ATE362931T1 - 8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendung - Google Patents
8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendungInfo
- Publication number
- ATE362931T1 ATE362931T1 AT96934662T AT96934662T ATE362931T1 AT E362931 T1 ATE362931 T1 AT E362931T1 AT 96934662 T AT96934662 T AT 96934662T AT 96934662 T AT96934662 T AT 96934662T AT E362931 T1 ATE362931 T1 AT E362931T1
- Authority
- AT
- Austria
- Prior art keywords
- heteroaryl
- alkynyl
- cycloalkyl
- alkenyl
- alkyl
- Prior art date
Links
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK115695 | 1995-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362931T1 true ATE362931T1 (de) | 2007-06-15 |
Family
ID=8101642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96934662T ATE362931T1 (de) | 1995-10-13 | 1996-10-11 | 8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendung |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6100275A (de) |
| EP (1) | EP0859777B1 (de) |
| JP (1) | JP3462505B2 (de) |
| KR (1) | KR100274829B1 (de) |
| CN (1) | CN1083840C (de) |
| AT (1) | ATE362931T1 (de) |
| AU (1) | AU709327B2 (de) |
| BR (1) | BR9610960A (de) |
| CA (1) | CA2233541C (de) |
| CZ (1) | CZ285093B6 (de) |
| DE (1) | DE69637097T2 (de) |
| DK (1) | DK0859777T3 (de) |
| EE (1) | EE03446B1 (de) |
| HU (1) | HUP9802433A3 (de) |
| IL (1) | IL123583A (de) |
| IS (1) | IS4681A (de) |
| NO (1) | NO980919L (de) |
| NZ (1) | NZ320216A (de) |
| PL (1) | PL185357B1 (de) |
| RU (1) | RU2157372C2 (de) |
| SK (1) | SK283425B6 (de) |
| TR (1) | TR199800628T2 (de) |
| UA (1) | UA63894C2 (de) |
| WO (1) | WO1997013770A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
| CA2251851A1 (en) * | 1996-05-13 | 1997-11-20 | Roger Salmon | Bicyclic amines as insecticides |
| GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
| GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
| GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
| TR199901704T2 (xx) | 1996-11-26 | 1999-12-21 | Zeneca Limited | 8-Azabisiklo$3.2.1]oktan-, 8-azabisiklo$3.2.1]okt-6-en-,9-azabisiklo$3.3.1] nonan-,9-aza-3-oksabisiklo$3.3.1]nonan-ve 9-aza-3-tiabisiklo$3.3.1]nonan t�revleri, bunlar�n haz�rlanmas� ve insektisidler olarak kullan�mlar�. |
| GB9706222D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Bicyclic amine derivatives |
| EE04057B1 (et) * | 1997-05-30 | 2003-06-16 | Neurosearch A/S | 8-asabitsüklo[3,2,1]okt-2-eeni ja -oktaani derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon |
| GB9726033D0 (en) | 1997-12-09 | 1998-02-04 | Zeneca Ltd | Chemical process |
| TWI221842B (en) * | 1997-12-11 | 2004-10-11 | Syngenta Ltd | Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives |
| AU2609999A (en) * | 1998-01-28 | 1999-08-16 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form |
| US6403605B1 (en) | 1998-05-29 | 2002-06-11 | Queen's University At Kingston | Methods for the normalization of sexual response and amelioration of long term genital tissue degradation |
| AU4819099A (en) * | 1998-06-19 | 2000-01-05 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| NZ510287A (en) | 1998-11-27 | 2003-05-30 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives useful as cholinergic ligands at the nicotinic acetyl choline receptor |
| RU2211216C2 (ru) * | 1998-12-22 | 2003-08-27 | Мерк Патент Гмбх | Производные амидов и мочевины в качестве ингибиторов вторичного поглощения 5-ht и лигандов 5-ht1b/1d |
| AU2278700A (en) | 1999-01-28 | 2000-08-18 | Neurosearch A/S | Novel azabicyclo derivatives and their use |
| DE60021859T2 (de) * | 1999-03-01 | 2006-06-01 | Pfizer Inc. | 1, 2, 3, 4-tetrahydro-1-naphthalenamin verbindungen zur therapeutsichen verwendung |
| BR0014166A (pt) | 1999-09-03 | 2002-05-14 | Lilly Co Eli | Método de utilização de inibidores de reabsorção de serotonina seletivo de rápido ataque para tratamento de disfunção sexual |
| AU2049501A (en) * | 1999-12-20 | 2001-07-03 | Eli Lilly And Company | Benzofuran derivatives |
| CA2409644A1 (en) | 2000-05-25 | 2001-11-29 | Targacept, Inc. | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands |
| US6667314B2 (en) | 2000-05-26 | 2003-12-23 | Pfizer, Inc. | Tropane derivatives useful in therapy |
| US6579878B1 (en) | 2000-07-07 | 2003-06-17 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US7307087B2 (en) * | 2000-10-13 | 2007-12-11 | Neurosearch A/S | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
| ATE424194T1 (de) | 2001-04-09 | 2009-03-15 | Neurosearch As | Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson |
| TW589312B (en) | 2001-05-25 | 2004-06-01 | Wyeth Corp | Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression |
| RU2203044C1 (ru) * | 2001-12-27 | 2003-04-27 | Закрытое акционерное общество "Брынцалов-А" | Антидепрессант амитриптилин-ферейн |
| CN100522976C (zh) | 2002-05-07 | 2009-08-05 | 神经研究公司 | 氮杂环乙炔基衍生物 |
| AU2004249441B2 (en) * | 2003-06-24 | 2009-11-12 | Neurosearch A/S | Novel 8-aza-bicyclo(3.2.1)octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| DE602005025785D1 (de) * | 2004-09-30 | 2011-02-17 | Neurosearch As | Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter-wiederaufnahmeinhibitoren |
| JP2008534653A (ja) * | 2005-04-08 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 |
| TW200744590A (en) * | 2005-09-01 | 2007-12-16 | Neurosearch As | Novel compounds |
| RU2315047C1 (ru) * | 2006-09-04 | 2008-01-20 | Институт нефтехимии и катализа РАН | Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана |
| KR100812499B1 (ko) * | 2006-10-16 | 2008-03-11 | 이도훈 | 항경련제 |
| TWI415850B (zh) * | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備ｍｕ類鴉片受體拮抗劑之中間物的方法 |
| EP2254868A1 (de) * | 2008-03-05 | 2010-12-01 | NeuroSearch A/S | Neue 4-benzhydryl-tetrahydropyridin-derivate und ihre verwendung als monoamin-neurotransmitter-wiederaufnahmeinhibitoren |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB247886A (en) * | 1925-11-02 | 1926-02-25 | Thomas Stewart Hamilton | Improvements in attachments for leaf springs |
| US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
| US3657257A (en) * | 1970-08-31 | 1972-04-18 | Robins Co Inc A H | 3-aryl-8-carbamoyl nortropanes |
| US4180669A (en) * | 1976-12-13 | 1979-12-25 | Abbott Laboratories | 2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol |
| US4132710A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| NZ192941A (en) * | 1979-02-22 | 1984-10-19 | Wellcome Found | 1-substituted imidazoles;pharmaceutical compositions |
| US5418240A (en) * | 1990-08-21 | 1995-05-23 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| DK198590D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| GB9019973D0 (en) * | 1990-09-12 | 1990-10-24 | Wyeth John & Brother Ltd | Azabicyclic derivatives |
| NZ241481A (en) * | 1991-02-04 | 1994-06-27 | Hoechst Roussel Pharma | Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DE4200145A1 (de) * | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| WO1994026274A1 (en) * | 1993-05-18 | 1994-11-24 | Wake Forest University | Treatment process with biologically active tropane derivatives |
| CA2187309C (en) * | 1994-04-19 | 2000-11-21 | Peter Moldt | Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors |
| US5731317A (en) * | 1995-03-10 | 1998-03-24 | Merck & Co., Inc. | Bridged piperidines promote release of growth hormone |
-
1996
- 1996-10-11 JP JP51472697A patent/JP3462505B2/ja not_active Expired - Fee Related
- 1996-10-11 RU RU98105169/04A patent/RU2157372C2/ru not_active IP Right Cessation
- 1996-10-11 AT AT96934662T patent/ATE362931T1/de active
- 1996-10-11 TR TR1998/00628T patent/TR199800628T2/xx unknown
- 1996-10-11 IL IL12358396A patent/IL123583A/xx not_active IP Right Cessation
- 1996-10-11 CZ CZ98758A patent/CZ285093B6/cs not_active IP Right Cessation
- 1996-10-11 EE EE9800062A patent/EE03446B1/xx not_active IP Right Cessation
- 1996-10-11 SK SK287-98A patent/SK283425B6/sk unknown
- 1996-10-11 CA CA002233541A patent/CA2233541C/en not_active Expired - Fee Related
- 1996-10-11 KR KR1019980702103A patent/KR100274829B1/ko not_active Expired - Fee Related
- 1996-10-11 AU AU72917/96A patent/AU709327B2/en not_active Ceased
- 1996-10-11 PL PL96326195A patent/PL185357B1/pl not_active IP Right Cessation
- 1996-10-11 BR BR9610960A patent/BR9610960A/pt not_active Application Discontinuation
- 1996-10-11 HU HU9802433A patent/HUP9802433A3/hu unknown
- 1996-10-11 WO PCT/EP1996/004449 patent/WO1997013770A1/en not_active Ceased
- 1996-10-11 DE DE69637097T patent/DE69637097T2/de not_active Expired - Lifetime
- 1996-10-11 US US09/043,294 patent/US6100275A/en not_active Expired - Fee Related
- 1996-10-11 CN CN96197566A patent/CN1083840C/zh not_active Expired - Fee Related
- 1996-10-11 NZ NZ320216A patent/NZ320216A/xx not_active IP Right Cessation
- 1996-10-11 EP EP96934662A patent/EP0859777B1/de not_active Expired - Lifetime
- 1996-10-11 DK DK96934662T patent/DK0859777T3/da active
- 1996-11-10 UA UA98031543A patent/UA63894C2/uk unknown
-
1998
- 1998-03-03 NO NO19980919A patent/NO980919L/no not_active Application Discontinuation
- 1998-03-04 IS IS4681A patent/IS4681A/is unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE362931T1 (de) | 8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendung | |
| UA49872C2 (uk) | Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування | |
| AU7563196A (en) | Fused tropane-derivatives as neurotransmitter reuptake inhibitors | |
| CA2187309A1 (en) | Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors | |
| AU7206398A (en) | Piperidine derivatives as neurotransmitter re-uptake inhibitors | |
| DE69707504D1 (de) | Diphenylalkyl-tetrahydropyridine, verfahren zu ihren herstellung und diese enthaltende arzneimittel | |
| DK0815109T3 (da) | Fremgangsmåde til fremstilling af estere af anhydroecgonin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0859777 Country of ref document: EP |