HUP0104831A2 - Készítmény és eljárás piridíniumszármazékok gyógyászati alkalmazására - Google Patents
Készítmény és eljárás piridíniumszármazékok gyógyászati alkalmazásáraInfo
- Publication number
- HUP0104831A2 HUP0104831A2 HU0104831A HUP0104831A HUP0104831A2 HU P0104831 A2 HUP0104831 A2 HU P0104831A2 HU 0104831 A HU0104831 A HU 0104831A HU P0104831 A HUP0104831 A HU P0104831A HU P0104831 A2 HUP0104831 A2 HU P0104831A2
- Authority
- HU
- Hungary
- Prior art keywords
- ion
- group
- alkyl
- aryl
- heteroaryl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- -1 nitro- Chemical class 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 238000009825 accumulation Methods 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-L Oxalate Chemical compound [O-]C(=O)C([O-])=O MUBZPKHOEPUJKR-UHFFFAOYSA-L 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 230000007760 free radical scavenging Effects 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Chemical compound [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 229940085991 phosphate ion Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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Abstract
A találmány szabadgyökbefogó (antioxidáns) aktivitású (I) általánosképletű piridiniumszármazékokat - amelyek képletében R1 -R4-R5, -N(R7)N(R7)R9 vagy -Y-R11 csoport, R4 -N(R7)R6O-, -N(R7)R6N(R7) -, -OR6O- vagy -OR6N(R7)- csoport, ahol R6 alkilcsoport, R5 alkil-, aril-,heteroaril-, -COR7, -SO2R7, -C(S)NHR7, -C(NH) NHR7, -COR10, -C (O)NHR7 vagy csoport, ahol R7 hidrogénatom, alkil-, aril-, heteroaril-csoport, ahol ugyanazon vegyületben R1 és R3 jelentésében R7 jelentéseazonos vagy egymástól eltérő lehet, R2 fluor-, klór-, bróm-, jódatom,-OR7, nitro-, alkil-, aril-, heteroaril-, formil-, acil-, -C(O)NR7R10,-C(O)OR7, - NR7R10, -N=C(R7) (R10), -SR7, amino-sulfonil-, alkil-szulfonil- vagy aril-szulfonil-csoport, m 0, 1 vagy 2, R3 -R7, -OR7, -N(R7)(R10)r, -N=C(R7)(R10)r, -N(R7)-N(R7)(R10), -N(R7)N=C(R7)(R10)vagy -CH(R7)C(O)R8 csoport, ahol R8 -R7, -OR7 vagy -NR-7R10 csoport,R9 hidrogénatom, alkil-, aril-, heteroaril-, -C(O)R10, -SO2R10, -C(S)NHR10, -C(NH)NH(R10) vagy -C(O)-NHR10 csoport, R10 hidrogénatom,alkil-, aril-, heteroaril-csoport Y oxigénatom, imino-, NR12 csoportvagy nincs jelen, R11 és R12 hidrogénatom, alkil- vagy arilcsoport, Xhalogenidion, acetátion, perklorátion, szulfonátion, oxalátion,citrátion, tozilátion, maleátion, mezilátion, karbonátion, szulfition,hidrogén-foszfát-ion, foszfátion,[tetrafluoro-borát(III)]-ion (BF4-)vagy[hexafluoro-foszfát (V)]-ion (PF6-), a leírásban meghatározottmegkötésekkel és gyógyszerészetileg elfogadható sóikat tartalmazógyógyszerkészítményekre vonatkozik. A találmány tárgyát képezi továbbáegy a test sejtjeiből származó szabad gyökök befogására felhasználhatógyógyszerkészítmény, egy eljárás emlősök testsejtjeiből származószabad gyökök befogására, valamint egy eljárás olyan betegségekkezelésére, amely betegségeket szabad gyököknek egy emlőstestsejtjeiben történő felhalmozódása (akkumulációja) okoz. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN605KO2001 | 2001-10-19 | ||
| IN620KO2001 | 2001-11-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU0104831D0 HU0104831D0 (en) | 2002-01-28 |
| HUP0104831A2 true HUP0104831A2 (hu) | 2003-08-28 |
Family
ID=26324887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104832A HUP0104832A2 (en) | 2001-10-19 | 2001-11-09 | Cosmetic composition and method |
| HU0104831A HUP0104831A2 (hu) | 2001-10-19 | 2001-11-09 | Készítmény és eljárás piridíniumszármazékok gyógyászati alkalmazására |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104832A HUP0104832A2 (en) | 2001-10-19 | 2001-11-09 | Cosmetic composition and method |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1304101A1 (hu) |
| JP (1) | JP2003137783A (hu) |
| CN (2) | CN1411800A (hu) |
| CZ (1) | CZ20014034A3 (hu) |
| HU (2) | HUP0104832A2 (hu) |
| PL (1) | PL350649A1 (hu) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130123356A1 (en) * | 2004-02-20 | 2013-05-16 | University College London | Modulator |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE299496T1 (de) * | 2001-03-21 | 2005-07-15 | Torrent Pharmaceuticals Ltd | Pyridiniumverbindungen zur behandlung von age- relatierten krankheiten |
| WO2004105722A1 (en) * | 2003-05-30 | 2004-12-09 | Gianfranco De Paoli Ambrosi | A formulation for chemical peeling |
| GB0328314D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Bath | Therapeutics |
| JP5508656B2 (ja) * | 2004-07-16 | 2014-06-04 | 太陽化学株式会社 | 最終糖化産物生成阻害組成物 |
| JP2007161660A (ja) * | 2005-12-15 | 2007-06-28 | Pola Chem Ind Inc | アドバンスド・グリケーション・エンドプロダクツを分解するための化粧料とその製造法 |
| JP2007161662A (ja) * | 2005-12-15 | 2007-06-28 | Pola Chem Ind Inc | アドバンスド・グリケーション・エンドプロダクツ分解用の化粧料 |
| JP2007161663A (ja) * | 2005-12-15 | 2007-06-28 | Pola Chem Ind Inc | ＡＧＥｓ分解化粧料 |
| JP2007161661A (ja) * | 2005-12-15 | 2007-06-28 | Pola Chem Ind Inc | アドバンスド・グリケーション・エンドプロダクツを分解するための化粧料とその製造法 |
| GB0605949D0 (en) * | 2006-03-24 | 2006-05-03 | Quest Int Serv Bv | Milk product for skin treatment |
| FR2918570B1 (fr) * | 2007-07-09 | 2012-10-05 | Engelhard Lyon | DIGLYCATION DES AGEs. |
| KR20120018185A (ko) * | 2009-05-07 | 2012-02-29 | 토렌트 파마슈티칼스 리미티드 | 당뇨병 치료에 유용한 피페리딘 유도체 |
| WO2012101095A1 (en) * | 2011-01-26 | 2012-08-02 | Roche Diagnostics Gmbh | Method and substances for preparation of n-substituted pyridinium compounds |
| WO2014144265A1 (en) * | 2013-03-15 | 2014-09-18 | The Procter & Gamble Company | A noninvasive method for measuring oxidative stress and oxidative damage from skin |
| FR3046171B1 (fr) * | 2015-12-23 | 2020-02-21 | L'oreal | Composition comprenant un ou plusieurs composes pyridinium double particuliers, utilisation et procedes de mise en oeuvre |
| CN109640934A (zh) * | 2016-09-16 | 2019-04-16 | 宝洁公司 | 增加毛发健康化合物的吸收和耐洗性的方法 |
| WO2023230205A1 (en) | 2022-05-25 | 2023-11-30 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| US11919860B1 (en) | 2023-10-06 | 2024-03-05 | King Faisal University | 1-2(-(substituted phenyl)-2-oxoethyl)-4-(isopropoxycarbonyl)pyridin-1-ium bromides as anti-tubercular agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9915962A (pt) * | 1999-10-06 | 2003-01-07 | Torrent Pharmaceuticals Ltd | Composto da série do piridìnio, processos para a preparação de composto da série do piridìnio e de uma formulação parenteral, uso de um composto, composição farmacêutica para tratar complicações diabéticas e doenças associadas ao envelhecimento, e, método para tratar um paciente diabético e para prevenir ou tratar doenças causadas por complicações associadas à diabetes e ao envelhecimento |
| DK1222171T3 (da) * | 1999-10-06 | 2004-07-05 | Torrent Pharmaceuticals Ltd | Pyridiniumderivater, til regulering af aldersrelaterede og diabetesvaskulære komplikationer, fremgangsmåde til fremstilling af disse samt terapeutiske anvendelser deraf |
-
2001
- 2001-11-09 HU HU0104832A patent/HUP0104832A2/hu unknown
- 2001-11-09 CZ CZ20014034A patent/CZ20014034A3/cs unknown
- 2001-11-09 JP JP2001344128A patent/JP2003137783A/ja active Pending
- 2001-11-09 HU HU0104831A patent/HUP0104831A2/hu unknown
- 2001-11-12 CN CN01137441A patent/CN1411800A/zh active Pending
- 2001-11-12 CN CN01137440A patent/CN1411809A/zh active Pending
- 2001-11-12 EP EP01204295A patent/EP1304101A1/en not_active Withdrawn
- 2001-11-12 PL PL01350649A patent/PL350649A1/xx not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130123356A1 (en) * | 2004-02-20 | 2013-05-16 | University College London | Modulator |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0104832A2 (en) | 2003-08-28 |
| JP2003137783A (ja) | 2003-05-14 |
| CN1411809A (zh) | 2003-04-23 |
| EP1304101A1 (en) | 2003-04-23 |
| CZ20014034A3 (cs) | 2003-06-18 |
| PL350649A1 (en) | 2003-04-22 |
| HU0104831D0 (en) | 2002-01-28 |
| HU0104832D0 (en) | 2002-01-28 |
| CN1411800A (zh) | 2003-04-23 |
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