HUP9802433A3 - 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use - Google Patents

8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Info

Publication number
HUP9802433A3
HUP9802433A3 HU9802433A HUP9802433A HUP9802433A3 HU P9802433 A3 HUP9802433 A3 HU P9802433A3 HU 9802433 A HU9802433 A HU 9802433A HU P9802433 A HUP9802433 A HU P9802433A HU P9802433 A3 HUP9802433 A3 HU P9802433A3
Authority
HU
Hungary
Prior art keywords
azabicyclo
oct
preparation
ene derivatives
ene
Prior art date
Application number
HU9802433A
Other languages
English (en)
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of HUP9802433A2 publication Critical patent/HUP9802433A2/hu
Publication of HUP9802433A3 publication Critical patent/HUP9802433A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU9802433A 1995-10-13 1996-10-11 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use HUP9802433A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK115695 1995-10-13

Publications (2)

Publication Number Publication Date
HUP9802433A2 HUP9802433A2 (hu) 1999-04-28
HUP9802433A3 true HUP9802433A3 (en) 2000-03-28

Family

ID=8101642

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802433A HUP9802433A3 (en) 1995-10-13 1996-10-11 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Country Status (24)

Country Link
US (1) US6100275A (hu)
EP (1) EP0859777B1 (hu)
JP (1) JP3462505B2 (hu)
KR (1) KR100274829B1 (hu)
CN (1) CN1083840C (hu)
AT (1) ATE362931T1 (hu)
AU (1) AU709327B2 (hu)
BR (1) BR9610960A (hu)
CA (1) CA2233541C (hu)
CZ (1) CZ285093B6 (hu)
DE (1) DE69637097T2 (hu)
DK (1) DK0859777T3 (hu)
EE (1) EE03446B1 (hu)
HU (1) HUP9802433A3 (hu)
IL (1) IL123583A (hu)
IS (1) IS4681A (hu)
NO (1) NO980919L (hu)
NZ (1) NZ320216A (hu)
PL (1) PL185357B1 (hu)
RU (1) RU2157372C2 (hu)
SK (1) SK283425B6 (hu)
TR (1) TR199800628T2 (hu)
UA (1) UA63894C2 (hu)
WO (1) WO1997013770A1 (hu)

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GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
EP0901490B1 (en) * 1996-05-13 2004-04-07 Syngenta Limited Bicyclic amines as insecticides
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
SK69299A3 (en) 1996-11-26 2000-01-18 Zeneca Ltd 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
ATE267199T1 (de) 1997-05-30 2004-06-15 Neurosearch As 8-azabicyclo(3,2,1)oct-2-en- und octanderivate als liganden der nicotinergen ach rezeptoren
GB9726033D0 (en) 1997-12-09 1998-02-04 Zeneca Ltd Chemical process
TWI221842B (en) * 1997-12-11 2004-10-11 Syngenta Ltd Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
JP2002501921A (ja) * 1998-01-28 2002-01-22 ニューロサーチ、アクティーゼルスカブ 標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法
US6403605B1 (en) * 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
AU4819099A (en) * 1998-06-19 2000-01-05 Eli Lilly And Company Inhibition of serotonin reuptake
ATE259804T1 (de) 1998-11-27 2004-03-15 Neurosearch As 8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate
ATE258176T1 (de) * 1999-01-28 2004-02-15 Neurosearch As Neue azabicyclo derivate und ihre verwendung
AU2315400A (en) * 1999-03-01 2000-09-21 Middleton, Donald Stuart 1,2,3,4-tetrahydro-1-naphthalenamine compounds useful in therapy
DK1225881T3 (da) 1999-09-03 2006-06-12 Apbi Holdings Llc Anvendelsen af dapoxetin, en hurtigt-virkende selektiv serotonin genoptagelseshæmmer, til behandling af seksuel dysfunktion
AU2049501A (en) 1999-12-20 2001-07-03 Eli Lilly And Company Benzofuran derivatives
US6852721B2 (en) 2000-05-25 2005-02-08 Targacept, Inc. Pharmaceutical compositions and methods for use
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
EP1757600A2 (en) * 2000-10-13 2007-02-28 NeuroSearch A/S Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
EP1379269B1 (en) 2001-04-09 2009-03-04 Neurosearch A/S Adenosine a2a receptor antagonists combined with neurotrophic activity compounds in the treatment of parkinson's disease
TW589312B (en) 2001-05-25 2004-06-01 Wyeth Corp Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
MXPA04010965A (es) 2002-05-07 2005-01-25 Neurosearch As Derivados de etinilo azaciclico novedoso.
EP2272847A1 (en) 2005-04-08 2011-01-12 NeuroSearch A/S Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
KR100812499B1 (ko) * 2006-10-16 2008-03-11 이도훈 항경련제
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
CN101959860A (zh) * 2008-03-05 2011-01-26 神经研究公司 新的4-二苯甲基-四氢-吡啶衍生物及其作为单胺神经递质再摄取抑制剂的用途

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US3133073A (en) * 1959-12-10 1964-05-12 Sterling Drug Inc 3-aryl-1, 5-iminocycloalkanes and preparation thereof
US3657257A (en) * 1970-08-31 1972-04-18 Robins Co Inc A H 3-aryl-8-carbamoyl nortropanes
US4180669A (en) * 1976-12-13 1979-12-25 Abbott Laboratories 2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol
US4132710A (en) * 1976-12-20 1979-01-02 Ayerst, Mckenna And Harrison, Ltd. [2]Benzopyrano[3,4-c]pyridines and process therefor
HU188123B (en) * 1979-02-22 1986-03-28 The Wellcome Foundation Ltd,Gb Process for preparing new substituted imidazole derivatives and acid addition salts thereof
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
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NZ241481A (en) * 1991-02-04 1994-06-27 Hoechst Roussel Pharma Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof
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DE4200145A1 (de) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
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JP2906085B2 (ja) * 1993-05-18 1999-06-14 ウエイク フォリスト ユニヴァーシティ 生物学的活性トロパン誘導体による治療方法
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Also Published As

Publication number Publication date
SK28798A3 (en) 1998-09-09
RU2157372C2 (ru) 2000-10-10
DK0859777T3 (da) 2007-09-03
PL185357B1 (pl) 2003-04-30
HUP9802433A2 (hu) 1999-04-28
NO980919L (no) 1998-06-08
ATE362931T1 (de) 2007-06-15
EP0859777A1 (en) 1998-08-26
AU7291796A (en) 1997-04-30
EE03446B1 (et) 2001-06-15
IS4681A (is) 1998-03-04
JP3462505B2 (ja) 2003-11-05
SK283425B6 (sk) 2003-07-01
DE69637097T2 (de) 2007-09-20
BR9610960A (pt) 1999-03-02
CZ75898A3 (cs) 1998-11-11
PL326195A1 (en) 1998-08-31
CA2233541C (en) 2002-04-30
CZ285093B6 (cs) 1999-05-12
CN1199400A (zh) 1998-11-18
NO980919D0 (no) 1998-03-03
EE9800062A (et) 1998-08-17
US6100275A (en) 2000-08-08
CA2233541A1 (en) 1997-04-17
DE69637097D1 (de) 2007-07-05
JPH10512589A (ja) 1998-12-02
KR19990063651A (ko) 1999-07-26
NZ320216A (en) 1999-05-28
EP0859777B1 (en) 2007-05-23
AU709327B2 (en) 1999-08-26
IL123583A (en) 2003-07-31
IL123583A0 (en) 1998-10-30
TR199800628T2 (xx) 1998-07-21
WO1997013770A1 (en) 1997-04-17
CN1083840C (zh) 2002-05-01
KR100274829B1 (ko) 2000-12-15
UA63894C2 (en) 2004-02-16

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees