CY1106171T1 - Διαδικασια παρασκευης παραγωγου του καρβοξυλικου οξεος της ναφθυριδινης (μεθανοσουλφονικο "ενα και ημισυ" ενυδρο αλας) - Google Patents
Διαδικασια παρασκευης παραγωγου του καρβοξυλικου οξεος της ναφθυριδινης (μεθανοσουλφονικο "ενα και ημισυ" ενυδρο αλας)Info
- Publication number
- CY1106171T1 CY1106171T1 CY20061101379T CY061101379T CY1106171T1 CY 1106171 T1 CY1106171 T1 CY 1106171T1 CY 20061101379 T CY20061101379 T CY 20061101379T CY 061101379 T CY061101379 T CY 061101379T CY 1106171 T1 CY1106171 T1 CY 1106171T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- carboxylic acid
- hydrate
- methanosulfonate
- acid derivative
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 2
- SNLMOXFUCILIPL-UHFFFAOYSA-N 1,8-naphthyridine-2-carboxylic acid Chemical class C1=CC=NC2=NC(C(=O)O)=CC=C21 SNLMOXFUCILIPL-UHFFFAOYSA-N 0.000 title 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 239000012265 solid product Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μία βελτιωμένη διαδικασία παρασκευής του μεθανοσουλφονικού "ένα και ήμισυ" ένυδρου άλατος, η οποία αποκαλύπτει άμεσο σχηματισμό του ένυδρου και μη άλατος. Σύμφωνα με την εφεύρεση παρέχεται μία διαδικασία παρασκευής του μεθανοσουλφονικού "ένα και ήμισυ" ένυδρου άλατος του 7-(3-αμινομεθυλο-4-συν-μεθοξυιμινοπυρρολιδιν-1-υλο)-1-κυκλοπροπυλο-6-φθορο-4-οξο-1,4-διυδρο-1,8-ναφθυριδίνη-3-καρβοξυλικού οξέος, η οποία περιλαμβάνει αντίδραση του 7-(3-αμινομεθυλο-4-συν-μεθοξυιμινοπυρρολιδιν-1-υλο)-1-κυκλοπροπυλο-6-φθορο-4-οξο-1,4-διυδρο-1,8-ναφθυριδίνη-3-καρβοξυλικού οξέος του τύπου I, το οποίο παρουσιάζει αντιβακτηριακή δράση, με μεθανοσουλφονικό οξύ σε διαλύτη που αποτελείται από τουλάχιστον έναν αναμίξιμο με το νερό συνδιαλύτη και νερό, και απομόνωση του προκύπτοντος στερεού προϊόντος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9820405.0A GB9820405D0 (en) | 1998-09-18 | 1998-09-18 | Process |
PCT/EP1999/007003 WO2000017199A1 (en) | 1998-09-18 | 1999-09-15 | Process for the production of a naphthyridine carboxylic acid derivative (methanesulfonate sesquihydrate) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106171T1 true CY1106171T1 (el) | 2011-06-08 |
Family
ID=10839123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101379T CY1106171T1 (el) | 1998-09-18 | 2006-09-26 | Διαδικασια παρασκευης παραγωγου του καρβοξυλικου οξεος της ναφθυριδινης (μεθανοσουλφονικο "ενα και ημισυ" ενυδρο αλας) |
Country Status (25)
Country | Link |
---|---|
US (1) | US6818771B1 (el) |
EP (1) | EP1114050B1 (el) |
JP (1) | JP2002526498A (el) |
KR (1) | KR100679062B1 (el) |
CN (1) | CN1315825C (el) |
AT (1) | ATE337315T1 (el) |
AU (1) | AU751060B2 (el) |
BR (1) | BR9913858A (el) |
CA (1) | CA2344439C (el) |
CY (1) | CY1106171T1 (el) |
CZ (1) | CZ297509B6 (el) |
DE (1) | DE69932938T8 (el) |
DK (1) | DK1114050T3 (el) |
ES (1) | ES2272084T3 (el) |
GB (1) | GB9820405D0 (el) |
HK (1) | HK1038557A1 (el) |
HU (1) | HU227068B1 (el) |
IL (2) | IL141933A0 (el) |
NO (1) | NO317997B1 (el) |
NZ (1) | NZ510590A (el) |
PL (1) | PL194707B1 (el) |
PT (1) | PT1114050E (el) |
TR (1) | TR200100797T2 (el) |
WO (1) | WO2000017199A1 (el) |
ZA (1) | ZA200102160B (el) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020032216A1 (en) | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
MA24500A1 (fr) | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
CA2281817C (en) * | 1999-06-29 | 2008-07-29 | Smithkline Beecham Corporation | Methods of use of fluoroquinolone compounds against maxillary sinus pathogenic bacteria |
GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
KR20010091379A (ko) * | 2000-03-15 | 2001-10-23 | 성재갑 | 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법 |
ATE410225T1 (de) | 2001-08-02 | 2008-10-15 | Lg Life Sciences Ltd | Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze |
KR100517638B1 (ko) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
US7304069B2 (en) * | 2004-10-18 | 2007-12-04 | Neurocrine Biosciences, Inc. | Hydrate of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5α]-pyrimidin-7-yl}phenyl)acetamide and processes and methods related thereto |
US7834027B2 (en) * | 2005-06-15 | 2010-11-16 | Hetero Drugs Limited | Gemifloxacin process and polymorphs |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57134482A (en) * | 1981-02-13 | 1982-08-19 | Dainippon Pharmaceut Co Ltd | 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation |
JPH0356479A (ja) * | 1989-07-24 | 1991-03-12 | Takeshi Yokota | 水溶性キノロン誘導体のp‐トルエンスルホン酸塩 |
WO1991002526A1 (en) * | 1989-08-16 | 1991-03-07 | Pfizer Inc. | Azabicyclo quinolone carboxylic acids |
US5776944A (en) * | 1994-06-16 | 1998-07-07 | Lg Chemical Ltd. | 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof |
DK0688772T3 (da) | 1994-06-16 | 1999-11-01 | Lg Chemical Ltd | Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling |
JP3449658B2 (ja) * | 1994-12-21 | 2003-09-22 | 杏林製薬株式会社 | 安定性に優れた8−アルコキシキノロンカルボン酸水和物並びにその製造方法 |
ES2117426T3 (es) * | 1995-06-06 | 1998-08-01 | Pfizer | Forma cristalina de la sal anhidra compuesta de los acidos 7-((1a,5a,6a)-6-amino-3-azabiciclo(3.1.0.)hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilico y metanosulfonico. |
AU710984B2 (en) * | 1995-08-11 | 1999-10-07 | Pfizer Inc. | (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin -1-yl)-1-propanolmethanesulfonate trihydrate |
DK0889880T3 (da) * | 1996-03-29 | 2003-09-01 | Smithkline Beecham Corp | Eprosartan-dihydrat og fremgangsmåde til fremstilling deraf samt formulering |
US20020032216A1 (en) | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
MA24500A1 (fr) | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
KR100286874B1 (ko) | 1998-03-04 | 2001-04-16 | 성재갑 | 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법 |
PT1082300E (pt) * | 1998-05-29 | 2004-02-27 | Upjohn Co | Monometanossulfonato de 3-¬(1'-n-metilamino)etil-n-benzil|pirrolidina |
-
1998
- 1998-09-18 GB GBGB9820405.0A patent/GB9820405D0/en not_active Ceased
-
1999
- 1999-09-15 PT PT99950532T patent/PT1114050E/pt unknown
- 1999-09-15 AU AU63283/99A patent/AU751060B2/en not_active Ceased
- 1999-09-15 JP JP2000574108A patent/JP2002526498A/ja active Pending
- 1999-09-15 EP EP99950532A patent/EP1114050B1/en not_active Expired - Lifetime
- 1999-09-15 CA CA2344439A patent/CA2344439C/en not_active Expired - Lifetime
- 1999-09-15 PL PL99346656A patent/PL194707B1/pl not_active IP Right Cessation
- 1999-09-15 CN CNB998108634A patent/CN1315825C/zh not_active Expired - Lifetime
- 1999-09-15 WO PCT/EP1999/007003 patent/WO2000017199A1/en active IP Right Grant
- 1999-09-15 TR TR2001/00797T patent/TR200100797T2/xx unknown
- 1999-09-15 AT AT99950532T patent/ATE337315T1/de active
- 1999-09-15 US US09/787,256 patent/US6818771B1/en not_active Expired - Lifetime
- 1999-09-15 KR KR1020017003424A patent/KR100679062B1/ko active IP Right Grant
- 1999-09-15 DK DK99950532T patent/DK1114050T3/da active
- 1999-09-15 CZ CZ20010978A patent/CZ297509B6/cs not_active IP Right Cessation
- 1999-09-15 DE DE69932938T patent/DE69932938T8/de active Active
- 1999-09-15 BR BR9913858-1A patent/BR9913858A/pt not_active Application Discontinuation
- 1999-09-15 ES ES99950532T patent/ES2272084T3/es not_active Expired - Lifetime
- 1999-09-15 NZ NZ510590A patent/NZ510590A/en not_active IP Right Cessation
- 1999-09-15 HU HU0103914A patent/HU227068B1/hu not_active IP Right Cessation
- 1999-09-15 IL IL14193399A patent/IL141933A0/xx active IP Right Grant
-
2001
- 2001-03-09 IL IL141933A patent/IL141933A/en not_active IP Right Cessation
- 2001-03-14 NO NO20011290A patent/NO317997B1/no not_active IP Right Cessation
- 2001-03-15 ZA ZA2001/02160A patent/ZA200102160B/en unknown
- 2001-12-08 HK HK01108616A patent/HK1038557A1/xx not_active IP Right Cessation
-
2006
- 2006-09-26 CY CY20061101379T patent/CY1106171T1/el unknown
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