EA201171368A1 - Новые гетероциклические соединения - Google Patents
Новые гетероциклические соединенияInfo
- Publication number
- EA201171368A1 EA201171368A1 EA201171368A EA201171368A EA201171368A1 EA 201171368 A1 EA201171368 A1 EA 201171368A1 EA 201171368 A EA201171368 A EA 201171368A EA 201171368 A EA201171368 A EA 201171368A EA 201171368 A1 EA201171368 A1 EA 201171368A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- heterocyclic compounds
- accumulation
- age
- formation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Данное изобретение относится к новому классу гетероциклических соединений и их фармацевтически приемлемых солей, к способу их получения, фармацевтической композиции, содержащей эти соединения, и к их применению при лечении заболеваний, вызванных образованием и накоплением AGE (конечные продукты гликации). Соединения данного изобретения применимы для лечения диабетических и связанных с возрастом осложнений, вызванных образованием и накоплением AGE, таких как невропатия, нефропатия, микроангиопатия, ретинопатия, гипертензия, сердечная недостаточность, атеросклероз, болезнь Альцгеймера и дерматологические нарушения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1207MU2009 | 2009-05-07 | ||
PCT/IN2010/000295 WO2010128528A2 (en) | 2009-05-07 | 2010-05-06 | Novel heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201171368A1 true EA201171368A1 (ru) | 2012-04-30 |
Family
ID=42937397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171368A EA201171368A1 (ru) | 2009-05-07 | 2010-05-06 | Новые гетероциклические соединения |
Country Status (16)
Country | Link |
---|---|
US (1) | US20120046317A1 (ru) |
EP (1) | EP2427432A2 (ru) |
JP (1) | JP2012526103A (ru) |
KR (1) | KR20120018185A (ru) |
CN (1) | CN102459175A (ru) |
AR (1) | AR080267A1 (ru) |
AU (1) | AU2010245596A1 (ru) |
BR (1) | BRPI1006611A2 (ru) |
CA (1) | CA2764232A1 (ru) |
EA (1) | EA201171368A1 (ru) |
IL (1) | IL216092A0 (ru) |
MX (1) | MX2011011650A (ru) |
SG (1) | SG175422A1 (ru) |
TW (1) | TW201102380A (ru) |
WO (1) | WO2010128528A2 (ru) |
ZA (1) | ZA201108702B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104744351B (zh) * | 2014-09-30 | 2017-06-06 | 三峡大学 | 一种小分子抑制剂及在抑制鸟氨酸脱羧酶(odc)上的应用 |
SG11201708142XA (en) * | 2015-04-08 | 2017-11-29 | Torrent Pharmaceuticals Ltd | Pharmaceutical formulations |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758583A (en) | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
JPH08502508A (ja) * | 1992-10-23 | 1996-03-19 | メルク シヤープ エンド ドーム リミテツド | ドーパミンレセプターサブタイプリガンド |
US5656261A (en) | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
JP4067562B2 (ja) | 1995-01-18 | 2008-03-26 | アルテオン インコーポレイテッド | 進行性グリコシル化最終生成物の生成を阻止し、反転するためのチアゾリウム化合物の使用 |
CZ291789B6 (cs) | 1999-10-06 | 2003-05-14 | Torrent Pharmaceuticals Ltd | Pyridiniová sloučenina, způsob její výroby, její použití, farmaceutický prostředek ji obsahující a jeho použití |
HUP0301687A2 (hu) | 1999-10-06 | 2003-08-28 | Torrent Pharmaceuticals Ltd. | Cukorbetegséggel és öregedéssel kapcsolatos érrendszeri szövődmények kezelésére szolgáló piridinium-vegyületek és eljárás az előállításukra |
DK1243581T3 (da) * | 2001-03-21 | 2005-10-31 | Torrent Pharmaceuticals Ltd | Pyridiniumforbindelser til behandling af AGE-relaterede sygdomme |
JP4485744B2 (ja) | 2001-04-05 | 2010-06-23 | トレント・ファーマシューティカルズ・リミテッド | 老化−関連及び糖尿病性血管性合併症のための複素環式化合物 |
HUP0104832A2 (en) * | 2001-10-19 | 2003-08-28 | Torrent Pharmaceuticals Ltd | Cosmetic composition and method |
KR100437972B1 (ko) * | 2001-10-27 | 2004-07-02 | 한국과학기술연구원 | 피롤리디논 유도체, 이의 제조 방법 및 이를 포함하는제약 조성물 |
EP2150543A2 (en) * | 2007-04-24 | 2010-02-10 | Solvay Pharmaceuticals B.V. | Heterocyclic compounds with affinity to muscarinic receptors |
-
2010
- 2010-05-06 AU AU2010245596A patent/AU2010245596A1/en not_active Abandoned
- 2010-05-06 JP JP2012509152A patent/JP2012526103A/ja active Pending
- 2010-05-06 EA EA201171368A patent/EA201171368A1/ru unknown
- 2010-05-06 US US13/318,740 patent/US20120046317A1/en not_active Abandoned
- 2010-05-06 EP EP10747952.9A patent/EP2427432A2/en not_active Withdrawn
- 2010-05-06 CN CN201080027757XA patent/CN102459175A/zh active Pending
- 2010-05-06 BR BRPI1006611A patent/BRPI1006611A2/pt not_active Application Discontinuation
- 2010-05-06 MX MX2011011650A patent/MX2011011650A/es not_active Application Discontinuation
- 2010-05-06 SG SG2011080140A patent/SG175422A1/en unknown
- 2010-05-06 WO PCT/IN2010/000295 patent/WO2010128528A2/en active Application Filing
- 2010-05-06 TW TW099114530A patent/TW201102380A/zh unknown
- 2010-05-06 KR KR1020117029260A patent/KR20120018185A/ko not_active Application Discontinuation
- 2010-05-06 CA CA2764232A patent/CA2764232A1/en not_active Abandoned
- 2010-05-07 AR ARP100101563A patent/AR080267A1/es unknown
-
2011
- 2011-11-01 IL IL216092A patent/IL216092A0/en unknown
- 2011-11-25 ZA ZA2011/08702A patent/ZA201108702B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2010128528A3 (en) | 2010-12-23 |
IL216092A0 (en) | 2012-01-31 |
MX2011011650A (es) | 2012-02-21 |
CN102459175A (zh) | 2012-05-16 |
AU2010245596A1 (en) | 2011-12-22 |
TW201102380A (en) | 2011-01-16 |
ZA201108702B (en) | 2012-09-26 |
KR20120018185A (ko) | 2012-02-29 |
CA2764232A1 (en) | 2010-11-11 |
US20120046317A1 (en) | 2012-02-23 |
WO2010128528A2 (en) | 2010-11-11 |
BRPI1006611A2 (pt) | 2016-04-19 |
WO2010128528A9 (en) | 2011-03-03 |
SG175422A1 (en) | 2011-11-28 |
EP2427432A2 (en) | 2012-03-14 |
JP2012526103A (ja) | 2012-10-25 |
AR080267A1 (es) | 2012-03-28 |
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