BR0208561A - Compostos heterocìclicos para complicações vasculares diabéticas e relacionadas ao envelhecimento - Google Patents

Compostos heterocìclicos para complicações vasculares diabéticas e relacionadas ao envelhecimento

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Publication number
BR0208561A
BR0208561A BR0208561-5A BR0208561A BR0208561A BR 0208561 A BR0208561 A BR 0208561A BR 0208561 A BR0208561 A BR 0208561A BR 0208561 A BR0208561 A BR 0208561A
Authority
BR
Brazil
Prior art keywords
compounds
aging
diabetic
vascular complications
age
Prior art date
Application number
BR0208561-5A
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English (en)
Inventor
Alangudi Sankaranarayanan
Original Assignee
Torrent Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd filed Critical Torrent Pharmaceuticals Ltd
Publication of BR0208561A publication Critical patent/BR0208561A/pt

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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
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    • A61P17/16—Emollients or protectives, e.g. against radiation
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P37/02—Immunomodulators
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
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    • A61P7/06—Antianaemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

"COMPOSTOS HETEROCìCLICOS PARA COMPLICAçõES VASCULARES DIABéTICAS E RELACIONADAS AO ENVELHECIMENTO". A invenção apresenta uma nova classe de compostos de anel heterocíclico com cinco membros da fórmula geral (1) e seus sais farmacêutica ou cosmeticamente aceitáveis, em que R1, R2, R3, R4, R5, A, B, X e Y são como definido no relatório descritivo. A invenção também apresenta um processo para a preparação desses compostos e suas aplicações terapêutica e cosmética particularmente no controle de complicações vasculares diabéticas e relacionadas ao envelhecimento. Os compostos em questão atuam por ação tripla de um meio de ruptura de AGE (Produtos finais de glicação avançada), inibidor de AGE e expurgador de radicais livres o que os torna mais adequados em diferentes aplicações terapêuticas e cosméticas. A invenção também apresenta produtos farmacêuticos e composições cosméticas que compreendem esses compostos e método de tratamento de doenças causadas pelo acúmulo de AGE e/ou radicais livres nas células do corpo.
BR0208561-5A 2001-04-05 2002-04-02 Compostos heterocìclicos para complicações vasculares diabéticas e relacionadas ao envelhecimento BR0208561A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28138001P 2001-04-05 2001-04-05
PCT/IB2002/001137 WO2002085897A1 (en) 2001-04-05 2002-04-02 Heterocyclic compounds for aging-related and diabetic vascular complications

Publications (1)

Publication Number Publication Date
BR0208561A true BR0208561A (pt) 2004-03-30

Family

ID=23077044

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208561-5A BR0208561A (pt) 2001-04-05 2002-04-02 Compostos heterocìclicos para complicações vasculares diabéticas e relacionadas ao envelhecimento

Country Status (22)

Country Link
US (2) US7223777B2 (pt)
EP (1) EP1373263B1 (pt)
JP (2) JP4485744B2 (pt)
KR (1) KR100785109B1 (pt)
CN (1) CN1259316C (pt)
AT (1) ATE280766T1 (pt)
AU (1) AU2002253432B2 (pt)
BR (1) BR0208561A (pt)
CA (1) CA2439593C (pt)
CZ (1) CZ20032013A3 (pt)
DE (1) DE60201740T2 (pt)
DK (1) DK1373263T3 (pt)
ES (1) ES2231685T3 (pt)
HK (1) HK1061234A1 (pt)
HU (1) HUP0400823A3 (pt)
MX (1) MXPA03008089A (pt)
PL (1) PL365441A1 (pt)
PT (1) PT1373263E (pt)
RU (1) RU2291154C2 (pt)
SI (1) SI1373263T1 (pt)
WO (1) WO2002085897A1 (pt)
ZA (1) ZA200306370B (pt)

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PL365441A1 (en) 2005-01-10
CA2439593A1 (en) 2002-10-31
ZA200306370B (en) 2004-06-07
CN1259316C (zh) 2006-06-14
US7223777B2 (en) 2007-05-29
US20030045554A1 (en) 2003-03-06
MXPA03008089A (es) 2004-01-22
SI1373263T1 (en) 2005-04-30
JP2004529154A (ja) 2004-09-24
HUP0400823A3 (en) 2010-06-28
EP1373263A1 (en) 2004-01-02
HUP0400823A2 (hu) 2004-07-28
CZ20032013A3 (cs) 2003-12-17
RU2003128076A (ru) 2005-04-10
JP4485744B2 (ja) 2010-06-23
DE60201740D1 (de) 2004-12-02
ES2231685T3 (es) 2005-05-16
WO2002085897A1 (en) 2002-10-31
DK1373263T3 (da) 2005-03-07
WO2002085897A9 (en) 2004-04-01
AU2002253432B2 (en) 2005-03-24
DE60201740T2 (de) 2005-11-03
RU2291154C2 (ru) 2007-01-10
CA2439593C (en) 2010-02-09
HK1061234A1 (en) 2004-09-10
JP2010100640A (ja) 2010-05-06
EP1373263B1 (en) 2004-10-27
WO2002085897A8 (en) 2002-11-28
KR20030086340A (ko) 2003-11-07
CN1498217A (zh) 2004-05-19
US20070167493A1 (en) 2007-07-19
PT1373263E (pt) 2005-03-31
KR100785109B1 (ko) 2007-12-12

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