DE69940378D1 - 4-i(Aryl)(aryloxy)methyl piperidinderivate und ihre Verwendung als Serotonin und/oder Noradrenalin Reuptake Inhibitoren - Google Patents

4-i(Aryl)(aryloxy)methyl piperidinderivate und ihre Verwendung als Serotonin und/oder Noradrenalin Reuptake Inhibitoren

Info

Publication number
DE69940378D1
DE69940378D1 DE69940378T DE69940378T DE69940378D1 DE 69940378 D1 DE69940378 D1 DE 69940378D1 DE 69940378 T DE69940378 T DE 69940378T DE 69940378 T DE69940378 T DE 69940378T DE 69940378 D1 DE69940378 D1 DE 69940378D1
Authority
DE
Germany
Prior art keywords
serotonin
aryloxy
aryl
reuptake inhibitors
methyl piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940378T
Other languages
English (en)
Inventor
Venero Aurelio Orjales
Avello Antonio Toledo
Duran Carmen Pumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Faes Farma SA
Original Assignee
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA filed Critical Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Application granted granted Critical
Publication of DE69940378D1 publication Critical patent/DE69940378D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69940378T 1998-11-18 1999-11-10 4-i(Aryl)(aryloxy)methyl piperidinderivate und ihre Verwendung als Serotonin und/oder Noradrenalin Reuptake Inhibitoren Expired - Lifetime DE69940378D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802420A ES2157148B1 (es) 1998-11-18 1998-11-18 Nuevas piperidinas 4-sustituidas.

Publications (1)

Publication Number Publication Date
DE69940378D1 true DE69940378D1 (de) 2009-03-19

Family

ID=8305832

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940378T Expired - Lifetime DE69940378D1 (de) 1998-11-18 1999-11-10 4-i(Aryl)(aryloxy)methyl piperidinderivate und ihre Verwendung als Serotonin und/oder Noradrenalin Reuptake Inhibitoren

Country Status (21)

Country Link
EP (1) EP1002794B1 (de)
JP (1) JP4667552B2 (de)
KR (1) KR100646675B1 (de)
AR (1) AR028805A1 (de)
AT (1) ATE422199T1 (de)
AU (1) AU757177B2 (de)
BR (1) BR9905634B1 (de)
CA (1) CA2288533C (de)
CY (1) CY1108955T1 (de)
CZ (1) CZ296053B6 (de)
DE (1) DE69940378D1 (de)
DK (1) DK1002794T3 (de)
ES (2) ES2157148B1 (de)
HR (1) HRP990354B1 (de)
HU (1) HU227558B1 (de)
IL (1) IL132862A0 (de)
NO (1) NO314401B1 (de)
PL (1) PL196329B1 (de)
PT (1) PT1002794E (de)
RU (1) RU2232753C2 (de)
TR (1) TR199902839A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1513510A1 (de) * 2002-05-30 2005-03-16 Head Explorer A/S Verwendung von milnacipran zur behandlung von spannungskopfschmerzen
UA77536C2 (en) * 2002-07-03 2006-12-15 Lundbeck & Co As H Secondary aminoaniline piperidines as mch1 antagonists and their use
WO2005092885A1 (en) * 2004-02-27 2005-10-06 Eli Lilly And Company 4-amino-piperidine derivatives as monoamine uptake inhibitors
CN1968932A (zh) 2004-06-18 2007-05-23 惠氏公司 制备6-烷基-5-芳基磺酰基-二氢菲啶的方法
EP1854785A1 (de) * 2006-05-12 2007-11-14 Faes Farma, S.A. 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulponat: Anwendungen, Verfahren zur Synthese und pharmazeutische Zusammensetzungen
CN101506164A (zh) * 2006-08-23 2009-08-12 辉瑞产品公司 哌啶衍生物
AU2009313951B2 (en) * 2008-11-14 2015-03-12 Theravance Biopharma R&D Ip, Llc 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
WO2010120910A1 (en) * 2009-04-15 2010-10-21 Theravance, Inc. 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
US20130131079A1 (en) 2010-05-24 2013-05-23 Faes Farma, S.A. Flufenoxine derivatives for the treatment and prevention of amyloid pathologies
EP2390248A1 (de) 2010-05-24 2011-11-30 Faes Farma, S.A. Flufenoxinderivate zur Behandlung und Vorbeugung von Amiloydpathologien

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203149A (en) * 1968-06-10 1970-08-26 Ici Ltd Piperidine derivatives
JPH0615529B2 (ja) * 1985-04-01 1994-03-02 エーザイ株式会社 新規ピペリジン誘導体
JPH0840999A (ja) * 1994-08-04 1996-02-13 Yamanouchi Pharmaceut Co Ltd フルオロインダン誘導体
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina

Also Published As

Publication number Publication date
HRP990354A2 (en) 2000-06-30
HRP990354B1 (en) 2008-11-30
HUP9904086A2 (hu) 2000-11-28
AR028805A1 (es) 2003-05-28
JP2000154176A (ja) 2000-06-06
HU9904086D0 (en) 2000-01-28
JP4667552B2 (ja) 2011-04-13
TR199902839A3 (tr) 2000-09-21
RU2232753C2 (ru) 2004-07-20
HUP9904086A3 (en) 2001-11-28
CA2288533C (en) 2009-01-06
ES2157148A1 (es) 2001-08-01
KR20000035525A (ko) 2000-06-26
AU5936699A (en) 2000-05-25
NO995643L (no) 2000-05-19
NO314401B1 (no) 2003-03-17
EP1002794B1 (de) 2009-02-04
PL336607A1 (en) 2000-05-22
BR9905634B1 (pt) 2012-09-04
CZ296053B6 (cs) 2005-12-14
ATE422199T1 (de) 2009-02-15
PT1002794E (pt) 2009-03-25
CY1108955T1 (el) 2014-07-02
ES2157148B1 (es) 2002-03-01
EP1002794A1 (de) 2000-05-24
BR9905634A (pt) 2000-09-26
AU757177B2 (en) 2003-02-06
HU227558B1 (en) 2011-08-29
ES2323742T3 (es) 2009-07-23
CA2288533A1 (en) 2000-05-18
IL132862A0 (en) 2001-03-19
CZ399599A3 (cs) 2000-08-16
KR100646675B1 (ko) 2006-11-17
PL196329B1 (pl) 2007-12-31
NO995643D0 (no) 1999-11-17
TR199902839A2 (xx) 2000-09-21
DK1002794T3 (da) 2009-04-14

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: FAES FARMA, S.A.,, LEJONA, VIZAYA, ES

8364 No opposition during term of opposition