HUP9802433A2 - 8-Azabiciklo[3.2.1]okt-2-én-származékok, eljárás előállításukra és alkalmazásuk - Google Patents

8-Azabiciklo[3.2.1]okt-2-én-származékok, eljárás előállításukra és alkalmazásuk

Info

Publication number
HUP9802433A2
HUP9802433A2 HU9802433A HUP9802433A HUP9802433A2 HU P9802433 A2 HUP9802433 A2 HU P9802433A2 HU 9802433 A HU9802433 A HU 9802433A HU P9802433 A HUP9802433 A HU P9802433A HU P9802433 A2 HUP9802433 A2 HU P9802433A2
Authority
HU
Hungary
Prior art keywords
compounds
azabicyclo
oct
preparation
enantiomers
Prior art date
Application number
HU9802433A
Other languages
English (en)
Inventor
Peter Moldt
Elsebet Ostergaard Nielsen
Gunnar M. Olsen
Jörgen Scheel-Krüger
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of HUP9802433A2 publication Critical patent/HUP9802433A2/hu
Publication of HUP9802433A3 publication Critical patent/HUP9802433A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány (I) általánős képletű vegyületek, enantiőmerjeikre,enantiőmerjeik keveréke és gyógyászatilag elfőgadható sóikravőnatkőzik, ahől a képletben R jelentése hdi vagy alkil-, alkenil-, alkinil-, ciklőalkil-,ciklőalkil-alkil- vagy 2-hidrőxi-etil-csőpőrt, R4 jelentése 3,4-metilén-diőxi-fenil-csőpőrt, vagy fenilcsőpőrt,benzilcsőpőrt, heterőarilcsőpőrt vagy naftilcsőpőrt, amelyekegyszeresen vagy többszörösen helyettesítve lehetnek halőgénatőmmal,CF3, CN, alkőxi-, ciklőalkőxi-, alkil-, ciklőalkil-, alkenil-,alkinil-, aminő-, nitrő-, hetrőaril- vagy arilcsőpőrttal. A vegyületeknek mint a mőnőaminő neűrőtranszmitter újrafelvételinhibitőrainak értékes gyógyászati tűlajdőnságai vannak. A találmány tárgya tővábbá a vegyületek előállítása és alkalmazása is. ŕ
HU9802433A 1995-10-13 1996-10-11 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use HUP9802433A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK115695 1995-10-13

Publications (2)

Publication Number Publication Date
HUP9802433A2 true HUP9802433A2 (hu) 1999-04-28
HUP9802433A3 HUP9802433A3 (en) 2000-03-28

Family

ID=8101642

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802433A HUP9802433A3 (en) 1995-10-13 1996-10-11 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Country Status (24)

Country Link
US (1) US6100275A (hu)
EP (1) EP0859777B1 (hu)
JP (1) JP3462505B2 (hu)
KR (1) KR100274829B1 (hu)
CN (1) CN1083840C (hu)
AT (1) ATE362931T1 (hu)
AU (1) AU709327B2 (hu)
BR (1) BR9610960A (hu)
CA (1) CA2233541C (hu)
CZ (1) CZ285093B6 (hu)
DE (1) DE69637097T2 (hu)
DK (1) DK0859777T3 (hu)
EE (1) EE03446B1 (hu)
HU (1) HUP9802433A3 (hu)
IL (1) IL123583A (hu)
IS (1) IS4681A (hu)
NO (1) NO980919L (hu)
NZ (1) NZ320216A (hu)
PL (1) PL185357B1 (hu)
RU (1) RU2157372C2 (hu)
SK (1) SK283425B6 (hu)
TR (1) TR199800628T2 (hu)
UA (1) UA63894C2 (hu)
WO (1) WO1997013770A1 (hu)

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GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
KR20000010972A (ko) * 1996-05-13 2000-02-25 사라 엔 람베쓰 살충제용 이환식 아민
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
SI20020A (sl) 1996-11-26 2000-02-29 Zeneca Limited 8-azabiciklo/3.2.1/oktan-, 8-azabiciklo/3.2.1/okt-6-en-, 9-azabiciklo/3.3.1/nonan-, 9-aza-3-oksabiciklo/3.3.1/nonan- in 9-aza-3-tiabiciklo/3.3.1/nonan- derivati, njihova priprava in njihova uporaba kot insekticidov
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
EP0984965B1 (en) * 1997-05-30 2004-05-19 Neurosearch A/S 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
GB9726033D0 (en) 1997-12-09 1998-02-04 Zeneca Ltd Chemical process
TWI221842B (en) * 1997-12-11 2004-10-11 Syngenta Ltd Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
ZA99681B (en) * 1998-01-28 1999-09-27 Neurosearch As 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled or unlabelled form in diagnostic methods.
US6403605B1 (en) * 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
WO1999065492A1 (en) * 1998-06-19 1999-12-23 Eli Lilly And Company Inhibition of serotonin reuptake
AU761055B2 (en) * 1998-11-27 2003-05-29 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene and -octane derivatives
WO2000044746A1 (en) * 1999-01-28 2000-08-03 Neurosearch A/S Novel azabicyclo derivatives and their use
EP1157002B1 (en) * 1999-03-01 2005-08-10 Pfizer Limited 1,2,3,4-tetrahydro-1-naphthalenamine compounds useful in therapy
PL211402B1 (pl) 1999-09-03 2012-05-31 Apbi Holdings Zastosowanie dapoksetyny do leczenia lub zwalczania przedwczesnej ejakulacji
EP1248786A1 (en) * 1999-12-20 2002-10-16 Eli Lilly And Company Benzofuran derivatives
ES2242749T3 (es) 2000-05-25 2005-11-16 Targacept, Inc. Hetoroarildiazabicycloalkanos como ligandos de receptores colinergicos nicotinicos.
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
WO2002030405A2 (en) * 2000-10-13 2002-04-18 Neurosearch A/S Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
US7160899B2 (en) 2001-04-09 2007-01-09 Neurosearch A/S Adenosine A2A receptor antangonists combined with neurotrophic activity compounds in the treatment of Parkinson's disease
AR035898A1 (es) 2001-05-25 2004-07-21 Wyeth Corp Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
AU2003222738B2 (en) * 2002-05-07 2009-09-17 Neurosearch A/S Novel azacyclic ethynyl derivatives
US20090137625A1 (en) * 2005-04-08 2009-05-28 Dan Peters Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
KR100812499B1 (ko) * 2006-10-16 2008-03-11 이도훈 항경련제
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
CA2717367A1 (en) * 2008-03-05 2009-09-11 Neurosearch A/S Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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Also Published As

Publication number Publication date
DE69637097T2 (de) 2007-09-20
KR100274829B1 (ko) 2000-12-15
BR9610960A (pt) 1999-03-02
CA2233541C (en) 2002-04-30
DE69637097D1 (de) 2007-07-05
EE9800062A (et) 1998-08-17
JPH10512589A (ja) 1998-12-02
KR19990063651A (ko) 1999-07-26
PL326195A1 (en) 1998-08-31
EP0859777B1 (en) 2007-05-23
WO1997013770A1 (en) 1997-04-17
CZ75898A3 (cs) 1998-11-11
US6100275A (en) 2000-08-08
PL185357B1 (pl) 2003-04-30
TR199800628T2 (xx) 1998-07-21
DK0859777T3 (da) 2007-09-03
SK283425B6 (sk) 2003-07-01
AU7291796A (en) 1997-04-30
IS4681A (is) 1998-03-04
JP3462505B2 (ja) 2003-11-05
IL123583A0 (en) 1998-10-30
NO980919L (no) 1998-06-08
CN1199400A (zh) 1998-11-18
IL123583A (en) 2003-07-31
CZ285093B6 (cs) 1999-05-12
NZ320216A (en) 1999-05-28
NO980919D0 (no) 1998-03-03
CN1083840C (zh) 2002-05-01
RU2157372C2 (ru) 2000-10-10
ATE362931T1 (de) 2007-06-15
EP0859777A1 (en) 1998-08-26
EE03446B1 (et) 2001-06-15
UA63894C2 (en) 2004-02-16
SK28798A3 (en) 1998-09-09
HUP9802433A3 (en) 2000-03-28
CA2233541A1 (en) 1997-04-17
AU709327B2 (en) 1999-08-26

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