HUP0303398A2 - 1,2-Dihidropiridin-származékok, eljárás előállításukra és alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
1,2-Dihidropiridin-származékok, eljárás előállításukra és alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0303398A2 HUP0303398A2 HU0303398A HUP0303398A HUP0303398A2 HU P0303398 A2 HUP0303398 A2 HU P0303398A2 HU 0303398 A HU0303398 A HU 0303398A HU P0303398 A HUP0303398 A HU P0303398A HU P0303398 A2 HUP0303398 A2 HU P0303398A2
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- HU
- Hungary
- Prior art keywords
- group
- hydrogen
- compounds
- same
- phenyl
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- MMWRGWQTAMNAFC-UHFFFAOYSA-N 1,2-dihydropyridine Chemical class C1NC=CC=C1 MMWRGWQTAMNAFC-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005156 substituted alkylene group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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Abstract
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JP2000175966 | 2000-06-12 | ||
GB0022483A GB0022483D0 (en) | 2000-09-13 | 2000-09-13 | 1 2 Dihydropyridine compounds manufacturing method thereof and use thereof |
PCT/JP2001/004857 WO2001096308A1 (fr) | 2000-06-12 | 2001-06-08 | Composes 1,2-dihydropyridine, leur procede de preparation et leur utilisation |
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HUP0303398A3 HUP0303398A3 (en) | 2010-03-29 |
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HU0303398A HU229553B1 (en) | 2000-06-12 | 2001-06-08 | 1,2-dihydropyridine compound, process for preparation of the same and use thereof |
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Families Citing this family (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2320973T3 (es) * | 2000-06-12 | 2009-06-01 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos. |
US6670380B2 (en) * | 2000-11-20 | 2003-12-30 | Bristol-Myers Squibb Co. | Pyridone inhibitors of fatty acid binding protein and method |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
JP4119114B2 (ja) * | 2001-11-28 | 2008-07-16 | 広栄化学工業株式会社 | 新規なジヒドロキシ(3−ピリジル)ボラン類 |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
AU2002351412B2 (en) * | 2001-12-21 | 2010-05-20 | Exelixis Patent Company Llc | Modulators of LXR |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
US7101883B2 (en) | 2002-03-18 | 2006-09-05 | Bristol-Myers Squibb Company | Uracil derivatives as inhibitors of TNF-α converting enzyme (TACE) and matrix metalloproteinases |
JP2005529117A (ja) * | 2002-04-19 | 2005-09-29 | グラクソ グループ リミテッド | 5HT2c受容体に対する親和性を有する化合物及びその治療における使用 |
JP4208512B2 (ja) * | 2002-07-23 | 2009-01-14 | 株式会社クラレ | 5−(2’−ピリジル)−2−ピリドン誘導体の製造方法 |
WO2004035563A1 (en) * | 2002-10-17 | 2004-04-29 | Syngenta Participations Ag | 3-heterocyclylpyridine derivatives useful as herbicides |
EA009027B1 (ru) * | 2002-12-16 | 2007-10-26 | Мицубиси Фарма Корпорейшн | Производные 3-замещенного-4-пиримидона |
EP1581539A4 (en) * | 2003-01-03 | 2007-09-19 | Bristol Myers Squibb Co | NEW TYROSINE KINASE HEMMER |
GB0305024D0 (en) * | 2003-03-05 | 2003-04-09 | Glaxo Group Ltd | Compounds |
SE0302324D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
SE0302323D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
EP2522670A1 (en) * | 2004-04-07 | 2012-11-14 | Takeda Pharmaceutical Company Limited | Heterocyclic CRF receptor antagonists |
MY148809A (en) * | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
JP2007099781A (ja) * | 2004-07-06 | 2007-04-19 | Eisai R & D Management Co Ltd | 1,2−ジヒドロピリジン化合物の結晶の製造方法 |
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
US20060069260A1 (en) * | 2004-09-28 | 2006-03-30 | Huiping Zhang | Preparation of N-aryl pyridones |
WO2006065946A1 (en) * | 2004-12-16 | 2006-06-22 | Vertex Pharmaceuticals Incorporated | Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases |
WO2006074419A2 (en) * | 2005-01-07 | 2006-07-13 | Roskamp Research Llc | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds |
TW200700392A (en) * | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
AU2006232517A1 (en) * | 2005-04-04 | 2006-10-12 | Eisai R&D Management Co., Ltd. | Dihydropyridine compounds and compositions for headaches |
AU2006234627C1 (en) * | 2005-04-08 | 2009-11-26 | Eisai R & D Management Co., Ltd. | Therapeutic agent for dyskinesia |
RS53599B1 (en) | 2005-05-10 | 2015-02-27 | Intermune, Inc. | PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS |
GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
MX2008001538A (es) * | 2005-08-02 | 2008-04-04 | Lexicon Pharmaceuticals Inc | Aril piridinas y metodos para su uso. |
JP2009506123A (ja) | 2005-08-29 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非受容体型チロシンキナーゼのtecファミリーの阻害剤として有用な3,5−二置換ピリド−2−オン |
CN101291926A (zh) * | 2005-08-29 | 2008-10-22 | 沃泰克斯药物股份有限公司 | 可用作Tec家族非受体酪氨酸激酶抑制剂的3,5-二取代的吡啶-2-酮 |
AU2006285038A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases |
RU2008112691A (ru) | 2005-10-03 | 2009-10-10 | Оно Фармасьютикал Ко., Лтд. (Jp) | Азотсодержащее гетероциклическое соединение и его фармацевтическое применение |
JPWO2007072868A1 (ja) * | 2005-12-21 | 2009-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 1,2−ジヒドロピリジン化合物の結晶(iv型) |
JPWO2007072869A1 (ja) * | 2005-12-21 | 2009-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 1,2−ジヒドロピリジン化合物の非晶質体 |
JP4865337B2 (ja) * | 2006-01-24 | 2012-02-01 | 富士フイルムファインケミカルズ株式会社 | 2,3’−ビピリジル−6’−オンの製造方法 |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
WO2007126060A1 (ja) * | 2006-04-28 | 2007-11-08 | Eisai R & D Management Co., Ltd | 1,2-ジヒドロピリジン化合物の塩 |
TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
US20080108603A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
US20080108622A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
JP2010520154A (ja) * | 2007-03-05 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患のためのampaレセプターアンタゴニストおよびnmdaレセプターアンタゴニスト |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
WO2008139984A1 (en) * | 2007-04-26 | 2008-11-20 | Eisai R & D Management Co., Ltd. | Cinnamide compounds for dementia |
EP2164488A1 (en) * | 2007-07-13 | 2010-03-24 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists and aldose reductase inhibitors for neuropathic pain |
CA2690110A1 (en) * | 2007-07-13 | 2009-01-22 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists for neuropathic pain |
US8252937B2 (en) | 2007-09-14 | 2012-08-28 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
BRPI0816767B8 (pt) | 2007-09-14 | 2021-05-25 | Addex Pharmaceuticals Sa | composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos |
AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
WO2009054544A1 (en) * | 2007-10-26 | 2009-04-30 | Eisai R & D Management Co., Ltd. | Ampa receptor antagonists for parkinson's disease and movement disorders |
TW200924770A (en) * | 2007-11-06 | 2009-06-16 | Astrazeneca Ab | Novel compounds 089 |
US8785486B2 (en) | 2007-11-14 | 2014-07-22 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
WO2009081872A1 (ja) | 2007-12-21 | 2009-07-02 | Kuraray Co., Ltd. | 6-ハロゲノ-3-アリールピリジン誘導体の製造方法 |
WO2009082038A2 (en) * | 2007-12-26 | 2009-07-02 | Eisai R & D Management Co., Ltd. | Ampa receptor antagonists and zonisamide for epilepsy |
JP2011507800A (ja) * | 2007-12-26 | 2011-03-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 癲癇、精神障害、または感覚器官の障害のためのampa受容体アンタゴニスト |
CN102083794A (zh) * | 2008-05-05 | 2011-06-01 | 安姆根有限公司 | 作为γ分泌酶调节剂的脲化合物 |
CA2726588C (en) * | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
US8859760B2 (en) | 2008-07-29 | 2014-10-14 | Frontier Scientific, Inc. | Compositions for killing or preventing the growth of microbes |
ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
EP2346505B1 (en) | 2008-10-16 | 2014-04-23 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
CA2741666C (en) * | 2008-10-31 | 2017-04-11 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
CA2745866A1 (en) | 2008-12-23 | 2010-07-01 | F.Hoffmann-La Roche Ag | Dihydropyridone ureas as p2x7 modulators |
SG172336A1 (en) | 2008-12-23 | 2011-07-28 | Hoffmann La Roche | Dihydropyridone amides as p2x7 modulators |
SG172785A1 (en) | 2008-12-23 | 2011-08-29 | Hoffmann La Roche | Dihydropyridone amides as p2x7 modulators |
WO2010072607A1 (en) | 2008-12-23 | 2010-07-01 | F. Hoffmann-La Roche Ag | Dihydropyridone amides as p2x7 modulators |
US8153808B2 (en) | 2008-12-23 | 2012-04-10 | Roche Palo Alto Llc | Dihydropyridone amides as P2X7 modulators |
TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
US8410144B2 (en) | 2009-03-31 | 2013-04-02 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
NZ596053A (en) | 2009-05-12 | 2013-05-31 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
BR112012007322A2 (pt) | 2009-10-02 | 2017-06-06 | Astrazeneca Ab | composto de 2-piridona usados como inibidores de neutrófilo elastase |
JP2013234123A (ja) * | 2010-09-03 | 2013-11-21 | Taisho Pharmaceutical Co Ltd | 3−ピラゾリル−2−ピリドン誘導体 |
US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
PL2648516T3 (pl) * | 2010-12-06 | 2019-04-30 | Aclaris Therapeutics Inc | Podstawione związki pirydynono-pirydynylowe |
EP3434669B1 (en) | 2011-03-04 | 2020-11-04 | Yale University | Intermediate compounds utilizable in synthesis of (-) huperzine and process for obtain one of these intermediate compounds |
ITMI20111952A1 (it) | 2011-10-27 | 2013-04-28 | Italiana Sint Spa | Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel |
WO2013102897A1 (en) | 2012-01-03 | 2013-07-11 | Mapi Pharma Ltd. | Polymorphs of perampanel |
EP2831056B1 (en) * | 2012-03-31 | 2016-12-14 | The University Of Georgia Research Foundation, Inc | New anti-mycobacterial drugs against tuberculosis |
AU2013292950C1 (en) * | 2012-07-18 | 2016-01-21 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
ITMI20121390A1 (it) | 2012-08-06 | 2014-02-07 | F I S Fabbrica Italiana Sint P A | Procedimento per la preparazione di acido 2-cianofenilboronico e suoi esteri, intermedi del perampanel o di e2040 |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
JO3225B1 (ar) * | 2012-11-27 | 2018-03-08 | Lilly Co Eli | 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8 |
TW201441193A (zh) | 2012-12-06 | 2014-11-01 | Kyowa Hakko Kirin Co Ltd | 吡啶酮化合物 |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
JP2016522786A (ja) * | 2013-04-04 | 2016-08-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | [11c]及び[18f]標識化1,3−ジフェニルー5−(ピリミジン−2−イル)−ピリジン−2(1h)−オン誘導体並びにampa受容体のpetイメージングのためのそれらの使用 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
CN103274993A (zh) * | 2013-06-13 | 2013-09-04 | 南京工业大学 | 二氢吡啶和吡咯类杂环的新合成方法 |
ES2646095T3 (es) * | 2013-07-25 | 2017-12-12 | Teva Pharmaceuticals International Gmbh | Proceso para la preparación de perampanel |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
US9120777B2 (en) | 2013-10-29 | 2015-09-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN103664756A (zh) * | 2013-11-26 | 2014-03-26 | 苏州晶云药物科技有限公司 | 吡仑帕奈新晶型a及其制备方法 |
CN104706604A (zh) * | 2013-12-12 | 2015-06-17 | 北京星昊医药股份有限公司 | 一种吡仑帕奈冻干口崩片及其制备方法 |
CN104725301A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种1,2-二氢吡啶-2-酮衍生物的制备方法 |
DK3431106T3 (da) | 2014-01-21 | 2021-03-15 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
DK3096790T3 (da) | 2014-01-21 | 2019-10-07 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
CN105085382B (zh) * | 2014-05-14 | 2019-10-18 | 江苏豪森药业集团有限公司 | 吡仑帕奈异构体晶型及其制备方法和用途 |
TW201609719A (zh) | 2014-05-28 | 2016-03-16 | 美國禮來大藥廠 | 作為TARP-γ8依賴性AMPA受體拮抗劑之6-經取代-3H-1,3-苯并噻唑-2-酮化合物 |
CN103980188B (zh) * | 2014-05-30 | 2016-01-27 | 浙江永宁药业股份有限公司 | 一种吡仑帕奈的合成方法及其中间体和中间体的合成方法 |
UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
US10227328B2 (en) * | 2015-02-04 | 2019-03-12 | Beyondbio Inc. | Heterocyclic compound and pharmaceutical composition comprising same |
US10111867B2 (en) | 2015-02-17 | 2018-10-30 | Mapi Pharma Ltd. | Process and intermediates for the preparation of perampanel |
AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
WO2016172333A1 (en) | 2015-04-21 | 2016-10-27 | Teva Pharmaceuticals International Gmbh | A solid state form of perampanel |
RU2705595C2 (ru) | 2015-07-06 | 2019-11-11 | Паблик Юниверсити Корпорейшн Йокогама Сити Юниверсити | Новое соединение, специфически связывающееся с рецептором ampa |
CN105085383B (zh) * | 2015-08-19 | 2017-09-01 | 四川大学 | 5‑甲基‑2(1h)吡啶酮衍生物及其制备方法和用途 |
CA3002930A1 (en) | 2015-11-13 | 2017-05-18 | Eisai R&D Management Co., Ltd. | Pyranodipyridine compound |
KR101652750B1 (ko) * | 2015-12-03 | 2016-08-31 | 김종선 | 피리딘 및 그 유도체의 정제방법 |
MA46589A (fr) | 2016-10-24 | 2019-08-28 | Yumanity Therapeutics Inc | Composés et utilisations de ces derniers |
EP3541785A4 (en) | 2016-11-18 | 2020-04-01 | Dow Agrosciences Llc | 4- ((6-BROMOPYRIDIN-3-YL) OXY) BENZONITRILE AND METHODS OF PREPARATION |
WO2018114989A1 (en) * | 2016-12-22 | 2018-06-28 | Biotronik Ag | Intratumoral drug delivery materials and methods for treating breast cancer |
JP6241974B1 (ja) | 2017-01-11 | 2017-12-06 | 公立大学法人横浜市立大学 | 霊長類生体の脳内ampa受容体のイメージング方法、プログラム、及びスクリーニング方法 |
GB201702221D0 (en) | 2017-02-10 | 2017-03-29 | Univ Of Sussex | Compounds |
CA3108048A1 (en) * | 2017-07-31 | 2019-02-07 | Washington University | Pirfenidone derivatives for modulation of b lymphocyte activity and organ protection |
CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
CN110028442B (zh) * | 2018-01-11 | 2020-07-17 | 新发药业有限公司 | 一种吡仑帕奈的简便制备方法 |
GB201803340D0 (en) * | 2018-03-01 | 2018-04-18 | Univ Of Sussex | Compounds |
EP3560934A1 (en) | 2018-04-26 | 2019-10-30 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040 |
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CN110483563B (zh) * | 2019-09-06 | 2021-12-28 | 山西医科大学 | 一种新型离子型β-萘酚醛席夫碱锆配合物的制备方法及应用 |
KR102392825B1 (ko) | 2020-02-18 | 2022-04-29 | 명인제약주식회사 | 2-(2-옥소-1-페닐-5-피리딘-2-일피리딘-3-일)벤조니트릴과 l-말릭산의 공결정 화합물 및 이의 제조 방법 |
CN111362930B (zh) * | 2020-04-15 | 2023-02-03 | 安徽医科大学 | 一种1,2,4-噁二唑-吡啶类化合物及其应用 |
WO2023042887A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
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CN114057630B (zh) * | 2021-12-23 | 2023-06-02 | 郑州大学 | 吡非尼酮衍生物及其合成方法和应用 |
WO2023230205A1 (en) | 2022-05-25 | 2023-11-30 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2024010585A1 (en) * | 2022-07-07 | 2024-01-11 | Yale University | Non-covalent inhibitors of the main protease of sars-cov-2 and methods of use |
KR20240008565A (ko) * | 2022-07-12 | 2024-01-19 | 이화여자대학교 산학협력단 | 연속 흐름 공정을 포함하는 페람파넬 유도체의 제조 방법 |
US11958832B1 (en) | 2023-10-12 | 2024-04-16 | King Faisal University | 2-alkoxy[4,3:6,3-terpyridine]-3-carbonitriles as antimicrobial compounds |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5283761A (en) * | 1976-01-01 | 1977-07-12 | Yamanouchi Pharmaceut Co Ltd | Novel pyridone derivative |
JPS5531072A (en) * | 1979-07-30 | 1980-03-05 | Rikagaku Kenkyusho | Preparation of 2-pyridone compound |
DE4003541C1 (hu) | 1990-02-06 | 1991-08-08 | Alter S.A., Madrid, Es | |
US5356902A (en) | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
IL109397A0 (en) | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
HU219777B (hu) | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
MX9702244A (es) | 1994-09-27 | 1997-06-28 | Yamanouchi Pharma Co Ltd | Derivado de 1,2,3,4-tetrahidroquinoxalinadiona. |
EP0826671B1 (en) * | 1995-04-27 | 2004-12-29 | Mitsubishi Pharma Corporation | Heterocyclic amide compounds and medicinal use of the same |
US5935551A (en) | 1995-11-15 | 1999-08-10 | California Institute Of Technology | Synthesis of zeolites by hydrothermal reaction of zeolite P1 |
DE19604920A1 (de) | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
US5891871A (en) | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
HU9600871D0 (en) | 1996-04-04 | 1996-05-28 | Gyogyszerkutato Intezet | New 2,3-benzodiazepine derivatives |
PT901487E (pt) | 1996-05-15 | 2003-08-29 | Pfizer | 4(3h)-quinazolinonas 2,3,6-trissubstituidas |
DE19643037A1 (de) | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
IL130181A0 (en) | 1996-12-05 | 2000-06-01 | Amgen Inc | Substituted pyrimidone and pyridone compounds and methods of use |
HUP0000914A3 (en) | 1997-02-28 | 2001-09-28 | Pfizer Prod Inc | Atropisomers of 3-aryl-4(3h)-quinazolinones and pharmaceutical compositions containing them |
GB9708945D0 (en) * | 1997-05-01 | 1997-06-25 | Merck Sharp & Dohme | Therapeutic agents |
GB9711753D0 (en) | 1997-06-06 | 1997-08-06 | Merck Sharp & Dohme | Therapeutic agents |
WO1999031062A1 (fr) * | 1997-12-17 | 1999-06-24 | Shionogi & Co., Ltd. | Nouveaux composes de pyridine |
WO2000001376A2 (en) | 1998-07-02 | 2000-01-13 | Eisai Co., Ltd | Pharmaceutical compositions and their uses for treatment of demyelinating disorders |
DE19835918A1 (de) | 1998-08-07 | 2000-02-10 | Dresden Arzneimittel | Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung |
ES2320973T3 (es) | 2000-06-12 | 2009-06-01 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos. |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
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