CY1111349T1 - Καρβαμιδικες ενωσεις προς χρηση στη θεραπεια του πονου - Google Patents
Καρβαμιδικες ενωσεις προς χρηση στη θεραπεια του πονουInfo
- Publication number
- CY1111349T1 CY1111349T1 CY20111100309T CY111100309T CY1111349T1 CY 1111349 T1 CY1111349 T1 CY 1111349T1 CY 20111100309 T CY20111100309 T CY 20111100309T CY 111100309 T CY111100309 T CY 111100309T CY 1111349 T1 CY1111349 T1 CY 1111349T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- phenyl
- alkyl
- carbamidic
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μια μέθοδο για τη θεραπεία του πόνου η οποία μέθοδος περιλαμβάνει τη χορήγηση σε ένα υποκείμενο που χρήζει αυτής μιας θεραπευτικώς αποτελεσματικής ποσότητας από μια ένωση που επιλέγεται από την ομάδα που περιλαμβάνει τον Τύπο (I) και τον Τύπο (II), όπου το φαινύλιο είναι υποκατεστημένο στο Χ με ένα έως πέντε άτομα αλογόνου που επιλέγονται από την ομάδα που περιλαμβάνει φθόριο, χλώριο, βρώμιο και ιώδιο· και, τα R1, R2, R3, R4, R5 και R6 επιλέγονται ανεξαρτήτως από την ομάδα που περιλαμβάνει υδρογόνο και C1-C4 αλκύλιο· όπου το C1-C4 αλκύλιο είναι προαιρετικώς υποκατεστημένο με φαινύλιο (όπου το φαινύλιο είναι προαιρετικώς υποκατεστημένο με υποκατάστατες ανεξαρτήτως επιλεγμένους από την ομάδα που περιλαμβάνει αλογόνο, C1-C4 αλκύλιο, C1-C4 αλκοξυ, αμινο, νίτρο και κυανό).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27188801P | 2001-02-27 | 2001-02-27 | |
| EP02723222A EP1404312B1 (en) | 2001-02-27 | 2002-02-21 | Carbamate compounds for use in the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111349T1 true CY1111349T1 (el) | 2015-08-05 |
Family
ID=23037511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100309T CY1111349T1 (el) | 2001-02-27 | 2011-03-22 | Καρβαμιδικες ενωσεις προς χρηση στη θεραπεια του πονου |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6815464B2 (el) |
| EP (1) | EP1404312B1 (el) |
| JP (1) | JP4276838B2 (el) |
| KR (1) | KR100906315B1 (el) |
| CN (1) | CN1849116A (el) |
| AR (1) | AR033427A1 (el) |
| AT (1) | ATE493125T1 (el) |
| AU (1) | AU2002254015B2 (el) |
| BR (1) | BR0207673A (el) |
| CA (1) | CA2439274C (el) |
| CY (1) | CY1111349T1 (el) |
| CZ (1) | CZ20032298A3 (el) |
| DE (1) | DE60238765D1 (el) |
| DK (1) | DK1404312T3 (el) |
| ES (1) | ES2356617T3 (el) |
| HU (1) | HUP0303236A3 (el) |
| IL (1) | IL157593A0 (el) |
| MX (1) | MXPA03007721A (el) |
| MY (1) | MY129312A (el) |
| NO (1) | NO20033804L (el) |
| NZ (1) | NZ527994A (el) |
| PL (1) | PL364647A1 (el) |
| PT (1) | PT1404312E (el) |
| RS (1) | RS67603A (el) |
| RU (1) | RU2283106C2 (el) |
| TW (1) | TWI304735B (el) |
| WO (1) | WO2002067922A1 (el) |
| ZA (1) | ZA200307475B (el) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04000554A (es) | 2001-07-16 | 2005-02-17 | Johnson & Johnson | Compuestos de carbamato para utilizarse en la prevencion o tratamiento del dolor neuropatico y el dolor asociado con la cefalea acuminada y migranosa. |
| MX2008012092A (es) * | 2006-03-24 | 2008-10-03 | Wyeth Corp | Tratamiento del dolor. |
| US20100160351A1 (en) * | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| WO2010071865A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| WO2011032175A1 (en) | 2009-09-14 | 2011-03-17 | Nuon Therapeutics, Inc. | Combination formulations of tranilast and allopurinol and methods related thereto |
| WO2011055965A2 (en) | 2009-11-06 | 2011-05-12 | Sk Holdings Co., Ltd. | Methods for treating attention-deficit/hyperactivity disorder |
| JP5901528B2 (ja) | 2009-11-06 | 2016-04-13 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 線維筋痛症候群の治療方法 |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| US9018253B2 (en) | 2010-07-02 | 2015-04-28 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| CN102266317A (zh) * | 2011-06-24 | 2011-12-07 | 中国人民解放军第三军医大学 | 丙戊酸及其衍生物的应用 |
| RU2632659C2 (ru) * | 2011-12-27 | 2017-10-09 | Байо-Фарм Солюшнс Ко., Лтд. | Фенилкарбаматные соединения для применения в предупреждении или лечении эпилепсии |
| WO2014142477A1 (en) | 2013-03-12 | 2014-09-18 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compounds for use in preventing or treating pediatric epilesy and epilesy-related syndromes |
| KR102421013B1 (ko) * | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 삼차신경통을 예방 또는 치료하기 위한 카바메이트 화합물의 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278380A (en) | 1962-02-06 | 1966-10-11 | Armour Pharma | Methods of calming employing diphenyl hydroxy carbamate compounds |
| US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| GB2340074A (en) * | 1998-08-01 | 2000-02-16 | Max Imaging Systems Limited | Printing process |
| NZ523851A (en) * | 2000-07-21 | 2004-09-24 | Ortho Mcneil Pharm Inc | A method for use of carbamate enantiomers in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
-
2002
- 2002-02-21 AT AT02723222T patent/ATE493125T1/de active
- 2002-02-21 BR BR0207673-0A patent/BR0207673A/pt not_active Application Discontinuation
- 2002-02-21 RU RU2003128984/14A patent/RU2283106C2/ru not_active IP Right Cessation
- 2002-02-21 ES ES02723222T patent/ES2356617T3/es not_active Expired - Lifetime
- 2002-02-21 PT PT02723222T patent/PT1404312E/pt unknown
- 2002-02-21 MX MXPA03007721A patent/MXPA03007721A/es active IP Right Grant
- 2002-02-21 JP JP2002567289A patent/JP4276838B2/ja not_active Expired - Fee Related
- 2002-02-21 NZ NZ527994A patent/NZ527994A/en unknown
- 2002-02-21 AU AU2002254015A patent/AU2002254015B2/en not_active Ceased
- 2002-02-21 DE DE60238765T patent/DE60238765D1/de not_active Expired - Lifetime
- 2002-02-21 CN CNA028089227A patent/CN1849116A/zh active Pending
- 2002-02-21 US US10/081,943 patent/US6815464B2/en not_active Expired - Fee Related
- 2002-02-21 EP EP02723222A patent/EP1404312B1/en not_active Expired - Lifetime
- 2002-02-21 RS YUP-676/03A patent/RS67603A/sr unknown
- 2002-02-21 WO PCT/US2002/005421 patent/WO2002067922A1/en active IP Right Grant
- 2002-02-21 CZ CZ20032298A patent/CZ20032298A3/cs unknown
- 2002-02-21 IL IL15759302A patent/IL157593A0/xx unknown
- 2002-02-21 CA CA2439274A patent/CA2439274C/en not_active Expired - Fee Related
- 2002-02-21 DK DK02723222.2T patent/DK1404312T3/da active
- 2002-02-21 KR KR1020037011260A patent/KR100906315B1/ko not_active IP Right Cessation
- 2002-02-21 HU HU0303236A patent/HUP0303236A3/hu unknown
- 2002-02-21 PL PL02364647A patent/PL364647A1/xx unknown
- 2002-02-27 TW TW091103502A patent/TWI304735B/zh not_active IP Right Cessation
- 2002-02-27 MY MYPI20020695A patent/MY129312A/en unknown
- 2002-02-27 AR ARP020100699A patent/AR033427A1/es unknown
-
2003
- 2003-08-26 NO NO20033804A patent/NO20033804L/no not_active Application Discontinuation
- 2003-09-25 ZA ZA200307475A patent/ZA200307475B/xx unknown
-
2011
- 2011-03-22 CY CY20111100309T patent/CY1111349T1/el unknown
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