AU3301700A - (n)-sulfonyl-dipeptide derivatives, production and use thereof in therapy - Google Patents

(n)-sulfonyl-dipeptide derivatives, production and use thereof in therapy

Info

Publication number
AU3301700A
AU3301700A AU33017/00A AU3301700A AU3301700A AU 3301700 A AU3301700 A AU 3301700A AU 33017/00 A AU33017/00 A AU 33017/00A AU 3301700 A AU3301700 A AU 3301700A AU 3301700 A AU3301700 A AU 3301700A
Authority
AU
Australia
Prior art keywords
sulfonyl
therapy
production
dipeptide derivatives
dipeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU33017/00A
Inventor
Chantal Alcouffe
Patrice Bellevergue
Genevieve Dellac
Christopher Latham
Valerie Martin
Christine Masson
Gary Mccort
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of AU3301700A publication Critical patent/AU3301700A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU33017/00A 1999-03-30 2000-03-21 (n)-sulfonyl-dipeptide derivatives, production and use thereof in therapy Abandoned AU3301700A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9903933A FR2791683A1 (en) 1999-03-30 1999-03-30 N-SULFONYL-DIPEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR9903933 1999-03-30
PCT/FR2000/000696 WO2000058346A1 (en) 1999-03-30 2000-03-21 N-sulfonyl-dipeptide derivatives, production and use thereof in therapy

Publications (1)

Publication Number Publication Date
AU3301700A true AU3301700A (en) 2000-10-16

Family

ID=9543786

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33017/00A Abandoned AU3301700A (en) 1999-03-30 2000-03-21 (n)-sulfonyl-dipeptide derivatives, production and use thereof in therapy

Country Status (3)

Country Link
AU (1) AU3301700A (en)
FR (1) FR2791683A1 (en)
WO (1) WO2000058346A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001281843B2 (en) * 2000-06-15 2005-06-09 Curacyte Ag Dipeptide inhibitors for the blood-clotting factor Xa

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7001887B2 (en) * 2001-02-02 2006-02-21 Chugai Seiyaku Kabushiki Kaisha Peptide derivatives
JP4209659B2 (en) 2001-11-15 2009-01-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 Amidino derivative and anticoagulant and thrombosis therapeutic agent using the same
DE10210590A1 (en) * 2002-03-11 2003-10-02 Curacyte Ag Inhibitors of coagulation factor Xa, their production and use
ATE399175T1 (en) 2002-03-11 2008-07-15 Curacyte Ag UROKINASE INHIBITORS, THEIR PRODUCTION AND USE
DE10301300B4 (en) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Use of acylated 4-amidino- and 4-guanidinobenzylamines for the inhibition of plasma kallikrein
DE10342108A1 (en) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basic substituted benzylamine analogs as coagulation factor Xa inhibitors, their preparation and use
AU2006330638B2 (en) * 2005-12-20 2012-05-31 Nps Pharmaceuticals, Inc. Fluorinated compounds
US7902401B2 (en) 2006-12-14 2011-03-08 Nps Pharmaceuticals, Inc. Fluorinated compounds
RS52030B (en) 2006-03-24 2012-04-30 Eisai R&D Management Co., Ltd. Triazolone derivative
DE102006050672A1 (en) * 2006-10-24 2008-04-30 Curacyte Discovery Gmbh New glycylglycine derivatives with a benzylsulfonylamido group and an amidino-organylamido group at the opposite chain ends, used in drugs for reducing loss of blood, e.g. in operations
US8450336B2 (en) 2006-12-14 2013-05-28 Nps Pharmaceuticals, Inc Use of D-serine derivatives for the treatment of anxiety disorders
WO2008107362A2 (en) * 2007-03-07 2008-09-12 Novo Nordisk Health Care Ag Stabiliser and inhibitors of factor vii
WO2009038157A1 (en) 2007-09-21 2009-03-26 Eisai R & D Management Co., Ltd. 2,3-dihydroiminoisoindole derivative
TW201206905A (en) 2010-05-20 2012-02-16 Eisai R & Amp D Man Co Ltd Prodrug of triazolone compound
EP2590945B1 (en) 2010-07-07 2014-04-30 The Medicines Company (Leipzig) GmbH Serine protease inhibitors
CN111170878B (en) * 2020-02-09 2023-01-03 滨海瀚鸿生化有限公司 Method for preparing D-type or L-type tert-leucine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593813A1 (en) * 1986-01-24 1987-08-07 Sanofi Sa Derivatives of N- alpha -arylsulphonylaminoacyl-p-amidinophenylalanine amides, process for their preparation, their application as medicaments and the compositions which contain them
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
CA2140598C (en) * 1994-01-27 2010-03-09 Masahiro Ohshima Prolineamide derivatives
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001281843B2 (en) * 2000-06-15 2005-06-09 Curacyte Ag Dipeptide inhibitors for the blood-clotting factor Xa
AU2001281843B8 (en) * 2000-06-15 2005-10-06 Curacyte Ag Dipeptide inhibitors for the blood-clotting factor Xa

Also Published As

Publication number Publication date
WO2000058346A1 (en) 2000-10-05
FR2791683A1 (en) 2000-10-06

Similar Documents

Publication Publication Date Title
AU1271201A (en) Azepinoindole derivatives, the production and use thereof
AU3957600A (en) Piperidyl-imidazole derivatives, their preparations and therapeutic uses
AU2002340999A1 (en) Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
HUP0203225A3 (en) Benzodiazepin derivatives, the production and use thereof
AU763094C (en) Benzimidazoles, production thereof and use thereof as medicaments
AU3301800A (en) 1,4-diazabicyclo(3.2.2)nonane-4-carboxylate and carboxamide derivatives, production and use thereof in therapeutics
AU2922600A (en) Pyridopyranoazepine derivatives, preparation and therapeutic use
AU3301700A (en) (n)-sulfonyl-dipeptide derivatives, production and use thereof in therapy
AU715620C (en) Therapeutic methods and uses
IL135451A0 (en) 3-amino-3-arylpropan-1-ol derivatives, their preparation and use
AU6635800A (en) Pyridomorphinans, thienomoprhinans and use thereof
AU2001260110A1 (en) Novel LHRH-antagonists, Production and Use Thereof as Medicament
AU6846500A (en) Novel 8-carbonyl chroman derivatives, preparation and therapeutic use thereof
AU2001254812A1 (en) 9-oxa-epothilon derivatives, method for the production and use thereof in pharmaceutical preparations
AU2001284084A1 (en) Polyfluoroalkyltriazole derivatives, preparation and therapeutic use thereof
HUP0203468A3 (en) Betha-d-5-thioxylose derivatives, preparation method and therapeutic use thereof
AU2002229870A1 (en) Mikanolide derivatives, their preparation and therapeutic uses
HU0001397D0 (en) 3-amino-3-arylpropan-1-ol derivatives, production and use thereof
AU5524400A (en) Novel 6-amino-uracil derivatives, preparation and use thereof
AU2001237518A1 (en) Polyfluoroalkylimidazole derivatives, their preparation and therapeutic application
AU2526001A (en) 2-phenyl-quinoline derivatives, preparation method and therapeutic use thereof
AU7517800A (en) 3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments
IL149653A0 (en) 2-arylquinoline derivatives, preparation and therapeutic use thereof
AU5988699A (en) Quinazolinedione derivatives, preparation and therapeutic uses
AU6924198A (en) Benzenesulphonamide derivatives, preparation and application thereof in therapy

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase