HUP0400784A2 - Biciklusos heterokondenzált pirrolkarboxamid-származékok, alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények - Google Patents
Biciklusos heterokondenzált pirrolkarboxamid-származékok, alkalmazásuk és az ezeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0400784A2 HUP0400784A2 HU0400784A HUP0400784A HUP0400784A2 HU P0400784 A2 HUP0400784 A2 HU P0400784A2 HU 0400784 A HU0400784 A HU 0400784A HU P0400784 A HUP0400784 A HU P0400784A HU P0400784 A2 HUP0400784 A2 HU P0400784A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- amino
- sulfamoyl
- carbamoyl
- group
- Prior art date
Links
- RLOQBKJCOAXOLR-UHFFFAOYSA-N 1h-pyrrole-2-carboxamide Chemical class NC(=O)C1=CC=CN1 RLOQBKJCOAXOLR-UHFFFAOYSA-N 0.000 title 1
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 nitro- Chemical class 0.000 abstract 23
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány (I) általános képletű vegyületekre vonatkozik - aképletben -X-Y-Z- -S-CR4=CR5-, -CR4=CR5-S-, -O-CR4=CR5-, -CR4=CR5-O-,-N=CR4-S-, -S-CR4=N-, -NR6-CR4=CR5- vagy -CR4=CR5-NR6- általánosképletű csoportot jelent; R1 hidrogénatomot, halogénatomot vagynitro-, ciano-, hidroxil-, amino-, karboxil-, karbamoil-, merkapto-,szulfamoil-, ureido-, 1-6 szénatomos alkil-, 2-6 szénatomos alkenil-,2-6 szénatomos alkinil-, 1-6 szénatomos alkoxi-, 1-6 szénatomosalkanoil-, 1-6 szénatomos alkanoil-oxi-, N-(1-6 szénatomos alkil)-amino-, N,N-di-(1-6 szénatomos alkil)-amino-, 1-6 szénatomos alkanoil-amino-, N-(1-6 szénatomos alkil)-karbamoil-, N,N-di-(1-6 szénatomosalkil)-karbamoil-, 1-6 szénatomos alkil-S(O)a (ahol a értéke 0-2), (1-6 szénatomos alkoxi)-karbonil-, (1-6 szénatomos alkoxi)-karbonil-amino-, N-(1-6 szénatomos alkil)-szulfamoil-, N,N-di-(1-6 szénatomosalkil)-szulfamoil-, 1-6 szénatomos alkil-szulfonil-amino-, 1-6szénatomos alkil-szulfonil-N-(1-6 szénatomos alkil)-amino-, 3-8szénatomos cikloalkil-, (3-8 szénatomos cikloalkil)-(1-6 szénatomosalkil)-, aril-, aril-(1-6 szénatomos alkil)-, heterociklil- vagyheterociklil-(1-6 szénatomos alkil)-csoportot jelent, mimellett az R1helyén álló csoportok szénatomjaihoz adott esetben egy vagy több Pszubsztituens kapcsolódhat, és ha a heterociklil-csoport -NH-molekularészt tartalmaz, ennek nitrogénatomjához adott esetben Rszubsztituens kapcsolódhat; R2 hidrogénatomot, halogénatomot vagynitro-, ciano-, hidroxil-, fluor-metil-, difluor-metil-, trifluor-metil-, trifluor-metoxi-, amino-, karboxil-, karbamoil-, merkapto-,szulfamoil-, ureido-, 1-6 szénatomos alkil-, 2-6 szénatomos alkenil-,2-6 szénatomos alkinil-, 1-6 szénatomos alkoxi-, 1-6 szénatomosalkanoil-, 1-6 szénatomos alkanoil-oxi-, N-(1-6 szénatomos alkil)-amino-, N,N-di-(1-6 szénatomos alkil)-amino-, 1-6 szénatomos alkanoil-amino-, N-(1-6 szénatomos alkil)-karbamoil-, N,N-di-(1-4 szénatomosalkil)-karbamoil-, N-(1-6 szénatomos alkil)-N-(1-6 szénatomos alkoxi)-karbamoil-, 1-6 szénatomos alkil-S(O)a (ahol a értéke 0-2), (1-6szénatomos alkoxi)-karbonil-, (1-6 szénatomos alkoxi)- -karbonil(-amino-, N-(1-6 szénatomos alkil)-szulfamoil-, N,N-di-(1-6 szénatomosalkil)-szulfamoil-, szulfamoil-amino-, N-(1-6 szénatomos alkil)-szulfamoil-amino-, N,N-di-(1-6 szénatomos alkil)-szulfamoil-amino-, 1-6 szénatomos alkil-szulfonil-amino-, 1-6 szénatomos alkil-szulfonil-amino-karbonil-, 1-6 szénatomos alkil-szulfonil-N-(1-6 szénatomosalkil)-amino- vagy -E-F-G-H csoportot jelent; R3 hidrogénatomot vagy1-6 szénatomos alkilcsoportot jelent; és n értéke 0-4, mimellett ha nértéke 1-nél nagyobb, a molekulában lévő egyes R1 csoportok és egyesR3 csoportok jelentése azonos vagy eltérő lehet; bizonyosmegkötésekkel. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0021831.3A GB0021831D0 (en) | 2000-09-06 | 2000-09-06 | Chemical compounds |
PCT/SE2001/001880 WO2002020530A1 (en) | 2000-09-06 | 2001-08-31 | Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0400784A2 true HUP0400784A2 (hu) | 2004-07-28 |
HUP0400784A3 HUP0400784A3 (en) | 2007-09-28 |
Family
ID=9898927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400784A HUP0400784A3 (en) | 2000-09-06 | 2001-08-31 | Bicyclic heterocondensated pyrrolcarboxamide derivatives, their use and pharmaceutical compositions containing them |
Country Status (31)
Country | Link |
---|---|
US (1) | US20030232875A1 (hu) |
EP (1) | EP1317459B1 (hu) |
JP (1) | JP2004508376A (hu) |
KR (1) | KR100802369B1 (hu) |
CN (2) | CN1264846C (hu) |
AT (1) | ATE263772T1 (hu) |
AU (2) | AU8283301A (hu) |
BG (1) | BG107624A (hu) |
BR (1) | BR0113606A (hu) |
CA (1) | CA2417594A1 (hu) |
CZ (1) | CZ2003616A3 (hu) |
DE (1) | DE60102710T2 (hu) |
DK (1) | DK1317459T3 (hu) |
EE (1) | EE200300083A (hu) |
ES (1) | ES2217183T3 (hu) |
GB (1) | GB0021831D0 (hu) |
HK (1) | HK1055299A1 (hu) |
HU (1) | HUP0400784A3 (hu) |
IL (1) | IL154291A0 (hu) |
IS (1) | IS2110B (hu) |
MX (1) | MXPA03001512A (hu) |
NO (1) | NO20031024L (hu) |
NZ (1) | NZ524011A (hu) |
PL (1) | PL361024A1 (hu) |
PT (1) | PT1317459E (hu) |
RU (1) | RU2003104013A (hu) |
SK (1) | SK2592003A3 (hu) |
TR (1) | TR200401659T4 (hu) |
UA (1) | UA73781C2 (hu) |
WO (1) | WO2002020530A1 (hu) |
ZA (1) | ZA200301013B (hu) |
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US6107329A (en) * | 1995-06-06 | 2000-08-22 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors |
US5952322A (en) * | 1996-12-05 | 1999-09-14 | Pfizer Inc. | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors |
US5998463A (en) * | 1998-02-27 | 1999-12-07 | Pfizer Inc | Glycogen phosphorylase inhibitors |
JP2002506073A (ja) * | 1998-03-12 | 2002-02-26 | ノボ ノルディスク アクティーゼルスカブ | プロテイン・チロシン・ホスファターゼ(PTPases)のモジュレーター |
DK1088824T3 (da) * | 1999-09-30 | 2004-04-13 | Pfizer Prod Inc | Bicykliske pyrrolylamider som glycogen phosphorylase inhibitorer |
CO5271699A1 (es) * | 2000-01-24 | 2003-04-30 | Pfizer Prod Inc | Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa |
US6555569B2 (en) * | 2000-03-07 | 2003-04-29 | Pfizer Inc. | Use of heteroaryl substituted N-(indole-2-carbonyl-) amides for treatment of infection |
US7057046B2 (en) * | 2002-05-20 | 2006-06-06 | Bristol-Myers Squibb Company | Lactam glycogen phosphorylase inhibitors and method of use |
-
2000
- 2000-09-06 GB GBGB0021831.3A patent/GB0021831D0/en not_active Ceased
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2001
- 2001-08-31 HU HU0400784A patent/HUP0400784A3/hu unknown
- 2001-08-31 NZ NZ524011A patent/NZ524011A/en unknown
- 2001-08-31 DK DK01961577T patent/DK1317459T3/da active
- 2001-08-31 BR BR0113606-2A patent/BR0113606A/pt not_active IP Right Cessation
- 2001-08-31 PT PT01961577T patent/PT1317459E/pt unknown
- 2001-08-31 EP EP01961577A patent/EP1317459B1/en not_active Expired - Lifetime
- 2001-08-31 ES ES01961577T patent/ES2217183T3/es not_active Expired - Lifetime
- 2001-08-31 KR KR1020037003265A patent/KR100802369B1/ko not_active IP Right Cessation
- 2001-08-31 TR TR2004/01659T patent/TR200401659T4/xx unknown
- 2001-08-31 AU AU8283301A patent/AU8283301A/xx active Pending
- 2001-08-31 UA UA2003021026A patent/UA73781C2/uk unknown
- 2001-08-31 CZ CZ2003616A patent/CZ2003616A3/cs unknown
- 2001-08-31 AT AT01961577T patent/ATE263772T1/de not_active IP Right Cessation
- 2001-08-31 CN CNB018183220A patent/CN1264846C/zh not_active Expired - Fee Related
- 2001-08-31 MX MXPA03001512A patent/MXPA03001512A/es active IP Right Grant
- 2001-08-31 PL PL01361024A patent/PL361024A1/xx unknown
- 2001-08-31 CN CNA2006100818966A patent/CN1896078A/zh active Pending
- 2001-08-31 US US10/344,506 patent/US20030232875A1/en not_active Abandoned
- 2001-08-31 WO PCT/SE2001/001880 patent/WO2002020530A1/en active IP Right Grant
- 2001-08-31 CA CA002417594A patent/CA2417594A1/en not_active Abandoned
- 2001-08-31 AU AU2001282833A patent/AU2001282833B2/en not_active Ceased
- 2001-08-31 IL IL15429101A patent/IL154291A0/xx unknown
- 2001-08-31 RU RU2003104013/04A patent/RU2003104013A/ru not_active Application Discontinuation
- 2001-08-31 SK SK259-2003A patent/SK2592003A3/sk unknown
- 2001-08-31 JP JP2002525151A patent/JP2004508376A/ja not_active Withdrawn
- 2001-08-31 DE DE60102710T patent/DE60102710T2/de not_active Expired - Fee Related
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2003
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- 2003-02-24 IS IS6727A patent/IS2110B/is unknown
- 2003-03-05 NO NO20031024A patent/NO20031024L/no not_active Application Discontinuation
- 2003-03-10 BG BG107624A patent/BG107624A/bg unknown
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