005-12-14
JP4667552B2 (ja) 2011-04-13
HRP990354A2 (en) 2000-06-30
HU9904086D0 (en) 2000-01-28
AU5936699A (en) 2000-05-25

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