AR035898A1 - Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion - Google Patents

Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion

Info

Publication number
AR035898A1
AR035898A1 ARP020101757A ARP020101757A AR035898A1 AR 035898 A1 AR035898 A1 AR 035898A1 AR P020101757 A ARP020101757 A AR P020101757A AR P020101757 A ARP020101757 A AR P020101757A AR 035898 A1 AR035898 A1 AR 035898A1
Authority
AR
Argentina
Prior art keywords
compounds
depression
manufacture
octans
azabiciclo
Prior art date
Application number
ARP020101757A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR035898A1 publication Critical patent/AR035898A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto aril-8-azabiciclo[3.2.1]octano de fórmula (1), en la cual: A es un radical que se combina con los átomos de carbono a los cuales está fijado de manera de completar un grupo ciclobutilo, ciclopentilo, ciclohexilo, cicloheptilo, pirrolilo, imidazolilo, piridinilo, piridazinilo o pirimidinilo; X es NH, O ó S; n es un número entero de 0 a 3; Ar1 es fenilo o piridilo sustituidos con 0 a 2 grupos alquilo C1-3, alcoxi C1-3, halo, ciano, nitro, trifluormetilo, difluormetilo, hidroxilo, o trifluormetoxi; y Ar2 es indolilo, benzimidazolilo, fenilo, naftilo, antracenilo, fenantrenilo, bencilo, benzofurilo, o benzotienilo, sustituidos con de 0 a 2 grupos alquilo C1-3, alcoxi C1-3, halo, ciano, nitro, trifluormetilo, difluormetilo, hidroxilo, o trifluormetoxi; y todas las formas cristalinas o una sal farmacéuticamente aceptable del mismo; estos compuestos pueden ser utilizados para tratar la depresión. También incluye formulaciones que contienen estos compuestos, y procesos para prepararlos y el uso de dichos compuestos para la manufactura de un medicamento para tratar la depresión.
ARP020101757A 2001-05-25 2002-05-14 Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion AR035898A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29356301P 2001-05-25 2001-05-25

Publications (1)

Publication Number Publication Date
AR035898A1 true AR035898A1 (es) 2004-07-21

Family

ID=23129588

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101757A AR035898A1 (es) 2001-05-25 2002-05-14 Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion

Country Status (14)

Country Link
US (1) US6632824B2 (es)
EP (1) EP1390364B1 (es)
JP (1) JP2004533459A (es)
CN (1) CN100408575C (es)
AR (1) AR035898A1 (es)
AT (1) ATE277924T1 (es)
BR (1) BR0209995A (es)
CA (1) CA2446532A1 (es)
DE (1) DE60201440T2 (es)
DK (1) DK1390364T3 (es)
ES (1) ES2227468T3 (es)
MX (1) MXPA03010737A (es)
TW (1) TW589312B (es)
WO (1) WO2002096906A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030130919A1 (en) * 2001-11-20 2003-07-10 Randy Templeton Systems and methods for selectively accessing financial account information
US7873566B1 (en) 2001-11-20 2011-01-18 First Data Corporation Systems and methods for selectively accessing or using financial account data for subsequent risk determination
US7668776B1 (en) 2002-01-07 2010-02-23 First Data Corporation Systems and methods for selective use of risk models to predict financial risk
US7653590B1 (en) 2002-01-14 2010-01-26 First Data Corporation System and method for overturning of risk evaluation performed by risk model to control financial risk
EP1496058A1 (en) * 2003-07-09 2005-01-12 Boehringer Ingelheim Pharma GmbH & Co.KG Novel N-(heterobicycloalkanes)-substituted Indoles or heteroderivatives thereof
KR20080030058A (ko) 2005-07-27 2008-04-03 에프. 호프만-라 로슈 아게 5-ｈｔ6 조절인자로서 4-아릴옥시 퀴놀린 유도체
CN111217747B (zh) * 2020-03-17 2022-02-22 济南韶远医药技术有限公司 一种扑疟喹啉的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340936A (en) * 1991-02-04 1994-08-23 Hoechst-Roussel Pharmaceuticals Inc. 8-azabicyclo[3.2.1]octane methanone and corresponding oximes
US5627196A (en) 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5789402A (en) 1995-01-17 1998-08-04 Eli Lilly Company Compounds having effects on serotonin-related systems
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5614523A (en) 1995-01-17 1997-03-25 Eli Lilly And Company Compounds having effects on serotonin-related systems
IL123583A (en) 1995-10-13 2003-07-31 Neurosearch As 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them
CZ285571B6 (cs) 1995-11-02 1999-09-15 Neurosearch A/S Kondenzované tropanové deriváty, způsob jejich výroby, farmaceutické prostředky, které je obsahují a jejich použití k léčení
US5912256A (en) 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
CA2335336A1 (en) 1998-06-19 1999-12-23 James Edmund Audia Inhibition of serotonin reuptake
GB9815317D0 (en) * 1998-07-15 1998-09-16 Merck Sharp & Dohme Therapeutic agents
US6432976B1 (en) * 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
WO2001046187A1 (en) * 1999-12-20 2001-06-28 Eli Lilly And Company Azabicyclo[3.2.1]octane derivatives

Also Published As

Publication number Publication date
ATE277924T1 (de) 2004-10-15
DE60201440T2 (de) 2006-02-23
TW589312B (en) 2004-06-01
BR0209995A (pt) 2004-04-06
CA2446532A1 (en) 2002-12-05
CN100408575C (zh) 2008-08-06
US20030032645A1 (en) 2003-02-13
EP1390364B1 (en) 2004-09-29
MXPA03010737A (es) 2004-03-02
ES2227468T3 (es) 2005-04-01
DE60201440D1 (de) 2004-11-04
US6632824B2 (en) 2003-10-14
JP2004533459A (ja) 2004-11-04
CN1509287A (zh) 2004-06-30
EP1390364A1 (en) 2004-02-25
DK1390364T3 (da) 2004-12-20
WO2002096906A1 (en) 2002-12-05

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AR035898A1 (es) Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
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