ATE248147T1 - Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme - Google Patents
Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahmeInfo
- Publication number
- ATE248147T1 ATE248147T1 AT98919091T AT98919091T ATE248147T1 AT E248147 T1 ATE248147 T1 AT E248147T1 AT 98919091 T AT98919091 T AT 98919091T AT 98919091 T AT98919091 T AT 98919091T AT E248147 T1 ATE248147 T1 AT E248147T1
- Authority
- AT
- Austria
- Prior art keywords
- alkynyl
- cycloalkyl
- alkenyl
- alkyl
- heteroaryl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000002858 neurotransmitter agent Substances 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 abstract 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK55397 | 1997-05-14 | ||
| PCT/DK1998/000185 WO1998051668A1 (en) | 1997-05-14 | 1998-05-12 | Piperidine derivatives as neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE248147T1 true ATE248147T1 (de) | 2003-09-15 |
Family
ID=8094843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98919091T ATE248147T1 (de) | 1997-05-14 | 1998-05-12 | Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6376673B1 (de) |
| EP (1) | EP0981515B1 (de) |
| JP (1) | JP2001525812A (de) |
| AT (1) | ATE248147T1 (de) |
| AU (1) | AU7206398A (de) |
| DE (1) | DE69817557T2 (de) |
| WO (1) | WO1998051668A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303627B1 (en) | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| AUPP627498A0 (en) | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
| US7215954B1 (en) | 1999-03-18 | 2007-05-08 | The Directv Group, Inc. | Resource allocation method for multi-platform communication system |
| JP2004509103A (ja) | 2000-09-11 | 2004-03-25 | セプレイコー インコーポレイテッド | モノアミン受容体及び輸送体のリガンドならびにその使用方法 |
| US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
| US20020161002A1 (en) * | 2001-01-02 | 2002-10-31 | Mel Epstein | Use of catecholamine reuptake inhibitors to enhance memory |
| DE60331762D1 (de) | 2002-11-01 | 2010-04-29 | Neurosearch As | Neue piperidinderivate und deren verwendung als monoaminneurotransmitter-wiederaufnahmehemmer |
| TW200504017A (en) * | 2002-11-01 | 2005-02-01 | Neurosearch As | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| SI1572725T1 (sl) | 2002-12-02 | 2012-08-31 | Xenome Ltd | Hi-konotoksin peptidi, ki imajo N-terminalno piroglutaminsko kislino |
| EP1578787B1 (de) | 2002-12-02 | 2012-11-14 | Xenome Ltd | Neue chi-conotoxinpeptide (-ii) |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| EP1963268B1 (de) | 2005-12-07 | 2010-12-01 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | Disubstituierte phenylpiperidine als modulatoren der corticalen catecholaminergen neurotransmission |
| WO2010130672A1 (en) * | 2009-05-12 | 2010-11-18 | Glaxo Group Limited | Azabicyclo [4.1.0] heptane derivatives and their use as monoamine reuptake inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4048165A (en) * | 1975-08-11 | 1977-09-13 | Basf Aktiengesellschaft | Manufacture of 1-substituted oximino cyclo alkenes-(1) |
| IT1233446B (it) | 1987-12-30 | 1992-04-01 | Roussel Maestretti Spa | Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci |
| EP0367393A3 (de) * | 1988-10-31 | 1991-03-27 | Takeda Chemical Industries, Ltd. | Heterocyclische Verbindungen, deren Herstellung und Verwendung |
| CN1256326C (zh) * | 1995-09-07 | 2006-05-17 | 弗·哈夫曼-拉罗切有限公司 | 治疗心脏和肾功能不全的新型4－(氧烷氧基苯基)－3－氧哌啶化合物 |
-
1998
- 1998-05-12 JP JP54871298A patent/JP2001525812A/ja not_active Ceased
- 1998-05-12 DE DE69817557T patent/DE69817557T2/de not_active Expired - Lifetime
- 1998-05-12 WO PCT/DK1998/000185 patent/WO1998051668A1/en not_active Ceased
- 1998-05-12 AT AT98919091T patent/ATE248147T1/de not_active IP Right Cessation
- 1998-05-12 EP EP98919091A patent/EP0981515B1/de not_active Expired - Lifetime
- 1998-05-12 AU AU72063/98A patent/AU7206398A/en not_active Abandoned
-
1999
- 1999-10-12 US US09/415,227 patent/US6376673B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU7206398A (en) | 1998-12-08 |
| DE69817557D1 (de) | 2003-10-02 |
| EP0981515A1 (de) | 2000-03-01 |
| US6376673B1 (en) | 2002-04-23 |
| EP0981515B1 (de) | 2003-08-27 |
| JP2001525812A (ja) | 2001-12-11 |
| WO1998051668A1 (en) | 1998-11-19 |
| DE69817557T2 (de) | 2004-06-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA49872C2 (uk) | Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування | |
| NO980919D0 (no) | 8-azabicyklo(3.2.1)okt-2-ene derivater, deres fremstilling og anvendelse | |
| CA2187309A1 (en) | Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors | |
| DK0858461T3 (da) | Kondenserede tropanderivater som neurotransmittergenoptagelsesinhibitorer | |
| ATE248147T1 (de) | Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme | |
| ATE383338T1 (de) | N-(phenyl(piperidin-2-yl)methyl)benzamid-deriva e,verfahren zu deren herstellung und ihre therapeutische verwendung | |
| BR0211201A (pt) | Composto, processo para a preparação desse composto, sua utilização, composição farmacêutica que compreende o mesmo e método para o tratamento de uma enfermidade em um mamìfero | |
| ATE343383T1 (de) | Hemmer der zelladhäsion | |
| ATE316961T1 (de) | Heterozyclische derivate für die behandlung von herzversagen und andere erkrankungen | |
| EA200401172A1 (ru) | Производные n-[фенил(пиперидин-2-ил)метил]бензамида, способ их получения и их применение в терапии | |
| BR0013409B1 (pt) | compostos fungicidas possuindo uma porção flúorvinil ou fluorpropenil-oxifeniloxima e processo para preparação dos mesmos. | |
| BR9812928A (pt) | Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |