HUP0202437A3 - New process for the preparation of (2s,3as,7as)-1-[(s)-alanile]octahydro-1h-indole-2-carboxy acid derivatives and their use for synthesing perindopril - Google Patents

New process for the preparation of (2s,3as,7as)-1-[(s)-alanile]octahydro-1h-indole-2-carboxy acid derivatives and their use for synthesing perindopril

Info

Publication number
HUP0202437A3
HUP0202437A3 HU0202437A HUP0202437A HUP0202437A3 HU P0202437 A3 HUP0202437 A3 HU P0202437A3 HU 0202437 A HU0202437 A HU 0202437A HU P0202437 A HUP0202437 A HU P0202437A HU P0202437 A3 HUP0202437 A3 HU P0202437A3
Authority
HU
Hungary
Prior art keywords
alanile
synthesing
perindopril
octahydro
indole
Prior art date
Application number
HU0202437A
Other languages
English (en)
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0202437(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of HU0202437D0 publication Critical patent/HU0202437D0/hu
Publication of HUP0202437A2 publication Critical patent/HUP0202437A2/hu
Publication of HUP0202437A3 publication Critical patent/HUP0202437A3/hu
Publication of HU229396B1 publication Critical patent/HU229396B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
HU0202437A 2001-07-24 2002-07-24 Új eljárás (2S,3aS,7aS)-1-[(S)-alanil]oktahidro-1H-indol-2-karbonsav vegyületek elõállítására és ezek alkalmazása perindopril elõállítására HU229396B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0109839A FR2827860B1 (fr) 2001-07-24 2001-07-24 Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Publications (4)

Publication Number Publication Date
HU0202437D0 HU0202437D0 (hu) 2002-10-28
HUP0202437A2 HUP0202437A2 (hu) 2003-02-28
HUP0202437A3 true HUP0202437A3 (en) 2003-05-28
HU229396B1 HU229396B1 (hu) 2013-11-28

Family

ID=8865826

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202437A HU229396B1 (hu) 2001-07-24 2002-07-24 Új eljárás (2S,3aS,7aS)-1-[(S)-alanil]oktahidro-1H-indol-2-karbonsav vegyületek elõállítására és ezek alkalmazása perindopril elõállítására

Country Status (25)

Country Link
US (1) US7060842B2 (hu)
EP (1) EP1256590B1 (hu)
JP (1) JP3868957B2 (hu)
KR (1) KR100607556B1 (hu)
CN (1) CN1533398A (hu)
AR (1) AR035081A1 (hu)
AT (1) ATE318838T1 (hu)
AU (1) AU2002334027B8 (hu)
BR (1) BR0211334A (hu)
CA (1) CA2455706C (hu)
DE (1) DE60209458T2 (hu)
DK (1) DK1256590T3 (hu)
EA (1) EA005490B1 (hu)
ES (1) ES2259071T3 (hu)
FR (1) FR2827860B1 (hu)
HU (1) HU229396B1 (hu)
MA (1) MA27130A1 (hu)
MX (1) MXPA04000443A (hu)
NO (1) NO328234B1 (hu)
NZ (1) NZ530427A (hu)
PL (1) PL212408B1 (hu)
PT (1) PT1256590E (hu)
SI (1) SI1256590T1 (hu)
WO (1) WO2003016336A1 (hu)
ZA (1) ZA200400246B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE365714T1 (de) * 2002-01-30 2007-07-15 Servier Lab Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
SI1603558T1 (sl) 2003-02-28 2008-12-31 Servier S A Lab Postopek za pripravo perindoprila in njegovih soli
SI1403277T1 (sl) * 2003-02-28 2005-12-31 Servier Lab NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-((S)-ALANIL)-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA PRI SINTEZI PERINDOPRILA
ES2250846T3 (es) * 2003-02-28 2006-04-16 Les Laboratoires Servier Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
ES2250847T3 (es) * 2003-02-28 2006-04-16 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido (2s,3as,7as)-perhidroindol-2-carboxilico y sus eteres y su aplicacion a la sintesis de perindropil.
EP1323729B1 (fr) * 2003-03-12 2004-11-03 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
DE60300581T2 (de) * 2003-03-12 2006-01-19 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmba- ren Salzen
SI1323729T1 (en) * 2003-03-12 2005-02-28 Les Laboratoires Servier Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
KR20060035636A (ko) 2003-06-24 2006-04-26 르 라보레또레 쎄르비에르 신규한 결정형의 페린도프릴 에르부민
SI1367063T1 (sl) * 2003-07-31 2006-10-31 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
JP4720132B2 (ja) * 2003-10-30 2011-07-13 住友化学株式会社 光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
ITFI20040174A1 (it) * 2004-08-03 2004-11-03 Protera S R L Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko) 2006-12-19 2013-11-15 에스케이바이오팜 주식회사 옥타하이드로인돌-2-카르복시산의 제조방법
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
PL355159A1 (en) 2003-01-13
EA005490B1 (ru) 2005-02-24
AU2002334027A1 (en) 2003-03-03
AR035081A1 (es) 2004-04-14
AU2002334027B8 (en) 2007-01-25
DK1256590T3 (da) 2006-06-06
KR100607556B1 (ko) 2006-08-02
NO328234B1 (no) 2010-01-11
WO2003016336A1 (fr) 2003-02-27
JP3868957B2 (ja) 2007-01-17
JP2005500386A (ja) 2005-01-06
NZ530427A (en) 2005-08-26
ES2259071T3 (es) 2006-09-16
US20040198988A1 (en) 2004-10-07
BR0211334A (pt) 2004-09-28
ZA200400246B (en) 2006-07-26
MA27130A1 (fr) 2005-01-03
CA2455706C (fr) 2012-01-24
NO20040151L (no) 2004-01-13
CN1533398A (zh) 2004-09-29
US7060842B2 (en) 2006-06-13
MXPA04000443A (es) 2004-03-18
EP1256590A1 (fr) 2002-11-13
EP1256590B1 (fr) 2006-03-01
EA200400110A1 (ru) 2004-06-24
HU229396B1 (hu) 2013-11-28
DE60209458T2 (de) 2006-10-12
PT1256590E (pt) 2006-06-30
PL212408B1 (pl) 2012-09-28
HUP0202437A2 (hu) 2003-02-28
AU2002334027B2 (en) 2006-12-14
FR2827860A1 (fr) 2003-01-31
DE60209458D1 (de) 2006-04-27
CA2455706A1 (fr) 2003-02-27
KR20040023673A (ko) 2004-03-18
SI1256590T1 (sl) 2006-06-30
ATE318838T1 (de) 2006-03-15
FR2827860B1 (fr) 2004-12-10
HU0202437D0 (hu) 2002-10-28

Similar Documents

Publication Publication Date Title
HUP0202437A3 (en) New process for the preparation of (2s,3as,7as)-1-[(s)-alanile]octahydro-1h-indole-2-carboxy acid derivatives and their use for synthesing perindopril
AU2001241068A1 (en) Indole derivatives, process for preparation of the same and use thereof
HUP0200309A2 (en) Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression, process for their preparation and pharmaceutical compositions containing them
HUP0101336A2 (hu) Eljárás perindopril és gyógyszerészetileg alkalmazható sói előállítására
HUP0101434A3 (en) Sulfonamide-containing indole compounds, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing the same
HUP0202263A3 (en) Benzimidazole, indole and imidazo-pyridine derivatives and pharmaceutical compositions containing them
HUP0000658A3 (en) Sulphonamide derivatives, process for their preparation, and their use as medicaments
AU5194999A (en) Benzothiepin derivatives, process for the preparation of the same and uses thereof
HUP0105480A3 (en) Benzofuran derivatives, process for preparation of the same and uses thereof
IL158289A (en) Mercaptoacetylamide derivatives, a process for their preparation and their use as medicaments for the treatment of hypertension and chf
HUP0202414A3 (en) Process for the preparation of perindopril, their analogous and their salts
IL214387A (en) History of tryptamine, method for their preparation and use for the preparation of pharmaceuticals and for the preparation of tryptamine
AU2001274049A1 (en) Process for the preparation of indole derivatives and intermediates of the process
HK1086280A1 (en) Novel method for synthesising derivtives (2S, 3AS,7AS)-1-Ä(S)-alanylÜ-octahydro,-1hindole-2-carboxy lic acid and the use thereof for perindopril synthesis
HUP0201338A3 (en) Novel indole derivatives, pharmaceutical compositions containing them and their use
HUP0100785A3 (en) Indole derivatives, process for producing them and pharmaceutical compositions containing them
HUP0203767A3 (en) Novel indole derivatives, pharmaceutical compositions containing them and their use
AU6866500A (en) Chromone derivatives, process for the preparation of the same and uses thereof
IS2315B (is) Nýjar greinóttar setnar amínó afleiður af 3-amínó-1-fenýl-1H[1,2,4]tríasóli, aðferðir til framleiðslu á þeim og lyfjasamsetningar sem innihalda þær
SI1319668T1 (en) Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril
AU5368699A (en) Derivatives of triptolide, and preparation and uses thereof
AU6846500A (en) Novel 8-carbonyl chroman derivatives, preparation and therapeutic use thereof
NO20005259L (no) Fremgangsmåte for fremstilling av enantiomerrent N-metyl-N- [(1S)-1-fenyl-2-((3S)-3-hydroksypyrrolidin-1-yl)etyl]-2,2- difenylacetamid
ZA200505779B (en) Novel method for synthesising (2S,3AS,7AS)-perhydroin-dole-2-carboxylic acid and the sters thereof and the use thereof for perindopril synthesis
PL380411A1 (pl) Sposób otrzymywania pochodnych kwasu (2S, 3aS, 7aS)-1- [(S)-alanylo]oktahydro-1H-indolo-2- karboksylowego i zastosowanie ich do syntezy perindoprilu

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees