AR032756A1 - Metodo de tratamiento para inhibir el progreso o para aliviar una condicion que se alivia por un antagonista de 5-ht3 o del receptor nicotinico neuronal y uso de 1-amino-alquilciclohexanos - Google Patents
Metodo de tratamiento para inhibir el progreso o para aliviar una condicion que se alivia por un antagonista de 5-ht3 o del receptor nicotinico neuronal y uso de 1-amino-alquilciclohexanosInfo
- Publication number
- AR032756A1 AR032756A1 ARP010102918A ARP010102918A AR032756A1 AR 032756 A1 AR032756 A1 AR 032756A1 AR P010102918 A ARP010102918 A AR P010102918A AR P010102918 A ARP010102918 A AR P010102918A AR 032756 A1 AR032756 A1 AR 032756A1
- Authority
- AR
- Argentina
- Prior art keywords
- disorders
- condition
- group
- inhibit
- antagonist
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Método para tratar a un animal vivo para inhibir el progreso o para aliviar una condicion que se alivia por un antagonista de 5-HT3 o del receptor nicotínico neuronal, que comprende el paso de administrar a dicho animal vivo una cantidad de un compuesto 1-aminoalquilciclohexano que se selecciona entre el grupo que consiste en aquéllos que tienen la formula (1), donde R* es-(CH2)n-(CR6R7)m-NR8R9, donde n + m = 0, 1, o 2, donde desde R1 hasta R7 se seleccionan independientemente entre el grupo que consiste en hidrogeno y alquilo inferior C1-6, donde R8 y R9 se seleccionan independientemente entre el grupo que consiste en hidrogeno y alquilo inferior C1-6 o juntos representan alquileno inferior -(CH2)x-donde x es 2 a 5, inclusive, e isomeros opticos, enantiomeros, hidrato, y sales aceptables para uso farmacéutico de los mismos, que es efectivo para dicho proposito. Estos 1-aminoalquilciclohexanos son antagonistas del receptor nicotínico y 5-HT3 sistemáticamente activos y son utiles para inhibir el progreso o para aliviar condiciones que se producen por alteraciones de la transmision serotoninérgica o nicotinérgica, con lo cual despliegan un amplio rango de utilidad para el tratamiento de trastornos del sistema nervioso central. Preferiblemente, la condicion alivianada o inhibida se selecciona entre el grupo que consiste en emesis, trastornos de ansiedad, esquizofrenia, trastornos por abuso de drogas y alcohol, trastornos depresivos, trastornos cognitivos, enfermedad de Alzheimer, temblor cerebeloso, enfermedad de Parkinson, mal de Tourette, y trastornos del apetito. Uso de 1-amino-alquilciclohexanos incluyendo sus isomeros opticos, enantiomeros, hidratos, y sales aceptables para uso farmacéutico de los mismos, en la fabricacion de un medicamento para tratar un animal vivo para inhibir la progresion de o aliviar una condicion que se alivia mediante un antagonista del receptor 5-HT3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59710200A | 2000-06-20 | 2000-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032756A1 true AR032756A1 (es) | 2003-11-26 |
Family
ID=24390098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010102918A AR032756A1 (es) | 2000-06-20 | 2001-06-19 | Metodo de tratamiento para inhibir el progreso o para aliviar una condicion que se alivia por un antagonista de 5-ht3 o del receptor nicotinico neuronal y uso de 1-amino-alquilciclohexanos |
Country Status (21)
Country | Link |
---|---|
US (2) | US20070105961A1 (es) |
EP (2) | EP1303477A2 (es) |
JP (1) | JP4159351B2 (es) |
KR (1) | KR100570374B1 (es) |
CN (1) | CN1307147C (es) |
AR (1) | AR032756A1 (es) |
AU (2) | AU8186101A (es) |
CA (1) | CA2410852C (es) |
CZ (1) | CZ2003497A3 (es) |
EA (1) | EA006067B1 (es) |
GE (1) | GEP20053431B (es) |
HK (1) | HK1076276A1 (es) |
HU (1) | HUP0301551A3 (es) |
IL (2) | IL153480A0 (es) |
MX (1) | MXPA02012244A (es) |
NO (1) | NO329491B1 (es) |
PL (1) | PL359583A1 (es) |
TW (1) | TW593223B (es) |
UA (1) | UA74194C2 (es) |
WO (1) | WO2001098253A2 (es) |
ZA (1) | ZA200104187B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
TW200306189A (en) | 2002-03-21 | 2003-11-16 | Merz Pharma Gmbh & Co Kgaa | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
PL376476A1 (en) * | 2002-10-24 | 2005-12-27 | Merz Pharma Gmbh & Co.Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
KR20060030469A (ko) | 2003-05-27 | 2006-04-10 | 포레스트 래보러토리즈, 인코포레이티드 | 우울증 및 그 밖의 기분장애의 치료를 위한 nmda수용체 길항제 및 선택적 세로토닌 재흡수 억제제의 배합물 |
WO2005009421A2 (en) * | 2003-07-28 | 2005-02-03 | Merz Pharma Gmbh & Co. Kgaa | The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity |
AR046314A1 (es) * | 2003-11-05 | 2005-11-30 | Merz Pharma Gmbh & Co Kgaa | Composiciones que comprenden ciclohexilaminas y aminoadamantanos |
TW200531680A (en) * | 2004-03-03 | 2005-10-01 | Merz Pharma Gmbh & Co Kgaa | Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease |
EA011290B1 (ru) * | 2004-06-17 | 2009-02-27 | Мерц Фарма Гмбх Унд Ко. Кгаа | Препаративные формы пероральных лекарственных форм мемантина с немедленным высвобождением |
WO2006078239A1 (en) | 2005-01-18 | 2006-07-27 | University Of Florida | Compositions and methods for inhibiting pain |
CA2894860C (en) | 2008-11-19 | 2018-11-06 | Gerhard Koenig | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
CN102159201A (zh) | 2008-12-19 | 2011-08-17 | 莫茨药物股份两合公司 | 用于治疗肥大细胞介导的疾病的1-氨基-烷基环己烷衍生物 |
TWI432188B (zh) * | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之1-胺基-烷基環己烷衍生物類 |
KR101495978B1 (ko) | 2010-05-17 | 2015-02-25 | 포럼 파마슈티칼즈 인크. | (R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태 |
EP3461481A1 (en) | 2012-05-08 | 2019-04-03 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9411955D0 (en) * | 1994-06-15 | 1994-08-03 | Merck Sharp & Dohme | Therapeutic agents |
US5886051A (en) * | 1995-11-08 | 1999-03-23 | University Of Florida Research Foundation, Inc. | Methods and compositions for the treatment of neurodegeneration |
ZA9610738B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
US5728728A (en) * | 1996-04-10 | 1998-03-17 | Kozachuk; Walter E. | Methods of providing neuroprotection |
US6436946B1 (en) * | 1997-05-02 | 2002-08-20 | Morris A. Mann | Xanthine-containing compositions for oral administration and uses related thereto |
US5866585A (en) * | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
US6071966A (en) * | 1997-06-30 | 2000-06-06 | Merz + Co. Gmbh & Co. | 1-amino-alkylcyclohexane NMDA receptor antagonists |
JP3963488B2 (ja) * | 1997-06-30 | 2007-08-22 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツンク ウント コンパニー コマンディゲゼルシャフト アウフ アクチェン | 1−アミノ−アルキルシクロヘキサンnmda受容体拮抗薬 |
AR016212A1 (es) * | 1998-04-28 | 2001-06-20 | Astra Ab | Uso de compuestos farmaceuticos que tienen una actividad antagonista de nmda para preparar un medicamento para el tratamiento del sindrome de intestino irritable (ibs), y composiciones farmaceuticas |
US6139861A (en) * | 1999-01-14 | 2000-10-31 | Friedman; Mark | Intraoral topical anti-inflammatory treatment for relief of migraine, tension-type headache, post-traumatic headache facial pain, and cervical-muscle spasm |
US6828462B2 (en) * | 2001-11-07 | 2004-12-07 | Merz Pharma Gmbh & Co. Kgaa | Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
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2001
- 2001-05-14 TW TW090111488A patent/TW593223B/zh not_active IP Right Cessation
- 2001-05-22 ZA ZA200104187A patent/ZA200104187B/xx unknown
- 2001-06-19 WO PCT/EP2001/006964 patent/WO2001098253A2/en active IP Right Grant
- 2001-06-19 CZ CZ2003497A patent/CZ2003497A3/cs unknown
- 2001-06-19 MX MXPA02012244A patent/MXPA02012244A/es active IP Right Grant
- 2001-06-19 AR ARP010102918A patent/AR032756A1/es unknown
- 2001-06-19 GE GE5059A patent/GEP20053431B/en unknown
- 2001-06-19 AU AU8186101A patent/AU8186101A/xx active Pending
- 2001-06-19 CN CNB01811413XA patent/CN1307147C/zh not_active Expired - Fee Related
- 2001-06-19 IL IL15348001A patent/IL153480A0/xx active IP Right Grant
- 2001-06-19 CA CA002410852A patent/CA2410852C/en not_active Expired - Fee Related
- 2001-06-19 PL PL01359583A patent/PL359583A1/xx not_active Application Discontinuation
- 2001-06-19 HU HU0301551A patent/HUP0301551A3/hu unknown
- 2001-06-19 EP EP01960342A patent/EP1303477A2/en not_active Withdrawn
- 2001-06-19 EP EP10184507A patent/EP2277850A1/en not_active Withdrawn
- 2001-06-19 EA EA200300040A patent/EA006067B1/ru not_active IP Right Cessation
- 2001-06-19 UA UA2003010457A patent/UA74194C2/uk unknown
- 2001-06-19 JP JP2002504209A patent/JP4159351B2/ja not_active Expired - Fee Related
- 2001-06-19 AU AU2001281861A patent/AU2001281861B2/en not_active Ceased
- 2001-06-19 KR KR1020027017329A patent/KR100570374B1/ko not_active IP Right Cessation
-
2002
- 2002-12-16 IL IL153480A patent/IL153480A/en not_active IP Right Cessation
- 2002-12-19 NO NO20026103A patent/NO329491B1/no not_active IP Right Cessation
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2005
- 2005-09-22 HK HK05108300A patent/HK1076276A1/xx not_active IP Right Cessation
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2006
- 2006-12-21 US US11/643,129 patent/US20070105961A1/en not_active Abandoned
-
2010
- 2010-07-26 US US12/804,610 patent/US20100298442A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20026103L (no) | 2003-02-19 |
MXPA02012244A (es) | 2004-09-06 |
GEP20053431B (en) | 2005-01-25 |
EP2277850A1 (en) | 2011-01-26 |
AU2001281861B2 (en) | 2006-08-17 |
IL153480A0 (en) | 2003-07-06 |
KR20030053475A (ko) | 2003-06-28 |
HUP0301551A2 (hu) | 2003-11-28 |
NO20026103D0 (no) | 2002-12-19 |
CN1307147C (zh) | 2007-03-28 |
UA74194C2 (uk) | 2005-11-15 |
ZA200104187B (en) | 2002-11-22 |
AU8186101A (en) | 2002-01-02 |
HK1076276A1 (en) | 2006-01-13 |
HUP0301551A3 (en) | 2005-04-28 |
JP4159351B2 (ja) | 2008-10-01 |
NO329491B1 (no) | 2010-10-25 |
EA006067B1 (ru) | 2005-08-25 |
CA2410852A1 (en) | 2001-12-27 |
US20100298442A1 (en) | 2010-11-25 |
EP1303477A2 (en) | 2003-04-23 |
CZ2003497A3 (cs) | 2004-08-18 |
TW593223B (en) | 2004-06-21 |
WO2001098253A3 (en) | 2002-04-25 |
CA2410852C (en) | 2007-04-24 |
KR100570374B1 (ko) | 2006-04-24 |
IL153480A (en) | 2007-08-19 |
PL359583A1 (en) | 2004-08-23 |
CN1620419A (zh) | 2005-05-25 |
US20070105961A1 (en) | 2007-05-10 |
JP2004501130A (ja) | 2004-01-15 |
WO2001098253A2 (en) | 2001-12-27 |
EA200300040A1 (ru) | 2003-06-26 |
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