HUP0100225A2 - Karboxamido-tiazol-származékok, előállításuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Karboxamido-tiazol-származékok, előállításuk és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0100225A2 HUP0100225A2 HU0100225A HUP0100225A HUP0100225A2 HU P0100225 A2 HUP0100225 A2 HU P0100225A2 HU 0100225 A HU0100225 A HU 0100225A HU P0100225 A HUP0100225 A HU P0100225A HU P0100225 A2 HUP0100225 A2 HU P0100225A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- derivatives
- carboxamidothiazole
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102100025841 Cholecystokinin Human genes 0.000 abstract 2
- 101800001982 Cholecystokinin Proteins 0.000 abstract 2
- 229940107137 cholecystokinin Drugs 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 101000585507 Solanum tuberosum Cytochrome b-c1 complex subunit 7 Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- -1 hydroxy- Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 150000007979 thiazole derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
A találmány (I) általános képletű cholecystokinin (CCK)-agonistahelyettesített tiazolszármazékokra vonatkozik, mely képletben aszubsztituensek főbb jelentése R1 jelentése szubsztituált fenilcsoport, R2 jelentése -CH2R7, -(CH2)2-R7, -S-CH2R7, -CH2S-R7 vagy -(C5-C8)-alkil-csoport, ahol R7jelentése (C5-C7)-cikloalkil-csoport, R3 jelentése (b) vagy (c)általános képletű csoport, ahol X1, X2, X3, X4 jelentése nitrogénatom,CR14 csoport, R8 jelentése (CH2)nR15 vagy R15 jelentése COOH vagyCOO(C1-C4)alkil-csoport R9 jelentése hidrogénatom vagy metilcsoport,R10, R11, R12, R13 jelentése hidrogénatom, alkil-, hidroxi-, alkoxi-,aminocsoport. A találmány tárgya továbbá eljárás a hatóanyagelőállítására, az azt tartalmazó gyógyszerkészítmények és előállításieljárásuk. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9711718A FR2768737B1 (fr) | 1997-09-19 | 1997-09-19 | Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant |
FR9805106A FR2777887B3 (fr) | 1998-04-23 | 1998-04-23 | Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant |
PCT/FR1998/002007 WO1999015525A1 (fr) | 1997-09-19 | 1998-09-18 | Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0100225A2 true HUP0100225A2 (hu) | 2001-09-28 |
HUP0100225A3 HUP0100225A3 (en) | 2003-05-28 |
Family
ID=26233812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0100225A HUP0100225A3 (en) | 1997-09-19 | 1998-09-18 | Carboxamidothiazole derivatives, preparation, pharmaceutical compositions containing them |
Country Status (27)
Country | Link |
---|---|
US (1) | US6380230B1 (hu) |
EP (1) | EP1017693A1 (hu) |
JP (1) | JP3456970B2 (hu) |
KR (1) | KR20010030629A (hu) |
CN (1) | CN1276790A (hu) |
AR (1) | AR013494A1 (hu) |
AU (1) | AU746707B2 (hu) |
BG (1) | BG104254A (hu) |
BR (1) | BR9812653A (hu) |
CA (1) | CA2304397A1 (hu) |
CO (1) | CO4970713A1 (hu) |
EA (1) | EA003093B1 (hu) |
EE (1) | EE200000168A (hu) |
HR (1) | HRP20000153A2 (hu) |
HU (1) | HUP0100225A3 (hu) |
ID (1) | ID25528A (hu) |
IL (1) | IL134961A (hu) |
IS (1) | IS5409A (hu) |
MY (1) | MY141444A (hu) |
NO (1) | NO314455B1 (hu) |
NZ (1) | NZ503339A (hu) |
PL (1) | PL339292A1 (hu) |
SK (1) | SK4052000A3 (hu) |
TR (1) | TR200001218T2 (hu) |
TW (1) | TW430664B (hu) |
UY (1) | UY25180A1 (hu) |
WO (1) | WO1999015525A1 (hu) |
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US7399777B2 (en) | 2001-08-31 | 2008-07-15 | Sanofi-Aventis Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals |
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DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
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KR101761682B1 (ko) | 2015-10-07 | 2017-07-31 | 한국화학연구원 | 신규한 인돌-2-카르복실레이트 유도체 및 이를 유효성분으로 포함하는 약학적 조성물 |
US10973812B2 (en) | 2016-03-03 | 2021-04-13 | Regents Of The University Of Minnesota | Ataxia therapeutic compositions and methods |
MX2018011278A (es) | 2016-03-17 | 2019-07-08 | Thiogenesis Therapeutics Inc | Composiciones para la liberacion controlada de cisteamina y el tratamiento sistemico de trastornos sensibles a la cisteamina. |
CN111683684B (zh) | 2017-09-20 | 2024-07-02 | 硫创治疗公司 | 用于治疗半胱胺敏感性病症的方法 |
IL291985A (en) | 2019-10-07 | 2022-06-01 | Kallyope Inc | gpr119 agonists |
KR20220151860A (ko) | 2021-05-07 | 2022-11-15 | 이민규 | 조립식 간이 의자팔걸이 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4060626A (en) * | 1972-01-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Indole-carboxylic carbon compounds and pharmaceutical compositions containing them |
IE68593B1 (en) | 1989-12-06 | 1996-06-26 | Sanofi Sa | Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them |
FR2677356B1 (fr) * | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
FR2701708B1 (fr) | 1993-02-19 | 1995-05-19 | Sanofi Elf | Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament. |
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1998
- 1998-09-09 CO CO98051671A patent/CO4970713A1/es unknown
- 1998-09-12 MY MYPI98004185A patent/MY141444A/en unknown
- 1998-09-14 UY UY25180A patent/UY25180A1/es unknown
- 1998-09-16 AR ARP980104588A patent/AR013494A1/es not_active Application Discontinuation
- 1998-09-18 AU AU91705/98A patent/AU746707B2/en not_active Ceased
- 1998-09-18 CN CN98810341A patent/CN1276790A/zh active Pending
- 1998-09-18 EP EP98944024A patent/EP1017693A1/fr not_active Withdrawn
- 1998-09-18 EA EA200000334A patent/EA003093B1/ru not_active IP Right Cessation
- 1998-09-18 KR KR1020007002905A patent/KR20010030629A/ko not_active Application Discontinuation
- 1998-09-18 SK SK405-2000A patent/SK4052000A3/sk unknown
- 1998-09-18 TW TW087115602A patent/TW430664B/zh active
- 1998-09-18 HU HU0100225A patent/HUP0100225A3/hu unknown
- 1998-09-18 JP JP2000512830A patent/JP3456970B2/ja not_active Expired - Fee Related
- 1998-09-18 ID IDW20000504A patent/ID25528A/id unknown
- 1998-09-18 NZ NZ503339A patent/NZ503339A/en unknown
- 1998-09-18 TR TR2000/01218T patent/TR200001218T2/xx unknown
- 1998-09-18 IL IL13496198A patent/IL134961A/en not_active IP Right Cessation
- 1998-09-18 WO PCT/FR1998/002007 patent/WO1999015525A1/fr not_active Application Discontinuation
- 1998-09-18 CA CA002304397A patent/CA2304397A1/fr not_active Abandoned
- 1998-09-18 PL PL98339292A patent/PL339292A1/xx unknown
- 1998-09-18 EE EEP200000168A patent/EE200000168A/xx unknown
- 1998-09-18 US US09/508,830 patent/US6380230B1/en not_active Expired - Fee Related
- 1998-09-18 BR BR9812653-9A patent/BR9812653A/pt not_active IP Right Cessation
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2000
- 2000-03-16 IS IS5409A patent/IS5409A/is unknown
- 2000-03-17 BG BG104254A patent/BG104254A/xx unknown
- 2000-03-17 HR HR20000153A patent/HRP20000153A2/hr not_active Application Discontinuation
- 2000-03-17 NO NO20001409A patent/NO314455B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3456970B2 (ja) | 2003-10-14 |
TW430664B (en) | 2001-04-21 |
TR200001218T2 (tr) | 2001-05-21 |
SK4052000A3 (en) | 2001-03-12 |
HRP20000153A2 (en) | 2001-04-30 |
IL134961A (en) | 2002-07-25 |
NO20001409L (no) | 2000-05-16 |
EE200000168A (et) | 2001-04-16 |
UY25180A1 (es) | 2001-06-29 |
AU746707B2 (en) | 2002-05-02 |
KR20010030629A (ko) | 2001-04-16 |
BR9812653A (pt) | 2000-08-22 |
AR013494A1 (es) | 2000-12-27 |
NZ503339A (en) | 2002-03-28 |
WO1999015525A1 (fr) | 1999-04-01 |
CA2304397A1 (fr) | 1999-04-01 |
IL134961A0 (en) | 2001-05-20 |
EA003093B1 (ru) | 2002-12-26 |
EP1017693A1 (fr) | 2000-07-12 |
MY141444A (en) | 2010-04-30 |
AU9170598A (en) | 1999-04-12 |
CN1276790A (zh) | 2000-12-13 |
IS5409A (is) | 2000-03-16 |
US6380230B1 (en) | 2002-04-30 |
NO20001409D0 (no) | 2000-03-17 |
EA200000334A1 (ru) | 2000-10-30 |
ID25528A (id) | 2000-10-12 |
CO4970713A1 (es) | 2000-11-07 |
BG104254A (en) | 2001-08-31 |
NO314455B1 (no) | 2003-03-24 |
HUP0100225A3 (en) | 2003-05-28 |
PL339292A1 (en) | 2000-12-04 |
JP2001517667A (ja) | 2001-10-09 |
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