DK0810991T3 - 1-Aryl-2-acylamino-ethan-forbindelser og deres anvendelse som neurokinin- især neurokinin-1-antagonister - Google Patents

1-Aryl-2-acylamino-ethan-forbindelser og deres anvendelse som neurokinin- især neurokinin-1-antagonister

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Publication number
DK0810991T3
DK0810991T3 DK96901800T DK96901800T DK0810991T3 DK 0810991 T3 DK0810991 T3 DK 0810991T3 DK 96901800 T DK96901800 T DK 96901800T DK 96901800 T DK96901800 T DK 96901800T DK 0810991 T3 DK0810991 T3 DK 0810991T3
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neurokinin
antagonists
aryl
acylamino
pct
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DK96901800T
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Danish (da)
English (en)
Inventor
Marc Gerspacher
Sprecher Andreas Von
Robert Mah
Silvio Ofner
Siem Jacob Veenstra
Claudia Betschart
Yves Auberson
Walter Schilling
Silvio Roggo
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Novartis Ag
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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DK96901800T 1995-02-22 1996-02-09 1-Aryl-2-acylamino-ethan-forbindelser og deres anvendelse som neurokinin- især neurokinin-1-antagonister DK0810991T3 (da)

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PCT/EP1996/000555 WO1996026183A1 (en) 1995-02-22 1996-02-09 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists

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CA2255910A1 (en) * 1996-05-24 1997-11-27 Mitchell Irvin Steinberg Methods of treating hypertension
MY132550A (en) 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
WO2005053702A2 (en) * 2003-12-01 2005-06-16 Cambridge University Technical Services Limited Anti-inflammatory agents
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
GB0607532D0 (en) * 2006-04-13 2006-05-24 Novartis Ag Organic compounds
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
JP4983616B2 (ja) 2008-01-16 2012-07-25 ソニー株式会社 熱転写記録媒体
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
CA2939687A1 (en) * 2014-02-18 2015-08-27 Daiichi Sankyo Company, Limited Aminopyrazolone derivative
EP4371613A3 (en) 2018-02-26 2024-07-24 Ospedale San Raffaele S.r.l. Compounds for use in the treatment of ocular pain
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение
WO2021150499A1 (en) 2020-01-20 2021-07-29 Monomer Software LLC Optical device field of view cleaning apparatus
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

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ATE164080T1 (de) * 1990-05-10 1998-04-15 Bechgaard Int Res Pharmazeutische zubereitung enthaltend n- glykofurole und n-äthylenglykole
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides

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CA2213080C (en) 2007-11-13
PL184226B1 (pl) 2002-09-30
FI973221A (fi) 1997-10-20
NO973857D0 (no) 1997-08-21
HUP9800051A2 (hu) 1998-05-28
FI120304B (fi) 2009-09-15
MX9706394A (es) 1997-11-29
DE69602087T2 (de) 1999-09-09
CN1175944A (zh) 1998-03-11
IL117209A (en) 2001-01-11
FI973221A0 (fi) 1997-08-04
SK113997A3 (en) 1998-02-04
KR100389253B1 (ko) 2003-08-19
CN1081625C (zh) 2002-03-27
US5929067A (en) 1999-07-27
TR199700834T1 (xx) 1998-01-21
WO1996026183A1 (en) 1996-08-29
CA2213080A1 (en) 1996-08-29
ATE178886T1 (de) 1999-04-15
HU226562B1 (en) 2009-04-28
AU4623396A (en) 1996-09-11
CZ266297A3 (en) 1997-11-12
GR3030626T3 (en) 1999-10-29
KR19980702391A (ko) 1998-07-15
JPH11500436A (ja) 1999-01-12
DE69602087D1 (de) 1999-05-20
SK282237B6 (sk) 2001-12-03
CZ288345B6 (en) 2001-05-16
BR9607335A (pt) 1997-11-25
ES2132882T3 (es) 1999-08-16
NO973857L (no) 1997-10-01
EP0810991B1 (en) 1999-04-14
CY2198B1 (en) 2002-11-08
JP3506714B2 (ja) 2004-03-15
ZA961364B (en) 1996-08-22
EA199900385A1 (ru) 1999-10-28
EA002348B1 (ru) 2002-04-25
HUP9800051A3 (en) 1998-08-28
PL322001A1 (en) 1998-01-05
NO325605B1 (no) 2008-06-23
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