ES2061992T3 - Procedimiento para la preparacion de acido metil-3-cefem-4-carboxilico substituido en posicion 3. - Google Patents

Procedimiento para la preparacion de acido metil-3-cefem-4-carboxilico substituido en posicion 3.

Info

Publication number
ES2061992T3
ES2061992T3 ES89305204T ES89305204T ES2061992T3 ES 2061992 T3 ES2061992 T3 ES 2061992T3 ES 89305204 T ES89305204 T ES 89305204T ES 89305204 T ES89305204 T ES 89305204T ES 2061992 T3 ES2061992 T3 ES 2061992T3
Authority
ES
Spain
Prior art keywords
carboxylic acid
methyl
cephem
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89305204T
Other languages
English (en)
Inventor
Kentaro Fukuzaki
Wataru Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2061992T3 publication Critical patent/ES2061992T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

UN NUEVO PROCESO PARA PREPARAR ACIDO - 3 - SUSTITUIDO METIL 3 -CEFEM - 4 - CARBOXILICO EN SAL FARMACEUTICAMENTE ACEPTABLE. EL PROCESO COMPRENDE LA REACCION DE UN ACIDO 3 - ACETOXIMETIL 3 -CEFEM - 4 - CARBOXILICO O SU SAL FARMACEUTICAMENTE ACEPTABLE CON UN COMPUESTO ESPECIFICO TAL COMO UN ACETAL, EN PRESENCIA DE AL MENOS UN CATALIZADOR ESPECIFICO SELECCIONADO DEL GRUPO CONSISTENTE EN ACIDOS LEWIS O COMPLEJOS DE ESTO, ACIDOS PROTONICOS Y MEZCLAS DE ESTO. EN EL PROCESO LA FORMACION DE IMPUREZAS, TAL COMO LACTONA, SE IMPIDE SUFICIENTEMENTE SIN PROTEECCION DEL ACIDO CARBOXILICO, DE MODO QUE EL PRODUCTO DE ALTA PUREZA DESEADO, P.E. UN ACIDO 3 - SUSTITUIDO -METIL 3 CEFEM - 4 CARBOXILICO O SU SAL FARMACEUTICAMENTE ACEPTABLE, QUE ES UTIL COMO INTERMEDIO PARA VARIOS ANTIBIOTICOS DE CEFALOPLASMA CON EXCELENTE ACTIVIDAD ANTIMICROBIANA, PUEDE SER PREPARADO EN UNA ETAPA CON ALTO RENDIMIENTO.
ES89305204T 1988-05-24 1989-05-23 Procedimiento para la preparacion de acido metil-3-cefem-4-carboxilico substituido en posicion 3. Expired - Lifetime ES2061992T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12487988 1988-05-24

Publications (1)

Publication Number Publication Date
ES2061992T3 true ES2061992T3 (es) 1994-12-16

Family

ID=14896353

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89305204T Expired - Lifetime ES2061992T3 (es) 1988-05-24 1989-05-23 Procedimiento para la preparacion de acido metil-3-cefem-4-carboxilico substituido en posicion 3.

Country Status (6)

Country Link
US (1) US5034521A (es)
EP (1) EP0343926B1 (es)
JP (1) JP2612493B2 (es)
AT (1) ATE103922T1 (es)
DE (1) DE68914326T2 (es)
ES (1) ES2061992T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4004370A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verfahren zur herstellung von 7-amino-3-methoxymethyl-ceph-3-em-4-carbonsaeure
ATE123286T1 (de) 1990-11-07 1995-06-15 Sankyo Co Verfahren zur herstellung von 3-alkoxymethyl cephalosporinderivate.
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
KR100343434B1 (ko) * 1999-10-13 2002-07-11 민경윤 7-아미노-3-메톡시메틸-3-세펨-4-카복실산의 제조방법
WO2013041999A1 (en) 2011-09-20 2013-03-28 Dhanuka Laboratories Ltd. An improved process for cefpodoxime acid
EP3426663B1 (en) 2016-03-07 2020-01-29 Dhanuka Laboratories Ltd. A process for alkylating the hydroxymethyl group at position -3 of cephalosporins

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1241657A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
GB1241656A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
US3846416A (en) * 1967-08-21 1974-11-05 Glaxo Lab Ltd Cephalosporin compounds
US3948906A (en) * 1967-08-21 1976-04-06 Glaxo Laboratories Limited Cephalosporin compounds
JPS57192392A (en) * 1981-05-19 1982-11-26 Sankyo Co Ltd Production of 3-alkoxymethylcephalosporin
JPS5896091A (ja) * 1981-12-01 1983-06-07 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリン類の製造法
JPS59163387A (ja) * 1983-03-07 1984-09-14 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリンの製造方法
AT384222B (de) * 1985-06-03 1987-10-12 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren
ES2061485T3 (es) * 1986-10-02 1994-12-16 Asahi Chemical Ind Procedimiento para la fabricacion de 3-alcoximetilcefalosporinas.
JPS63115887A (ja) * 1986-11-04 1988-05-20 Asahi Chem Ind Co Ltd ７−アミノ−３−アルコキシメチルセフアロスポリン類の製造方法

Also Published As

Publication number Publication date
EP0343926A2 (en) 1989-11-29
ATE103922T1 (de) 1994-04-15
EP0343926A3 (en) 1991-08-28
JPH0249790A (ja) 1990-02-20
US5034521A (en) 1991-07-23
JP2612493B2 (ja) 1997-05-21
DE68914326T2 (de) 1994-07-21
DE68914326D1 (de) 1994-05-11
EP0343926B1 (en) 1994-04-06

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