ES2157148A1 - Nuevas piperidinas 4-sustituidas. - Google Patents
Nuevas piperidinas 4-sustituidas.Info
- Publication number
- ES2157148A1 ES2157148A1 ES009802420A ES9802420A ES2157148A1 ES 2157148 A1 ES2157148 A1 ES 2157148A1 ES 009802420 A ES009802420 A ES 009802420A ES 9802420 A ES9802420 A ES 9802420A ES 2157148 A1 ES2157148 A1 ES 2157148A1
- Authority
- ES
- Spain
- Prior art keywords
- serotonin
- noradrenaline reuptake
- substituted
- aryloxy
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nuevas piperidinas 4-sustituidas. Se describen nuevas piperidinas-4 sustituidas de fórmula general (I), donde R{sub, 1}, y R{sub, 2} son radicales arilo, sustituidos o sin sustituir, y que son obtenidas como mezclas racémicas y como enantiómeros puros. **FORMULA** . Estos compuestos, y sus sales farmacéuticamente aceptables, inhiben la recaptación de serotonina y/o noradrenalina, siendo de utilidad como antidepresivos. Otras posibles aplicaciones terapéuticas de estos compuestos son el tratamiento de la bulimia nerviosa, los desórdenes obsesivo-compulsivos, la adicción al alcohol, la ansiedad, el pánico, el dolor, el síndrome premenstrual y la fobia social, así como la profilaxis de la migraña.
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802420A ES2157148B1 (es) | 1998-11-18 | 1998-11-18 | Nuevas piperidinas 4-sustituidas. |
CA002288533A CA2288533C (en) | 1998-11-18 | 1999-11-04 | New 4-substituted piperidines |
HU9904086A HU227558B1 (en) | 1998-11-18 | 1999-11-08 | 4-substituted piperidine derivatives and pharmaceutical compositions containing them |
ARP990105657A AR028805A1 (es) | 1998-11-18 | 1999-11-09 | Nuevas piperidinas 4-sustituidas, asi como sus sales farmaceuticas con acidos inoranicos y organicos, obtenidas como mezclas racemicas y como enantiomeros puros, mezclados con excipientes para administracion oral, parental y topica |
AT99500208T ATE422199T1 (de) | 1998-11-18 | 1999-11-10 | 4- (aryl)(aryloxy)methyl piperidinderivate und ihre verwendung als serotonin und/oder noradrenalin reuptake inhibitoren |
ES99500208T ES2323742T3 (es) | 1998-11-18 | 1999-11-10 | Derivados de 4-(aril)(ariloxi)metil piperidina y su uso como inhibidores de la recaptacion de serotonina y/o noradrenalina. |
DE69940378T DE69940378D1 (de) | 1998-11-18 | 1999-11-10 | 4-i(Aryl)(aryloxy)methyl piperidinderivate und ihre Verwendung als Serotonin und/oder Noradrenalin Reuptake Inhibitoren |
DK99500208T DK1002794T3 (da) | 1998-11-18 | 1999-11-10 | 4-(aryl)(aryloxy)methylpiperidinderivater og anvendelse deraf som serotonin og/eller noradrenalingenoptagelsesinhibitorer |
EP99500208A EP1002794B1 (en) | 1998-11-18 | 1999-11-10 | 4-¬(Aryl)(aryloxy)methyl piperidine derivatives and their use as serotonin and/or noradrenaline reuptake inhibitors |
IL13286299A IL132862A0 (en) | 1998-11-18 | 1999-11-10 | New 4-substituted piperidines |
PT99500208T PT1002794E (pt) | 1998-11-18 | 1999-11-10 | Derivados de 4-(aril)(aroloxi)metilpiperidina e sua utilização como inibidores da reabsorção da serotonina e/ou noradrenalina |
CZ19993995A CZ296053B6 (cs) | 1998-11-18 | 1999-11-10 | 4-Substituované piperidiny |
AU59366/99A AU757177B2 (en) | 1998-11-18 | 1999-11-11 | New 4-substituted piperidines |
HR990354A HRP990354B1 (en) | 1998-11-18 | 1999-11-16 | New 4-substituted piperidines |
KR1019990051053A KR100646675B1 (ko) | 1998-11-18 | 1999-11-17 | 신규의 4-치환된 피페리딘 |
RU99124412/04A RU2232753C2 (ru) | 1998-11-18 | 1999-11-17 | 4-замещенные пиперидины, фармацевтическая композиция на их основе и способ лечения заболеваний центральной нервной системы |
PL336607A PL196329B1 (pl) | 1998-11-18 | 1999-11-17 | 4-podstawione piperydyny, kompozycja farmaceutyczna zawierająca takie związki oraz zastosowanie |
TR1999/02839A TR199902839A2 (xx) | 1998-11-18 | 1999-11-17 | Yeni 4-ikameli piperidinler. |
BRPI9905634-8A BR9905634B1 (pt) | 1998-11-18 | 1999-11-17 | piperidinas 4-substituìdas. |
NO19995643A NO314401B1 (no) | 1998-11-18 | 1999-11-17 | Nye, 4-substituerte piperidiner, farmasöytisk preparat inneholdende disse og anvendelse av dem for fremstilling av et medikament |
JP32888599A JP4667552B2 (ja) | 1998-11-18 | 1999-11-18 | 新規な4−置換ピペリジン |
US09/824,189 US6518284B2 (en) | 1998-11-18 | 2001-04-02 | 4-substituted piperidines |
CY20091100388T CY1108955T1 (el) | 1998-11-18 | 2009-04-02 | Παραγωγα 4-(αρυλ)-(αρυλοξυ)μεθυλοπιπεριδινης και η χρηση τους ως αναστολεις επαναπροσληψης σεροτονινης και/ή νοραδρεναλινης |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802420A ES2157148B1 (es) | 1998-11-18 | 1998-11-18 | Nuevas piperidinas 4-sustituidas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2157148A1 true ES2157148A1 (es) | 2001-08-01 |
ES2157148B1 ES2157148B1 (es) | 2002-03-01 |
Family
ID=8305832
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009802420A Expired - Fee Related ES2157148B1 (es) | 1998-11-18 | 1998-11-18 | Nuevas piperidinas 4-sustituidas. |
ES99500208T Expired - Lifetime ES2323742T3 (es) | 1998-11-18 | 1999-11-10 | Derivados de 4-(aril)(ariloxi)metil piperidina y su uso como inhibidores de la recaptacion de serotonina y/o noradrenalina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99500208T Expired - Lifetime ES2323742T3 (es) | 1998-11-18 | 1999-11-10 | Derivados de 4-(aril)(ariloxi)metil piperidina y su uso como inhibidores de la recaptacion de serotonina y/o noradrenalina. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1002794B1 (es) |
JP (1) | JP4667552B2 (es) |
KR (1) | KR100646675B1 (es) |
AR (1) | AR028805A1 (es) |
AT (1) | ATE422199T1 (es) |
AU (1) | AU757177B2 (es) |
BR (1) | BR9905634B1 (es) |
CA (1) | CA2288533C (es) |
CY (1) | CY1108955T1 (es) |
CZ (1) | CZ296053B6 (es) |
DE (1) | DE69940378D1 (es) |
DK (1) | DK1002794T3 (es) |
ES (2) | ES2157148B1 (es) |
HR (1) | HRP990354B1 (es) |
HU (1) | HU227558B1 (es) |
IL (1) | IL132862A0 (es) |
NO (1) | NO314401B1 (es) |
PL (1) | PL196329B1 (es) |
PT (1) | PT1002794E (es) |
RU (1) | RU2232753C2 (es) |
TR (1) | TR199902839A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1513510A1 (en) * | 2002-05-30 | 2005-03-16 | Head Explorer A/S | The use of milnacipran for the treatment of tension-type headache |
UA77536C2 (en) * | 2002-07-03 | 2006-12-15 | Lundbeck & Co As H | Secondary aminoaniline piperidines as mch1 antagonists and their use |
WO2005092885A1 (en) * | 2004-02-27 | 2005-10-06 | Eli Lilly And Company | 4-amino-piperidine derivatives as monoamine uptake inhibitors |
CN1968932A (zh) | 2004-06-18 | 2007-05-23 | 惠氏公司 | 制备6-烷基-5-芳基磺酰基-二氢菲啶的方法 |
EP1854785A1 (en) * | 2006-05-12 | 2007-11-14 | Faes Farma, S.A. | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions |
CN101506164A (zh) * | 2006-08-23 | 2009-08-12 | 辉瑞产品公司 | 哌啶衍生物 |
AU2009313951B2 (en) * | 2008-11-14 | 2015-03-12 | Theravance Biopharma R&D Ip, Llc | 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds |
WO2010120910A1 (en) * | 2009-04-15 | 2010-10-21 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
US20130131079A1 (en) | 2010-05-24 | 2013-05-23 | Faes Farma, S.A. | Flufenoxine derivatives for the treatment and prevention of amyloid pathologies |
EP2390248A1 (en) | 2010-05-24 | 2011-11-30 | Faes Farma, S.A. | Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3634437A (en) * | 1968-06-10 | 1972-01-11 | Ici Ltd | 3-aryloxyalkylpiperidine derivatives |
JPS61227565A (ja) * | 1985-04-01 | 1986-10-09 | Eisai Co Ltd | 新規ピペリジン誘導体 |
JPH0840999A (ja) * | 1994-08-04 | 1996-02-13 | Yamanouchi Pharmaceut Co Ltd | フルオロインダン誘導体 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5150201A1 (es) * | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
-
1998
- 1998-11-18 ES ES009802420A patent/ES2157148B1/es not_active Expired - Fee Related
-
1999
- 1999-11-04 CA CA002288533A patent/CA2288533C/en not_active Expired - Fee Related
- 1999-11-08 HU HU9904086A patent/HU227558B1/hu not_active IP Right Cessation
- 1999-11-09 AR ARP990105657A patent/AR028805A1/es active IP Right Grant
- 1999-11-10 IL IL13286299A patent/IL132862A0/xx not_active IP Right Cessation
- 1999-11-10 CZ CZ19993995A patent/CZ296053B6/cs not_active IP Right Cessation
- 1999-11-10 DK DK99500208T patent/DK1002794T3/da active
- 1999-11-10 ES ES99500208T patent/ES2323742T3/es not_active Expired - Lifetime
- 1999-11-10 PT PT99500208T patent/PT1002794E/pt unknown
- 1999-11-10 EP EP99500208A patent/EP1002794B1/en not_active Expired - Lifetime
- 1999-11-10 AT AT99500208T patent/ATE422199T1/de active
- 1999-11-10 DE DE69940378T patent/DE69940378D1/de not_active Expired - Lifetime
- 1999-11-11 AU AU59366/99A patent/AU757177B2/en not_active Ceased
- 1999-11-16 HR HR990354A patent/HRP990354B1/xx not_active IP Right Cessation
- 1999-11-17 BR BRPI9905634-8A patent/BR9905634B1/pt not_active IP Right Cessation
- 1999-11-17 KR KR1019990051053A patent/KR100646675B1/ko not_active IP Right Cessation
- 1999-11-17 NO NO19995643A patent/NO314401B1/no not_active IP Right Cessation
- 1999-11-17 RU RU99124412/04A patent/RU2232753C2/ru not_active IP Right Cessation
- 1999-11-17 PL PL336607A patent/PL196329B1/pl not_active IP Right Cessation
- 1999-11-17 TR TR1999/02839A patent/TR199902839A2/xx unknown
- 1999-11-18 JP JP32888599A patent/JP4667552B2/ja not_active Expired - Fee Related
-
2009
- 2009-04-02 CY CY20091100388T patent/CY1108955T1/el unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3634437A (en) * | 1968-06-10 | 1972-01-11 | Ici Ltd | 3-aryloxyalkylpiperidine derivatives |
JPS61227565A (ja) * | 1985-04-01 | 1986-10-09 | Eisai Co Ltd | 新規ピペリジン誘導体 |
JPH0840999A (ja) * | 1994-08-04 | 1996-02-13 | Yamanouchi Pharmaceut Co Ltd | フルオロインダン誘導体 |
Non-Patent Citations (3)
Title |
---|
Chemical Abstracts, Vol. 106, no 25, 1987, abstract 213767 "Piperidine derivatives" & JP 61227565 A (EISAI) 09.10.1986 * |
Chemical Abstracts, Vol. 124, no 25, 1996, abstract 343333 "Preparation of piperidinyl derivatives as antidepressants and anxiolytics" & JP 8040999 A (YAMANOUCHI PHARM) 13.02.1996 * |
European Journal of Medicinal Chemistry. Chimica Therapeutica, Vol. 19, no 3, 1984, paginas 235-242. P. MELLONI et al. "Potential antidepressant agents". Pagina 238, compuesto 62. * |
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