HUP9800051A2 - 1-Aril-2-acil-amino-etán-vegyületek, alkalmazásuk neurokinin-antagonista gyógyszerkészítmények előállítására és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

1-Aril-2-acil-amino-etán-vegyületek, alkalmazásuk neurokinin-antagonista gyógyszerkészítmények előállítására és a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP9800051A2
HUP9800051A2 HU9800051A HUP9800051A HUP9800051A2 HU P9800051 A2 HUP9800051 A2 HU P9800051A2 HU 9800051 A HU9800051 A HU 9800051A HU P9800051 A HUP9800051 A HU P9800051A HU P9800051 A2 HUP9800051 A2 HU P9800051A2
Authority
HU
Hungary
Prior art keywords
powder
aryl
neurokinin
pipe
medicaments
Prior art date
Application number
HU9800051A
Other languages
English (en)
Inventor
Yves Auberson
Claudia Betschart
Marc Gerspacher
Robert Mah
Silvio Ofner
Silvio Roggo
Walter Schilling
Siem Jacob Veenstra
Andreas Von Sprecher
Original Assignee
Novartis Ag.
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Filing date
Publication date
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of HUP9800051A2 publication Critical patent/HUP9800051A2/hu
Publication of HUP9800051A3 publication Critical patent/HUP9800051A3/hu
Publication of HU226562B1 publication Critical patent/HU226562B1/hu

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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Abstract

A találmány tárgya (I) általánős képletű vegyületekre és azők sóiravőnatkőzik - ahől a képletbenR1jelentése arilcsőpőrt vagy heterőarilcsőpőrt,R2jelentése hidrőgénatőm, rövid szénláncú alkilcsőpőrt vagy aril-rövidszénláncú alkilcsőpőrt,R3jelentése hidrőgénatőm, rövid szénláncú alkilcsőpőrt, arilcsőpőrt vagyheterőarilcsőpőrt,R4jelentése arilcsőpőrt vagy heterőarilcsőpőrt,Xjelentése 1-7 szénatőmős alkiléncsőpőrt, 2-7 szénatőmősalkeniléncsőpőrt vagy 4-7 szénatőmős alkándieniléncsőpőrt, ésAmjelentése szűbsztitűálatlan vagy mőnő- vagy diszűbsztitűáltaminőcsőpőrt, ahől a diszűbsztitűált aminőcsőpőrt alatt őlyanaminőcsőpőrtőt is értenek, amelynek az aminő nitrőgénje egy gyűrűbekapcsőlódik -.A találmány szerinti vegyületek neűrőkinin-1 antagőnisták, és ezértalkalmasak őlyan betegségtünetek megegőzésére, amelyeket több között Panyag és a neűrőkinin A idéznek elő.(I)ŕ
HU9800051A 1995-02-22 1996-02-09 1-aryl-2-acylamino-ethane compounds as neurokinin, especially neurokinin-1 antagonists, and medicaments containing the said compounds. HU226562B1 (en)

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EP95810117 1995-02-22
PCT/EP1996/000555 WO1996026183A1 (en) 1995-02-22 1996-02-09 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists

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HUP9800051A2 true HUP9800051A2 (hu) 1998-05-28
HUP9800051A3 HUP9800051A3 (en) 1998-08-28
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JP2000511193A (ja) * 1996-05-24 2000-08-29 イーライ・リリー・アンド・カンパニー 高血圧の処置法
MY132550A (en) 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
TWI356821B (en) * 2003-12-01 2012-01-21 Cambridge Entpr Ltd Anti-inflammatory agents
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
GB0607532D0 (en) * 2006-04-13 2006-05-24 Novartis Ag Organic compounds
JO2630B1 (en) 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
JP4983616B2 (ja) 2008-01-16 2012-07-25 ソニー株式会社 熱転写記録媒体
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
EP3109239A4 (en) * 2014-02-18 2017-07-05 Daiichi Sankyo Company, Limited Aminopyrazolone derivative
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WO2021150499A1 (en) 2020-01-20 2021-07-29 Monomer Software LLC Optical device field of view cleaning apparatus
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TR199700834T1 (xx) 1998-01-21
NO973857D0 (no) 1997-08-21
CN1175944A (zh) 1998-03-11
FI973221A0 (fi) 1997-08-04
CZ266297A3 (en) 1997-11-12
EA002348B1 (ru) 2002-04-25
GR3030626T3 (en) 1999-10-29
MX9706394A (es) 1997-11-29
BR9607335A (pt) 1997-11-25
HU226562B1 (en) 2009-04-28
JPH11500436A (ja) 1999-01-12
CN1081625C (zh) 2002-03-27
DE69602087D1 (de) 1999-05-20
CA2213080A1 (en) 1996-08-29
NO325605B1 (no) 2008-06-23
PL184226B1 (pl) 2002-09-30
AU701560B2 (en) 1999-01-28
AU4623396A (en) 1996-09-11
FI973221A (fi) 1997-10-20
CZ288345B6 (en) 2001-05-16
ZA961364B (en) 1996-08-22
DE69602087T2 (de) 1999-09-09
SK282237B6 (sk) 2001-12-03
CY2198B1 (en) 2002-11-08
EA199900385A1 (ru) 1999-10-28
KR100389253B1 (ko) 2003-08-19
FI120304B (fi) 2009-09-15
KR19980702391A (ko) 1998-07-15
WO1996026183A1 (en) 1996-08-29
SK113997A3 (en) 1998-02-04
PL322001A1 (en) 1998-01-05
IL117209A0 (en) 1996-06-18
NO973857L (no) 1997-10-01
ES2132882T3 (es) 1999-08-16
JP3506714B2 (ja) 2004-03-15
CA2213080C (en) 2007-11-13
NZ300942A (en) 1998-12-23
ATE178886T1 (de) 1999-04-15
IL117209A (en) 2001-01-11
EP0810991B1 (en) 1999-04-14
US5929067A (en) 1999-07-27
HUP9800051A3 (en) 1998-08-28
DK0810991T3 (da) 1999-10-25
EP0810991A1 (en) 1997-12-10

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