DE68914326D1 - Verfahren zur Herstellung 3-substituierter Methyl-3-cephem-4-carboxyl-Säure. - Google Patents

Verfahren zur Herstellung 3-substituierter Methyl-3-cephem-4-carboxyl-Säure.

Info

Publication number
DE68914326D1
DE68914326D1 DE89305204T DE68914326T DE68914326D1 DE 68914326 D1 DE68914326 D1 DE 68914326D1 DE 89305204 T DE89305204 T DE 89305204T DE 68914326 T DE68914326 T DE 68914326T DE 68914326 D1 DE68914326 D1 DE 68914326D1
Authority
DE
Germany
Prior art keywords
carboxylic acid
cephem
pharmaceutically acceptable
acceptable salt
substituted methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89305204T
Other languages
English (en)
Other versions
DE68914326T2 (de
Inventor
Kentaro Fukuzaki
Wataru Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of DE68914326D1 publication Critical patent/DE68914326D1/de
Publication of DE68914326T2 publication Critical patent/DE68914326T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
DE68914326T 1988-05-24 1989-05-23 Verfahren zur Herstellung 3-substituierter Methyl-3-cephem-4-carboxyl-Säure. Expired - Fee Related DE68914326T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12487988 1988-05-24

Publications (2)

Publication Number Publication Date
DE68914326D1 true DE68914326D1 (de) 1994-05-11
DE68914326T2 DE68914326T2 (de) 1994-07-21

Family

ID=14896353

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914326T Expired - Fee Related DE68914326T2 (de) 1988-05-24 1989-05-23 Verfahren zur Herstellung 3-substituierter Methyl-3-cephem-4-carboxyl-Säure.

Country Status (6)

Country Link
US (1) US5034521A (de)
EP (1) EP0343926B1 (de)
JP (1) JP2612493B2 (de)
AT (1) ATE103922T1 (de)
DE (1) DE68914326T2 (de)
ES (1) ES2061992T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4004370A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verfahren zur herstellung von 7-amino-3-methoxymethyl-ceph-3-em-4-carbonsaeure
ATE123286T1 (de) 1990-11-07 1995-06-15 Sankyo Co Verfahren zur herstellung von 3-alkoxymethyl cephalosporinderivate.
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
KR100343434B1 (ko) * 1999-10-13 2002-07-11 민경윤 7-아미노-3-메톡시메틸-3-세펨-4-카복실산의 제조방법
EP2758407A1 (de) 2011-09-20 2014-07-30 Dhanuka Laboratories Ltd. Verbessertes verfahren für cefpodoximsäure
WO2017153824A1 (en) 2016-03-07 2017-09-14 Dhanuka Laboratories Ltd. A process for alkylating the hydroxymethyl group at position -3 of cephalosporins

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1241656A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
US3948906A (en) * 1967-08-21 1976-04-06 Glaxo Laboratories Limited Cephalosporin compounds
GB1241657A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
US3846416A (en) * 1967-08-21 1974-11-05 Glaxo Lab Ltd Cephalosporin compounds
JPS57192392A (en) * 1981-05-19 1982-11-26 Sankyo Co Ltd Production of 3-alkoxymethylcephalosporin
JPS5896091A (ja) * 1981-12-01 1983-06-07 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリン類の製造法
JPS59163387A (ja) * 1983-03-07 1984-09-14 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリンの製造方法
AT384222B (de) * 1985-06-03 1987-10-12 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren
DE3789412T2 (de) * 1986-10-02 1994-06-30 Asahi Chemical Ind Verfahren zur Herstellung von 3-Alkoxymethylcephalosporinen.
JPS63115887A (ja) * 1986-11-04 1988-05-20 Asahi Chem Ind Co Ltd ７−アミノ−３−アルコキシメチルセフアロスポリン類の製造方法

Also Published As

Publication number Publication date
EP0343926A2 (de) 1989-11-29
EP0343926B1 (de) 1994-04-06
US5034521A (en) 1991-07-23
JPH0249790A (ja) 1990-02-20
JP2612493B2 (ja) 1997-05-21
DE68914326T2 (de) 1994-07-21
EP0343926A3 (de) 1991-08-28
ATE103922T1 (de) 1994-04-15
ES2061992T3 (es) 1994-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee