BR9915962A - Composto da série do piridìnio, processos para a preparação de composto da série do piridìnio e de uma formulação parenteral, uso de um composto, composição farmacêutica para tratar complicações diabéticas e doenças associadas ao envelhecimento, e, método para tratar um paciente diabético e para prevenir ou tratar doenças causadas por complicações associadas à diabetes e ao envelhecimento - Google Patents

Composto da série do piridìnio, processos para a preparação de composto da série do piridìnio e de uma formulação parenteral, uso de um composto, composição farmacêutica para tratar complicações diabéticas e doenças associadas ao envelhecimento, e, método para tratar um paciente diabético e para prevenir ou tratar doenças causadas por complicações associadas à diabetes e ao envelhecimento

Info

Publication number
BR9915962A
BR9915962A BR9915962-7A BR9915962A BR9915962A BR 9915962 A BR9915962 A BR 9915962A BR 9915962 A BR9915962 A BR 9915962A BR 9915962 A BR9915962 A BR 9915962A
Authority
BR
Brazil
Prior art keywords
aging
diabetes
complications
treat
compound
Prior art date
Application number
BR9915962-7A
Other languages
English (en)
Inventor
Alangudi Sankaranarayanan
Original Assignee
Torrent Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd filed Critical Torrent Pharmaceuticals Ltd
Publication of BR9915962A publication Critical patent/BR9915962A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO DA SéRIE DO PIRIDìNIO, PROCESSOS PARA A PREPARAçãO DE COMPOSTO DA SéRIE DO PIRIDìNIO E DE UMA FORMULAçãO PARENTERAL, USO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA PARA TRATAR COMPLICAçõES DIABéTICAS E DOENçAS ASSOCIADAS AO ENVELHECIMENTO, E, MéTODOS PARA TRATAR UM PACIENTE DIABéTICO E PARA PREVENIR OU TRATAR DOENçAS CAUSADAS POR COMPLICAçõES ASSOCIADAS à DIABETES E AO ENVELHECIMENTO". A invenção descreve compostos da série do piridínio úteis para tratar complicações vasculares associadas com o envelhecimento e a diabetes e, particularmente para o tratamento de complicações associadas a diabetes mellitus assim como outras condições relacionadas com o envelhecimento entre as que se incluem as doenças renais, as alterações nervosas, a aterioesclerose, a retinopatia, as condições dermatológicas e a descoloração dos dentes mediante a fragmentação do AGE preformado, da fórmula geral I, ou seus sais farmaceuticamente aceitáveis, onde R^ 1^, R^ 2^ e X são como definidos no relatório descritivo. A invenção também descreve um método para preparar os compostos desta série e as composições farmacêuticas que apresentem um ou mais compostos como definido anteriormente como ingredientes ativos. A invenção descreve, além disso, um método para tratar pacientes diabéticos administrando os compostos da maneira descrita anteriormente, tanto de maneira individual como na combinação com os outros medicamentos para terapia contra diabetes.
BR9915962-7A 1999-10-06 1999-10-15 Composto da série do piridìnio, processos para a preparação de composto da série do piridìnio e de uma formulação parenteral, uso de um composto, composição farmacêutica para tratar complicações diabéticas e doenças associadas ao envelhecimento, e, método para tratar um paciente diabético e para prevenir ou tratar doenças causadas por complicações associadas à diabetes e ao envelhecimento BR9915962A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN827CA1999 1999-10-06
PCT/IB1999/001687 WO2001025209A1 (en) 1999-10-06 1999-10-15 Pyridinium derivatives for the treatment of diabetic and aging-related vascular complications

Publications (1)

Publication Number Publication Date
BR9915962A true BR9915962A (pt) 2003-01-07

Family

ID=11084921

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915962-7A BR9915962A (pt) 1999-10-06 1999-10-15 Composto da série do piridìnio, processos para a preparação de composto da série do piridìnio e de uma formulação parenteral, uso de um composto, composição farmacêutica para tratar complicações diabéticas e doenças associadas ao envelhecimento, e, método para tratar um paciente diabético e para prevenir ou tratar doenças causadas por complicações associadas à diabetes e ao envelhecimento

Country Status (12)

Country Link
EP (1) EP1220843A1 (pt)
JP (1) JP2003511370A (pt)
CN (1) CN1329597A (pt)
AU (1) AU5994499A (pt)
BR (1) BR9915962A (pt)
CA (1) CA2351075A1 (pt)
CZ (1) CZ20011808A3 (pt)
HK (1) HK1044336A1 (pt)
HU (1) HUP0301687A2 (pt)
MX (1) MXPA02003496A (pt)
PL (1) PL348049A1 (pt)
WO (1) WO2001025209A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002067851A2 (en) * 2000-12-29 2002-09-06 Alteon, Inc. Method for treating fibrotic diseases or other indications iiic
ATE299496T1 (de) * 2001-03-21 2005-07-15 Torrent Pharmaceuticals Ltd Pyridiniumverbindungen zur behandlung von age- relatierten krankheiten
CZ303214B6 (cs) * 2001-03-21 2012-05-30 Torrent Pharmaceuticals Ltd Pyridiniová sloucenina, zpusob její výroby, její použití, farmaceutický prostredek ji obsahující, zpusob jeho výroby a jeho použití
ES2231685T3 (es) * 2001-04-05 2005-05-16 Torrent Pharmaceuticals Ltd Compuestos heterociclicos para complicaciones vasculares diabeticas y relacionadas con la edad.
HUP0104832A2 (en) * 2001-10-19 2003-08-28 Torrent Pharmaceuticals Ltd Cosmetic composition and method
GB0328314D0 (en) * 2003-12-05 2004-01-07 Univ Bath Therapeutics
WO2007132179A2 (en) * 2006-05-15 2007-11-22 University Of Bath Therapeutics comprising pyridinium derivatives
JP2009155315A (ja) * 2007-12-26 2009-07-16 Fujiyakuhin Co Ltd 注射剤
KR20120018185A (ko) * 2009-05-07 2012-02-29 토렌트 파마슈티칼스 리미티드 당뇨병 치료에 유용한 피페리딘 유도체
EP2903614B1 (en) * 2012-10-05 2021-09-29 Sphaera Pharma Pte. Ltd Novel compounds, their synthesis and their uses
EP3280711A1 (en) * 2015-04-08 2018-02-14 Torrent Pharmaceuticals Limited Novel pyridinium compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH335521A (de) * 1955-06-02 1959-01-15 Cilag Ag Verfahren zur Herstellung neuer quaternärer Salze
US3318787A (en) * 1964-02-07 1967-05-09 Udylite Corp Electrodeposition of zinc
US3823076A (en) * 1972-05-23 1974-07-09 Du Pont Zinc electroplating additive
JPS5936247B2 (ja) * 1977-04-20 1984-09-03 ティーディーケイ株式会社 電気的表示装置
JPS55138742A (en) * 1979-04-17 1980-10-29 Fuji Photo Film Co Ltd Silver halide emulsion developing method
JPH0253759A (ja) * 1988-08-18 1990-02-22 Hamari Yakuhin Kogyo Kk 新規な４級アンモニウム化合物
DD275872A1 (de) * 1988-09-27 1990-02-07 Univ Dresden Tech Verfahren zur herstellung von 5h-pyrido[1',2':1,2]imidazo[5,4-c]chinolin-6-onen
MX9705449A (es) * 1995-01-18 1998-02-28 Alteon Inc Uso de compuestos de tiazolio para evitar y revertir la formacion de productos finales de glicosilacion avanzada.
CA2285556A1 (en) * 1997-04-04 1998-10-15 Smithkline Beecham Corporation Calcilytic compounds

Also Published As

Publication number Publication date
AU5994499A (en) 2001-05-10
PL348049A1 (en) 2002-05-06
MXPA02003496A (es) 2005-06-20
CA2351075A1 (en) 2001-04-12
HK1044336A1 (zh) 2002-10-18
JP2003511370A (ja) 2003-03-25
WO2001025209A1 (en) 2001-04-12
EP1220843A1 (en) 2002-07-10
HUP0301687A2 (hu) 2003-08-28
CN1329597A (zh) 2002-01-02
CZ20011808A3 (cs) 2001-08-15

Similar Documents

Publication Publication Date Title
Eisen et al. Minocycline-induced pigmentation: incidence, prevention and management
DE69903750T2 (de) Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten
BR9813373A (pt) Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, processos para efetuar imunossupressão e para tratar ou reduzir o risco de uma doença das vias aérias obstrutiva reversìvel em um paciente
JPS60109522A (ja) 神経病の治療のためのビロバリド含有製剤組成物
BRPI0513824A (pt) derivados glucitol, seu pró-fármaco e seu sal e agente terapêutico contendo os mesmos para diabetes
BRPI9913746B8 (pt) composto da série de piridínio, processo para prepará-lo, uso do mesmo, composição farmacêutica para o tratamento de complicações diabéticas e doenças relacionadas ao envelhecimento, e, métodos para a preparação de uma formulação parenteral
BR0010257A (pt) Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, método para tratamento ou profilaxia de condições associadas com a inibição da carboxipeptidase u, kits de partes, e, método de tratamento de um paciente sofrendo de ou susceptìvel a uma condição em que a inibição da carboxipeptidase u e um mecanismo antitrombótico diferente são necessários ou desejados
BR9915962A (pt) Composto da série do piridìnio, processos para a preparação de composto da série do piridìnio e de uma formulação parenteral, uso de um composto, composição farmacêutica para tratar complicações diabéticas e doenças associadas ao envelhecimento, e, método para tratar um paciente diabético e para prevenir ou tratar doenças causadas por complicações associadas à diabetes e ao envelhecimento
MXPA04007183A (es) Composicion farmaceutica para el control de la glucosa en sangre de pacientes con diabetes tipo 2.
Lawrence Drug management in skin surgery
EP0922460B1 (en) Neuro-Function regulatory agent comprising glycosyl vitamin P
Manor et al. Effect of adhesive antibiotic TA on plaque and gingivitis in man
Wood et al. Trial of aspirin and RA 233 in prevention of post-operative deep vein thrombosis
BR0010256A (pt) Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, método de tratamento ou profilaxia de condições associadas com a inibição da carboxipeptidase u, kit de partes, e, método de tratamento de um paciente sofrendo de ou susceptìvel a uma condição em que a inibição da carboxipeptidase u e um mecanismo antitrombótico diferente são necessários
KR940013503A (ko) 동맥경화증의 예방 또는 치료용 약제학적 조성물
US5679713A (en) Pharmaceutical composition containing carbachol and other cholinergic substances
LUDWIG et al. Ochronosis from quinacrine (atabrine)
PT1243581E (pt) Compostos de piridinio uteis no tratamento de doencas relacionadas com age
EP0402208B1 (fr) Association de vitamine A à dose physiologique et de différents principes actifs ayant une activité thérapeutique
RU2267335C1 (ru) Способ комбинированной анальгезии у пожилых пациентов после операций на тазобедренном суставе и бедре
RU2290191C2 (ru) Способ лечения туберкулезных увеитов
RU2208402C1 (ru) Способ профилактики тромбоза сосудов пересаженного лоскута
JP5685362B2 (ja) 有痛性末梢糖尿病性神経障害の予防のためのアセチルｌ−カルニチン
Turner et al. The Drugs Handbook 1985–86
JPS6281315A (ja) 水虫等細菌性皮膚病の治療薬

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.