HUP9903852A2 - Eljárás kontrasztközegek előállítására - Google Patents

Eljárás kontrasztközegek előállítására

Info

Publication number
HUP9903852A2
HUP9903852A2 HU9903852A HUP9903852A HUP9903852A2 HU P9903852 A2 HUP9903852 A2 HU P9903852A2 HU 9903852 A HU9903852 A HU 9903852A HU P9903852 A HUP9903852 A HU P9903852A HU P9903852 A2 HUP9903852 A2 HU P9903852A2
Authority
HU
Hungary
Prior art keywords
preparation
contrast agents
alkylation
carboxylic acid
phenyl carboxylic
Prior art date
Application number
HU9903852A
Other languages
English (en)
Inventor
Trygve Gulbrandsen
Lars Terje Holmaas
Odd Einar Ingvoldstad
Original Assignee
Nycomed Imaging A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging A.S. filed Critical Nycomed Imaging A.S.
Publication of HUP9903852A2 publication Critical patent/HUP9903852A2/hu
Publication of HUP9903852A3 publication Critical patent/HUP9903852A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Glass Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány szerinti eljárás N-alkil-acil-aminő-fenil-karbőnsav vagyszármazékai előállítására szőlgál megfelelő aminő-fenil-karbőnsav vagyszármazékának főlyadékfázisú acilezése és ezt követő N-alkilezéseútján. Az eljárás sőrán az N-alkillezést úgy főlytatják le, hőgy azacilezést reakciótermékeit tartalmazó őldathőz alkilezőszert adnak. ŕ
HU9903852A 1996-08-29 1997-08-29 Process for the preparation of contrast agents HUP9903852A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9618055.9A GB9618055D0 (en) 1996-08-29 1996-08-29 Process
PCT/GB1997/002335 WO1998008805A1 (en) 1996-08-29 1997-08-29 Process for the preparation of contrast agents

Publications (2)

Publication Number Publication Date
HUP9903852A2 true HUP9903852A2 (hu) 2000-03-28
HUP9903852A3 HUP9903852A3 (en) 2001-08-28

Family

ID=10799119

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903852A HUP9903852A3 (en) 1996-08-29 1997-08-29 Process for the preparation of contrast agents

Country Status (21)

Country Link
EP (1) EP0923537B1 (hu)
JP (1) JP4113587B2 (hu)
KR (1) KR100539647B1 (hu)
CN (1) CN1092182C (hu)
AT (1) ATE207880T1 (hu)
AU (1) AU717842B2 (hu)
BG (1) BG103288A (hu)
BR (1) BR9711358A (hu)
CA (1) CA2263426A1 (hu)
CZ (1) CZ296230B6 (hu)
DE (1) DE69707901T2 (hu)
EE (1) EE9900081A (hu)
ES (1) ES2167014T3 (hu)
GB (1) GB9618055D0 (hu)
HU (1) HUP9903852A3 (hu)
IL (1) IL128685A0 (hu)
NO (1) NO322141B1 (hu)
NZ (1) NZ334818A (hu)
PL (1) PL193698B1 (hu)
SK (1) SK26399A3 (hu)
WO (1) WO1998008805A1 (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9903109D0 (en) 1999-02-11 1999-04-07 Nycomed Imaging As Process
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
CN100344606C (zh) * 2005-12-28 2007-10-24 江苏省原子医学研究所 一种碘昔兰的制备方法
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
CN103058880B (zh) * 2011-10-21 2015-08-05 连云港润众制药有限公司 碘克沙醇及其合成中间体的制备方法
PT3077368T (pt) * 2013-12-06 2018-10-19 Ge Healthcare As Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x
WO2015082718A1 (en) * 2013-12-06 2015-06-11 Ge Healthcare As Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
CN104356023B (zh) * 2014-10-29 2016-04-13 武汉工程大学 一种碘曲仑的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2132530B1 (hu) * 1971-04-07 1974-08-02 Guerbet Lab Andre
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
EP0105752B1 (en) * 1982-10-01 1986-05-07 NYEGAARD & CO. A/S X-ray contrast agents
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
AU600672B2 (en) * 1985-08-09 1990-08-23 Guerbet Llc 2,4,6-triiodo-isophthalamides in x-ray imaging

Also Published As

Publication number Publication date
CN1228762A (zh) 1999-09-15
ATE207880T1 (de) 2001-11-15
WO1998008805A1 (en) 1998-03-05
AU4026797A (en) 1998-03-19
CZ67099A3 (cs) 1999-08-11
DE69707901D1 (de) 2001-12-06
DE69707901T2 (de) 2002-07-18
HUP9903852A3 (en) 2001-08-28
NO322141B1 (no) 2006-08-21
BG103288A (en) 2000-01-31
ES2167014T3 (es) 2002-05-01
KR100539647B1 (ko) 2005-12-29
JP2000517313A (ja) 2000-12-26
JP4113587B2 (ja) 2008-07-09
BR9711358A (pt) 1999-08-17
CA2263426A1 (en) 1998-03-05
PL331821A1 (en) 1999-08-02
GB9618055D0 (en) 1996-10-09
AU717842B2 (en) 2000-04-06
EP0923537B1 (en) 2001-10-31
PL193698B1 (pl) 2007-03-30
IL128685A0 (en) 2000-01-31
NZ334818A (en) 2000-08-25
CZ296230B6 (cs) 2006-02-15
EE9900081A (et) 1999-10-15
NO990890D0 (no) 1999-02-25
NO990890L (no) 1999-02-25
KR20000035944A (ko) 2000-06-26
EP0923537A1 (en) 1999-06-23
CN1092182C (zh) 2002-10-09
SK26399A3 (en) 2000-03-13

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