UY23757A1 - Procedimiento para la preparación de derivados de cefalosporina.- - Google Patents

Procedimiento para la preparación de derivados de cefalosporina.-

Info

Publication number
UY23757A1
UY23757A1 UY23757A UY23757A UY23757A1 UY 23757 A1 UY23757 A1 UY 23757A1 UY 23757 A UY23757 A UY 23757A UY 23757 A UY23757 A UY 23757A UY 23757 A1 UY23757 A1 UY 23757A1
Authority
UY
Uruguay
Prior art keywords
formula
compound
salts
hydrates
amino
Prior art date
Application number
UY23757A
Other languages
English (en)
Inventor
Peter Angehrn
Wei Chung-Chen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY23757A1 publication Critical patent/UY23757A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a derivados de la cefalosporina de fórmula general I (figura 1), en la cual R1 es un grupo acilo derivado de un ácido carboxílico; R2 es, entre otras posibilidades, un anillo heterocíclico no sustituido o sustituido con por lo menos un grupo seleccionado de entre carboxi, amino, nitro, ciano, entre otros; así como ésteres fácilmente hidrolizables de los mismos, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de fórmula I y de sus ésteres y sales. El procedimiento comprende: (a) tratar a un compuesto que posee la fórmula IID (figura 2) (b) para la obtención de un compuesto de fórmula I, o (c) para la fabricación de un éster facilmente hidrolizable de un compuesto de fórmula I someter a un ácido carboxílico de fórmula I a la esterificación correspondiente de un modo de por sí conocido, o (d) para la fabricación de sales o hidratos de un compuesto de fórmula I o hidratos de dichas sales, convertir un compuesto de fórmula I en una sal o hidrato de dichas sales de un modo de por sí conocido. Como ejemplo no limitante del compuesto: ácido [6R-[3(E), 6alfa, 7beta(7)]]-7-[[(2-amino-4-tiazolil)(hidroxiimino)acetil]-amino]-3-[1-(2-fluoroetil)-2-oxo-3-pirrolidinilideno]metil]-8-oxo-5-tia-1-azabiciclo[4.2.0]oct-2-eno-2-carboxílico. Los productos son bacterialmente activos.
UY23757A 1993-04-16 1994-04-13 Procedimiento para la preparación de derivados de cefalosporina.- UY23757A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4868893A 1993-04-16 1993-04-16

Publications (1)

Publication Number Publication Date
UY23757A1 true UY23757A1 (es) 1994-10-03

Family

ID=21955891

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23757A UY23757A1 (es) 1993-04-16 1994-04-13 Procedimiento para la preparación de derivados de cefalosporina.-

Country Status (7)

Country Link
US (1) US5523400A (es)
KR (1) KR100309516B1 (es)
EC (1) ECSP941068A (es)
RO (1) RO114965B1 (es)
TN (1) TNSN94030A1 (es)
UY (1) UY23757A1 (es)
YU (1) YU19494A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026943A1 (en) * 1995-02-27 1996-09-06 F.Hoffmann-La Roche Ag Derivatives of 3-pyrrolidylidene-2-one-cephalosporines
CZ251896A3 (en) * 1995-09-12 1997-04-16 Hoffmann Ka Roche Ag F Cephalosporin derivatives
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives
US5883247A (en) * 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
TW446707B (en) * 1996-10-22 2001-07-21 Hoffmann La Roche Cephalosporin pyridinium derivatives
EP0841339B1 (en) 1996-11-06 2007-02-21 Basilea Pharmaceutica AG Vinylpyrrolidinon cephalosporin derivatives
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
US6114541A (en) * 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
PL345266A1 (en) * 1998-06-22 2001-12-03 Hoffmann La Roche Propenyl cephalosporin derivatives
EP1067131B1 (en) 1999-07-05 2007-08-15 Basilea Pharmaceutica AG New process for the manufacture of cephalosporin derivatives
AU2003294161A1 (en) * 2003-03-20 2004-10-11 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of cefoxitin
US7105659B2 (en) * 2003-06-02 2006-09-12 Aurobind - Pharma Ltd. Process for preparing cefdinir
US20090214600A1 (en) * 2008-02-25 2009-08-27 Debrouse Daniel R Methods and compositions for gastric resistant oral formulations for intestinal delivery
EP3616695A1 (en) 2011-09-09 2020-03-04 Merck Sharp & Dohme Corp. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN105418641B (zh) * 2015-12-30 2018-08-10 广东金城金素制药有限公司 一种原研制品质头孢曲松钠及其药物制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496562A (en) * 1977-03-14 1985-01-29 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-cephem-4-carboxylic acid esters
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
US5171854A (en) * 1987-05-26 1992-12-15 Bayer Aktiengesellschaft Substituted vinylcephalosporins
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
EP0620225B1 (en) * 1993-04-16 2002-11-13 Basilea Pharmaceutica AG Cephalosporin derivatives

Also Published As

Publication number Publication date
ECSP941068A (es) 1994-11-16
YU19494A (sh) 1998-05-15
KR100309516B1 (ko) 2006-05-25
US5523400A (en) 1996-06-04
TNSN94030A1 (fr) 1995-04-25
RO114965B1 (ro) 1999-09-30

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Legal Events

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VENC Patent expired

Effective date: 20141115