AU5368699A - Derivatives of triptolide, and preparation and uses thereof - Google Patents

Derivatives of triptolide, and preparation and uses thereof

Info

Publication number
AU5368699A
AU5368699A AU53686/99A AU5368699A AU5368699A AU 5368699 A AU5368699 A AU 5368699A AU 53686/99 A AU53686/99 A AU 53686/99A AU 5368699 A AU5368699 A AU 5368699A AU 5368699 A AU5368699 A AU 5368699A
Authority
AU
Australia
Prior art keywords
triptolide
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU53686/99A
Inventor
Xiaoping Gao
Bogang Li
Wenwu Li
Dayuan Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
W & K International Inc
Chengdu Diao Pharmaceutical Group Co Ltd
Original Assignee
W & K International Inc
Chengdu Diao Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by W & K International Inc, Chengdu Diao Pharmaceutical Group Co Ltd filed Critical W & K International Inc
Publication of AU5368699A publication Critical patent/AU5368699A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
AU53686/99A 1999-04-16 1999-08-20 Derivatives of triptolide, and preparation and uses thereof Abandoned AU5368699A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN99105796 1999-04-16
CN99105796 1999-04-16
PCT/CN1999/000123 WO2000063212A1 (en) 1999-04-16 1999-08-20 Derivatives of triptolide, and preparation and uses thereof

Publications (1)

Publication Number Publication Date
AU5368699A true AU5368699A (en) 2000-11-02

Family

ID=5272134

Family Applications (1)

Application Number Title Priority Date Filing Date
AU53686/99A Abandoned AU5368699A (en) 1999-04-16 1999-08-20 Derivatives of triptolide, and preparation and uses thereof

Country Status (2)

Country Link
AU (1) AU5368699A (en)
WO (1) WO2000063212A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569893B2 (en) 2001-03-15 2003-05-27 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
AU2003243351B2 (en) 2002-05-31 2009-04-30 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
CN100398544C (en) * 2002-09-18 2008-07-02 成都达远药物有限公司 Aqueous triptolide alcohol derivative with high immunesuppressive activity and its application
US7820834B2 (en) 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
CN1917893A (en) 2004-02-09 2007-02-21 美国泛华医药公司 Methods for isolation of triptolide compounds from tripterygium wilfordii
US7863464B2 (en) 2004-03-02 2011-01-04 Pharmagenesis, Inc. Triptolide lactone ring derivatives as immunomodulators and anticancer agents
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
AU2010245669B2 (en) 2009-05-07 2015-11-26 Regents Of The University Of Minnesota Triptolide prodrugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
CN1052861A (en) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 The preparation method of wilfordii alcoholic lactone and antifertility purposes
CN1052859A (en) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 The structure of 17-hydroxyl triptolide alcohol and analogue and preparation method
CN1052860A (en) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 The preparation method of tripchlorolide and antifertility purposes
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
WO2000063212A1 (en) 2000-10-26

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase