HUP0400823A2 - Heterociklusos vegyületek, előállításuk, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk öregedéssel kapcsolatos és diabeticus vascularis komplikációk kezelésére - Google Patents
Heterociklusos vegyületek, előállításuk, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk öregedéssel kapcsolatos és diabeticus vascularis komplikációk kezeléséreInfo
- Publication number
- HUP0400823A2 HUP0400823A2 HU0400823A HUP0400823A HUP0400823A2 HU P0400823 A2 HUP0400823 A2 HU P0400823A2 HU 0400823 A HU0400823 A HU 0400823A HU P0400823 A HUP0400823 A HU P0400823A HU P0400823 A2 HUP0400823 A2 HU P0400823A2
- Authority
- HU
- Hungary
- Prior art keywords
- ion
- alkyl
- same
- compound
- aryl
- Prior art date
Links
- 230000032683 aging Effects 0.000 title 1
- 201000009101 diabetic angiopathy Diseases 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 150000002500 ions Chemical class 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- -1 oxalation ion Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Chemical compound [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 229940085991 phosphate ion Drugs 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000006277 sulfonation reaction Methods 0.000 abstract 1
- 238000007070 tosylation reaction Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
A találmány (I) általános képletű vegyületekre - amelyek képletében R1alkil- vagy arilcsoport; Y kén-, oxigén-, nitrogénatom vagyalkilcsoport; A és B heteroaromás gyűrűrendszert alkotó nitrogén-,kén-, oxigén- vagy szénatom; R2, R3 és R4 fluor-, klór-, bróm-,jódatom, -OR7, nitro-, alkil-, aril-, heteroaril-, formil-, acil-, -C(O)NR6R7, -C(O)OR6, -NR6R7, -N=C(R6)(R7), -SR6, szulfamoil-, alkil-szulfonil- vagy aril-szulfonil-csoport; vagy adott esetben R2, R3 ésR4 egymással kapcsolódva egy gyűrűrendszert képezhet; R5 - ha avegyület kvaternerizált - alkil- vagy arilcsoport; vagy ha a vegyületnem kvaternerizált, akkor R5 és X nincs értelmezve; R6 hidrogénatom,alkil-, aril-, heteroaril-, biztosítva azt, hogy ugyanazon vegyületbenRl, R2 és R3 jelentésében R6 jelentése azonos vagy egymástól eltérőlehet; R7 hidrogénatom, alkil-, aril-, heteroarilcsoport, valamintvalamennyi esetben az R6 szubsztituens jelentésével azonos vagy attóleltérő lehet, biztosítva azt, hogy ugyanazon vegyületben R1, R2 és R3jelentésében R7 jelentése azonos vagy egymástól eltérő lehet; X - ha avegyület kvaternerizált - halogenidion, acetátion, perklorátion,szulfonátion, oxalátion, citrátion, tozilátion, maleátion, mezilátion,karbonátion, szulfition, hidrogén-foszfát-ion, foszfonátion,foszfátion,[tetrafluoro-borát(III)]-ion (BF4-) vagy[hexafluoro-foszfát(V)]-ion (PF6-): biztosítva azt, hogy ha ugyanazon a szén- vagynitrogénatomon két alkilcsoport van jelen, a két alkilcsoport adottesetben egymással kapcsolódva egy ciklikus szerkezetet képezhet - és avegyületek gyógyszerészetileg elfogadható sóira vonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28138001P | 2001-04-05 | 2001-04-05 | |
| PCT/IB2002/001137 WO2002085897A1 (en) | 2001-04-05 | 2002-04-02 | Heterocyclic compounds for aging-related and diabetic vascular complications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0400823A2 true HUP0400823A2 (hu) | 2004-07-28 |
| HUP0400823A3 HUP0400823A3 (en) | 2010-06-28 |
Family
ID=23077044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400823A HUP0400823A3 (en) | 2001-04-05 | 2002-04-02 | Heterocyclic compounds for treating aging-related and diabetic vascular complications, their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7223777B2 (hu) |
| EP (1) | EP1373263B1 (hu) |
| JP (2) | JP4485744B2 (hu) |
| KR (1) | KR100785109B1 (hu) |
| CN (1) | CN1259316C (hu) |
| AT (1) | ATE280766T1 (hu) |
| AU (1) | AU2002253432B2 (hu) |
| BR (1) | BR0208561A (hu) |
| CA (1) | CA2439593C (hu) |
| CZ (1) | CZ20032013A3 (hu) |
| DE (1) | DE60201740T2 (hu) |
| DK (1) | DK1373263T3 (hu) |
| ES (1) | ES2231685T3 (hu) |
| HK (1) | HK1061234A1 (hu) |
| HU (1) | HUP0400823A3 (hu) |
| MX (1) | MXPA03008089A (hu) |
| PL (1) | PL365441A1 (hu) |
| PT (1) | PT1373263E (hu) |
| RU (1) | RU2291154C2 (hu) |
| SI (1) | SI1373263T1 (hu) |
| WO (1) | WO2002085897A1 (hu) |
| ZA (1) | ZA200306370B (hu) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1355645A4 (en) * | 2000-12-29 | 2005-02-23 | Alteon Inc | METHOD FOR THE TREATMENT OF FIBROUS OR OTHER IIIC INDICATIONS |
| ATE280766T1 (de) * | 2001-04-05 | 2004-11-15 | Torrent Pharmaceuticals Ltd | Heterocyclische verbindungen für alterungs und diabetes bedingte vasculare erkrankungen |
| EP1591443B1 (en) | 2003-02-07 | 2010-08-25 | Daiichi Sankyo Company, Limited | Pyrazole derivative |
| ZA200505734B (en) * | 2003-02-07 | 2006-12-27 | Daiichi Seiyaku Co | Pyrazole Derivative |
| EP1669348A4 (en) * | 2003-09-30 | 2009-03-11 | Eisai R&D Man Co Ltd | NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND |
| US7354938B2 (en) * | 2004-03-23 | 2008-04-08 | Amgen Inc. | Pyrazole compounds and uses related thereto |
| US20050241110A1 (en) * | 2004-04-09 | 2005-11-03 | Bruce Baker | Ergonomic handles, especially for garden tools |
| WO2006002983A1 (en) * | 2004-07-06 | 2006-01-12 | Novartis Ag | Combination of organic compounds |
| US20090227799A1 (en) * | 2004-08-09 | 2009-09-10 | Kazutaka Nakamoto | Novel Antimalarial Agent Containing Heterocyclic Compound |
| EP1797072A4 (en) | 2004-09-17 | 2009-09-09 | Exelixis Inc | PYRAZOLKINASE MODULATORS AND USE METHOD |
| KR20120127754A (ko) | 2004-12-20 | 2012-11-23 | 제넨테크, 인크. | Ｉａｐ의 피롤리딘 억제제 |
| JP2008531586A (ja) * | 2005-02-24 | 2008-08-14 | ユニバーシティ・オブ・ワシントン | 網膜変性疾患の治療法 |
| US7829585B2 (en) | 2005-03-30 | 2010-11-09 | Eisai R&D Management Co., Ltd. | Antifungal agent containing pyridine derivative |
| TWI385169B (zh) * | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| CN101300250B (zh) * | 2005-10-31 | 2012-09-05 | 卫材R&D管理有限公司 | 杂环取代吡啶衍生物及含有该衍生物的抗真菌剂 |
| NZ567191A (en) | 2005-10-31 | 2010-06-25 | Eisai R&D Man Co Ltd | Heterocyclic substituted pyridine derivatives and antifungal agent containing same |
| SA07280004B1 (ar) | 2006-02-02 | 2011-10-29 | استرازينيكا ايه بي | ملح سترات من مركب 2- هيدروكسي –3- [5- (مورفولين –4- يل ميثيل) بيريدين –2- يل] 1h- إندول –5- كربونيتريل سترات |
| RS20090036A (en) * | 2006-07-05 | 2010-06-30 | Pfizer Products Inc. | Pyrazole derivatives as cytochrom p450 inhibitors |
| WO2008035726A1 (fr) | 2006-09-21 | 2008-03-27 | Eisai R & D Management Co., Ltd. | Dérivé de pyridine substitué par un cycle hétéroaryle, et agent antifongique le comprenant |
| NZ597247A (en) | 2006-11-29 | 2013-06-28 | Abbott Lab | Inhibitors of diacylglycerol O-acylotransferase type 1 enzyme |
| US20090197819A1 (en) * | 2007-03-20 | 2009-08-06 | Clarence Albert Johnson | Compositions for improving and repairing skin |
| US20080312169A1 (en) * | 2007-03-20 | 2008-12-18 | Clarence Albert Johnson | Cosmetic use of D-ribose |
| TW200841879A (en) | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| CA2685194A1 (en) * | 2007-04-27 | 2008-11-13 | Eisai R&D Management Co., Ltd. | Heterocycle-substituted pyridine derivatives salt or crystal thereof |
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- 2002-04-02 WO PCT/IB2002/001137 patent/WO2002085897A1/en active IP Right Grant
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