BR0308785A - Derivados de alcoxipiridina - Google Patents

Derivados de alcoxipiridina

Info

Publication number
BR0308785A
BR0308785A BR0308785-9A BR0308785A BR0308785A BR 0308785 A BR0308785 A BR 0308785A BR 0308785 A BR0308785 A BR 0308785A BR 0308785 A BR0308785 A BR 0308785A
Authority
BR
Brazil
Prior art keywords
substituted
derivatives
alkoxypyridine
imidazo
pyridin
Prior art date
Application number
BR0308785-9A
Other languages
English (en)
Inventor
Wolf-R Diger Ulrich
Thomas Fuchss
Johannes Barsig
Rainer Boer
Degenhard Marx
Manfrid Eltze
Thomas Klein
R Diger Nave
Ulrich Grodler
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of BR0308785A publication Critical patent/BR0308785A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

"DERIVADOS DE ALCOXIPIRIDINA". A presente invenção refere-se a compostos da fórmula (I) nos quais R1 é 1-4C-alcóxi, A é 1-4C-alquileno, B representa 3H-imidazo[4,5-b]piridin-2-ila, 3H-imidazo[4,5-b]piridin-ila substituída por R2 e/ou R8, 9H-purin-8-ila ou 9H-purin-8-ila substituída por R4 e/ou R5 são inibidores eficazes de iNOs.
BR0308785-9A 2002-03-27 2003-03-25 Derivados de alcoxipiridina BR0308785A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02007049 2002-03-27
PCT/EP2003/003076 WO2003080607A1 (en) 2002-03-27 2003-03-25 Novel alkoxypyridine-derivatives

Publications (1)

Publication Number Publication Date
BR0308785A true BR0308785A (pt) 2005-01-11

Family

ID=28051741

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308785-9A BR0308785A (pt) 2002-03-27 2003-03-25 Derivados de alcoxipiridina

Country Status (19)

Country Link
US (1) US7138399B2 (pt)
EP (1) EP1490366B1 (pt)
JP (1) JP4448695B2 (pt)
KR (1) KR20050002910A (pt)
CN (1) CN1307176C (pt)
AT (1) ATE384722T1 (pt)
AU (1) AU2003226706A1 (pt)
BR (1) BR0308785A (pt)
CA (1) CA2480385A1 (pt)
DE (1) DE60318826T2 (pt)
ES (1) ES2300599T3 (pt)
HK (1) HK1078850A1 (pt)
IL (1) IL163625A0 (pt)
MX (1) MXPA04009283A (pt)
NO (1) NO20044633L (pt)
NZ (1) NZ535959A (pt)
PL (1) PL372409A1 (pt)
WO (1) WO2003080607A1 (pt)
ZA (1) ZA200407766B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2540239A1 (en) * 2003-10-01 2005-04-07 Altana Pharma Ag Imidazo(4,5-b)pyridine-derivatives as inducible no-synthase inhibitors
NZ546437A (en) * 2003-10-01 2009-09-25 Altana Pharma Ag Imidazopyridine-derivatives as inducible NO-synthase inhibitors
MXPA06003351A (es) 2003-10-01 2006-06-08 Altana Pharma Ag Derivados de imidazopiridina como inhibidores de no-sintasa inducible.
KR20060092219A (ko) * 2003-10-01 2006-08-22 알타나 파마 아게 유도성 ｎｏ-합성효소 억제제로서의 아미노피리딘-유도체
JP2007507465A (ja) * 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト 誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体
US8088935B2 (en) 2003-12-23 2012-01-03 Ironwood Pharmaceuticals, Inc. Compounds and methods for the treatment of asthma
KR20070037578A (ko) 2004-05-28 2007-04-05 알타나 파마 아게 테트라히드로피리도티오펜
US7714134B2 (en) 2004-06-11 2010-05-11 4Sc Ag Compounds and use of tetrahydropyridothiophenes
US7714135B2 (en) 2005-02-09 2010-05-11 4Sc Ag Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
EP1851230A1 (en) 2005-02-11 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer
ES2328626T3 (es) * 2005-03-31 2009-11-16 Nycomed Gmbh Derivados de imidazopiridina utiles como inhibidores de inos.
AU2006251169A1 (en) 2005-05-25 2006-11-30 4Sc Ag Tetrahydropyridothiophenes for use in the treatment of cancer
WO2006125813A2 (en) 2005-05-25 2006-11-30 Nycomed Gmbh Tetrahydropyridothiophenes for use in the treatment of cancer
AR055669A1 (es) * 2005-10-03 2007-08-29 Astrazeneca Ab Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
AR057525A1 (es) * 2005-10-03 2007-12-05 Astrazeneca Ab Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion
WO2008031788A1 (en) * 2006-09-12 2008-03-20 Nycomed Gmbh Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase
US20080139608A1 (en) * 2006-12-06 2008-06-12 Universiteit Leiden 2,6,8, Trisubstituted 1-deazapurines and their different uses
MX348131B (es) * 2011-02-25 2017-05-26 Merck Sharp & Dohme Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos.
US9567330B2 (en) * 2011-07-15 2017-02-14 Shionogi & Co., Ltd. Azabenzimidazole derivative having AMPK-activating activity
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
SE512835C2 (sv) * 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare

Also Published As

Publication number Publication date
CN1307176C (zh) 2007-03-28
ES2300599T3 (es) 2008-06-16
JP4448695B2 (ja) 2010-04-14
EP1490366A1 (en) 2004-12-29
AU2003226706A1 (en) 2003-10-08
US20050171125A1 (en) 2005-08-04
DE60318826T2 (de) 2009-01-22
EP1490366B1 (en) 2008-01-23
MXPA04009283A (es) 2005-01-25
CA2480385A1 (en) 2003-10-02
KR20050002910A (ko) 2005-01-10
DE60318826D1 (de) 2008-03-13
ATE384722T1 (de) 2008-02-15
NO20044633L (no) 2004-12-23
IL163625A0 (en) 2005-12-18
CN1642955A (zh) 2005-07-20
JP2005525388A (ja) 2005-08-25
NZ535959A (en) 2006-05-26
WO2003080607A1 (en) 2003-10-02
ZA200407766B (en) 2006-06-28
HK1078850A1 (en) 2006-03-24
PL372409A1 (en) 2005-07-25
US7138399B2 (en) 2006-11-21

Similar Documents

Publication Publication Date Title
BR0308785A (pt) Derivados de alcoxipiridina
ATE301653T1 (de) Pyrazolopyridine
MXPA04001323A (es) Dihidro-3-halo-1h-pirazol-5-carboxilatos sustituidos, su preparacion y uso.
MA27933A1 (fr) Inhibiteurs de l'activite de akt
NO20044731L (no) Kinolin- og isokinolinderivater fremgangsmate for fremstilling derav og anvendelse derav som betennelseshemmere
AP1902A (en) N-aryl-2-oxazolidinone-5-carboxamides and their derivatives and their use as antibacterials
DE60204452D1 (de) Pyrazolo[1,5]pyridinderivate
IL158667A0 (en) Imidazo [1,2-a] pyridine derivatives for the prophylaxis and treatment of herpes viral infections
MXPA04012965A (es) Inhibidores virales.
NZ595000A (en) Imidazo[4,5-c]pyridine derivative for treating viral infections
NO20063132L (no) Naftyridinderivater og deres anvendelse som modulatorer av muskarinreceptorer
MXPA03012013A (es) Derivados de 1-oxa-2,8-diaza-spiro[4,5]dec-2-eno sustituidos como medicamento para el tratamiento de dolor.
CY1107747T1 (el) Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
DE60212949D1 (de) Antivirale pyrazolopyridin verbindungen
ATE300541T1 (de) Pyrazolopyridinderivate
NO20032841L (no) Heterocykloindol- eller azaindol-forbindelser som 5- hydroksytryptamin-6-ligander
MXPA05009688A (es) Derivados de naftiridina como agentes antibacterianos.
ATE274515T1 (de) Pyrazolopyridinderivate
DE60222465D1 (de) Pyrazolopyridin-derivate als antiherpesmittel
BR0004787A (pt) Processo para a preparação de compostos pirazolo[4,3-d] pirimidin-7-onas-3-piridilsulfonila bem como intermediários dos mesmos
DE60130009D1 (de) Makrolide
TR200101443T2 (tr) 8-siyano-1-siklopropil-7- (1S,6S-2,8-diazabisiklo[4,3,0]-nonan-8-il) -6-flüoro-1, 4-dihidro-4-okso-3-kinolinkarboksilik asidin yarı-hidroklorürü
SE0100297D0 (sv) New compounds
WO2002057286A3 (en) 9-amino erythromycin derivatives with antibacterial activity
HUP0004621A2 (hu) Egy HIV proteáz inhibitor fokozott orális felszívódást és biológiai hozzáférhetőséget mutató szulfátsója

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 7A, 8A E 9A ANUIDADES.