DE69940970D1 - Rolling circle replikation von padlock-sonden - Google Patents

Rolling circle replikation von padlock-sonden

Info

Publication number
DE69940970D1
DE69940970D1 DE69940970T DE69940970T DE69940970D1 DE 69940970 D1 DE69940970 D1 DE 69940970D1 DE 69940970 T DE69940970 T DE 69940970T DE 69940970 T DE69940970 T DE 69940970T DE 69940970 D1 DE69940970 D1 DE 69940970D1
Authority
DE
Germany
Prior art keywords
rolling circle
circle replication
padlock probes
padlock
probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940970T
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English (en)
Inventor
Ulf Landegren
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Olink AB
Original Assignee
Olink AB
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Filing date
Publication date
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Publication of DE69940970D1 publication Critical patent/DE69940970D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69940970T 1998-03-25 1999-03-25 Rolling circle replikation von padlock-sonden Expired - Lifetime DE69940970D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98302278 1998-03-25
PCT/EP1999/002111 WO1999049079A1 (en) 1998-03-25 1999-03-25 Rolling circle replication of padlock probes

Publications (1)

Publication Number Publication Date
DE69940970D1 true DE69940970D1 (de) 2009-07-23

Family

ID=8234734

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940970T Expired - Lifetime DE69940970D1 (de) 1998-03-25 1999-03-25 Rolling circle replikation von padlock-sonden

Country Status (8)

Country Link
US (2) US6558928B1 (de)
EP (3) EP1997909B1 (de)
JP (3) JP4493844B2 (de)
AU (1) AU3601599A (de)
CA (1) CA2325468C (de)
DE (1) DE69940970D1 (de)
DK (1) DK1997909T3 (de)
WO (1) WO1999049079A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108779488A (zh) * 2016-02-26 2018-11-09 小利兰·斯坦福大学托管委员会 采用双探针邻近性连接系统的多重单分子rna可视化

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
US6771152B2 (en) * 2001-03-21 2004-08-03 Leviton Manufacturing Co., Inc. Pivot point reset lockout mechanism for a ground for fault circuit interrupter
US6437700B1 (en) 2000-10-16 2002-08-20 Leviton Manufacturing Co., Inc. Ground fault circuit interrupter
US6288882B1 (en) * 1998-08-24 2001-09-11 Leviton Manufacturing Co., Inc. Circuit breaker with independent trip and reset lockout
US7400477B2 (en) 1998-08-24 2008-07-15 Leviton Manufacturing Co., Inc. Method of distribution of a circuit interrupting device with reset lockout and reverse wiring protection
DE69911641T2 (de) * 1998-11-27 2004-08-05 Synaptics (Uk) Ltd., Harston Positionssensor
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) * 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
JP2003515149A (ja) * 1999-11-26 2003-04-22 キュラジェン コーポレイション 核酸プローブアレイ
WO2001061024A2 (en) * 2000-02-16 2001-08-23 Large Scale Biology Corporation Rolling circle replicon expression vectors
US20040106112A1 (en) * 2000-04-11 2004-06-03 Nilsson Mats Bo Johan Nucleic acid detection medium
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US6531283B1 (en) * 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US6312913B1 (en) * 2000-07-21 2001-11-06 Incyte Genomics, Inc. Method for isolating and characterizing nucleic acid sequences
AU2002246612B2 (en) * 2000-10-24 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
US20030082559A1 (en) * 2001-01-19 2003-05-01 David Beach Methods and reagents for amplification and manipulation of vector and target nucleic acid sequences
HUP0501021A3 (en) * 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
CZ20033143A3 (en) * 2001-05-21 2004-04-14 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US7118864B2 (en) 2001-06-15 2006-10-10 Quiatech Ab Amplifiable probe
JP2005052002A (ja) * 2001-07-06 2005-03-03 Wakunaga Pharmaceut Co Ltd 非環状核酸断片の増幅方法
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US7361489B2 (en) * 2001-10-15 2008-04-22 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
GB2382137A (en) * 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
GB0207063D0 (en) * 2002-03-26 2002-05-08 Amersham Biosciences Uk Ltd Immobilised probes
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US7105308B2 (en) * 2002-07-25 2006-09-12 Monogram Biosciences, Inc. Detecting receptor oligomerization
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
WO2004016755A2 (en) * 2002-08-16 2004-02-26 Geneohm Sciences Amplification of target nucleotide sequence without polymerase chain reaction
CA2505687A1 (en) * 2002-11-19 2004-06-03 Applera Corporation Polynucleotide sequence detection assays and analysis
AU2003295745A1 (en) * 2002-11-19 2004-06-15 Applera Corporation Polynucleotide sequence detection assays
GB0228614D0 (en) * 2002-12-07 2003-01-15 Fu Guoliang Oligonucleotide guided analysis of gene expression
WO2004061131A1 (en) * 2002-12-18 2004-07-22 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
GB0315160D0 (en) * 2003-06-28 2003-08-06 Royal Holloway University Of L In vitro amplification of DNA
US20070014058A1 (en) * 2003-07-03 2007-01-18 Chan David Y Neutral switch test mechanism for a circuit interrupter
US20050186590A1 (en) * 2003-11-10 2005-08-25 Crothers Donald M. Nucleic acid detection method having increased sensitivity
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
EP1756307A1 (de) * 2004-05-20 2007-02-28 Trillion Genomics Limited Verwendung massenmarkierter sonden zum nachweis von zielnukleinsäuren mittels massenspektrometrie
EP1774035A4 (de) * 2004-06-14 2009-02-18 Univ Leland Stanford Junior Verfahren und zusammensetzungen zur verwendung zum nachweis von analyten mittels näherungssensoren
US20080305142A1 (en) * 2004-12-11 2008-12-11 Cytogenix, Inc. Cell Free Biosynthesis of High-Quality Nucleic Acid and Uses Thereof
WO2006071582A2 (en) * 2004-12-29 2006-07-06 Applera Corporation Methods, compositions, and kits for forming self-complementary polynucleotides
EP1833994A4 (de) * 2005-01-04 2009-09-02 Hitachi Chemical Co Ltd Rolling-circle-verstärkung einer primer-erzeugung
US7989166B2 (en) 2005-04-12 2011-08-02 In Situ Rcp A/S Circle probes and their use in the identification of biomolecules
EP1871897B1 (de) 2005-04-12 2010-09-29 Olink AB Verfahren zur herstellung von oligonukleotiden
US7709197B2 (en) 2005-06-15 2010-05-04 Callida Genomics, Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
WO2007005649A2 (en) * 2005-06-30 2007-01-11 Applera Corporation Proximity probing of target proteins comprising restriction and/or extension field
US7960104B2 (en) * 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
BRPI0619665B1 (pt) 2005-11-08 2022-04-12 University Of Cape Town Método para melhorar a expressão de um transgene em uma célula hospedeira in vitro, cassete de expressão em mamífero, vetor, vacina de dna e composição farmacêutica
US20070168197A1 (en) * 2006-01-18 2007-07-19 Nokia Corporation Audio coding
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
JP5180845B2 (ja) * 2006-02-24 2013-04-10 カリダ・ジェノミックス・インコーポレイテッド Ｄｎａアレイ上でのハイスループットゲノム配列決定
SG10201405158QA (en) * 2006-02-24 2014-10-30 Callida Genomics Inc High throughput genome sequencing on dna arrays
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US7897747B2 (en) * 2006-05-25 2011-03-01 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
EP2484781B1 (de) * 2006-08-01 2017-08-23 Applied Biosystems, LLC Nachweis von Analyten und Nukleinsäuren
GB0621361D0 (en) 2006-10-26 2006-12-06 Fermentas Uab Use of DNA polymerases
US7910302B2 (en) * 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090105961A1 (en) * 2006-11-09 2009-04-23 Complete Genomics, Inc. Methods of nucleic acid identification in large-scale sequencing
US20090111705A1 (en) * 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by hybrid capture
US7862999B2 (en) 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
US7897344B2 (en) * 2007-11-06 2011-03-01 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs
US20090263872A1 (en) * 2008-01-23 2009-10-22 Complete Genomics Inc. Methods and compositions for preventing bias in amplification and sequencing reactions
US8518640B2 (en) * 2007-10-29 2013-08-27 Complete Genomics, Inc. Nucleic acid sequencing and process
US8298768B2 (en) 2007-11-29 2012-10-30 Complete Genomics, Inc. Efficient shotgun sequencing methods
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
WO2009061840A1 (en) * 2007-11-05 2009-05-14 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
US20090156412A1 (en) * 2007-12-17 2009-06-18 Helicos Biosciences Corporation Surface-capture of target nucleic acids
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
WO2009132028A1 (en) * 2008-04-21 2009-10-29 Complete Genomics, Inc. Array structures for nucleic acid detection
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
WO2010017228A1 (en) * 2008-08-04 2010-02-11 Atom Sciences, Inc. Nucleic acid sequence detection by void extension ligation amplification
AU2010242073C1 (en) 2009-04-30 2015-12-24 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
EP2504448B1 (de) * 2009-11-25 2016-10-19 Bio-Rad Laboratories, Inc. Verfahren und zusammensetzung zur erkennung von genetischem material
GB0921264D0 (en) 2009-12-03 2010-01-20 Olink Genomics Ab Method for amplification of target nucleic acid
GB201001088D0 (en) 2010-01-23 2010-03-10 Trillion Genomics Ltd Detection
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
GB201004292D0 (en) * 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US8444309B2 (en) 2010-08-13 2013-05-21 Leviton Manufacturing Company, Inc. Wiring device with illumination
EP2627781B1 (de) 2010-10-15 2017-02-22 Olink Bioscience AB Dynamikbereich verfahren
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
EP3940084A1 (de) 2011-02-09 2022-01-19 Bio-Rad Laboratories, Inc. Analyse von nukleinsäuren
US9556473B2 (en) 2011-02-15 2017-01-31 Leica Biosystems Newcastle Ltd Methods for identifying nucleic acid sequences
JP5881746B2 (ja) 2011-02-15 2016-03-09 ライカ バイオシステムズ ニューキャッスル リミテッド ｍＲＮＡの局在インサイチュー検出のための方法
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
US8526144B2 (en) 2011-03-31 2013-09-03 Leviton Manufacturing Company, Inc. Reset lockout with grounded neutral test
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
US9193994B2 (en) * 2012-04-20 2015-11-24 Samsung Electronics Co., Ltd. Polynucleotide and use thereof
WO2014030066A2 (en) 2012-08-22 2014-02-27 Bernitz Mats Nilsson Methods for identifying nucleic acid sequences
WO2014076214A1 (en) * 2012-11-14 2014-05-22 Olink Ab Rca reporter probes and their use in detecting nucleic acid molecules
EP2920324B1 (de) * 2012-11-14 2017-12-27 Olink Bioscience AB Lokalisiertes rca-basiertes verstärkungsverfahren
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
AU2014248759B2 (en) 2013-03-13 2020-02-27 Meso Scale Technologies, Llc. Improved assay methods
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
EP3005200A2 (de) 2013-06-03 2016-04-13 Good Start Genetics, Inc. Verfahren und systeme zur speicherung von sequenzlesedaten
WO2014200579A1 (en) 2013-06-13 2014-12-18 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
WO2015013681A1 (en) 2013-07-25 2015-01-29 Bio-Rad Laboratories, Inc. Genetic assays
KR102160389B1 (ko) 2013-08-05 2020-09-28 트위스트 바이오사이언스 코포레이션 드 노보 합성된 유전자 라이브러리
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
EP3058096A1 (de) 2013-10-18 2016-08-24 Good Start Genetics, Inc. Verfahren zur beurteilung eines genomischen bereichs einer person
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
US9957554B1 (en) 2013-12-19 2018-05-01 National Technology & Engineering Solutions Of Sandia, Llc Microfluidic platform for multiplexed detection in single cells and methods thereof
US10112194B2 (en) 2014-04-14 2018-10-30 Q-Linea Ab Detection of microscopic objects
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
AU2015259048B2 (en) 2014-05-15 2021-09-09 Meso Scale Technologies, Llc. Improved assay methods
GB201413717D0 (en) 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
GB201413718D0 (en) 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
JP2017536087A (ja) 2014-09-24 2017-12-07 グッド スタート ジェネティクス， インコーポレイテッド 遺伝子アッセイのロバストネスを増大させるためのプロセス制御
EP4098753A1 (de) 2014-10-23 2022-12-07 Ricardo Mancebo Reagenzien und verfahren für eine isothermische kettenreaktion
CA3010579A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
WO2016126987A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3329010B1 (de) 2015-07-29 2019-07-10 Progenity, Inc. Nukleinsäuren und verfahren zum nachweis chromosomaler anomalien
EP3350314A4 (de) 2015-09-18 2019-02-06 Twist Bioscience Corporation Oligonukleinsäurevariantenbibliotheken variante und synthese davon
KR20180058772A (ko) 2015-09-22 2018-06-01 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
JP6858783B2 (ja) 2015-10-18 2021-04-14 アフィメトリックス インコーポレイテッド 一塩基多型及びインデルの複対立遺伝子遺伝子型決定
GB201518655D0 (en) 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
CN108779487A (zh) 2015-11-16 2018-11-09 普罗格尼迪公司 用于检测甲基化状态的核酸和方法
CN115920796A (zh) 2015-12-01 2023-04-07 特韦斯特生物科学公司 功能化表面及其制备
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
CA3034769A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
GB2573069A (en) 2016-12-16 2019-10-23 Twist Bioscience Corp Variant libraries of the immunological synapse and synthesis thereof
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
CA3054303A1 (en) 2017-02-22 2018-08-30 Twist Bioscience Corporation Nucleic acid based data storage
US10894959B2 (en) 2017-03-15 2021-01-19 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
EP3601610A1 (de) 2017-03-30 2020-02-05 Pioneer Hi-Bred International, Inc. Verfahren zur identifizierung und charakterisierung von geneditierungsvariationen in nukleinsäuren
JP7313645B2 (ja) 2017-04-24 2023-07-25 国立大学法人広島大学 Ｒｎａ検出方法
AU2018284227B2 (en) 2017-06-12 2024-05-02 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN111201327A (zh) 2017-08-17 2020-05-26 音图基因公司 检测一个或多个dna端部的方法及其用途
CN111566125A (zh) 2017-09-11 2020-08-21 特韦斯特生物科学公司 Gpcr结合蛋白及其合成
GB2583590A (en) 2017-10-20 2020-11-04 Twist Bioscience Corp Heated nanowells for polynucleotide synthesis
AU2018355575A1 (en) 2017-10-27 2020-05-21 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
AU2019205269A1 (en) 2018-01-04 2020-07-30 Twist Bioscience Corporation DNA-based digital information storage
AU2019247652A1 (en) 2018-04-02 2020-10-15 Enumera Molecular, Inc. Methods, systems, and compositions for counting nucleic acid molecules
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN112639130B (zh) 2018-05-18 2024-08-09 特韦斯特生物科学公司 用于核酸杂交的多核苷酸、试剂和方法
WO2020176678A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
JP2022522668A (ja) 2019-02-26 2022-04-20 ツイスト バイオサイエンス コーポレーション 抗体を最適化するための変異体核酸ライブラリ
JP2022525953A (ja) 2019-03-27 2022-05-20 ジュノ ダイアグノスティックス，インク． 最適化された超微量リキッドバイオプシーの方法、システム、およびデバイス
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
US20200347443A1 (en) 2019-05-01 2020-11-05 Element Biosciences, Inc. Nucleic acid hybridization methods
CA3144644A1 (en) 2019-06-21 2020-12-24 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
AU2020356471A1 (en) 2019-09-23 2022-04-21 Twist Bioscience Corporation Variant nucleic acid libraries for CRTH2
WO2021113290A1 (en) 2019-12-03 2021-06-10 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (nulisa)
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
EP4128287B1 (de) 2020-04-03 2024-05-22 Lybe Scientific AS Verfahren zur herstellung von produkten zur isolierung von nukleinsäuren
CA3195721A1 (en) 2020-09-21 2022-03-24 Progenity, Inc. Compositions and methods for isolation of cell-free dna
GB202203185D0 (en) 2022-03-08 2022-04-20 Rarity Bioscience Ab Method for detecting nucleic acid amplification products
GB202203182D0 (en) * 2022-03-08 2022-04-20 Rarity Bioscience Ab Method of detection of a target nucleic acid sequence in a single reaction vessel

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06500014A (ja) * 1990-07-25 1994-01-06 シンジーン，インコーポレイテッド 多数の核酸相補体を生成させる環状伸長法
US5942391A (en) * 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
AU714486B2 (en) * 1995-11-21 2000-01-06 Yale University Unimolecular segment amplification and detection
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108779488A (zh) * 2016-02-26 2018-11-09 小利兰·斯坦福大学托管委员会 采用双探针邻近性连接系统的多重单分子rna可视化
CN108779488B (zh) * 2016-02-26 2022-01-21 小利兰·斯坦福大学托管委员会 采用双探针邻近性连接系统的多重单分子rna可视化

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EP1997909B1 (de) 2012-02-01
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US7074564B2 (en) 2006-07-11
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US20050282158A1 (en) 2005-12-22
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