NO980919L - 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel - Google Patents

8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel

Info

Publication number
NO980919L
NO980919L NO19980919A NO980919A NO980919L NO 980919 L NO980919 L NO 980919L NO 19980919 A NO19980919 A NO 19980919A NO 980919 A NO980919 A NO 980919A NO 980919 L NO980919 L NO 980919L
Authority
NO
Norway
Prior art keywords
heteroaryl
alkynyl
cycloalkyl
alkenyl
alkyl
Prior art date
Application number
NO19980919A
Other languages
English (en)
Other versions
NO980919D0 (no
Inventor
Peter Moldt
Jorgen Scheel-Krueger
Gunnar M Olsen
Elsebet Ostergaard Nielsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO980919D0 publication Critical patent/NO980919D0/no
Publication of NO980919L publication Critical patent/NO980919L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19980919A 1995-10-13 1998-03-03 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel NO980919L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK115695 1995-10-13
PCT/EP1996/004449 WO1997013770A1 (en) 1995-10-13 1996-10-11 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
NO980919D0 NO980919D0 (no) 1998-03-03
NO980919L true NO980919L (no) 1998-06-08

Family

ID=8101642

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19980919A NO980919L (no) 1995-10-13 1998-03-03 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel

Country Status (24)

Country Link
US (1) US6100275A (no)
EP (1) EP0859777B1 (no)
JP (1) JP3462505B2 (no)
KR (1) KR100274829B1 (no)
CN (1) CN1083840C (no)
AT (1) ATE362931T1 (no)
AU (1) AU709327B2 (no)
BR (1) BR9610960A (no)
CA (1) CA2233541C (no)
CZ (1) CZ285093B6 (no)
DE (1) DE69637097T2 (no)
DK (1) DK0859777T3 (no)
EE (1) EE03446B1 (no)
HU (1) HUP9802433A3 (no)
IL (1) IL123583A (no)
IS (1) IS4681A (no)
NO (1) NO980919L (no)
NZ (1) NZ320216A (no)
PL (1) PL185357B1 (no)
RU (1) RU2157372C2 (no)
SK (1) SK283425B6 (no)
TR (1) TR199800628T2 (no)
UA (1) UA63894C2 (no)
WO (1) WO1997013770A1 (no)

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GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
CZ184199A3 (cs) 1996-11-26 1999-08-11 Zeneca Limited Deriváty 8-azabicyklo[3,2,1]oktanu, 8-azabicyklo[3,2,1]okt-6-enu, 9-azabicyklo[3,3,1]nonanu, 9-aza-3-oxabicyklo[3,3,1]nonanu a 9-aza-3-thiabicyklo[3,3,1]nonanu, způsob jejich přípravy a insekticidní, akaricidní nebo nematocidní prostředky, které je obsahují
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
CZ298824B6 (cs) 1997-05-30 2008-02-20 Neurosearch A/S Deriváty 8-azabicyklo[3.2.1]okt-2-enu, zpusob jejich prípravy a jejich použití
GB9726033D0 (en) 1997-12-09 1998-02-04 Zeneca Ltd Chemical process
TWI221842B (en) * 1997-12-11 2004-10-11 Syngenta Ltd Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
WO1999038866A1 (en) * 1998-01-28 1999-08-05 Neurosearch A/S 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form
US6403605B1 (en) 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
CA2335336A1 (en) * 1998-06-19 1999-12-23 James Edmund Audia Inhibition of serotonin reuptake
ATE259804T1 (de) 1998-11-27 2004-03-15 Neurosearch As 8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate
WO2000044746A1 (en) 1999-01-28 2000-08-03 Neurosearch A/S Novel azabicyclo derivatives and their use
JP2002538134A (ja) * 1999-03-01 2002-11-12 ファイザー・インク 療法に有用な１，２，３，４−テトラヒドロ−１−ナフタレンアミン化合物
DE122009000036I2 (de) 1999-09-03 2010-05-06 Apbi Holdings Llc Verwendung von Dapoxetin, ein selektiver Serotonin Aufnahme Inhibitor mit schnellem Wirkungseintritt, zur Behandlung von sexueller Dysfunktion
AU2049501A (en) 1999-12-20 2001-07-03 Eli Lilly And Company Benzofuran derivatives
PT1289996E (pt) 2000-05-25 2005-07-29 Targacept Inc Heteroarildiazabicicloalcanos como ligandos do receptor colinergico nicotinico
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
JP4312456B2 (ja) * 2000-10-13 2009-08-12 ニューロサーチ、アクティーゼルスカブ ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法
EP1379269B1 (en) 2001-04-09 2009-03-04 Neurosearch A/S Adenosine a2a receptor antagonists combined with neurotrophic activity compounds in the treatment of parkinson's disease
AR035898A1 (es) 2001-05-25 2004-07-21 Wyeth Corp Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
MXPA04010965A (es) 2002-05-07 2005-01-25 Neurosearch As Derivados de etinilo azaciclico novedoso.
EP2272847A1 (en) 2005-04-08 2011-01-12 NeuroSearch A/S Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
KR100812499B1 (ko) * 2006-10-16 2008-03-11 이도훈 항경련제
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2009109518A1 (en) * 2008-03-05 2009-09-11 Neurosearch A/S Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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Also Published As

Publication number Publication date
AU709327B2 (en) 1999-08-26
NO980919D0 (no) 1998-03-03
IL123583A0 (en) 1998-10-30
JPH10512589A (ja) 1998-12-02
CA2233541C (en) 2002-04-30
NZ320216A (en) 1999-05-28
CN1083840C (zh) 2002-05-01
RU2157372C2 (ru) 2000-10-10
BR9610960A (pt) 1999-03-02
EE9800062A (et) 1998-08-17
SK28798A3 (en) 1998-09-09
DE69637097D1 (de) 2007-07-05
DE69637097T2 (de) 2007-09-20
TR199800628T2 (xx) 1998-07-21
EE03446B1 (et) 2001-06-15
EP0859777A1 (en) 1998-08-26
KR19990063651A (ko) 1999-07-26
DK0859777T3 (da) 2007-09-03
CZ75898A3 (cs) 1998-11-11
EP0859777B1 (en) 2007-05-23
CZ285093B6 (cs) 1999-05-12
ATE362931T1 (de) 2007-06-15
PL185357B1 (pl) 2003-04-30
CA2233541A1 (en) 1997-04-17
AU7291796A (en) 1997-04-30
KR100274829B1 (ko) 2000-12-15
HUP9802433A3 (en) 2000-03-28
US6100275A (en) 2000-08-08
JP3462505B2 (ja) 2003-11-05
PL326195A1 (en) 1998-08-31
UA63894C2 (en) 2004-02-16
HUP9802433A2 (hu) 1999-04-28
WO1997013770A1 (en) 1997-04-17
IL123583A (en) 2003-07-31
CN1199400A (zh) 1998-11-18
IS4681A (is) 1998-03-04
SK283425B6 (sk) 2003-07-01

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