HUP0103914A2 - Eljárás naftiridin-karbonsav metánszulfonát-szeszkvihidrát előállítására - Google Patents
Eljárás naftiridin-karbonsav metánszulfonát-szeszkvihidrát előállításáraInfo
- Publication number
- HUP0103914A2 HUP0103914A2 HU0103914A HUP0103914A HUP0103914A2 HU P0103914 A2 HUP0103914 A2 HU P0103914A2 HU 0103914 A HU0103914 A HU 0103914A HU P0103914 A HUP0103914 A HU P0103914A HU P0103914 A2 HUP0103914 A2 HU P0103914A2
- Authority
- HU
- Hungary
- Prior art keywords
- carboxylic acid
- naphthyridine
- methanesulfonate sesquihydrate
- production
- sesquihydrate
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 title 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- KVERQKOZMUXLTL-UHFFFAOYSA-N methanesulfonic acid trihydrate Chemical compound O.O.O.CS(O)(=O)=O.CS(O)(=O)=O KVERQKOZMUXLTL-UHFFFAOYSA-N 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012265 solid product Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Abstract
lign=J;>(57) A találmány metánszulfonát-szeszkvihidrát javítottelőállítási eljárásra vonatkozik, amelynek során közvetlenül só éshidrát képződik. A találmány szerinti eljárásban 7-(3-amino-metil-4-syn-metoximino-pirrolidin-1-il)-1-ciklopropil-6-fluor-4-oxo-1,4-dihidro-1,8-naftiridin-3-karbonsav-metánszulfonát- zeszkvihidrátotállítanak elő antibakteriális hatású (I) képletű 7-(3-amino-metil-4-metoximino-pirrolidin-1-il)-1-ciklopropil-6-fluor-4-oxo-1,4-dihidro-1,8-naftiridin-3-karbonsav és metánszulfonsav reagáltatásával legalábbegy vízzel elegyedő társoldószert és vizet tartalmazó oldószerben, ésa képződő szilárd terméket izolálják. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9820405.0A GB9820405D0 (en) | 1998-09-18 | 1998-09-18 | Process |
| PCT/EP1999/007003 WO2000017199A1 (en) | 1998-09-18 | 1999-09-15 | Process for the production of a naphthyridine carboxylic acid derivative (methanesulfonate sesquihydrate) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0103914A2 true HUP0103914A2 (hu) | 2002-03-28 |
| HUP0103914A3 HUP0103914A3 (en) | 2002-05-28 |
| HU227068B1 HU227068B1 (hu) | 2010-06-28 |
Family
ID=10839123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103914A HU227068B1 (hu) | 1998-09-18 | 1999-09-15 | Eljárás naftiridin-karbonsav (metánszulfonát-szeszkvihidrát) elõállítására |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6818771B1 (hu) |
| EP (1) | EP1114050B1 (hu) |
| JP (1) | JP2002526498A (hu) |
| KR (1) | KR100679062B1 (hu) |
| CN (1) | CN1315825C (hu) |
| AT (1) | ATE337315T1 (hu) |
| AU (1) | AU751060B2 (hu) |
| BR (1) | BR9913858A (hu) |
| CA (1) | CA2344439C (hu) |
| CY (1) | CY1106171T1 (hu) |
| CZ (1) | CZ297509B6 (hu) |
| DE (1) | DE69932938T8 (hu) |
| DK (1) | DK1114050T3 (hu) |
| ES (1) | ES2272084T3 (hu) |
| GB (1) | GB9820405D0 (hu) |
| HK (1) | HK1038557A1 (hu) |
| HU (1) | HU227068B1 (hu) |
| IL (2) | IL141933A0 (hu) |
| NO (1) | NO317997B1 (hu) |
| NZ (1) | NZ510590A (hu) |
| PL (1) | PL194707B1 (hu) |
| PT (1) | PT1114050E (hu) |
| TR (1) | TR200100797T2 (hu) |
| WO (1) | WO2000017199A1 (hu) |
| ZA (1) | ZA200102160B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020032216A1 (en) | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
| MA24500A1 (fr) | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
| CA2281817C (en) * | 1999-06-29 | 2008-07-29 | Smithkline Beecham Corporation | Methods of use of fluoroquinolone compounds against maxillary sinus pathogenic bacteria |
| GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
| GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
| KR20010091379A (ko) * | 2000-03-15 | 2001-10-23 | 성재갑 | 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법 |
| EP1412078B1 (en) | 2001-08-02 | 2008-10-08 | LG Life Sciences Limited | Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one, gemifloxacin or a salt thereof |
| KR100517638B1 (ko) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
| JP5156381B2 (ja) * | 2004-10-18 | 2013-03-06 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｎ−メチル−Ｎ−（３−｛３−［２−チエニルカルボニル］−ピラゾール−［１，５−α］−ピリミジン−７−イル｝フェニル）アセトアミドの水和物ならびにそれに関連するプロセスおよび方法 |
| EP2159225A1 (en) * | 2005-06-15 | 2010-03-03 | Hetero Drugs Limited | Gemifloxacin process and polymorphs |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57134482A (en) * | 1981-02-13 | 1982-08-19 | Dainippon Pharmaceut Co Ltd | 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation |
| JPH0356479A (ja) * | 1989-07-24 | 1991-03-12 | Takeshi Yokota | 水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩 |
| WO1991002526A1 (en) * | 1989-08-16 | 1991-03-07 | Pfizer Inc. | Azabicyclo quinolone carboxylic acids |
| EP0688772B1 (en) * | 1994-06-16 | 1999-05-06 | LG Chemical Limited | Quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime) pyrrolidine substituents and processes for their preparation |
| US5776944A (en) | 1994-06-16 | 1998-07-07 | Lg Chemical Ltd. | 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof |
| JP3449658B2 (ja) * | 1994-12-21 | 2003-09-22 | 杏林製薬株式会社 | 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法 |
| CA2223404C (en) * | 1995-06-06 | 2001-01-16 | Thomas A. Morris | Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt |
| DK0843661T3 (da) * | 1995-08-11 | 2002-07-22 | Pfizer | (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethansulfonat-trihydrat |
| UY24504A1 (es) | 1996-03-29 | 1997-09-19 | Smithkline Beecham Corp | Dihidrato de eprosartano y un procedimiento para su produccion y formulacion |
| US20020032216A1 (en) | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
| MA24500A1 (fr) * | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
| KR100286874B1 (ko) | 1998-03-04 | 2001-04-16 | 성재갑 | 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법 |
| DK1082300T3 (da) * | 1998-05-29 | 2003-12-15 | Upjohn Co | 3-[1'-N-Methylamino)ethyl-N-benzyl]pyrrolidin-monomethansulfonat |
-
1998
- 1998-09-18 GB GBGB9820405.0A patent/GB9820405D0/en not_active Ceased
-
1999
- 1999-09-15 DK DK99950532T patent/DK1114050T3/da active
- 1999-09-15 ES ES99950532T patent/ES2272084T3/es not_active Expired - Lifetime
- 1999-09-15 NZ NZ510590A patent/NZ510590A/en not_active IP Right Cessation
- 1999-09-15 JP JP2000574108A patent/JP2002526498A/ja active Pending
- 1999-09-15 WO PCT/EP1999/007003 patent/WO2000017199A1/en active IP Right Grant
- 1999-09-15 AT AT99950532T patent/ATE337315T1/de active
- 1999-09-15 US US09/787,256 patent/US6818771B1/en not_active Expired - Lifetime
- 1999-09-15 TR TR2001/00797T patent/TR200100797T2/xx unknown
- 1999-09-15 DE DE69932938T patent/DE69932938T8/de active Active
- 1999-09-15 HU HU0103914A patent/HU227068B1/hu not_active IP Right Cessation
- 1999-09-15 CN CNB998108634A patent/CN1315825C/zh not_active Expired - Lifetime
- 1999-09-15 AU AU63283/99A patent/AU751060B2/en not_active Ceased
- 1999-09-15 IL IL14193399A patent/IL141933A0/xx active IP Right Grant
- 1999-09-15 CZ CZ20010978A patent/CZ297509B6/cs not_active IP Right Cessation
- 1999-09-15 EP EP99950532A patent/EP1114050B1/en not_active Expired - Lifetime
- 1999-09-15 BR BR9913858-1A patent/BR9913858A/pt not_active Application Discontinuation
- 1999-09-15 PT PT99950532T patent/PT1114050E/pt unknown
- 1999-09-15 CA CA2344439A patent/CA2344439C/en not_active Expired - Lifetime
- 1999-09-15 KR KR1020017003424A patent/KR100679062B1/ko active IP Right Grant
- 1999-09-15 PL PL99346656A patent/PL194707B1/pl not_active IP Right Cessation
-
2001
- 2001-03-09 IL IL141933A patent/IL141933A/en not_active IP Right Cessation
- 2001-03-14 NO NO20011290A patent/NO317997B1/no not_active IP Right Cessation
- 2001-03-15 ZA ZA2001/02160A patent/ZA200102160B/en unknown
- 2001-12-08 HK HK01108616A patent/HK1038557A1/xx not_active IP Right Cessation
-
2006
- 2006-09-26 CY CY20061101379T patent/CY1106171T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |