HUP0202810A2 - Szubsztituált 2-tio-3.5-diciano-4-aril-6-aminopiridinek és eljárás az előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Szubsztituált 2-tio-3.5-diciano-4-aril-6-aminopiridinek és eljárás az előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0202810A2
HUP0202810A2 HU0202810A HUP0202810A HUP0202810A2 HU P0202810 A2 HUP0202810 A2 HU P0202810A2 HU 0202810 A HU0202810 A HU 0202810A HU P0202810 A HUP0202810 A HU P0202810A HU P0202810 A2 HUP0202810 A2 HU P0202810A2
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Hungary
Prior art keywords
group
aryl
compounds
alkyl
disorders
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HU0202810A
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English (en)
Inventor
Marcus Bauser
Klaus Dembowsky
Rolf Henning
Walter Hübsch
Thomas Krahn
Thomas Krämer
Elisabeth Perzborn
Ulrich Rosentreter
Olga Salcher-Schraufstätter
Johannes-Peter Stasch
Andrea Vaupel
Original Assignee
Bayer Ag.
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Application filed by Bayer Ag. filed Critical Bayer Ag.
Publication of HUP0202810A2 publication Critical patent/HUP0202810A2/hu
Publication of HUP0202810A3 publication Critical patent/HUP0202810A3/hu

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

A találmány (I) általános képletű vegyületekre és tautomereikre,valamint a megfelelő sóikra, hidrátjaikra és alkoxidjaikra vonatkozik,ahol a képletben a helyettesítők jelentése: R1, R2 és R3 egymástólfüggetlenül hidrogénatom, hidroxil-, alkil-, aril-, alkoxicsoport, -O-(CH2)n-CH=CH2, halogénatom, nitrocsoport, cianocsoport, -C(O)-R5, -C(O)-R5, -C(O)-NR6R7, -NR6R7, -NR6-C(O)-R8, -O-C(O)-R8, -SO2-NR6R7, és-NR6-SO2R8. ahol R5 jelentése hidrogénatom, hidroxilcsoport,alkilcsoport, cikloalkilcsoport, alkoxicsoport, arilcsoport, ariloxi-csoport, telített vagy telítetlen heterociklus, heteroarilcsoport, ésR6 és R7 jelentése egymástól függetlenül hidrogénatom, alkilcsoport,arilcsoport, vagy heteroarilcsoport, vagy R6 és R7 a nitrogénatommalegyütt, amelyhez adott esetben kapcsolódnak, telített vagy telítetlenheterociklust alkot, és R8 jelentése hidroxilcsoport, NR6R7, ahol R6és R7 j elentése a korábban megadott, alkil-, alkoxi-, aril-,ariloxicsoport; R4 jelentése adott esetben szubsztituált alkil- vagyalkenilcsoport, vagy adott esetben szubsztituált, telített vagytelítetlen heterociklus. A találmány tárgya továbbá eljárás avegyületek előállítására, a vegyületek alkalmazása gyógyászatihatóanyagokként, valamint a vegyületeket tartalmazó gyógyászatikészítmények. A találmány szerinti vegyületek adenozin-receptorszelektív ligandumokként hatnak és alkalmasak különfélerendellenességek, különösen szív- és érrendszeri rendellenességek vagygyulladásos rendellenességek megelőzésére és/vagy kezelésére, továbbáaz urogenitális rendszer, a légutak és a központi idegrendszerrendellenességeinek, valamint cukorbetegség és rák kezelésére. Ó
HU0202810A 1999-10-01 2000-09-19 Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof as adenosine receptor ligands, process for their preparation and pharmaceutical compositions containing them HUP0202810A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19947154A DE19947154A1 (de) 1999-10-01 1999-10-01 Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
PCT/EP2000/009153 WO2001025210A2 (de) 1999-10-01 2000-09-19 Substituierte 2-thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre verwendung als adenosin-rezeptorliganden

Publications (2)

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HUP0202810A2 true HUP0202810A2 (hu) 2002-12-28
HUP0202810A3 HUP0202810A3 (en) 2003-02-28

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HU0202810A HUP0202810A3 (en) 1999-10-01 2000-09-19 Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof as adenosine receptor ligands, process for their preparation and pharmaceutical compositions containing them

Country Status (26)

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US (2) US7135486B1 (hu)
EP (1) EP1240145A2 (hu)
JP (1) JP2003511371A (hu)
KR (2) KR100832934B1 (hu)
CN (1) CN1407971A (hu)
AU (1) AU775159B2 (hu)
BG (1) BG106546A (hu)
BR (1) BR0014679A (hu)
CA (1) CA2386147A1 (hu)
CU (1) CU20020064A7 (hu)
CZ (1) CZ301202B6 (hu)
DE (1) DE19947154A1 (hu)
EE (1) EE200200175A (hu)
HK (1) HK1054386A1 (hu)
HR (1) HRP20020375A2 (hu)
HU (1) HUP0202810A3 (hu)
IL (1) IL148545A0 (hu)
MA (1) MA25688A1 (hu)
MX (1) MXPA02003271A (hu)
NO (1) NO323848B1 (hu)
PL (1) PL353969A1 (hu)
RU (1) RU2267482C2 (hu)
SK (1) SK4342002A3 (hu)
UA (1) UA73957C2 (hu)
WO (1) WO2001025210A2 (hu)
ZA (1) ZA200201806B (hu)

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