AU1271201A - Azepinoindole derivatives, the production and use thereof - Google Patents
Azepinoindole derivatives, the production and use thereofInfo
- Publication number
- AU1271201A AU1271201A AU12712/01A AU1271201A AU1271201A AU 1271201 A AU1271201 A AU 1271201A AU 12712/01 A AU12712/01 A AU 12712/01A AU 1271201 A AU1271201 A AU 1271201A AU 1271201 A AU1271201 A AU 1271201A
- Authority
- AU
- Australia
- Prior art keywords
- production
- azepinoindole derivatives
- azepinoindole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19946289 | 1999-09-28 | ||
DE19946289A DE19946289A1 (en) | 1999-09-28 | 1999-09-28 | Benzodiazepine derivatives, their production and use |
DE10039610A DE10039610A1 (en) | 2000-08-09 | 2000-08-09 | Azepinoindole derivatives are PARP inhibitors and are useful for the treatment of neurodegenerative diseases, ischemia, tumor, septic shock, inflammation, rheumatic diseases, ARDS and diabetes mellitus |
DE10039610 | 2000-08-09 | ||
PCT/EP2000/009024 WO2001023390A2 (en) | 1999-09-28 | 2000-09-15 | Azepinoindole derivatives, the production and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU1271201A true AU1271201A (en) | 2001-04-30 |
Family
ID=26006691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU12712/01A Abandoned AU1271201A (en) | 1999-09-28 | 2000-09-15 | Azepinoindole derivatives, the production and use thereof |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1183259A2 (en) |
JP (1) | JP2003510328A (en) |
KR (1) | KR20010087401A (en) |
CN (1) | CN1374961A (en) |
AU (1) | AU1271201A (en) |
BG (1) | BG105650A (en) |
BR (1) | BR0007174A (en) |
CA (1) | CA2352194A1 (en) |
CZ (1) | CZ20012373A3 (en) |
HK (1) | HK1048999A1 (en) |
HU (1) | HUP0104917A3 (en) |
IL (1) | IL143349A0 (en) |
NO (1) | NO20012567L (en) |
PL (1) | PL347885A1 (en) |
SK (1) | SK8842001A3 (en) |
TR (1) | TR200101499T1 (en) |
WO (1) | WO2001023390A2 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2218110T3 (en) | 1999-01-11 | 2004-11-16 | Agouron Pharmaceuticals, Inc. | TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES. |
US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
AU3652102A (en) | 2000-12-01 | 2002-06-11 | Guilford Pharm Inc | Compounds and their uses |
US7026311B2 (en) * | 2002-01-10 | 2006-04-11 | Abbott Gmbh & Co., Kg | Dibenzodiazepine derivatives, their preparation and use |
AU2003229953A1 (en) | 2002-04-30 | 2003-11-17 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
US7786344B2 (en) | 2002-07-26 | 2010-08-31 | Basf Plant Science Gmbh | Selection method |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
US7223759B2 (en) | 2003-09-15 | 2007-05-29 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds |
EP2305221B1 (en) | 2003-12-01 | 2015-05-20 | Kudos Pharmaceuticals Limited | DNA damage repair inhibitors for treatment of cancer |
US8013006B2 (en) | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
WO2006019832A1 (en) | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
BRPI0609283A2 (en) | 2005-03-08 | 2010-11-23 | Basf Plant Science Gmbh | methods for identifying an intron with plant expression enhancing properties, to enrich the number of introns with plant expression enhancing properties, to isolate, supply or produce an intron with plant expression enhancing properties, to provide an expression cassette and to enhance expression of a nucleic acid sequence in a plant or a plant cell, computer algorithm, computer device or data storage device, recombinant DNA expression construct, expression vector, transgenic cell, or nonhuman organism transgenic material, cell culture, propagating parts or material, and, use of a transgenic organism or cell cultures, transgenic propagating material parts derived from these |
WO2006101937A1 (en) | 2005-03-18 | 2006-09-28 | Janssen Pharmaceutica N.V. | Acylhydrazones as kinase modulators |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
UY30639A1 (en) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | SUBSTITUTED DERIVATIVES OF 2H-FTALAZIN-1-ONA, ITS CRYSTAL FORMS, PREPARATION PROCESS AND APPLICATIONS |
CA2699038A1 (en) | 2007-09-14 | 2009-03-19 | Astrazeneca Ab | Phthalazinone derivatives |
UY31603A1 (en) | 2008-01-23 | 2009-08-31 | DERIVATIVES OF FTALAZINONA | |
GB0804755D0 (en) * | 2008-03-14 | 2008-04-16 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
ME02640B (en) | 2008-10-07 | 2017-06-20 | Kudos Pharm Ltd | Pharmaceutical formulation 514 |
WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
DE112010004583T5 (en) | 2009-11-27 | 2012-10-18 | Basf Plant Science Company Gmbh | Chimeric endonucleases and applications thereof |
EP2504439B1 (en) | 2009-11-27 | 2016-03-02 | BASF Plant Science Company GmbH | Optimized endonucleases and uses thereof |
BR112012012444A2 (en) | 2009-11-27 | 2015-09-22 | Basf Plant Science Co Gmbh | "chimeric endonuclease, isolated polynucleotide, expression cassette, vector, non-human organism, method for providing a chimeric endonuclease, method for homologous polynucleotide recombination, method for targeted polynucleotide mutation, and method for homologous recombination or targeted mutation" |
CN103096893B (en) | 2010-06-04 | 2016-05-04 | 阿尔巴尼分子研究公司 | Glycine transporter-1 inhibitor, Its Preparation Method And Use |
EP3594343B1 (en) | 2015-07-23 | 2021-04-21 | Institut Curie | Use of a combination of dbait molecule and parp inhibitors to treat cancer |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
EP3615026B1 (en) | 2017-04-28 | 2021-03-03 | Akribes Biomedical GmbH | A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
EP3630287A4 (en) * | 2017-05-24 | 2021-06-02 | The Trustees Of The University Of Pennsylvania | Radiolabeled and fluorescent parp inhibitors for imaging and radiotherapy |
CN111819282A (en) | 2018-03-13 | 2020-10-23 | 欧恩科斯欧公司 | Dbait molecules against acquired resistance in cancer therapy |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CA3128435A1 (en) * | 2019-02-02 | 2020-08-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Indolo heptamyl oxime analogue as parp inhibitor |
WO2021018298A1 (en) * | 2019-08-01 | 2021-02-04 | 南京明德新药研发有限公司 | Indolo-seven-membered acyloxime compounds as parp inhibitors |
GB201913030D0 (en) | 2019-09-10 | 2019-10-23 | Francis Crick Institute Ltd | Treatment of hr deficient cancer |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
KR20230044416A (en) * | 2020-07-31 | 2023-04-04 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Determination of indolo heptamyl oxime analogs as PARP inhibitors and method for their preparation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011644A1 (en) * | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
ES2218110T3 (en) * | 1999-01-11 | 2004-11-16 | Agouron Pharmaceuticals, Inc. | TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES. |
ECSP003637A (en) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES |
-
2000
- 2000-09-15 CA CA002352194A patent/CA2352194A1/en not_active Abandoned
- 2000-09-15 CZ CZ20012373A patent/CZ20012373A3/en unknown
- 2000-09-15 HU HU0104917A patent/HUP0104917A3/en unknown
- 2000-09-15 EP EP00974379A patent/EP1183259A2/en not_active Withdrawn
- 2000-09-15 BR BR0007174-9A patent/BR0007174A/en not_active IP Right Cessation
- 2000-09-15 CN CN00802408A patent/CN1374961A/en active Pending
- 2000-09-15 PL PL00347885A patent/PL347885A1/en not_active Application Discontinuation
- 2000-09-15 SK SK884-2001A patent/SK8842001A3/en unknown
- 2000-09-15 IL IL14334900A patent/IL143349A0/en unknown
- 2000-09-15 JP JP2001526542A patent/JP2003510328A/en active Pending
- 2000-09-15 AU AU12712/01A patent/AU1271201A/en not_active Abandoned
- 2000-09-15 WO PCT/EP2000/009024 patent/WO2001023390A2/en not_active Application Discontinuation
- 2000-09-15 KR KR1020017006614A patent/KR20010087401A/en not_active Application Discontinuation
- 2000-09-15 TR TR2001/01499T patent/TR200101499T1/en unknown
-
2001
- 2001-05-25 NO NO20012567A patent/NO20012567L/en not_active Application Discontinuation
- 2001-06-26 BG BG105650A patent/BG105650A/en unknown
-
2003
- 2003-02-18 HK HK03101179.8A patent/HK1048999A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001023390A2 (en) | 2001-04-05 |
PL347885A1 (en) | 2002-04-22 |
CN1374961A (en) | 2002-10-16 |
NO20012567L (en) | 2001-06-25 |
KR20010087401A (en) | 2001-09-15 |
HK1048999A1 (en) | 2003-04-25 |
WO2001023390A3 (en) | 2001-12-27 |
JP2003510328A (en) | 2003-03-18 |
EP1183259A2 (en) | 2002-03-06 |
BR0007174A (en) | 2001-09-04 |
CA2352194A1 (en) | 2001-04-05 |
HUP0104917A2 (en) | 2002-04-29 |
SK8842001A3 (en) | 2002-01-07 |
IL143349A0 (en) | 2002-04-21 |
HUP0104917A3 (en) | 2002-12-28 |
NO20012567D0 (en) | 2001-05-25 |
BG105650A (en) | 2002-02-28 |
TR200101499T1 (en) | 2002-09-23 |
CZ20012373A3 (en) | 2002-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |