HUP0300602A2 - A központi idegrendszerre ható diazabiciklusos hatóanyagok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

A központi idegrendszerre ható diazabiciklusos hatóanyagok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0300602A2
HUP0300602A2 HU0300602A HUP0300602A HUP0300602A2 HU P0300602 A2 HUP0300602 A2 HU P0300602A2 HU 0300602 A HU0300602 A HU 0300602A HU P0300602 A HUP0300602 A HU P0300602A HU P0300602 A2 HUP0300602 A2 HU P0300602A2
Authority
HU
Hungary
Prior art keywords
alkyl
group
alkoxy
ch2ch2
hydrogen atom
Prior art date
Application number
HU0300602A
Other languages
English (en)
Inventor
Anwer Basha
William H. Bunnelle
Jerome F. Daanen
Jianguo Ji
Jennifer M. Pace
Michael R. Schrimpf
Kevin B. Sippy
Karin R. Tietje
Richard B. Toupence
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/833,914 external-priority patent/US6809105B2/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of HUP0300602A2 publication Critical patent/HUP0300602A2/hu
Publication of HUP0300602A3 publication Critical patent/HUP0300602A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány (I) általános képletű N-szubsztituált diazabiciklusosvegyületek egy csoportjára valamint e vegyületek és e vegyületekettartalmazó gyógyszerkészítmények alkalmazásával neurotranszmitterekszelektív kibocsátásának szabályzására vonatkozik emlősben. Az (I)általános képletben A jelentése kovalens kötés, -CH2, -CH2CH2- vagy -CH2CH2CH2- csoport; B jelentése -CH2- vagy -CH2CH2-csoport, azzal amegkötéssel, hogy ha A jelentélse -CH2CH2CH2-, akkor B jelentése -CH2-csoport; Y jelentése kovalens kötés, -CH2 vagy -CH2CH2 csoport; Zjelentése kovalens kötés, -CH2- vagy -CH2CH2 csoport, azzal amegkötéssel, hogy ha Y jelentése -CH2CH2- csoport, akkor Z jelentésekovalens kötés; R1 jelentése az (X)-(XXV) általános képletű csoportokközül választható; R3 jelentése hidrogénatom, alkilcsoport vagyhalogénatom; R4 jelentése hidrogénatom, alkoxi-, alkil-, aminocsoport,halogénatom vagy nitrocsoport; R5 jelentése hidrogénatom, alkenil-,alkoxi-, alkoxi-alkoxi-, alkoxi-alkil-, alkoxi-karbonil-, alkoxi-karbonil-alkil-, alkil-, alkil-karbonil-, alkil-karbonil-oxi-, alkil-tio-, alkinil-, amino-, amino-alkil-, amino-karbonil-, amino-karbonil-alkil-, amino-szulfonil-, karboxil-, karboxi-alkil-, ciano-, ciano-alkil-, formil- formil-alkil-, halogénezett alkoxi-, halogénezettalkilcsoport, halogénatom, hidroxil-, hidroxi-alkil-, merkapto-,merkapto-alkil-, nitro-, 5-tetrazolil-csoport, -NR6S(O)2R7, -C(NR6)NR7R8, -CH2C(NR6)NR7R8, -C(NOR6)R7, -C(NCN)R6, -C(NNR6R7)R8, -S(O)2OR6 vagy -S(O)2R6 általános képletű csoport; R6, R7 és R8jelentése egymástól függetlenül hidrogénatom, vagy alkilcsoport; és R9jelentése hidrogénatom, alkoxi-karbonil-, alkil-, amino-, amino-alkil-, amino-karbonil-alkil-, benzil-oxi-karbonil-, ciano-alkil-,dihidro-3-piridinil-karbonil-, hidroxil-, hidroxi-alkil- vagy fenoxi-karbonil-csoport. Ó
HU0300602A 2000-04-27 2001-04-27 Diazabicyclic central nervous system active agents, pharmaceutical compositions containing them and their use HUP0300602A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55994300A 2000-04-27 2000-04-27
US09/833,914 US6809105B2 (en) 2000-04-27 2001-04-12 Diazabicyclic central nervous system active agents
PCT/US2001/013798 WO2001081347A2 (en) 2000-04-27 2001-04-27 Diazabicyclic central nervous system active agents

Publications (2)

Publication Number Publication Date
HUP0300602A2 true HUP0300602A2 (hu) 2003-06-28
HUP0300602A3 HUP0300602A3 (en) 2005-12-28

Family

ID=27072208

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300602A HUP0300602A3 (en) 2000-04-27 2001-04-27 Diazabicyclic central nervous system active agents, pharmaceutical compositions containing them and their use

Country Status (22)

Country Link
EP (3) EP2298775A1 (hu)
JP (2) JP4981232B2 (hu)
KR (4) KR100947187B1 (hu)
CN (3) CN100430398C (hu)
AR (1) AR030421A1 (hu)
AU (2) AU2001266559C1 (hu)
BG (2) BG66151B1 (hu)
BR (1) BR0107246A (hu)
CA (2) CA2683045A1 (hu)
CZ (4) CZ301324B6 (hu)
HK (1) HK1054375A1 (hu)
HU (1) HUP0300602A3 (hu)
IL (3) IL152231A0 (hu)
MX (1) MXPA02010594A (hu)
MY (3) MY145722A (hu)
NO (1) NO324250B1 (hu)
NZ (1) NZ521734A (hu)
PE (1) PE20011305A1 (hu)
PL (2) PL398491A1 (hu)
SK (2) SK287273B6 (hu)
TW (4) TWI323733B (hu)
WO (1) WO2001081347A2 (hu)

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